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| 1 | Does Helicobacter pylori eradication therapy for peptic ulcer prevent gastric cancer?显示文摘AIM:To investigate the effects of Helicobacter pylori (H pylori)eradication therapy for treatment of peptic ulcer on the incidence of gastric cancer. METHODS:A multicenter prospective cohort study was conducted between November 2000 and December 2007 in Yamagata Prefecture,Japan.The study included patients with H pylori-positive peptic ulcer who decided themselves whether to receive H pylori eradication(eradication group)or conventional antacid therapy(non-eradication group).Incidence of gastric cancer in the two groups was determined based on the results of annual endoscopy and questionnaire surveys,as well as Yamagata Prefectural Cancer Registry data,and was compared between the two groups and by results of H pylori therapy.RESULTS:A total of 4133 patients aged between 13 and 91 years(mean 52.9 years)were registered,and 56 cases of gastric cancer were identified over a mean follow-up of 5.6 years.The sex-and age-adjusted incidence ratio of gastric cancer in the eradication group, as compared with the non-eradication group,was 0.58 (95%CI:0.28-1.19)and ratios by follow-up period(<1 year,1-3 years,>3 years)were 1.16(0.27-5.00),0.50 (0.17-1.49),and 0.34(0.09-1.28),respectively.Longer follow-up tended to be associated with better prevention of gastric cancer,although not to a significant extent.No significant difference in incidence of gastric cancer was observed between patients with successful eradication therapy(32/2451 patients,1.31%)and those with treatment failure(11/639 patients,1.72%).Among patients with duodenal ulcer,which is known to be more prevalent in younger individuals,the incidence of gastric cancer was significantly less in those with successful eradication therapy(2/845 patients,0.24%)than in those with treatment failure(3/216 patients,1.39%). CONCLUSION:H pylori eradication therapy for peptic ulcer patients with a mean age of 52.9 years at registration did not significantly decrease the incidence of gastric cancer. | Katsuhiro Mabe Mikako Takahashi Haruhumi Oizumi Hideaki Tsukuma Akiko Shibata Kazutoshi Fukase Toru Matsuda Hiroaki Takeda Sumio Kawata | 2009 | World Journal of Gastroenterology2009，15，34： | 10 |
| 2 | Phase Ⅱ study of protracted irinotecan infusion and a low-dose cisplatin for metastatic gastric cancer显示文摘AIM: To test protracted irinotecan infusion plus a low-dose cisplatin in this Phase Ⅱ trial to decrease its toxic-ity. METHODS: The eligibility criteria were: (1) histologi-cally proven measurable gastric cancer; (2) performance status of 0 or 1; (3) no prior chemotherapy or comple-tion of prior therapy at least 4 wk before enrollment; (4) adequate function of major organs; (5) no other active malignancy; and (6) written informed consent. The regi-men consisted of irinotecan (60 mg/m2) on d 1 and 15 by 24-h infusion and cisplatin (10 mg/m2) on d 1, 2, 3, 15, 16, and 17. Treatment was repeated every 4 wk. RESULTS: Thirty-one patients were registered between April 2000 and January 2001. The response rate for all 31 patients, 20 patients without prior chemotherapy, and 11 patients with prior chemotherapy was 52% (16/31), 60% (12/20), and 36% (4/11), respectively. The median survival time was 378 d. The median number of courses given to all patients was 2. Grade 4 neutropenia oc-curred in 11 (35%) patients, while grade 3 to 4 diarrhea or nausea occurred in 1 (3%) and 3 (10%) patients, respectively. Fatigue was minimal as grade 1 fatigue was found only in 3 (10%) patients. Other adverse events were mild and no treatment-related deaths occurred.CONCLUSION: This regimen showed a high level of ac-tivity and acceptable toxicity in patients with metastatic gastric cancer. | Hiroshi Imamura Masataka Ikeda Hiroshi Furukawa Toshimasa Tsujinaka Kazumasa Fujitani Kenji Kobayashi Hiroyuki Narahara Michio Kato Haruhiko Imamoto Arimichi Takabayashi Hideaki Tsukuma | 2006 | World Journal of Gastroenterology2006，12，40： | 7 |
