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| 1 | Cetuximab plus FOLFOX6 or FOLFIRI in metastatic colorectal cancer: CECOG trial显示文摘AIM: To investigate efficacy and safety of cetuximab combined with two chemotherapy regimens in patients with unresectable metastatic colorectal cancer (mCRC). METHODS: Randomized patients received cetuximab with 5-fluorouracil (5-FU), folinic acid (FA) and oxaliplatin (FOLFOX) 6 (arm A, n = 74) or 5-FU, FA and irinotecan (FOLFIRI) (arm B, n = 77). KRAS mutation status was determined retrospectively in a subset of tumors (n = 117). RESULTS: No significant difference was found between treatment arms A and B in the progression-free survival (PFS) rate at 9 mo, 45% vs 34%; median PFS, 8.6 mo vs 8.3 mo [hazard ratio (HR) = 1.06]; overall response rate (ORR) 43% vs 45% [odds ratio (OR) = 0.93] and median overall survival (OS), 17.4 mo vs 18.9 mo (HR = 0.98). Patients with KRAS wild-type tumors demonstrated improved PFS (HR = 0.55, P = 0.0051), OS, (HR = 0.62, P = 0.0296) and ORR (53% vs 36%) and in arm A, improved PFS (HR = 0.49, P = 0.0196), OS (HR = 0.48, P = 0.0201) and ORR (56%vs 30%), compared with patients with KRAS mutated tumors. In arm B no significant differences were found in efficacy by KRAS mutation status. Treatment in arms A and B was generally well tolerated. CONCLUSION: This study confirms that combinations of cetuximab with FOLFOX6 or FOLFIRI are effective and significantly improve clinical outcome in KRAS wild-type compared with KRAS mutated mCRC. | Janja Ocvirk Thomas Brodowicz Fritz Wrba Tudor E Ciuleanu Galina Kurteva Semir Beslija Ivan Koza Zsuzsanna Pápai Diethelm Messinger Ugur Yilmaz Zsolt Faluhelyi Suayib Yalcin Demetris Papamichael Miklós Wenczl Zrinka Mrsic-Krmpotic Einat Shacham-Shmueli Damir Vrbanec Regina Esser Werner Scheithauer Christoph C Zie-linski | 2010 | World Journal of Gastroenterology2010，16，25： | 17 |
| 2 | Cusp mirror heat-pipe evacuated tubular solar thermal coll-ector显示文摘 | Ugur Ortabasit Francis P Fehlner | 1980 | Solar Energy1980，，24： | 1 |
| 3 | In vivo characterisation of parathyroid lesions by use of gamma probe: comparison with ex vivo count method and frozen section results 显示文摘 | Ugur O Kara P O Bozkurt M F | 2006 | Otolaryngol Head Neck Surg2006，134，2： | 1 |
| 4 | Liquid water transport in gas diffusion layer of polymer electrolyte fuel cells显示文摘 | Ugur P Wang C Y | 2004 | J Electrochem Soc2004，151，2： | 1 |
| 5 | A minimal universal test set for self-test of EXOR-sum-of-products circuits显示文摘 | UGUR K DOUGLAS V H MAREK A P | 2000 | IEEE Transactions on Computers2000，49，3： | 1 |
| 6 | Regression of endometrial explants in rats treated with the cyclooxygenase22 inhibitor rofecoxib显示文摘 | Erbil D Ugur S Cemal P | 2004 | Fertil Steril2004，82，3： | 1 |
| 7 | Evaluation of heay metals (Cd, Cu, Ni, Pb, and Zn) distribu- tion sowing regions potato fields in the province of Nige, Turkey显示文摘 | EMINE E K UGUR P HASAN g | 2004 | Water Air and Soil Pollution2004，153，4： | 1 |
| 8 | Regression of endometrial explants in rats treated with the eyelooxygenase-2 inhibitor rofeeoxib显示文摘 | Erbil D Ugur S Cemal P | 2004 | Fertil Steril2004，82，16： | 1 |
| 9 | Regression of endometrial explants in rats treated with the cyclooxygenase-2 inhibitor rofecoxib显示文摘 | Erbil D Ugur S Cemal P | 2004 | Fertil Steril2004，82，3： | 1 |
| 10 | Optoelectronic and thermoelectric properties of Zintl YLi_(3)A_(2)(A = Sb,Bi) compounds through modified Becke-Johnson potential显示文摘In the present work,we investigate the structural,optoelectronic and thermoelectric properties of the YLi_3X_2(X = Sb,Bi) compounds using the full potential augmented plane wave plus local orbital(FP-APW+lo) method.The exchangecorrelation potential is treated with the generalized gradient approximation/local density approximation(GGA/LDA) and with the modified Becke-Johnson potential(TB-mBJ) in order to improve the electronic band structure calculations.In addition,the estimated ground state properties such as the lattice constants,external parameters,and bulk moduli agree well with the available experimental data.Our band structure calculations with GGA and LDA predict that both compounds have semimetallic behaviors.However,the band structure calculations with the GGA/TB-mBJ approximation indicate that the ground state of the YLi_3Sb_2 compound is semiconducting and has an estimated indirect band gap(Γ-L) of about 0.036 eV while the ground state of YLi_3Bi_2 compound is semimetallic.Conversely the LDA/TB-mBJ calculations indicate that both compounds exhibit semiconducting characters and have an indirect band gap(Γ-L) of about 0.15 eV and 0.081 eV for YLi_3Sb and YLi_3Bi_2 respectively.Additionally,the optical properties reveal strong responses of the herein materials in the energy range between the IR and extreme UV regions.Thermoelectric properties such as thermal conductivity,electrical conductivity,Seebeck coefficient,and thermo power factors are also calculated. | T Seddik G Ugur R Khenata S Ugur F Soyalp G Murtaza D P Rai A Bouhemadou S Bin Omran | 2016 | Chinese Physics B2016，25，10： | 1 |
| 11 | Amplitude and frequency detec- tion of power system signals with chaotic distortions using inde- pendent component analysis 显示文摘 | Ugur M Cekli S Uzunoglu C P | 2014 | Electric Power Systems Re- search2014，108，： | 1 |
| 12 | Comparison of pre-emptive tonsillar lodge infiltration with ropivacaine versus intravenous tramadol in pediatric tonsillectomies : A randomized placebo-controlled study显示文摘 | Cocelli L P Ugur B K Durucu C | 2012 | Int J Pediatr Otorhinolaryngol2012，76，5： | 1 |
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