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| 1 | Mitochondrial neuronal uncoupling proteins:a target for potential disease-modification in Parkinson’s disease Philip显示文摘This review gives a brief insight into the role of mitochondrial dysfunction and oxidative stress in the converging pathogenic processes involved in Parkinson’s disease(PD).Mitochondria provide cellular energy in the form of ATP via oxidative phosphorylation,but as an integral part of this process,superoxides and other reactive oxygen species are also produced.Excessive free radical production contributes to oxidative stress.Cells have evolved to handle such stress via various endogenous anti-oxidant proteins.One such family of proteins is the mitochondrial uncoupling proteins(UCPs),which are anion carriers located in the mitochondrial inner membrane.There are five known homologues(UCP1 to 5),of which UCP4 and 5 are predominantly expressed in neural cells.In a series of previous publications,we have shown how these neuronal UCPs respond to 1-methyl-4-phenylpyridinium(MPP+;toxic metabolite of MPTP)and dopamine-induced toxicity to alleviate neuronal cell death by preserving ATP levels and mitochondrial membrane potential,and reducing oxidative stress.We also showed how their expression can be influenced by nuclear factor kappa-B(NF-B)signaling pathway specifically in UCP4.Furthermore,we previously reported an interesting link between PD and metabolic processes through the protective effects of leptin(hormone produced by adipocytes)acting via UCP2 against MPP+-induced toxicity.There is increasing evidence that these endogenous neuronal UCPs can play a vital role to protect neurons against various pathogenic stresses including those associated with PD.Their expression,which can be induced,may well be a potential therapeutic target for various drugs to alleviate the harmful effects of pathogenic processes in PD and hence modify the progression of this disease. | WL Ho Jessica WM Ho Hui-Fang Liu Danny HF So Zero HM Tse Koon-Ho Chan David B Ramsden Shu-Leong Ho | 2012 | Translational Neurodegeneration2012，1，1： | 3 |
| 2 | An innovative design for using flexible printed coils for magnetostrictive-based longitudinal guided wave sensors in steel strand inspection显示文摘 | Tse P W Liu X C Liu Z H Wu B He C F Wang XJ | 2011 | Smart Materials and Structures2011，20，05： | 1 |
| 3 | The SF-36 summary scales were valid, reliable, and equivalent in a Chinese population 显示文摘 | Lain CL Tse EY Gandek B | 2005 | J Clin Epidemiol2005，58，8： | 1 |
| 4 | The SF-36 summary scales were valid, reliable, and equivalent in a Chinese population显示文摘 | Lam CL Tse EY Gandek B | 2005 | J Clin Epidemiol2005，58，8： | 1 |
| 5 | Aconitine poisoning due to Chinese herbal medicines : a review 显示文摘 | Chan TYK Tomlinson B Tse LK | 1994 | Vet Hum Toxi- col1994，36，5： | 1 |
| 6 | Enhanced localization of osteoid osteoma with radiolabeling and intraoperative gamma counter guidance:a case report显示文摘 | Tse WL Hung LK Law B | 2003 | J Hand Surg(Am)2003，28，4： | 1 |
| 7 | Relationship Marketing Orientation:Scale Development and Cross-cuhural Validation显示文摘 | SIN L Y M TSE A C B YAU O H M | 2005 | Journal of Business Research2005，58，2： | 1 |
| 8 | The effects of stra- tegic orientations on technology-and market-based break-through innovations显示文摘 | Zhou K Z Yim C K B Tse D K | 2005 | Joumal of Marketing2005，29，2： | 1 |
| 9 | Accelerated atherosclerosis and premature calcified cartilaginous metaplasia in the aorta of diabetic male ApoE knockout mice can be prevented by chronic treatment with 17 beta-estradiol显示文摘 | TSE J MARTIN-MCNAULTY B HALKS-MILLER M | 1999 | Atherosclerosis1999，144，： | 1 |
| 10 | Epidemiology of basal-like breast cancer 显示文摘 | Millikan RC Newman B Tse C-K | 2008 | Breast Cancer Res Treat2008，109，1： | 1 |
| 11 | Mucinous breast lesions:diagnostic challenges显示文摘 | Tan P H Tse G M Bay B H | 2008 | J Clin Pathol2008，61，1： | 1 |
| 12 | Isoprenoid biosyn- thesis via themethylerythritol phosphate pathway: The (E)-4-hydroxy-3-methylbut-2-enyl diphosphate reductase (LytB/IspH) from Escherichia coli is a protein 显示文摘 | Wolff M Seernann M Tse B S B | 2003 | FEBS Lett2003，541，： | 1 |
| 13 | Ac- celerated atherosclerosis and premature calcified cartilagi- nous metaplasia in the aorta of diabetic male Apo E knockout mice can be prevented by chronic treatment with 17 beta-estradiol 显示文摘 | Tse J Martin-McNaulty B Halks-Miller M | 1999 | Atherosclerosis1999，144，2： | 1 |
| 14 | Prophylactic nasogastric decompression after abdominal surgery显示文摘 | Nelson R Edwards S Tse B | 2007 | Cochrane Database Syst Rev2007，18，00： | 1 |
| 15 | Epidemiology of basal-like breast cancer显示文摘 | Millikan RC Newman B Tse C-K | 2008 | Breast Cancer Res Treat2008，109，1： | 1 |
| 16 | Radiofrequency catheter ablation of inappropriate sinus tachycardia guided by activation mapping显示文摘 | Man KC Kaight B Tse HF | 2000 | J Am Coll Cardiol2000，25，： | 1 |
| 17 | Thermally switchable periodici ties and diffraction from mesoscopically ordered materials 显示文摘 | Weissman J M Sunkara H B Tse A S | 1996 | Science1996，274，： | 1 |
| 18 | Disintermediation of Travel Agents in the Hotel Industry 显示文摘 | TSE C B | 2003 | International Journal of Hospitality Management2003，22，4： | 1 |
| 19 | Diagnosis, management, and prognosis of preschool wheeze显示文摘 | DUCHARME F M TSE S M CHAUHAN B | 2014 | Lancet2014，383，9928： | 1 |
| 20 | Do traditional Chinese cultural values nourish a market for pirated CDs ? 显示文摘 | Wan W W N Luk C-L Yau O H M Tse A C B Sin L Y M Kwong K K Chow R M | 2009 | Journal of Business Ethics2009，88，1： | 1 |
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