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| 1 | Feasibility of allogeneic mesenchymal stem cells in pediatric hypoxic-ischemic encephalopathy: Phase I study显示文摘BACKGROUND Hypoxic-ischemic encephalopathy(HIE)is one of the leading causes of death and long-term neurological impairment in the pediatric population.Despite a limited number of treatments to cure HIE,stem cell therapies appear to be a potential treatment option for brain injury resulting from HIE.AIM To investigate the efficacy and safety of stem cell-based therapies in pediatric patients with HIE.METHODS The study inclusion criteria were determined as the presence of substantial deficit and disability caused by HIE.Wharton’s jelly-derived mesenchymal stem cells(WJ-MSCs)were intrathecally(IT),intramuscularly(IM),and intravenously administered to participants at a dose of 1×10^(6)/kg for each administration route twice monthly for 2 mo.In different follow-up durations,the effect of WJ-MSCs administration on HIE,the quality of life,prognosis of patients,and side effects were investigated,and patients were evaluated for neurological,cognitive functions,and spasticity using the Wee Functional Independence Measure(Wee FIM)Scale and Modified Ashworth(MA)Scale.RESULTS For all participants(n=6),the mean duration of exposure to hypoxia was 39.17+18.82 min,the mean time interval after HIE was 21.83±26.60 mo,the mean baseline Wee FIM scale score was 13.5±0.55,and the mean baseline MA scale score was 35±9.08.Three patients developed only early complications such as low-grade fever,mild headache associated with IT injection,and muscle pain associated with IM injection,all of which were transient and disappeared within 24 h.The treatment was evaluated to be safe and effective as demonstrated by magnetic resonance imaging examinations,electroencephalographies,laboratory tests,and neurological and functional scores of patients.Patients exhibited significant improvements in all neurological functions through a 12-mo follow-up.The mean Wee FIM scale score of participants increased from 13.5±0.55 to 15.17±1.6 points(mean±SD)at 1 mo(z=-1.826,P=0.068)and to 23.5±3.39 points at 12 mo(z=-2.207,P=0.027)post-treatment.The percentage of patients who achieved an excellent functional improvement(Wee FIM scale total score=126)increased from 10.71%(at baseline)to 12.03%at 1 mo and to 18.65%at 12 mo posttreatment.CONCLUSION Both the triple-route and multiple WJ-MSC implantations were safe and effective in pediatric patients with HIE with significant neurological and functional improvements.The results of this study support conducting further randomized,placebo-controlled studies on this treatment in the pediatric population. | Serdar Kabatas Erdinç Civelek Eyüp Can Savrunlu Necati Kaplan Osman Boyalı Furkan Diren Halil Can Ali Genç Tunç Akkoç Erdal Karaöz | 2021 | World Journal of Stem Cells2021，13，5： | 2 |
| 2 | Performance of lithium ion bat- teries using a carbon nanotube film as a cathode current collector 显示文摘 | Zhong C W Hu J W Tun Z B | 2015 | Carbon2015，81，： | 1 |
| 3 | Electrochemical modification of the passive oxide layer on a Ti film observed by in situ neutron reflectometry显示文摘 | Tun Z Noel J J Shoesmith D W | | 0，，3： | 1 |
| 4 | Meningiomas of the lateral ventricle. Report on six cases显示文摘 | Hakan Caner Bekta? A?ikg?z Tun?alp ?zgen Ahmet ?olak Behsan ?nol | 1992 | Neuro Surgical Review1992，，4： | 1 |
| 5 | Rapid and clear detection of ABO genotypes by simultaneous PCR-RFLP method显示文摘 | Tun Z Honda K Nakatome M | 1996 | J Forensic Sci1996，41，6： | 1 |
| 6 | Cold-neutron depth profiling as a research tool for the study of surface oxides on metals显示文摘 | Tun Z Noel J J Bohdanowicz T H | 2010 | Canadian J Phys2010，88，10： | 1 |
| 7 | Cold-neutron depth profiling as a research tool for the study of surface oxides on metals显示文摘 | Tun Z Noel J J Bohdanowicz T | 2010 | Canadi- an Journal of Physics2010，88，10： | 1 |
| 8 | Cadmium concentration in sea bottom sediment and its potential risk in the upper Gulf of Thailand显示文摘 | Tun Z H E Parkpian P Delaune R | 2009 | Journal of Environmental Science and Health Part A2009，44，： | 1 |
| 9 | Polymer/carbon nanotubes coated graphite surfaces for highly sensitive nitrite detection显示文摘 | Kuralay F Dumang z M Tun S | 2015 | Talanta2015，1，144： | 1 |
| 10 | Cold-neutron depth profiling as a research tool for the study of surface oxides on metals显示文摘 | Tun Z Noel J J Bohdanowicz T H | 2010 | Canadian J Phys2010，88，10： | 1 |
| 11 | Rapid and clear detection of ABO genotypes by simultaneous PCR-RFLP method显示文摘 | Tun Z Honda K Nakatome M | 1996 | J Forensic Sci1996，41，6： | 1 |
| 12 | Simultaneous detec tion of multiple STR loci on sex chromosomes for forensic testing of sex and identity 显示文摘 | Honda K Nakatome M | 1999 | J Forensic Sci1999，44，4： | 1 |
| 13 | Neutron scattering studies of geometrically frustrated pyrochlore antiferromagnets显示文摘 | Gaulin B D Gardner J S Dunsiger S R Tun Z Lumsden M D Kiefl R F Raju N P Reimers J N Greedan J E | | 0，，： | 1 |
| 14 | A compilation of accurate structural parameters for KDP and DKDP显示文摘 | Nelmes R J Tun Z Kuhs W F | 1987 | Ferroelectrics1987，71，： | 1 |
| 15 | Identifying sex chromosome abnormalities in forensic DNA testing using amelogenin and sex chromosome shor tandem repeats显示文摘 | Young DR Tun Z Honda K | 2001 | J Forensic Sci2001，46，2： | 1 |
| 16 | Detection and analysis of four polymorphic markers at the human monoamine oxidase(MAO) gene in Japanese controls and patients with Parkinson's disease显示文摘 | Nakatome M Tun Z Shimada S | 1998 | Biochem Biophys Res Commun1998，247，2： | 1 |
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