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| 1 | Hepatocellular carcinoma: Review of disease and tumor biomarkers显示文摘Hepatocellular carcinoma(HCC) is a common malignancy and now the second commonest global cause of cancer death. HCC tumorigenesis is relatively silent and patients experience late symptomatic presentation. As the option for curative treatments is limited to early stage cancers, diagnosis in non-symptomatic individuals is crucial. International guidelines advise regular surveillance of high-risk populations but the current tools lack sufficient sensitivity for early stage tumors on the background of a cirrhotic nodular liver. A number of novel biomarkers have now been suggested in the literature, which may reinforce the current surveillance methods. In addition, recent metabonomic and proteomic discoveries have established specific metabolite expressions in HCC, according to Warburg's phenomenon of altered energy metabolism. With clinical validation, a simple and non-invasive test from the serum or urine may be performed to diagnose HCC, particularly benefiting low resource regions where the burden of HCC is highest. | Jin Un Kim Mohamed I F Shariff Mary M E Crossey Maria Gomez-Romero Elaine Holmes I Jane Cox Haddy K S Fye Ramou Njie Simon D Taylor-Robinson | 2016 | World Journal of Hepatology2016，8，10： | 13 |
| 2 | Diffusion-weighted imaging of biliopancreatic disorders:Correlation with conventional magnetic resonance imaging显示文摘Diffusion-weighted magnetic resonance imaging(DWI)is a well established method for the evaluation of intracranial diseases,such as acute stroke.DWI for extracranial application is more difficult due to physiological motion artifacts and the heterogeneous composition of the organs.However,thanks to the newer technical development of DWI,DWI has become increasingly used over the past few years in extracranial organs including the abdomen and pelvis.Most previous studies of DWI have been limited to the evaluation of diffuse parenchymal abnormalities and focal lesions in abdominal organs,whereas there are few studies about DWI for the evaluation of the biliopancreatic tract.Although further studies are needed to determine its performance in evaluating bile duct,gallbladder and pancreas diseases,DWI has potential in the assessment of the functional information on the biliopancreatic tract concerning the status of tissue cellularity,because increased cellularity is associated with impeded diffusion,as indicated by a reduction in the apparent diffusion coefficient.The detection of malignant lesions and their differentiation from benign tumor-like lesions in the biliopancreatic tract could be improved using DWI in conjunction with findings obtained with conventional magnetic resonance cholagiopancreatography.Additionally,DWI can be useful for the assessment of the biliopancreatic tract in patients with renal impairment because contrast-enhanced computed tomography or magnetic resonance scans should be avoided in these patients. | Nam Kyung Lee Suk Kim Gwang Ha Kim Dong Uk Kim Hyung Il Seo Tae Un Kim Dae Hwan Kang Ho Jin Jang | 2012 | World Journal of Gastroenterology2012，18，31： | 8 |
| 3 | Accelerated precipitation behavior of cast Mg-Al-Zn alloy by grain refinement显示文摘This study demonstrates that the precipitation behavior of ?-Mg17 Al12 phase during aging and the resultant variation in hardness and mechanical properties of cast Mg-Al-Zn alloy are strongly dependent on initial grain size. Grain size reduction accelerates discontinuous precipitation at the early stage of aging treatment by increasing the area fraction of grain boundaries that can act as nucleation sites for discontinuous precipitates(DP), but it does not influence DP growth rate. Grain refinement also prematurely terminates continuous precipitation because the formation of a large number of DP reduces the amount of Al dissolved in the matrix, which is required for the formation of continuous precipitates(CP). This promotion of DP formation and early termination of CP formation significantly decrease the peak-aging time to one-third. The enhanced precipitation behavior also leads to an additional hardness improvement in the aged alloy, along with an increase in hardness owing to grain boundary strengthening by grain refinement. The amount of increase in hardness changes with aging time, which is determined by the variation of three variables with aging time: DP fraction difference between refined and nonrefined alloys, hardness difference between DP and matrix, and matrix hardness difference between the two alloys. Grain refinement improves both tensile strength and ductility of the homogenized alloy owing to grain boundary strengthening and suppression of twinning activation, respectively. However, the loss of ductility after peak-aging treatment is greater in the refined alloy because of the larger amount of DP acting as a crack source in this alloy. | Sang-Hoon Kim Jong Un Lee Ye Jin Kim Jun Ho Bae Bong Sun You Sung Hyuk Park | 2018 | Journal of Materials Science & Technology2018，34，2： | 5 |