| 3 | Longterm outcomes after endoscopic mucosal resection for early gastric cancer显示文摘 | Noriya Uedo Hiroyasu Iishi Masaharu Tatsuta Ryu Ishihara Koji Higashino Yoji Takeuchi Kazuho Imanaka Takuya Yamada Sachiko Yamamoto Shunsuke Yamamoto Hideaki Tsukuma Shingo Ishiguro | 2006 | Gastric Cancer2006，，2： | 2 |
| 4 | Longterm outcomes after endoscopic mucosal resection for early gastric cancer显示文摘 | Noriya Uedo Hiroyasu Iishi Masaharu Tatsuta Ryu Ishihara Koji Higashino Yoji Takeuchi Kazuho Imanaka Takuya Yamada Sachiko Yamamoto Shunsuke Yamamoto Hideaki Tsukuma Shingo Ishiguro | 2006 | Gastric Cancer2006，，2： | 2 |
| 5 | Suicide risk among cancer patients: experience at one medical center in Japan,1978-1994显示文摘 | Tanaka H Tsukuma H Masaoka T | 1999 | JpnJ Cancer Res1999，90，8： | 1 |
| 6 | Relationship between the duration of the preoperalive smoke-free period and the incidence of postoperative pulmonary complicalions after pulmonary surgery 显示文摘 | Nakagawa M Tanaka H Tsukuma H | 2001 | Chest2001，120，3： | 1 |
| 7 | Descriptive epidemiology of colorectal cancer--international comparison显示文摘 | Tsukuma H Ajiki W | | 0，，07： | 1 |
| 8 | Natural history of early gastric cancer:a non-concurrent, long term, follow up study显示文摘 | Tsukuma H Oshima A Narahara H | 2000 | Gut2000，47，5： | 1 |
| 9 | Natural history of colorectal polyps and the effect of polypectomy on occurrence of subsequent cancer 显示文摘 | Murakami R Tsukuma H Kanamori S | 1990 | Int J Cancer1990，46，2： | 1 |
| 10 | Descriptive and analytical epidemiology of second primaries in Osaka, Japan 显示文摘 | Tanaka H Koyama Y | 1999 | Gan To Kagaku Ryoho1999，26，13： | 1 |
| 11 | Descriptive epidemiology of colorectalcancer - international comparison显示文摘 | TSUKUMA H AJIKI W | 2003 | Nippon Rinsho2003，61，： | 1 |
| 12 | Risk factors for hepatocellular carcinoma among patients with chronic liver disease显示文摘 | Tsukuma H Hiyama T Tanaka S Nakao M Yabuuchi T Kitamura T | | New England Journal of Medicine0，，： | 1 |
| 13 | Descriptive epidemiology of colorectal cancer - International comparison 显示文摘 | Hideaki Tsukuma Wakiko Ajiki | 2003 | Nippon Rinsho2003，61，7： | 1 |
| 14 | Influence of age on cervi- cal smwival in Japan显示文摘 | loka A Tsukuma H Ajiki W | 2005 | Jpn J Clin Oncol2005，35，8： | 1 |
| 15 | Survival of cancer patients diagnosed between 1993 and 1996 : a collaborative study of pop- ulation based cancer registries in Japan 显示文摘 | Tsukuma H Ajiki W Ioka A | 2006 | Jpn J Clin Oncol2006，36，9： | 1 |
| 16 | Estimation of individ- ualized probabilities of developing breast cancer for Japanese women显示文摘 | Ueda K Tsukuma H Tanaka H | 2003 | Breast Cancer2003，10，1： | 1 |
| 17 | Relationship between the duration of the preoperative smokE-free period and the incidence of postoperative pulmonary complications after pulmonary surgery显示文摘 | Nakagawa M Tanaka H Tsukuma H | 2001 | Chest2001，120，3： | 1 |
| 18 | Natuaral history of early gastric cancer: a non - concurent, long term, follow up study 显示文摘 | Tsukuma H Oshima A Narahara H | 2000 | Gut2000，47，： | 1 |
| 19 | Descriptive epidemiology of colorectal cancer-international comparison 显示文摘 | Tsukuma H Ajiki W | 2003 | Nippon Rinsho2003，61，7： | 1 |
| 20 | Risk factors for hepatocellular carcinoma among patients with chronic liver disease显示文摘 | Tsukuma H Hiyama T Tanaka S | 1993 | N Engl J Med1993，24，328： | 1 |
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