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| 1 | Nonalcoholic fatty liver disease in patients with inflammatory bowel disease: Beyond the natural history显示文摘BACKGROUND Nonalcoholic fatty liver disease(NAFLD)is a frequently reported condition in patients with inflammatory bowel disease(IBD).Both intestinal inflammation and metabolic factors are believed to contribute to the pathogenesis of IBDassociated NAFLD.AIM To evaluate the prevalence of steatosis and liver fibrosis(LF)in a cohort of IBD patients and the identification of metabolic-and IBD-related risk factors for NAFLD and LF.METHODS IBD patients were consecutively enrolled from December 2016 to January 2018.Demographic,anthropometric and biochemical data were collected so as eating habits.Abdominal ultrasound and transient elastography were performed to evaluate the presence of NAFLD and LF respectively.RESULTS A total of 178 consecutive patients were enrolled and included in the analysis(95 Ulcerative colitis,83 Crohn’s disease).NAFLD was detected by imaging in 72(40.4%)patients.Comparison between patients with and without NAFLD showed no significant differences in terms of IBD severity,disease duration,location/extension,use of IBD-related medications(i.e.,steroids,anti-TNFs,and immunomodulators)and surgery.NAFLD was significantly associated with the presence of metabolic syndrome[MetS;odds ratio(OR):4.13,P=0.001]and obesity defined by body mass index(OR:9.21,P=0.0002).IBD patients with NAFLD showed higher caloric intake and lipid consumption than those without NAFLD,regardless disease activity.At the multivariate analysis,male sex,advanced age and high lipid consumption were independent risk factors for the development of NAFLD.An increased liver stiffness was detected in 21 patients(16%)and the presence of MetS was the only relevant factor associated to LF(OR:3.40,P=0.01).CONCLUSION In this study,we demonstrate that risk factors for NAFLD and LF in the IBD population do not differ from those in the general population. | Salvatore Magrì Danilo Paduano Fabio Chicco Arianna Cingolani Cristiana Farris Giovanna Delogu Francesca Tumbarello Mariantonia Lai Alessandro Melis Laura Casula Massimo C Fantini Paolo Usai | 2019 | World Journal of Gastroenterology2019，25，37： | 8 |
| 2 | Predictors of mortality in patients with bloodstream infections caused by extended-spectrum-beta-lactamase-producing Entero- bacteriaceae: importance of inadequate initial antimicrobial treatment 显示文摘 | Tumbarello M Sanguinetti M Montuori E | 2007 | Antimicrob Agents Chemother2007，51，6： | 1 |
| 3 | Costs of blood- stream infections caused by Escherichia coli and influence of ex- tended-spectrum-beta-lactamase production and inadequate initial antibiotic therapy 显示文摘 | Tumbarello M Spanu T Di Bidino R | 2010 | Antimicrob Agents Chemother2010，54，10： | 1 |
| 4 | Predictors of Mortality in Bloodstream Infections Caused by Klebsiella pneumoniae Carbapenemase–Producing K. pneumoniae: Importance of Combination Therapy显示文摘 | Mario Tumbarello Pierluigi Viale Claudio Viscoli Enrico Maria Trecarichi Fabio Tumietto Anna Marchese Teresa Spanu Simone Ambretti Francesca Ginocchio Francesco Cristini Angela Raffaella Losito Sara Tedeschi Roberto Cauda Matteo Bassetti | 2012 | Clinical Infectious Diseases2012，，7： | 1 |