| 4 | Texture tailoring and bendability improvement of rolled AZ31 alloy using {10-12} twinning: The effect of precompression levels显示文摘In this study,the texture of a rolled Mg alloy is effectively modified through the application of precompression and subsequent annealing treatment,leading to a remarkable improvement in the bending formability of the alloy at room temperature.Precompression induces lattice reorientation through{10-12}twinning,and annealing treatment reduces the stored strain energy of the precompressed material,which results in the formation of a stable grain structure with two dominant texture components.With an increase in precompression,the tensile strain in the outer region of the bending samples is accommodated to a greater extent due to more pronounced{10-12}twinning and basal slip.As a result,the bending formability of the material at room temperature improves with greater precompression.The variation in microstructure,texture,and bending behavior in relation to the degree of precompression is discussed in detail. | Jong Un Lee Ye Jin Kim Sang-Hoon Kim Jeong Hun Lee Min-Seong Kim Shi-Hoon Choi Byoung Gi Moon Young Min Kim Sung Hyuk Park | 2019 | Journal of Magnesium and Alloys2019，7，4： | 5 |
| 5 | Microstructural evolution and grain growth mechanism of pre-twinned magnesium alloy during annealing显示文摘The microstructural evolution and underlying grain growth mechanism of a{1012}-twin-containing Mg alloy during annealing are investigated through quasi in situ electron backscatter diffraction measurements of a rolled AZ31 alloy subjected to precompression along the rolling direction(RD).The precompressed material shows a partially twinned structure consisting of a twinned region and a residual matrix region,and this structure changes to an almost twin-free structure consisting of grown grains with serrated grain boundaries in twinand matrix-originated regions after annealing at 250℃ for 1 h.In addition,the average grain size almost doubles and the internal strain energy decreases significantly after annealing.These microstructural variations are induced mainly by grain growth through the strain-induced migration of high-angle grain boundaries without the movement of twin boundaries.The twinned region of the precompressed material has higher stored strain energy than the residual matrix region because the crystallographic orientation of the former region is favorable for basal slip and because of the occurrence of the dislocation transmutation reaction in the twins.For reducing the total strain energy accumulated in the precompressed material,the residual matrix region—having lower stored strain energy—preferentially grows while consuming the twinned regions formed in the surrounding grains during annealing.As a result,the area fraction of grains with a matrix texture increases whereas that of grains with a twin texture decreases after annealing.The twin texture intensity increases significantly and this texture becomes more concentrated along the RD because the highly RD oriented twins tend to grow during annealing on account of their fairly low stored strain energy. | Ye Jin Kim Jong Un Lee Young Min Kim Sung Hyuk Par | 2021 | Journal of Magnesium and Alloys2021，9，4： | 3 |
| 6 | Therapeutic efficacy and stent patency of transhepatic portal vein stenting after surgery显示文摘AIM To evaluate portal vein(PV) stenosis and stent patency after hepatobiliary and pancreatic surgery, using abdominal computed tomography(CT).METHODS Percutaneous portal venous stenting was attempted in 22 patients with significant PV stenosis(> 50%)-after hepatobiliary or pancreatic surgery- diagnosed by abdominal CT. Stents were placed in various stenotic lesions after percutaneous transhepatic portography. Pressure gradient across the stenotic segment was measured in 14 patients. Stents were placed when the pressure gradient across the stenotic segment was > 5 mm Hg or PV stenosis was > 50%, as observed on transhepatic portography. Patients underwent followup abdominal CT and technical and clinical success, complications, and stent patency were evaluated.RESULTS Stent placement was successful in 21 patients(technical success rate: 95.5%). Stents were positioned through the main PV and superior mesenteric vein(n = 13), main PV(n = 2), right and main PV(n = 1), left and main PV(n = 4), or main PV and splenic vein(n = 1). Patients showed no complications after stent placement. The time between procedure and final follow-up CT was 41-761 d(mean: 374.5 d). Twenty stents remained patent during the entire follow-up. Stent obstruction-caused by invasion of the PV stent by a recurrent tumor- was observed in 1 patient in a follow-up CT performed after 155 d after the procedure. The cumulative stent patency rate was 95.7%. Small in-stent low-density areas were found in 11(55%) patients; however, during successive follow-up CT, the extent of these areas had decreased.CONCLUSION Percutaneous transhepatic stent placement can be safe and effective in cases of PV stenosis after hepatobiliary and pancreatic surgery. Stents show excellent patency in follow-up abdominal CT, despite development of small in-stent low-density areas. | Ung Bae Jeon Chang Won Kim Tae Un Kim Ki Seok Choo Joo Yeon Jang Kyung Jin Nam Chong Woo Chu Je Ho Ryu | 2016 | World Journal of Gastroenterology2016，22，44： | 1 |
| 7 | Needle track tumor seeding after radiofrequency ablation of a thyroid tumor显示文摘 | Chang Un Lee Soo Jin Kim Jin Yong Sung Sung Hee Park Semin Chong Jung Hwan Baek | 2014 | Japanese Journal of Radiology2014，，： | 1 |
