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| 1 | Circulating lymphangiogenic growth factors in gastrointestinal solid tumors, could they be of any clinical significance?显示文摘Metastasis is the principal cause of cancer mortality, with the lymphatic system being the first route of tumor dissemination. The glycoproteins VEGF-C and VEGF-D are members of the vascular endothelial growth factor (VEGF) family, whose role has been recently recognized as lymphatic system regulators during embryogenesis and in pathological processes such as inflammation, lymphatic system disorders and malignant tumor metastasis. They are ligands for the VEGFR-3 receptor on the membrane of the lymphatic endothelial cell, resulting in dilatation of existing lymphatic vessels as well as in vegetation of new ones (lymphangiogenesis). Their determination is feasible in the circulating blood by immunoabsorption and in the tissue specimen by immunohistochemistry and reverse transcription polymerase chain reaction (RT-PCR). Experimental and clinicopathological studies have linked the VEGF-C, VEGF-D/VEGFR3 axis to lymphatic spread as well as to the clinical outcome in several human solid tumors. The majority of these data are derived from surgical specimens and malignant cell series, rendering their clinical application questionable, due to subjectivity factors and post-treatment quantification. In an effort to overcome these drawbacks, an alternative method of immunodetection of the circulating levels of these molecules has been used in studies on gastric, esophageal and colorectal cancer. Their results denotethat quantification of VEGF-C and VEGF-D in blood samples could serve as lymph node metastasis predictive biomarkers and contribute to preoperative staging of gastrointestinal malignancies. | Theodore D Tsirlis George Papastratis Kyriaki Masselou Christos Tsigris Antonis Papachristodoulou Alkiviadis Kostakis Nikolaos I Nikiteas | 2008 | World Journal of Gastroenterology2008，14，17： | 12 |
| 2 | Malignant carcinoid tumor of the cystic duct:a rare cause of bile duct obstruction显示文摘BACKGROUND:Carcinoid tumors of the extrahepatic biliary tree are extremely rare malignancies,accounting for 0.2%-2%of all gastrointestinal carcinoid tumors,while carcinoids of the cystic duct are an uncommon entity and an extremely unusual cause of bile duct obstruction.METHODS:After an extensive literature review,we retrospectively analysed 61 cases of carcinoid tumor of the biliary tree as well as one additional case of a 60-yearold female with symptoms and laboratory/imaging examination findings compatible with those of a malignant biliary tract obstruction.At laparotomy,resection of the gallbladder and common bile duct was performed.Histological study revealed a well-differentiated neuroendocrine carcinoma of the cystic duct.The patient remained disease-free at 16 months.RESULTS:Our presentation is the seventh case reported in the world literature.Compared to cholangiocarcinoma,analysis of the reviewed group indicates an increased incidence of extrahepatic carcinoid tumors in younger persons along with a slight female predominance.Statistically,the most common anatomic location is the common bile duct,followed by the perihilar region and the cystic duct.Jaundice is the most common finding.Curative surgery was realized in the majority of cases and longterm disease-free survival was achieved when surgery was curative.CONCLUSIONS:Carcinoid tumors obstructing the biliary tree are extremely difficult to diagnose preoperatively,and nearly impossible to differentiate from non-neuroendocrine tumors.As surgery offers the only potential cure for both biliary carcinoids and cholangiocarcinoma,we recommend aggressive surgical therapy as the treatment of choice in every case of potentially resectable biliary tumor. | Evangelos Felekouras Athanasios Petrou Konstantinos Bramis Evangelos Prassas Ioannis Papaconstantinou Nikoleta Dimitriou Anastasia Pazaiti Christos Tsigris Athanasios Giannopoulos | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，6： | 5 |
