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| 1 | Elevated pro-inflammatory and lipotoxic mucosal lipids characterise irritable bowel syndrome显示文摘AIM:To investigate the pathophysiology of irritable bowel syndrome(IBS)by comparing the global mucosal metabolic profiles of IBS patients with those of healthy controls.METHODS:Fifteen IBS patients fulfilling the Rome Ⅱcriteria,and nine healthy volunteers were included in the study.A combined lipidomics(UPLC/MS)and metabolomics(GC×GC-TOF)approach was used to achieve global metabolic profiles of mucosal biopsies from the ascending colon.RESULTS:Overall,lipid levels were elevated in patients with IBS.The most significant upregulation was seen for pro-inflammatory lysophosphatidylcholines.Other lipid groups that were significantly upregulated in IBS patients were lipotoxic ceramides,glycosphingolipids,and di-and triacylglycerols.Among the metabolites,the cyclic ester 2(3H)-furanone was almost 14-fold upregulated in IBS patients compared to healthy subjects(P=0.03).CONCLUSION:IBS mucosa is characterised by a distinct pro-inflammatory and lipotoxic metabolic profile.Especially,there was an increase in several lipid species such as lysophospholipids and ceramides. | Kajsa Kajander Eveliina Myllyluoma Sinikka Kyrnpalo Martin Rasmussen Pentti Sipponen Ismo Mattila Tuulikki Seppnen-Laakso Heikki Vapaatalo Matej Orei Riitta Korpela | 2009 | World Journal of Gastroenterology2009，15，48： | 5 |
| 2 | Metabolomic changes in fatty liver can be modified by dietary protein and calcium during energy restriction显示文摘AIM: To characterise the effect of energy restriction (ER) on liver lipid and primary metabolite profile by using metabolomic approach. We also investigated whether the effect of energy restriction can be further enhanced by modif ication of dietary protein source and calcium. METHODS: Liver metabolomic profile of lean and obese C57Bl/6J mice (n = 10/group) were compared with two groups of weight-reduced mice. ER was performed on control diet and whey protein-based high-calcium diet (whey + Ca). The metabolomicanalyses were performed using the UPLC/MS based lipidomic platform and the HPLC/MS/MS based primary metabolite platform. RESULTS: ER on both diets significantly reduced hepatic lipid accumulation and lipid droplet size, while only whey + Ca diet significantly decreased blood glucose (P < 0.001) and serum insulin (P < 0.01). In hepatic lipid species the biggest reduction was in the level of triacylglycerols and ceramides while the level of cholesterol esters was significantly increased during ER. Interestingly, diacylglycerol to phospholipid ratio, an indicator of relative amount of diabetogenic diglyceride species, was increased in the control ER group, but decreased in the whey + Ca ER group (P < 0.001, vs obese). ER on whey + Ca diet also totally reversed the obesity induced increase in the relative level of lipotoxic ceramides (P < 0.001, vs obese; P > 0.05, vs lean). These changes were accompanied with up-regulated TCA cycle and pentose phosphate pathway metabolites. CONCLUSION: ER-induced changes on hepatic metabolomic profile can be significantly affected by dietary protein source. The therapeutic potential of whey protein and calcium should be further studied. | Taru K Pilvi Tuulikki Seppnen-Laakso Helena Simolin Piet Finckenberg Anne Huotari Karl-Heinz Herzig Riitta Korpela Matej Orei Eero M Mervaala | 2008 | World Journal of Gastroenterology2008，14，28： | 1 |
| 3 | Radiographic Measures to Assess Patients with Rheumatoid Arthritis: Advantages and Limitations显示文摘 | Yusuf Yazici Tuulikki Sokka Theodore Pincus | 2009 | Rheumatic Disease Clinics of North America2009，，4： | 1 |
| 4 | Fast identification of Echinacea purpurea Dried Roots Using near-infrared spectroscopy显示文摘 | Magali L Tuulikki H P Christine L S | 2002 | Anal Chem2002，74，： | 1 |
| 5 | Ergonomic Workplace Analysis 显示文摘 | Mauno A Martti L Tuulikki K | 1989 | Finland : The Fir mish Institute of Occupational Health1989，，： | 1 |
| 6 | Manufacture of polyalkylcyanoacrylate nanoparticles with pilocarpine and timolol by micellepolymerization: Factors influencing particle formation显示文摘 | Tuulikki Harmia-Pulkkinen Ari Tuomi and Eeva Kristoffersson | 1989 | Journal of Microencapsulation1989，6，1： | 1 |
