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| 1 | Calcitriol analog ZK191784 ameliorates acute and chronic dextran sodium sulfate-induced colitis by modulation of intestinal dendritic cell numbers and phenotype显示文摘AIM: To investigate the effects of ZK1916784, a low calcemic analog of calcitriol on intestinal inflammation. METHODS: Acute and chronic colitis was induced by dextran sodium sulfate (DSS) according to standard procedures. Mice were treated intraperitoneally with ZK1916784 or placebo and colonic inflammation was evaluated. Cytokine production by mesenterial lymph node (MLN) cells was measured by ELISA. Immunohistochemistry was performed to detect intestinal dendritic cells (DCs) within the colonic tissue, and the effect of the calcitriol analog on DCs was investigated. RESULTS: Treatment with ZK191784 resulted in significant amelioration of disease with a reduced histological score in acute and chronic intestinal inflammation. In animals with acute DSS colitis, down- regulation of colonic inflammation was associated with a dramatic reduction in the secretion of the proinflammatory cytokine interferon (IFN)-γ and a significant increase in intereleukin (IL)-10 by MLN cells. Similarly, in chronic colitis, IL-10 expression in colonic tissue increased 1.4-fold when mice were treated with ZK191784, whereas expression of the Th1-specific transcription factor T-beta decreased by 81.6%. Lower numbers of infiltrating activated CD11c+ DCs were found in the colon in ZK191784-treated mice with acute DSScolitis, and secretion of proinflammatory cytokines by primary mucosal DCs was inhibited in the presence of the calcitriol analog. CONCLUSION: The calcitriol analog ZK191784 demonstrated significant anti-inflammatory properties in experimental colitis that were at least partially mediated by the immunosuppressive effects of the derivate on mucosal DCs. | Ulrike G Strauch Florian Obermeier Nicole Grunwald Nadja Dunger Heiko C Rath Jürgen Schlmerich A Steinmeyer U Zügel HH Herfarth | 2007 | World Journal of Gastroenterology2007，13，48： | 4 |
| 2 | Loss of CD103^+ intestinal dendritic cells during colonic inflammation显示文摘AIM:To investigate possible differences in dendritic cells(DC)within intestinal tissue of mice before and after induction of colitis. METHODS:Mucosal DC derived from intestinal tissue,as well as from mesenteric lymph nodes and spleen,were analyzed by fluorescence activated cell sorting(FACS) analysis.Supernatants of these cells were analyzed for secretion of different pro-and anti-inflammatory cytokines. Immunohistochemistry and immunofluorescence were performed on cryosections of mucosal tissue derived from animals with colitis as well as from healthy mice. RESULTS:It was shown that DC derived from healthy intestinal lamina propria(LP)represented an immature phenotype as characterized by low-level expression of costimulatory cytokines.In contrast to DC from spleen and mesenteric lymph nodes(MLN)that secreted proinflammatory cytokines,LP-DC produced high levels of the anti-inflammatory cytokine IL-10.After induction of mu-rine colitis in a CD4 + CD62L + transfer model or in chronic Dextran sulfate sodium-colitis,a marked increase of activated CD80 + DC could be observed within the inflamed colonic tissue.Interestingly,in contrast to splenic DC,a significant population of DC within MLN and colonic LP expressed the mucosal integrin CD103 which was lost during colitis. CONCLUSION:The constitutive secretion of antiinflammatory cytokines by immature DC within the intestinal LP might regulate the homeostatic balance between mucosal immunity and tolerance.CD103 + DC could mediate this important function. | Ulrike G Strauch Nicole Grunwald Florian Obermeier Sonja Gürster Heiko C Rath | 2010 | World Journal of Gastroenterology2010，16，1： | 2 |
| 3 | Nutritional sta- tus and long-term mortality in hospitalised patients with chronic ob- structive pulmonary disease (COPD) 显示文摘 | Hallin R Gudmundsson G Suppli Ulrik C | 2007 | Respir Med2007，101，9： | 1 |
| 4 | Risk Factors of Onset of Asthma, A 12-year Prospective Follow-up Study 显示文摘 | Porsbjerg C Von Linstow M L Ulrik C S | 2006 | Chest2006，129，2： | 1 |
| 5 | A generalized skeletal hyperostosis in two siblings caused by a novel mutation in the SOST gene 显示文摘 | Wendy B Erna C Ulrike S | 2005 | Bone2005，36，： | 1 |
| 6 | Genetic and environmental contributions to hay fever among young adult twins显示文摘 | Thomsen S F Ulrik C S Kyvik K O | 2006 | Respir Med2006，100，12： | 1 |
| 7 | Parrical-based modeling of aggregation and fragmentation process: Fractal-like aggregates 显示文摘 | Zahnow J C Joeran M Ulrike F | 2004 | Phys D2004，240，： | 1 |
| 8 | AcHdinium Bromide: Clinical Benefit in Patients withModerate to Severe COPD显示文摘 | Suppli Ulrik C | 2012 | Open Respir Med J2012，6，： | 1 |
| 9 | Nutritional status and long-term mortality in hospitalized patients with chronic obstructive pulmonary disease (COPD)显示文摘 | Hallin R Gudmundsson G Suppli Ulrik C | 2007 | Respir Med2007，101，9： | 1 |
| 10 | Generalized synthesis of periodic surfactant/inorganic composite materials显示文摘 | Huo Q Margolese D I Ulrike C | 1994 | Nature1994，368，： | 1 |
| 11 | Risk factors for onset of asthma a 12-year prospective follow-up study 显示文摘 | Porsbjerg C yon Linstow ML Ulrik CS | 2006 | Chest2006，129，2： | 1 |
| 12 | Nutritional status and long-team mortality in hospitalised patients with chronic obstr4ctive pulmonary disease (COPD) 显示文摘 | Hallin R Gudmundsson G Suppli Ulrik C | 2007 | Respiratory Medicine2007，101，9： | 1 |
| 13 | Nutritional status and long - term mortality in hospitalised patients with chronic ob- structive pulmonary disease (COPD) 显示文摘 | Hallin R Gudmundsson G Suppli Ulrik C | 2007 | Respir Med2007，101，9： | 1 |
| 14 | Risk factors for onset of asthma, a 12 - year prospective follow-up study 显示文摘 | Porsbjerg C Linstow ML Ulrik CS | 2006 | Chest2006，129，： | 1 |
| 15 | Lung function impair- ment increases with age of diagnosis in adult onset asth- ma显示文摘 | Porsbjerg C Lange P Ulrik CS | 2015 | Respir Med2015，109，7： | 1 |
| 16 | Long-term mortality among adults with asthma: a 25-year follow-up of 1 075 outpatients with asthma显示文摘 | Ali Z Dirks C G Ulrik C S | 2013 | Chest2013，143，6： | 1 |
| 17 | Effects of trophoblast invasion on the distribution of leukocytes in uterine and tubal impantation site显示文摘 | Ulrike R Irmgard C L | 2001 | Repro Endocrinol2001，76，： | 1 |
| 18 | Risk factors foronset of asthma a 12-year prospective follow-up study显示文摘 | Porsbjerg C von Linstow ML Ulrik CS | 2006 | Chest2006，129，2： | 1 |
| 19 | Reproductive protein protects functionally sterile honey bee workers from oxidative stress显示文摘 | Siri C S Karl N Ulrike G | 2006 | PNAS2006，103，4： | 1 |
| 20 | Nutritional status and long-term mortality in hospitalized patients with chronic obstructive pulmonary disease (COPD)显示文摘 | Hallin R Gudmundsson G Suppli Ulrik C | 2007 | Respir Med2007，101，9： | 1 |
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