| 3 | Barrett's esophagus with high-grade dysplasia:Focus on current treatment options显示文摘High-grade dysplasia(HGD) in Barrett's esophagus(BE) is the critical step before invasive esophageal adenocarcinoma.Although its natural history remains unclear,an aggressive therapeutic approach is usually indicated.Esophagectomy represents the only treatment able to reliably eradicate the neoplastic epithelium.In healthy patients with reasonable life expectancy,vagal-sparing esophagectomy,with associated low mortality and low early and late postoperative morbidity,is considered the treatment of choice for BE with HGD.Patients unfit for surgery should be managed in a less aggressive manner,using endoscopic ablation or endoscopic mucosal resection of the entire BE segment,followed by lifelong surveillance.Patients eligible for surgery who present with a long BE segment,multifocal dysplastic lesions,severe reflux symptoms,a large fixed hiatal hernia or dysphagia comprise a challenging group with regard to the appropriate treatment,either surgical or endoscopic. | Leonidas Lekakos Nikolaos P Karidis Dimitrios Dimitroulis Christos Tsigris Gregory Kouraklis Nikolaos Nikiteas | 2011 | World Journal of Gastroenterology2011，17，37： | 2 |
| 4 | Improvement of skingraftsurvival after autologous transplantation of adipose-derivedstem cells in rats显示文摘 | Zografou A Tsigris C Papadopoulos O | 2011 | J Plast Reconstr Aesthet Surg2011，64，： | 1 |
| 5 | Improvement of transplantation of adipose-derived stem cells in rats 显示文摘 | Zografou skin-graft A Tsigris C Papadopoulos O et survival after autologous al | 2011 | J Plast Reconstr Aesthet Surg2011，64，12： | 1 |
| 6 | Open tension-free hernia repair in soccer players:preservation or primary neurectomy of the ilioinguinal nerve?显示文摘 | Zieren J Tsigris C Menenakos C | 2007 | Clin J Sport Med2007，17，5： | 1 |
| 7 | Fibrinolytic and coagulation pathways after laparoscopic and open surgery : a pro- spective randomized trial 显示文摘 | Tsiminikakis N Chouillard E Tsigris C | 2009 | Surg Endosc2009，23，12： | 1 |
| 8 | No association with risk for colorectal cancer of the inser- tion/deletion polymorphism which affects levels of an- giotensin-converting enzyme显示文摘 | Nikiteas N Tsigris C Chatzitheofylaktou A | 2007 | In vivo2007，21，6： | 1 |
| 9 | Bile duct injuries associated with laparoscopic and open cholecystectomy:an 11-year experience in one institute显示文摘 | Diamantis T Tsigris C Kiriakopoulos A | | 0，，10： | 1 |
| 10 | NF-κB signaling at the cross- roads of inflammation and atherogenesis : searching for new therapeutic links 显示文摘 | Pateras I Giaginis C Tsigris C | 2014 | Expert Opin Ther Targets2014，18，10： | 1 |
| 11 | No associ ation with risk for colorectal cancer of the insertion/deletion polymorphism which affects levels of angiotensin converting enzyme显示文摘 | Nikiteas N Tsigris C Chatzitheofylaktou A | 2007 | In Vivo2007，21，6： | 1 |
| 12 | Autologous transplantation of adipose-derived stem cells enhances skin graft survival and wound healing in diabetic rats显示文摘 | Zografou A Papadopoulos O Tsigris C | 2013 | Ann Plast Surg2013，71，2： | 1 |
| 13 | Increased incidence of papillary thyroid cancer detection among thyroidectomies in Greece between 1991 and 2006 显示文摘 | Griniatsos J Tsigris C Kanakis M | 2009 | Anticancer Res2009，29，12： | 1 |
| 14 | NF - KB signaling at the crossroads of inflammation and atherogenesis: searching for new therapeutic links显示文摘 | Pateras I Giaginis C Tsigris C | 2014 | Expert Opin Ther Targets2014，18，9： | 1 |
| 15 | Laparoscopic cholecystecto- my in cirrhotic patients with symptomatic gallstone disease 显示文摘 | Leandros E Albanopoulos K Tsigris C | 2008 | ANZ J Surg2008，78，5： | 1 |
| 16 | Association of angiotensin converting enzyme gene insertion/deletion polymorphism with increased risk for oral cancer显示文摘 | Vairaktaris E Yapijakis C Tsigris C | 2007 | Acta Oncol2007，46，8： | 1 |
| 17 | Association of angiotensin- converting enzyme gene insertion/deletion polymorphism with increased risk for oral cancer 显示文摘 | Vairaktaris E Yapijakis C Tsigris C | 2007 | Acta Oncol2007，46，8： | 1 |
| 18 | Improvement of skin-graft survival after autologous transplantation of adipose-derived stem cells in rats显示文摘 | Zografou A Tsigris C Papadopoulos O | 2011 | J Plas Reconstr Aesthet Surg2011，64，12： | 1 |
| 19 | Clinical significance of serum and urinary c+HER2 levels in colorectal cancer 显示文摘 | Tsigris C Karayiannakis A J Zbar A | 2002 | Cancerett2002，184，2： | 1 |
| 20 | Laparoscopic adrenalectomy:where do we stand now?显示文摘 | Karanikola E Tsigris C Kontzoglou K | 2010 | Tohoku J Exp Med2010，220，4： | 1 |
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