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| 1 | Pain sensation in pancreatic diseases is not uniform: The different facets of pancreatic pain显示文摘AIM: To systematically characterize specific pain patterns in the most frequent pancreatic diseases.METHODS: Pain in patients with chronic pancreatitis(n = 314), pancreatic cancer(n = 469), and other pancreatic tumors(n = 249) including mucinous(n = 20) and serous cystadenoma(n = 31), invasive(n = 37) and non-invasive intraductal papillary mucinous neoplasia(IPMN; n = 48), low stage(n = 18) and high stage neuroendocrine neoplasia(n = 44), and ampullary cancer(n = 51) was registered and correlated with clinicopathological data. Survival times were estimated by the Kaplan-Meier method. Patients alive at the follow-up time were censored. Survival curves were compared statistically using the log-rank test.RESULTS: Forty-nine point one percent of pancreatic cancer patients revealed no pain, whereas in chronic pancreatitis only 18.3% were pain free. In contrary, moderate/severe pain was registered in 15.1% in pancreatic cancer patients that was increased in chronic pancreatitis with up to 34.2%. Serous cystadenoma was asymptomatic in most cases(58.1%), whereas 78.9% of all mucinous cystadenoma patients suffered pain. In neuroendocrine neoplasia pain was not a key clinical symptom since 64% of low stage neuroendocrine neoplasia and 59% of high stage neuroendocrine neoplasia patients were pain free. Cancer localization in the pancreatic body and patients with malignant pancreatic neoplasms were associated with more severe pain. Tumor grading and stage did not show any impact on pain. Only in pancreatic cancer, pain was directly associated with impaired survival.CONCLUSION: Pancreatic pain depicts different patterns of abdominal pain sensation according to the respective pancreatic disorder and does not allow a unification of the term pancreatic pain. | Jan G D'Haese Mark Hartel Ihsan Ekin Demir Ulf Hinz Frank Bergmann Markus W Büchler Helmut Friess Güralp O Ceyhan | 2014 | World Journal of Gastroenterology2014，20，27： | 8 |
| 2 | Improving the catalytic nitrate reduction 显示文摘 | Ulf P Marc H Jorg D | 2000 | Catalysis Today2000，55，： | 2 |
| 3 | Modified alloy 28 (UNS N08028 )with increased resistance to localized cor- rosion in sour environments 显示文摘 | Juhlin A Leande D Ulf Kivis~kk | 2007 | Corrosion2007，，： | 1 |
| 4 | Supported bimetallic palladium catalysts for waterphase nitrate reduction 显示文摘 | Ulf P Klaus D V | 2001 | Journal of Molecular Catalysis A:Chemical2001，173，： | 1 |
| 5 | 难治性类风湿关节炎的临床特点:一项国际问卷调查研究显示文摘目的尽管按照目前欧洲抗风湿联盟(EULAR)的推荐对类风湿关节炎(rheumatoid arthritis,RA)患者进行治疗,难治性RA患者的临床症状却仍然没有得到完全控制,目前EULAR指南主要关注的是RA的早期治疗和药物治疗。本研究的目的在于分析难治性RA患者的临床特点,以及在患者管理中需要探索然而现有EULAR指南并未涉及的问题。方法对多个国家的风湿科医生进行问卷调查,分析难治性RA的临床特点。问卷包括多选题以及开放性问题,从开放性问题的回答中发现需要进一步阐明的问题以及现有EULAR指南需要增加的内容。结果410名受访者完成了调查问卷,关于难治性RA的特点:50%受访者认为基于28个关节评估的疾病活动评分(disease activity score assessing 28 joints,DAS28)>3.2或存在疾病活动的征象;42%受访者认为疲劳是其特点;48%认为至少两种传统合成改变病情抗风湿药(DMARDs)以及使用至少两种生物制剂或靶向合成DMARDs治疗失败;89%认为糖皮质激素不能减量到5 mg/天或泼尼松不能减量到10 mg/天或同等剂量的其他激素。另外,现有EULAR指南中应增加合并症和关节外表现的干预以及多种药物联合治疗等重要内容。结论目前风湿科医生对难治性RA的定义有很大争议。难治性RA患者的很多重要问题目前EULAR指南中均没有涉及。 | Nadia MT Roodenrijs Maria J H de Hair Marlies C van der Goes Johannes WG Jacobs Paco MJ Welsing Désirée van der Heijde Daniel Aletaha Maxime Dougados Kimme L Hyrich Iain B McInnes Ulf Mueller-Ladner Ladislav Senolt Zoltan Szekanecz Jacob Mvan Laar Nagy Gyorgy 黄艳荣(译) 张卓莉(审校) | 2019 | 英国医学杂志中文版2019，22，2： | 1 |
