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| 1 | Molecular mechanism of extrinsic factors affecting antiaging of stem cells显示文摘Scientific evidence suggests that stem cells possess the anti-aging ability to self-renew and maintain differentiation potentials, and quiescent state. The objective of this review is to discuss the microenvironment where stem cells reside in vivo, the secreted factors to which stem cells are exposed, thehypoxic environment, and intracellular factors including genome stability, mitochondria integrity, epigenetic regulators, calorie restrictions, nutrients, and vitamin D. Secreted tumor growth factor-β and fibroblast growth factor-2 are reported to play a role in stem cell quiescence. Extracellular matrices may interact with caveolin-1, the lipid raft on cell membrane to regulate quiescence. N-cadherin, the adhesive protein on niche cells provides support for stem cells. The hypoxic micro-environment turns on hypoxia-inducible factor-1 to prevent mesenchymal stem cells aging through p16 and p21 down-regulation. Mitochondria express glucosephosphate isomerase to undergo glycolysis and prevent cellular aging. Epigenetic regulators such as p300, protein inhibitors of activated Stats and H19 help maintain stem cell quiescence. In addition, calorie restriction may lead to secretion of paracrines cyclic ADP-ribose by intestinal niche cells, which help maintain intestinal stem cells. In conclusion, it is crucial to understand the anti-aging phenomena of stem cells at the molecular level so that the key to solving the aging mystery may be unlocked. | Tzyy Yue Wong Mairim Alexandra Solis Ying-Hui Chen Lynn Ling-Huei Huang | 2015 | World Journal of Stem Cells2015，7，2： | 4 |
| 2 | Vacuolar Ca2+/H+ transport activity is required for systemic phosphate homeostasis involving shoot-out-root signaling in araidnpsis 显示文摘 | Tzu Y L Kyaw A Ching Y T Tzu Y C Ying S C Tzyy J C | 2011 | Plant Physiology2011，156，3： | 1 |
| 3 | Analysis and visualization of single-trial event-related potentials显示文摘 | TZYY P J SCOTT M MARISSA W | 2001 | Human Brain Mapping2001，14，： | 1 |
| 4 | Signaling network in sensingphosphate availability in plants显示文摘 | Tzyy Jen Chiou Shu I Lin | 2011 | Annu Rev Plant Bi-ol2011，62，： | 1 |
| 5 | Sucrose is a signal molecule in assimilate partitioning显示文摘 | TZYY J C DANIEL R B | 1998 | Plant Biology1998，95，： | 1 |
| 6 | A region-based quantum evolution- ary algorithm (RQEA) for global numerical optimization 显示文摘 | Tzyy Chyang Lu Jyh Ching Juang | 2013 | Journal of Computational and Applied Mathematics2013，239，： | 1 |
| 7 | Over expression of acyl carrier protein-1alters fatty acid composition of leaf tissue inArabidopsis显示文摘 | Branen Jill K Chiou Tzyy Jen Engeseth Nicki J | 2001 | Plant Physiol2001，127，1： | 1 |
| 8 | A region-based quantum evolution- ary algorithm (RQEA) for global numerical optimization 显示文摘 | Tzyy Chyang Lu Jyh Ching Juang | 2013 | Journal of Computational and Applied Mathematics2013，239，： | 1 |
| 9 | The role of microRNAs in sensing nutrient stress显示文摘 | TZYY‐JENCHIOU | 2007 | Plant Cell & Environment2007，，3： | 1 |
| 10 | The role of microRNAs in sensing nutrient stress显示文摘 | TZYY‐JENCHIOU | 2007 | Plant, Cell & Environment2007，，3： | 1 |
| 11 | Dual Wideband Printed Monopole Antenna for WLAN/WiMAX App liCations显示文摘 | Pan Chien Yuan Horng Tzyy Sheng Chen Wen Shan | 2007 | IEEE Antennas and Wireless Propagation Letters2007，06，： | 1 |
| 12 | Dynamics of biofilm formation under different nutrient levels and the effect on biofouling of a reverse osmosis membrane system显示文摘 | Xi Chen Stanislaus Raditya Suwarno Tzyy Haur Chong Diane McDougald Staffan Kjelleberg Yehuda Cohen Anthony G. Fane Scott A. Rice | 2013 | Biofouling2013，，3： | 1 |
| 13 | A new printed G‐shaped monopole antenna for dual‐band WLAN applications显示文摘 | Chien‐YuanPan Chien‐HsiangHuang Tzyy‐ShengHorng | 2005 | Lett2005，，4： | 1 |
| 14 | Genetic diversity of the S-type small subunit ribosomal RNA gene of Plasmodium knowlesi isolates from Sabah,Malaysian Borneo and Peninsular Malaysia显示文摘Objective:To determine the genetic diversity of Plasmodium(P.)knowlesi isolates from Sabah,Malaysian Borneo and Peninsular Malaysia,targeting the S-type SSU rRNA gene and including aspects of natural selection and haplotype.Methods:Thirty-nine blood samples infected with P.knowlesi were collected in Sabah,Malaysian Borneo and Peninsular Malaysia.The S-type SSU rRNA gene was amplified using polymerase chain reaction,cloned into a vector,and sequenced.The natural selection and haplotype of the S-type SSU rRNA gene sequences were determined using DnaSP v6 and illustrated using NETWORK v10.This study's 39 S-type SSU rRNA sequences and eight sequences from the Genbank database were subjected to phylogenetic analysis using MEGA 11.Results:Overall,the phylogenetic analysis showed no evidence of a geographical cluster of P.knowlesi isolates from different areas in Malaysia based on the S-type SSU rRNA gene sequences.The S-type SSU rRNA gene sequences were relatively conserved and with a purifying effect.Haplotype sharing of the S-type SSU rRNA gene was observed between the P.knowlesi isolates in Sabah,Malaysian Borneo,but not between Sabah,Malaysian Borneo and Peninsular Malaysia.Conclusions:This study suggests that the S-type SSU rRNA gene of P.knowlesi isolates in Sabah,Malaysian Borneo,and Peninsular Malaysia has fewer polymorphic sites,representing the conservation of the gene.These features make the S-type SSU rRNA gene suitable for comparative studies,such as determining the evolutionary relationships and common ancestry among P.knowlesi species. | Eric Tzyy Jiann Chong Joveen Wan Fen Neoh Tiek Ying Lau Kek Heng Chua Yvonne Ai-Lian Lim Ping-Chin Lee | 2024 | Asian Pacific Journal of Tropical Medicine2024，17，2： | 0 |
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