| 7 | Method for determination of the sulfatecontent of glycosaminoglycans 显示文摘 | TUULIKKI T TERHO K HARTIALA | 1971 | Analytical Biochemistry1971，41，2： | 1 |
| 8 | Effect of Chitosan on the Permeability of Monolayers of Intestinal Epithelial Cells (Caco-2)显示文摘 | Per Artursson Tuulikki Lindmark Stanley S. Davis Lisbeth Illum | 1994 | Pharmaceutical Research1994，，9： | 1 |
| 9 | Upregulation of angiotensin converting enzyme by vascular endothelial growth factor显示文摘 | Saijonmaa O Tuulikki N Riikka K | 2001 | Am J Physiol Heart Cire Physiol2001，280，： | 1 |
| 10 | Effect of Chitosan on the Permeability of Monolayers of Intestinal Epithelial Cells (Caco-2)显示文摘 | Per Artursson Tuulikki Lindmark Stanley S. Davis Lisbeth Illum | 1994 | Pharmaceutical Research1994，，9： | 1 |
| 11 | Prevalence of the metabolic syndrome is increased in rheumatoid arthritis and is associated with coronary atherosclerosis显示文摘 | Cecilia P. Chung Annette Oeser Joseph F. Solus Ingrid Avalos Tebeb Gebretsadik Ayumi Shintani Paolo Raggi Tuulikki Sokka Theodore Pincus C. Michael Stein | 2007 | Atherosclerosis2007，，2： | 1 |
| 12 | Cyclic AMP increases bradykinin receptor binding affinity in human endothelial cells 显示文摘 | Stewen P Outi S Tuulikki N | 2004 | Life Sci2004，74，23： | 1 |
| 13 | Capillary electrophoresis with UV detection and mass spectrometry in method de- velopment for profiling metabolites of steroid hormone metabolism 显示文摘 | Heli S Tuulikki S L Matej O | 2008 | Journal of Chromatography B2008，871，2： | 1 |
| 14 | Gene to-metabolite networks for terpenoid indole alkaloid biosynthesis in Catharanthus roseus cells 显示文摘 | Heiko R Matej O Tuulikki SL | 2006 | PNAS2006，105，： | 1 |
| 15 | Effect of Chitosan on the Permeability of Monolayers of Intestinal Epithelial Cells (Caco-2)显示文摘 | Per Artursson Tuulikki Lindmark Stanley S. Davis Lisbeth Illum | 1994 | Pharmaceutical Research1994，，9： | 1 |
| 16 | Capillary electrophoresis with UV detection and mass spectrometry in method development for profiling metabo- lites of steroid hormone metabolism 显示文摘 | Heli S Tuulikki S L Matej O | 2008 | J Chromatogr B2008，871，2： | 1 |
| 17 | Effect of probiotic Lactobacillus rhamnosus GG intervention on global serum lipidomic profiles in healthy adults显示文摘AIM: To investigate the effect of three weeks’ intervention with a probiotic Lactobacillus rhamnosus GG (LGG) bacteria on global serum lipidomic profiles and evaluate whether the changes in inflammatory variables (CRP, TNF-α and IL-6) are reflected in the global lipidomic profiles of healthy adults. METHODS: We performed UPLC/MS-based global lipidomic platform analysis of serum samples (n = 26) in a substudy of a randomised, double-blind, placebo- controlled 3-wk clinical intervention trial investigating the immunomodulatory effects of probiotics in healthy adults. RESULTS: A total of 407 lipids were identified, corresponding to 13 different lipid classes. Serum samples showed decreases in the levels of lysophosphatidylcholines (LysoGPCho), sphingomyelins (SM) and several glycerophosphatidylcholines (GPCho), while triacylglycerols (TAG) were mainly increased in the probiotic LGG group during the intervention. Among the inflammatory variables, IL-6 was moderatelyassociated by changes in global lipidomic profiles, with the top-ranked lipid associated with IL-6 being the proinflammatory LysoGPCho (20:4). There was a weak association between the lipidomic profiles and the two other inflammatory markers, TNF-α and CRP. CONCLUSION: This was the first study to investigate the effects of probiotic intervention on global lipidomic profiles in humans. There are indications that probiotic LGG intervention may lead to changes in serum global lipid profiles, as reflected in decreased GPCho, LysoGPCho and SM as well as mainly increased TAG. | Riina A Kekkonen Marko Sysi-Aho Tuulikki Seppnen-Laakso Ilkka Julkunen Heikki Vapaatalo Matej Orei Riitta Korpela | 2008 | World Journal of Gastroenterology2008，14，20： | 0 |
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