| 6 | The Association Between Low Birth Weight and Type 2 Diabetes: Contribution of Genetic Factors显示文摘 | Stefan Johansson Anastasia Iliadou Niklas Bergvall Ulf dé Fairé Michael S. Kramer Yudi Pawitan Nancy L. Pedersen Mikael Norman Paul Lichtenstein Sven Cnattingius | 2008 | Epidemiology2008，，5： | 1 |
| 7 | Characterization and Identification of Numerically Abundant Culturable Bacteria from the Anoxic Bulk Soil of Rice Paddy Microcosms显示文摘 | Chin KJ Hahn D Hengstmann ULF | 1999 | Appl Environ Microbiol1999，65，： | 1 |
| 8 | Trough integration into power plants- a study on the performance and economy of integrated solar combined cycle systems显示文摘 | Jurgen D Michael G Ulf H | 2004 | Energy2004，29，56： | 1 |
| 9 | Patients with congestive heart failure and their conceptions of their sleep situation显示文摘 | Anders B Anna S Ulf D | 2001 | J Adv Nurs2001，34，4： | 1 |
| 10 | A causal role for E-cadherin in the transition from adenoma to carcinoma 显示文摘 | Anne-karina P Petra W Ulf D | 1998 | Nature1998，392，6672： | 1 |
| 11 | Patients with congestive heart failure and their conceptions of their sleep situation显示文摘 | Anders B Anna S Ulf D | 2001 | J Adv Nurs2001，34，4： | 1 |
| 12 | Bone Regeneration With Osteogenically Enhanced Mesenchymal Stem Cells and Their Extracellular Matrix Proteins显示文摘 | Bret H Clough Matthew R McCarley Ulf Krause Suzanne Zeitouni Jeremiah J Froese Eoin P McNeill Christopher D Chaput H Wayne Sampson Carl A Gregory | 2015 | J Bone Miner Res2015，，1： | 1 |
| 13 | Sleep difficulties,daytime sleepiness,and health-related quality of life in patients with chronic heart failure显示文摘 | Anders B Anna S Ulf D | 2004 | J Cardiovas Nurs2004，19，4： | 1 |
| 14 | Mesoscopic model: advanced simulation of microforming processes显示文摘 | Manfred Geiger Stefan Gei?d?rfer Ulf Engel | 2007 | Production Engineering2007，，1： | 1 |
| 15 | 显示文摘 | Schuchardt Ulf Jannini Marcelo J D M Richens David T | 2001 | Tetrahedron2001，57，： | 1 |
| 16 | Mesoscopic model: advanced simulation of microforming processes显示文摘 | Manfred Geiger Stefan Gei?d?rfer Ulf Engel | 2007 | Production Engineering2007，，1： | 1 |
| 17 | Extracellular lipases from Bacillus subtilis :regu- lation of gene expression and enzyme activity by amino acid supply and external pH 显示文摘 | EGGERT T BROCKMEIER ULF MELLONEY J D | 2003 | FEMS Microbiology Letters2003，，225： | 1 |
| 18 | Trough integration into power plants-a study on the performance and economy of integrated solar combined cycle systems 显示文摘 | Jurgen D Michael G Ulf H | 2004 | Energy2004，29，5： | 1 |
| 19 | Engineering aspects of a molten salt heat transfer fluid in a trough solar field显示文摘 | Kearney D Kelly Bruce Herrmann Ulf | 2004 | Energy2004，29，5： | 1 |
| 20 | Clinical relevance and cellular source of elevated soluble urokinase plasminogen activator receptor (su PAR ) in acute liver failure显示文摘 | Alexander Koch Henning W. Zimmermann Nikolaus Gassler Christoph Jochum Ralf Weiskirchen Jan Bruensing Lukas Buendgens Hanna Dückers Tony Bruns Guido Gerken Ulf P. Neumann David H. Adams Christian Trautwein Ali Canbay Frank Tacke | 2014 | Liver Int2014，，9： | 1 |
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