| 8 | Capsicum annuum WRKYb transcription factor that binds to the CaPR-10 promoter functions as a positive regulator in innate immunity upon TMV infection显示文摘 | Jee Hyuck Lim Chang-Jin Park Sung Un Huh La Mee Choi Gil Je Lee Young Jin Kim Kyung-Hee Paek | 2011 | Biochemical and Biophysical Research Communications2011，，3： | 1 |
| 9 | Assembling a novel bifunctional cellulase–xylanase from Thermotoga maritima by end-to-end fusion显示文摘 | Su Young Hong Jin Suk Lee Kye Man Cho Renukaradhya K Math Yong Hee Kim Sun Joo Hong Yong Un Cho Hoon Kim Han Dae Yun | 2006 | Biotechnology Letters2006，，22： | 1 |
| 10 | Modulation of lipid metabolism by polyphenol‐rich grape skin extract improves liver steatosis and adiposity in high fat fed mice显示文摘 | Hae‐Jin Park Un Ju Jung Mi‐Kyung Lee Su‐Jung Cho Hee‐Kyoung Jung Joo Heon Hong Yong Bok Park Sang Ryong Kim Sangphil Shim Jieun Jung Myung‐Sook Choi | 2012 | Mol. Nutr. Food Res2012，，2： | 1 |
| 11 | RETRACTED: Enhancement of learning and memory by a medicinal formulation, Saenhyetang, in mice 显示文摘 | Un - Ho Jin Jang - Hyun Kim Gyu - Tae Chang | 2007 | Journal of Ethnopharmacology2007，109，2： | 1 |
| 12 | Microstructural evolution of pre-twinned Mg alloy with annealing temperature and underlying boundary migration mechanism显示文摘This study investigates the variations in the microstructural characteristics of a pre-twinned Mg alloy with the temperature of the subsequent annealing treatment.To this end,a rolled AZ31 alloy is compressed to 3%plastic strain along the rolling direction(RD)to activate{10-12}twinning and is subsequently annealed at 200,250,300,350,and 400℃.Numerous{10-12}twins are formed throughout the compressed material,leading to the formation of a RD-oriented texture.At an annealing temperature of 200℃,no microstructural variations occur during annealing.As the annealing temperature increases from 250 to 400℃,the residual strain energy and remaining twin boundaries of the annealed material decrease owing to the promoted static recovery and the increased area fraction of twin-free grown grains.Consequently,an increase in the annealing temperature results in a gradual microstructural transition from a fully twinned grain structure to a completely twin-free grain structure.The microstructural evolution during annealing is predominantly governed by the movement of high-angle grain boundaries via a strain-induced boundary migration mechanism,and a few twin boundaries migrate above 350℃ because of their lower boundary energy.The boundary migration behavior and resultant microstructural evolution are discussed in detail based on the variations in boundary mobility and driving force for boundary migration with annealing temperature. | Ye Jin Kim Jong Un Lee Gyo Myeong Lee Sung Hyuk Park | 2023 | Journal of Magnesium and Alloys2023，11，8： | 0 |
| 13 | Recent research progress on magnesium alloys in Korea:A review显示文摘This review highlights the recent advancements in Mg research in South Korea with a prime focus on high-speed-extrudable Mg–Bi-based alloys for high productivity and strength, innovative techniques utilizing {10–12} twinning for improved mechanical properties, and alloying and processing methods for enhanced corrosion resistance. High-alloyed Mg–Bi-based alloys possess thermally stable α-Mg matrix and secondary phase, which ensures high-speed extrusion of these alloys at elevated temperatures without hot cracking. Consequently, they exhibit outstanding extrudability with a maximum extrusion speed of up to 70 m/min. Furthermore, their high alloying contents offer excellent strength even after high-speed extrusion through strong solid solution hardening and particle hardening effects, making them suitable for high-performance extruded Mg products. The pre-twinning process utilizing {10–12} twinning and the combined process of pre-twinning and subsequent annealing have shown promise in controlling microstructure and texture of wrought Mg alloys and thus enhancing their mechanical properties. The pre-twinning process enhances tensile strength, fatigue properties, and age-hardening rate of Mg alloys. Furthermore, the combined processes of pre-twinning and subsequent annealing considerably improve their ductility, stretch formability, bending formability,and damping capacity. Efforts have been made to improve the corrosion resistance of Mg alloys through alloying additions, process treatments,and surface coatings. Alloying elements like Ca, Sc, and Sm alter the microstructural features(such as secondary phases and grain size)that affect the corrosion phenomenon. Process treatments such as multidirectional forging, screw rolling, and pulse electron beam can also improve the corrosion resistance by refining the microstructure. Furthermore, advanced surface coating technologies can create durable and corrosion-resistant layers for effectively protecting the Mg alloys. All these research activities conducted in South Korea have considerably contributed to the widespread utilization of Mg alloys in diverse applications by overcoming the inherent limitations of Mg alloys such as low extrudability, formability, and corrosion resistance. | Sung Hyuk Park Ye Jin Kim Hyun Ji Kim Sang-Cheol Jin Jong Un Lee Alexander Komissarov Kwang Seon Shin | 2023 | Journal of Magnesium and Alloys2023，11，10： | 0 |
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