| 5 | Multidrug-resistant Pseudomonas aeruginosa bloodstream infections : risk factors and mortality 显示文摘 | Tumbarello M Repetto E Trecarichi EM | 2011 | Epidemiol Infect2011，139，11： | 1 |
| 6 | Bloodstream in- fections caused by cxtended-spectrum-beta-lactamase- producing Escherichia coli: risk factors for inadequate initial antimicrobial therapy 显示文摘 | Tumbarello M Sali M Trecarichi EM | 2008 | Antiwicrob Agents Chemother2008，52，9： | 1 |
| 7 | Hic-5 Promotes the Hypertrophic Scar Myofibroblast Phenotype by Regulating the TGF-beta1 Autocrine Loop显示文摘 | TUMBARELLO D A TURNER C E | 2008 | J Invest Dermatol2008，10，： | 1 |
| 8 | ESBL-producing mul- tidrug-resistant Providencia stuartii infections in a university hospital显示文摘 | Tumbarello M Citton R Spanu T | 2004 | J Antimicrob Chemother2004，53，： | 1 |
| 9 | Predictors of mortality in patients with bloodstream infections caused by extended-spectrum-β-lactamases-producing Enterobacteriaceae: importance of inadequate initial antimicrobial treatment 显示文摘 | Tumbarello M Sanguinetti M Montuori E | 2007 | Antimicrob Agents Chemother2007，51，6： | 1 |
| 10 | Severe pneumonia in intensive care:cause,diagnosis,treatment and management:a review of the literature显示文摘 | De Pascale G Bello G Tumbarello M | 2012 | Curr Opin Pulm Med2012，18，3： | 1 |
| 11 | ESBL- producing multidrug- resistant Providencia stuartii infections in a university hospital显示文摘 | TUMBARELLO M CITTON R SPANU T | 2004 | J Antimicrob Chemother2004，53，2： | 1 |
| 12 | Detecting risk andpredicting patient mortality in patients with extended-spec-trum -lactamase-producing Enterobacteriaceae bloodstreaminfections显示文摘 | Trecarichi EM Cauda R Tumbarello M | 2012 | Future Microbiol2012，7，10： | 1 |
| 13 | Multidrug resistant Pseudomonas aeruginosa bloodstream infections:risk factors and mortality显示文摘 | Tumbarello M Repetto E Trecarichi EM | | 0，，： | 1 |
| 14 | Multidrugresistant Pseudomonas aeruginosa bloodstream infections:risk factors and mortality显示文摘 | Tumbarello M Repetto E Trecarichi EM | 2011 | Epidemiol Infect2011，139，11： | 1 |
| 15 | Muhidrug resistant Pseudomonas aeruginosa bloodstream infection in adult patients with hematologic malignancies显示文摘 | Trecarichi EM Tumbarello M Caira M | 2011 | Haematologiea2011，96，1： | 1 |
| 16 | Bloodstream infections caused by extend-spectrum---lactamase-pro- ducing klebisella pneumoniae: risk factors, molecular epi- demiology and clinical outcome显示文摘 | Tumbarello M Spanu T Sanguinetti M | 2006 | Antomicrob Agents Chemother2006，50，： | 1 |
| 17 | Risk Factors and Prognostic Indicators of Bacterial Meningitis in a Cohort of 3580 Postneurosurgical Patients显示文摘 | Giovanni Federico Mario Tumbarello Teresa Spanu Romeo Roselli Maurizio Iacoangeli Massimo Scerrati Evelina Tacconelli | 2001 | Scandinavian Journal of Infectious Diseases2001，，7： | 1 |
| 18 | Paxillin is essential for PTP-PEST-dependent regulation of cell spreading and motility: a role for paxillin kinase linker 显示文摘 | JAMIESON J S TUMBARELLO D A HALLEM | 2005 | J Cell Sci2005，118，24： | 1 |
| 19 | Muhidrug-resistant Pseudomonas aeruginosa bloodstream infections:risk factors and mortality显示文摘 | Tumbarello M Repetto E Trecarichi EM | 2011 | Epidemiol Infect2011，139，11： | 1 |
| 20 | Relapsing bloodstream infections during treatment of acute leukemia显示文摘 | Cattaneo C Antoniazzi F Tumbarello M | 2014 | Ann Hematol2014，93，5： | 1 |
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