|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sustained Type I interferon signaling as a mechanism of resistance to PD-1 blockade显示文摘PD-1 blockade represents a major therapeutic avenue in anticancer immunotherapy.Delineating mechanisms of secondary resistance to this strategy is increasingly important.Here,we identified the deleterious role of signaling via the type I interferon(IFN)receptor in tumor and antigen presenting cells,that induced the expression of nitric oxide synthase 2(N0S2),associated with intratumor accumulation of regulatory T cells(Treg)and myeloid cells and acquired resistance to anti-PD-1 monoclonal antibody(mAb).Sustained IFNP transcription was observed in resistant tumors,in turn inducing PD-L1 and N0S2 expression in both tumor and dendritic cells(DC).Whereas PD-L1 was not involved in secondary resistance to anti-PD-1 mAb,pharmacological or genetic inhibition of N0S2 maintained long-term control of tumors by PD-1 blockade,through reduction of Treg and DC activation.Resistance to immunotherapies,including anti-PD-1 mAb in melanoma patients,was also correlated with the induction of a type I IFN signature.Hence,the role of type I IFN in response to PD-1 blockade should be revisited as sustained type I IFN signaling may contribute to resistance to therapy. | Nicolas Jacquelot Takahiro Yamazaki Maria PRoberti Connie PMDuong Miles CAndrews Loic Verlingue Gladys Ferrere Sonia Becharef Marie Vetizou Romain Daillere Meriem Messaoudene David PEnot Gautier Stoll Stefano Ugel Maria Marigo Shin Foong Ngiow Aurelien Marabelle Armelle Prevost-Blondel Pierre-Olivier Gaudreau Vancheswaran Gopalakrishnan Alexander MEggermont Paule Opolon Christophe Klein Gabriele Madonna Paolo AAscierto Antje Sucker Dirk Schadendorf Mark JSm yth Jean-Charles Soria Guido Kroemer Vincenzo Bronte Jennifer Wargo and Laurence Zitvogel | 2019 | Cell Research2019，29，10： | 6 |
| 2 | Tumor-Induced Tolerance and Immune Suppression Depend on the C/EBPβ Transcription Factor显示文摘 | Ilaria Marigo Erika Bosio Samantha Solito Circe Mesa Audry Fernandez Luigi Dolcetti Stefano Ugel Nada Sonda Silvio Bicciato Erika Falisi Fiorella Calabrese Giuseppe Basso Paola Zanovello Emanuele Cozzi Susanna Mandruzzato Vincenzo Bronte | 2010 | Immunity2010，，6： | 2 |
| 3 | Hierarchy of irmnunosuppressive strength among myeloid-derived suppressor eell subsets is detennin~ed by GM-CSF显示文摘 | Dolcetti L Peranzoni E Ugel S | 2010 | Eur J Immuno2010，40，1： | 1 |
| 4 | Uptake of chemically reactive,DNA-damaging sulfuric acid esters into renal cells by human organic anion transporters显示文摘 | Bakhiya N Stephani M Bahn A Ugele B Seidel A Burckhardt G | 2006 | J Am Soc Nephrol2006，17，5： | 1 |
| 5 | Binding of human IgG and F(ab) 2 and Fc fragments to cultured trophoblast cells from humanterm placenta 显示文摘 | Ugele B Hecht J Kuss E | 1998 | Exp Cell Res1998，244，1： | 1 |
| 6 | Therapeutic targeting of myeloid-derived suppressor cells显示文摘 | UGEL S DELPOZZO F DESANTJS G | 2009 | Curr Opin Pharrnacol2009，9，4： | 1 |
| 7 | Murine renal organic anion transporters mOAT1 and mOAT3 facilitate the transport of neuroactive tryptophan metabolites显示文摘 | Bahn A Ljubojevic M Lorenz H Schultz C Ghebremedhin E Ugele B | 2005 | Am J Physiol Cell Physiol2005，289，5： | 1 |
| 8 | Human renal organic anion transporter 4 operates as an asymmetric urate transporter显示文摘 | Hagos Y Stein D Ugele B | | 0，，： | 1 |
| 9 | Total bilirubin measurement by photometry on a blood gas analyzer:potential for use in neonatal testing at the point of care显示文摘 | Rolinski B Kuster H Ugele B | 2001 | Clin Chem2001，47，： | 1 |
| 10 | Hierarchyof immunosuppressive strength among myeloid-derivedsuppressor cell subsets is determined by GM-CSF 显示文摘 | DOLCETTI L PERANZONIE UGEL S | 2010 | Eur JImmunoh2010，40，1： | 1 |
| 11 | Binding of human IgG and F(ab')2 and Fc fragme nts to cultured trophoblast cells from human term placenta显示文摘 | Ugele B Hecht J Kuss E | | Exp Cell Res0，244，： | 1 |
| 12 | Therapeutic targeting of myeloid-derived suppressor cells 显示文摘 | Ugel S Delpozzo F Desantis G | 2009 | Curt Opin Pharmacol2009，9，4： | 1 |
| 13 | Character- ization and identification of steroid sulfate transporters of human placenta 显示文摘 | Ugele B St-Pierre MV Pihusch M | 2003 | Am J Physiol Endocrinol Metab2003，284，2： | 1 |
| 14 | Human renal organic anion transporter 4 operates as an asymmetric urate transporter显示文摘 | Hagos Y Stein D Ugele B | 2007 | J Am Soc Nephrol2007，18，： | 1 |
| 15 | Characterization and identification of steroid sulfate transporters of human placenta显示文摘 | Ugele B St-Pierre M V Pihusch M | | 0，，02： | 1 |
| 16 | Human renal organic anion transporter 4 operates as an asymmetric urate transporter 显示文摘 | Hagos Y Stein D Ugele B | 2007 | J Am Soc Nephrol2007，18，2： | 1 |
| 17 | Characterization of an organic anion transporting polypeptide (OATP-B) in human placenta显示文摘 | St-Pierre M V Hagenbuch B Ugele B | | 0，，04： | 1 |
| 18 | Presynaptic P2X receptors facilitate inhibitory GABA ergic transmission between cultured rat spinal cord dotal horn neurons显示文摘 | Ugel S Schlichter R | 2000 | J Neurosci2000，20，6： | 1 |
| 19 | Hierarchy ofimmunosuppressive strength among myeloid-derived suppressor cell subsets is determined by GM-CSF显示文摘 | Dolcetti L Peranzoni E Ugel S | 2010 | Eur J Immunol2010，40，1： | 1 |
| 20 | Binding of human IgG and F(ab')2 and Fc fragments to cultured trophoblast cells from human term placenta显示文摘 | Ugele B Hecht J Kuss E | 1998 | Exp Cell Res1998，244，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员