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| 1 | Hepatocellular carcinoma: Review of disease and tumor biomarkers显示文摘Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest. | Jin Un Kim Mohamed I F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes I Jane Cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson | 2016 | World Journal of Hepatology2016，8，10： | 13 |
| 2 | Precontoured buttress plate vs reconstruction plate for acetabulum posterior wall fractures: A biomechanical study显示文摘BACKGROUND The purpose of open reduction and internal fixation of acetabulum posterior wall fractures is to restore anatomical structure and stability of the hip joint, in order to start weight bearing as soon as possible and prevent hip arthrosis; restoration of the anatomy should preserve function of the joint as well. Although 'special shaped precontoured plates' have been developed in recent years for surgical treatment of this region, studies comparing the traditional plates with the newly designed precontoured plates are lacking.AIM To evaluate the biomechanical properties of precontoured anatomic buttress and conventional curved reconstruction plates(CCRPs) for posterior wall acetabulum fracture treatment.METHODS Twelve pelvis models were created for testing plate treatment of fracture in the posterior wall of the acetabulum. These 12 pelvis models were used to create 24 hemipelvis models(experimental) by cutting from the sagittal plane and passing over the center of gravity, after which the posterior wall acetabular fractures(of similar type and size) were created. In these experimental models, the right acetabulum was fixed with a 5-hole CCRP, while the left was fixed with a precontoured anatomic buttress plate(PABP). Samples were placed through thetest device and were subjected to static load testing, with a constant testing velocity of 2 mm/min until the load reached 2.3 kN or the acetabular fixation failed. Dynamic tests were also performed with sinusoidal wave load, with a maximal load of 2.3 kN and a load ratio of 0.1.RESULTS The average stiffness values were 460.83 ± 95.47 N/mm for the PABP and 291.99± 118.58 N/mm for the 5-hole CCRP. The precontoured anatomic acetabulum buttress plates had significantly higher rigidity than the CCRPs(P = 0.022). There was a statistically significant difference between the unloaded and 2.3 kN-loaded values of AL(posterosuperior fracture line vertical to the ground surface) and CL(posteroinferior fracture line vertical to the ground surface) parameters for both the PABPs and the 5-hole CCRPs(P = 0.036 and P = 0.045, respectively).According to the static tests, the amount of total displacement was significantly less in the PABPs than in the CCRPs. Comparative analysis of the displacement in the BL(posterior wall fracture line horizontal to the ground) parameter yielded no statistically significant differences between the PABP and the 5-hole CCRPs(P= 0.261).CONCLUSION PABP provides more stable fixation in acetabulum posterior wall fractures than5-hole CCRP, allowing for proximal or distal fracture line screw application without reshaping. | Güray Altun Gürsel Saka Teyfik Demir Fatma Kübra Erbay Elibol Mehmet Or?un Polat | 2019 | World Journal of Orthopedics2019，10，5： | 3 |
| 3 | A new distributed location management algorithm for broadband personal communication networks显示文摘 | KIN B C CHOI J S UN C K | 1995 | IEEE Transactions on Vehicular Technology1995，44，3： | 1 |
| 4 | Determinants for in vivo antitumor effect of angiogenesis inhibitor SU5416 formulated in PEGylated emulsion显示文摘 | OGAWARA K ABE S UN K | 2014 | J Pharm Sci2014，103，8： | 1 |
| 5 | Comparison of atherosclerotic plaque burden and composition between diabetic and non diabetic patients by non invasive CT angiography显示文摘 | Ibebuogu UN Nasir K Gopal A | 2009 | Int J Cardiovasc Imaging2009，25，7： | 1 |
| 6 | Molecular typing and epidemiological survey of preva- lence of Clostridium perfringens types by multiplex PCR 显示文摘 | Yoo Han sang Sang Un Lee K young Yoon Park | 1997 | Journal of Clinical Microbiology1997，35，1： | 1 |
| 7 | Development of an ultrasound-responsive and mannose-modified gene carri- er for DNA vaccine therapy 显示文摘 | Un K Kawakami S Suzuki R | 2010 | Biomaterials2010，31，30： | 1 |
| 8 | Comparison of atherosclerotic plaque burden and composition between diabetic and non diabetic patients by non invasive CT angiography显示文摘 | Ibebuogu UN Nasir K Gopal A | | 0，，： | 1 |
| 9 | 查看详情显示文摘 | Yao K L Li Y C un X Z Liu Q M Qin Y Fu H H Gao G Y | | 0，，： | 1 |
| 10 | Self - Diagnosing Intelligent Motors: a Key Enabler for Next Generation Manufacturing Systems 显示文摘 | Diseenzo F M Un~sworth P J Loparo K A | 2000 | Computing & Control Engineering Journal2000，，5： | 1 |
| 11 | Co-production of dimethyl ether and methanol from CO2 hydrogenation,development of a stable hybrid catalyst显示文摘 | Tao J L J un K W Lee K W | 2001 | Appl Organomet Chem2001，15，2： | 1 |
| 12 | On the cellular source and function of IL - 6 production in the central nervous system in viral diseases显示文摘 | Malipiero UN Leist TP | 1989 | Eur J Immunol1989，19，4： | 1 |
| 13 | In vivo anti-tumor effect of PEG liposomal doxombicin (DOX) in DOX-resistant tumor-bearing mice: involvement of cytotoxic effect on vascular endothelial cells 显示文摘 | OGAWARA K I UN K TANAKA K I | 2009 | J Controlled Release2009，133，1： | 1 |
| 14 | Short communication in vitro antitumour activity of flavonoids from Sophora flavescens显示文摘 | Shi Yong R Sang Un C Seong-Kie K | 1997 | Phytother Research1997，01，11： | 1 |
| 15 | Suppression of melanomagrowth and metastasis by DNA vaccination using an ultrasound-responsive and mannose-modified gene carrier 显示文摘 | Un K Kaweikami S Suzuki R | 2011 | Mol Pharm2011，8，2： | 1 |
| 16 | Nanoparticle-based passive drug targeting to tumors: considerations and implications for optimization显示文摘 | Ogawara K Yoshizawa Y Un K | 2013 | Biol Pharm Bull2013，36，5： | 1 |
| 17 | R&D collaborations and product innovation显示文摘 | Un C A Cuervo-Cazurra A Asakawa K | 2010 | Journal of Product Innovation Management2010，27，5： | 1 |
| 18 | Improved MUSIC algorithm for high-resolution array processing 显示文摘 | OH S K UN C K | 1989 | Electronic Letters1989，25，22： | 1 |
| 19 | R&D collaborati-ons and product innovation显示文摘 | Un C A Cuervo-Cazurra A Asakawa K | 2010 | Journal of Product Inno-vation Management2010，27，5： | 1 |
| 20 | Heart rate recovery: a practical clinical indicator of abnormal cardiac autonomic function显示文摘 | Okutucu S Karakulak UN Aytemir K | 2011 | Expert Rev Cardiovasc Ther2011，9，11： | 1 |
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