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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Enterovirus 71 infection of human dendritic cells显示文摘 | Lin YW Wang sw Tung YY | 2009 | Exp Biol Med2009，234，10： | 1 |
| 3 | Cyclin D1 protein expressed in pterygia is associated with β-catenin protein localization显示文摘 | Tung JN Chiang CC Tsai YY | | 0，，： | 1 |
| 4 | Vascular endothelial growth factor gene polymorphism and pro- tein expression in the pathogenesis of pterygium显示文摘 | Peng ML Tsai YY Tung JN Chiang CC Huang YC Lee H | 2014 | Br J Oph- thalmol2014，98，4： | 1 |
| 5 | Enterovirus 71 infection of human dendritic cells显示文摘 | Lin YW Wang SW Tung YY | | 0，，： | 1 |
| 6 | Enterovirus 71 infection of human dendritic cells 显示文摘 | Lin YW Wang SW Tung YY | 2009 | Exp Biol Med(Maywood)2009，13，： | 1 |
| 7 | Enterovirus 71 infection of human dendritic cells 显示文摘 | Lin YW Wang SW Tung YY | 2009 | Exp Biol Med (Maywood)2009，234，10： | 1 |
| 8 | Effects of threaddepth, taper shape, and taper length on the mechanical properties of mini-implants 显示文摘 | Chang JZ Chen YJ Tung YY | 2012 | Am J Orthod Dentofacial Orthop2012，141，3： | 1 |
| 9 | Enterovirus 71 infection of human dendritic cells显示文摘 | Lin YW Wang SM Tung YY | 2009 | Exp Biol Med(Maywood)2009，234，10： | 1 |
| 10 | Vascular endothe- lial growth factor gene polymorphism and protein ex- pression in the pathogenesis of pterygium显示文摘 | Peng ML Tsai YY Tung JN | 2014 | Br J Oph- thalmol2014，98，4： | 1 |
| 11 | Enterovirus 71 infection of human dendritic cells显示文摘 | Lin YW Wang SW Tung YY | | 0，，： | 1 |
| 12 | Modulation of platelet aggregation by areca nut and betel leaf ingredients:roles of reactive oxygen species and cyclooxygenase显示文摘 | Jeng JH Chen SY Liao CH Tung YY Lin BR Hahn LJ Chang MC | 2002 | Free Radic Biol Med2002，32，9： | 1 |
| 13 | Enterovirus 71 infection of human dendritic cells 显示文摘 | Lin YW Wang SW Tung YY Chert SH | 2009 | Exp Biol Med2009，234，10： | 1 |
| 14 | Enterovirus 71 infection of human dendritic cells显示文摘 | Lin YW Wang SW Tung YY | 2009 | Exp Biol Med2009，234，： | 1 |
| 15 | Vascular endothelial growth fac-tor gene polymorphism and protein expression in the pathogenesis ofpterygium 显示文摘 | Peng ML Tsai YY Tung JN | 2014 | Br J Ophthalmol2014，98，4： | 1 |
| 16 | Effects of thread depth, taper shape, and taper length on the me- chanical properties of mini-implants显示文摘 | Chang JZ Chen YJ Tung YY | 2012 | Am J Orthod Dentofacial Orthop2012，141，3： | 1 |
| 17 | Maternal autoantibody triggers de novo T cel-mediated neonatal autoimmune disease显示文摘 | Setiady YY Samy ET Tung KS | | 0，，09： | 1 |
| 18 | Vascular endothelial growth factorgene polymorphism and protein expression in the pathogenesis ofpteiygium显示文摘 | Peng ML Tsai YY Tung JN | 2014 | Br J 0phthalmol2014，98，4： | 1 |
| 19 | Maternal antoantibady triggers de novo T cell-mediated neonatal autoimmune disease显示文摘 | Setiady YY Samy ET Tung KS | 2003 | J Immunol2003，170，9： | 1 |
| 20 | Comparison of multilocus variable-number tandem repeat analysis and pulsed-field gel electrophoresis in molecular subtyping of Salmonella enterica serovars Paratyphi A显示文摘 | Tien YY Wang YW Tung SK | 2011 | Diagn Microbiol Infect Dis2011，69，1： | 1 |
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