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| 1 | 甲氨蝶呤治疗前后银屑病皮损中ICAM-3、Ki-67、PCNA及CD31表达的变化显示文摘Although the effectiveness of methotrexate (MTX) in the treatment of psoriasis is very well established, the mechanism of action is poorly understood. It was suggested that the therapeutic effect of MTX in psoriasis might be mediated by inhibition of adhesion molecule expression. The aim of our study was to investigate the different effects of MTX treatment on cell proliferation, inflammatory infiltrate, adhesion molecules, and angiogenesis in psoriasis, and to clarify the mechanism by which MTX exerts its therapeutic effects. Clinical response, the morpho- phenot- ypic changes, epidermal thickness, and mitosis count were analyzed and the expression of CD31 and ICAM- 3, proliferative markers such as Ki- 67, PCNA, were evaluated by immunohistochemical techniques in lesional psoriatic epidermis, before and after the treatment with MTX in ten patients. In posttreatment biopsies a decrease in the degree of epidermal hyperplasia and a significant reduction in the severity of the inflammatory infiltrate (P< 0.05) were observed. In addition,CD31 and ICAM- 3 expression was significantly decreased ondermal cellular infiltrate, (respectively; P< 0.05,P< 0.01). Ki67 and PCNA expression were suppressed concurrently in about 90% of cases (P< 0.01). We suggest that MTX may have an inhibitory effect on an initial integral component of the pathways that lead to psoriasis. Immunopharmacologic intervention in adhesion event has the potential to improve psoriasis. Inhibition of revascularization may be another mechanism of actionof MTX. | Yazici A.C. Tursen U. Apa D.D. 潘敏 | 2006 | 世界核心医学期刊文摘(皮肤病学分册)2006，0，4： | 2 |
| 2 | Clinical improvement in chronic plaque-type psoriasis lesions after narrow-band UVB therapy is accompanied by a decrease in the expression of IFN-gamma inducers IL-12,IL-18 and IL-23显示文摘 | Piskin G Tursen U Sylva-Steenland RM | 2004 | Exp Dermatol2004，13，12： | 1 |
| 3 | Association between catechol-O-methyhransferase polymorphism and vitiligo显示文摘 | Tursen U Kaya T I Erdal M E | 2002 | Arch Dermatol Res2002，294，3： | 1 |
| 4 | Giant recurrent pyogenic granuloma on the face with satellitosis responsive to systemic steroids显示文摘 | Tursen U Demirkan F Ikizoglu G | 2004 | Clin Exp Dermato12004，29，： | 1 |
| 5 | Evaluation of clinical findings according to sex in 2313 Turkish patients with Behcet's disease显示文摘 | Tursen U Gurler A Boyvat A | | 0，，： | 1 |
| 6 | 显示文摘 | QIN WEIDONG TURSEN J | 2009 | Anal Sci2009，25，3： | 1 |
| 7 | he changes in expression of ICAM-3,Ki-67,PCNA, and CD31 in psoriatic lesions before and after methotrexate treatment 显示文摘 | Yazici AC Tursen U Apa DD | 2005 | Arch Dermatol Res2005，297，6： | 1 |
| 8 | The changes in expression of ICAM-3, Ki-67, PCNA, and CD31 in psoriatic lesions before and after methotrexate treatment 显示文摘 | Yazici AC Tursen U Apa DD | 2005 | Arch Dermatol Res2005，297，6： | 1 |
| 9 | A simple open comedone extraction technique for Favre-Racouchot disease显示文摘 | Kaya TI Tursen U Yazici AC | 2005 | Photodermatol Photoimmunol Photomed2005，21，5： | 1 |
| 10 | Clinical improvementin chronic plaque-type psoriasis lesions after narrow-band UVBtherapy is accompanied by a decrease in the expression of IFN-gamma inducers--IL-12,IL-18 and IL-23显示文摘 | Piskin G Tursen U Sylva-Steenland RM | 2004 | Exp Dermatol2004，13，： | 1 |
| 11 | The changes in expression of ICAM-3,Ki-67,PCNA,and CD31 in psoriatic lesions before and after methotrexate treatment显示文摘 | Yazici AC Tursen U Apa DD | 2005 | Arch Dermatol Res2005，297，： | 1 |
| 12 | Clinical improvement in chronic plaque-type Psoriasis lessions after narrow - band UVB therapy is accompanied by a decrease in the expression of IFN-gamma inducers IL-12, IL-18 and IL-23 显示文摘 | Piskin G Tursen U Sylva-Steenland RM | 2004 | Exp Dematol2004，13，12： | 1 |
| 13 | Surgical approach to benign small popular and dome -shaped melanocytic naevi on the face显示文摘 | Kaya TI Ikizoglu G | 2003 | J Cosmet Dermatol2003，2，34： | 1 |
| 14 | N-acetyltransferase 2 polymorphisms in patients with Behcet's disease显示文摘 | TAMER L TURSEN U ESKANDARI G | 2005 | Clin Exp Dermatol2005，30，1： | 1 |
| 15 | Clinical improvement in chronic plaque-type psoriasis lesions after narrow-band UVB therapy is accompanied by a decrease in the expression of IFN-gamma inducers IL-12,IL-18 and IL-23显示文摘 | Piskin C Tursen U Sylva-Steenland RM | 2004 | Exp Dermatol2004，13，12： | 1 |
| 16 | Clinical improvement in chronic p laque-type p soriasis lesions after narrow-band UVB therapy is accompanied by a decrease in the exp ression of IFN -gamma inducers IL-12,IL-18 and IL-23显示文摘 | Pisking Tursen U Sylva-steenland RM | 2004 | Exp Der matol2004，13，12： | 1 |
| 17 | Rapid healing of chronic leg ulcers duringperilesional injections of granulocyte- macrophage colonwstimulating factortherapy in a patient with cutaneous polyarteritis nodosa显示文摘 | Tursen U Api H Kaya TI | 2006 | J Eur Acad Der- matol Venereol2006，20，10： | 1 |
| 18 | Evaluation of clinical findings according to sex in 2313 Turkish patients with Behcet' s disease 显示文摘 | Tursen U Gurler A Boyvat A | 2003 | Int J Dermatol2003，42，： | 1 |
| 19 | The changes in expression of ICAM-3,Ki-67, PCNA, and CD31 in psoriatic lesions before and after methotrexate treatment 显示文摘 | Yazici A C Tursen U Apa D D | 2005 | Arch Dermatol Res2005，297，6： | 1 |
| 20 | Clinical improvement in chronic plaque type psoriasis lesions after narrow-band UVB therapy is a accompanied by a decrease in the expression of INF-gamma inducers IL-12, IL-18 and IL-23 显示文摘 | Pisrin G Tursen U Sylva-Steenland RM | 2004 | Exp Dermatol2004，13，： | 1 |
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