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| 1 | AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。 | Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) | 2016 | 实用药物与临床2016，19，10： | 37 |
| 2 | CaMKII in cerebral ischemia显示文摘神经原上的 Ischemic 侮辱触发引起 Ca 导致 neuronal 房间死亡(excitotoxicity ) 的 2+ 超载的过多的、病理学的 glutamate 版本。Ca 2+/calmodulin (凸轮) 依赖者蛋白质 kinase II (CaMKII ) 是位于 neuronal 粘性下面并且学习的生理的有刺激性的 glutamate 信号的一个主要调停人。Glutamate 刺激在 T286 触发 CaMKII 的 autophosphorylation,使 kinase 成为 “ 的一个过程; autonomous”(从 Ca 2+ 刺激的部分活跃的独立人士) 并且那为 synaptic 的形式被要求粘性。最近的研究为侮辱以后的 neuroprotection 作为潜在的药目标也建议了自治 CaMKII 活动,在在 neuronal 文化的 glutamate 侮辱以后并且在在 vivo 的焦点的服的局部缺血以后。然而, CaMKII 和凸轮 kinase 家庭的另外的成员在 neuronal 死亡和幸存的规定被含有。这里,我们在 excitotoxicity 和服的局部缺血讨论过去的调查结果和凸轮 kinase 功能的可能的机制,与 CaMKII 和它的规定的一个焦点。 | Steven J COULTRAP Rebekah S VEST Nicole M ASHPOLE Andy HUDMON K Ulrich BAYEF | 2011 | Acta Pharmacologica Sinica2011，32，7： | 6 |
| 3 | SEMS vs cSEMS in duodenal and small bowel obstruction:High risk of migration in the covered stent group显示文摘AIM:To compare clinical success and complications of uncovered self-expanding metal stents(SEMS)vs covered SEMS(cSEMS)in obstruction of the small bowel.METHODS:Technical success,complications and outcome of endoscopic SEMS or cSEMS placement in tumor related obstruction of the duodenum or jejunum were retrospectively assessed.The primary end points were rates of stent migration and overgrowth.Secondary end points were the effect of concomitant biliary drainage on migration rate and overall survival.The data was analyzed according to the Strengthening the Reporting of Observational Studies in Epidemiology guidelines.RESULTS:Thirty-two SEMS were implanted in 20 patients.In all patients,endoscopic stent implantation was successful.Stent migration was observed in 9 of16 cSEMS(56%)in comparison to 0/16 SEMS(0%)implantations(P=0.002).Stent overgrowth did not significantly differ between the two stent types(SEMS:3/16,19%;cSEMS:2/16,13%).One cSEMS dislodged and had to be recovered from the jejunum by way of laparotomy.Time until migration between SEMS and cSEMS in patients with and without concomitant biliary stents did not significantly differ(HR=1.530,95%CI0.731-6.306;P=0.556).The mean follow-up was 57±71 d(range:1-275 d).CONCLUSION:SEMS and cSEMS placement is safe in small bowel tumor obstruction.However,cSEMS is accompanied with a high rate of migration in comparison to uncovered SEMS. | Oliver Waidmann Jrg Trojan Mireen Friedrich-Rust Christoph Sarrazin Wolf Otto Bechstein Frank Ulrich Stefan Zeuzem Jrg Gerhard Albert | 2013 | World Journal of Gastroenterology2013，19，37： | 4 |
| 4 | Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study显示文摘AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV coinfection.METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes.RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls.CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. | Golo Ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled Tilman Sauerbruch Ulrich Spengler Rainer P Woitas | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 5 | Angiotensin Type 1 Receptor Blockers Induce Peroxisome Proliferator–Activated Receptor-γ Activity显示文摘 | Michael Schupp Jürgen Janke Ronald Clasen Thomas Unger Ulrich Kintscher | 2004 | Circulation: Journal of the American Heart Association2004，，17： | 3 |
| 6 | ENETS Consensus Guidelines for the Management of Patients with Gastroduodenal Neoplasms显示文摘 | Delle Fave Gianfranco Kwekkeboom Dik J Van Cutsem Erik Rindi Guido Kos-kudla Beata Knigge Ulrich Sasano Hironobu Tomassetti Paola Salazar Ramon Ruszniewski Philippe | 2012 | Neuroendocrinology2012，，2： | 3 |
| 7 | Vertebroplasty and Kyphoplasty: A Systematic Review of 69 Clinical Studies显示文摘 | Paul A. Hulme J?rg Krebs Stephen J. Ferguson Ulrich Berlemann | 2006 | Spine2006，，17： | 2 |
| 8 | Prognostic relevance of minimal residual disease in colorectal cancer显示文摘Presence of occult minimal residual disease in patients with colorectal cancer(CRC)has a strong prognostic impact on survival.Minimal residual disease plays a major role in disease relapse and formation of metastases in CRC.Analysis of circulating tumor cells(CTC)in the blood is increasingly used in clinical practice for disease monitoring of CRC patients.In this review article the role of CTC,disseminated tumor cells(DTC)in the bone marrow and micrometastases and isolated tumor cells(ITC)in the lymph nodes will be discussed,including literature published until September 2013.Occult disease is a strong prognostic marker for patient survival in CRC and defined by the presence of CTC in the blood,DTC in the bone marrow and/or micrometastases and ITC in the lymph nodes.Minimal residual disease could be used in the future to identify patient groups at risk,who might benefit from individualized treatment options. | Ulrich Bork Robert Grützmann Nuh N Rahbari Sebastian Schlch Marius Distler Christoph Reissfelder Moritz Koch Jürgen Weitz | 2014 | World Journal of Gastroenterology2014，20，30： | 2 |
| 9 | Zener-Hollomon参数对含铁锻造铝合金热变形处理过程中亚结构和织构演变的影响(英文)显示文摘研究Zener-Hollomon参数对含铁锻造铝合金(AA8011)亚结构和织构演变的影响。采用X射线织构分析、电子背散射衍射(EBSD)和光学显微镜等技术进行表征。结果表明,Zener-Hollomon参数对含铁铝合金热变形处理过程中立方织构的演变具有显著影响。增大Zener-Hollomon参数会减少热变形过程中立方织构的数量,且能加强退火过程中的颗粒诱发形核(PSN)的能力。然而,低温热变形处理会导致活性沉淀,这些细而分散的颗粒会阻碍除了产生立方大晶粒的晶核外的所有晶核。综上,在含铁锻造铝合金中,Zener-Hollomon参数与亚晶粒尺寸之间的相关性与在3xxx系列合金中观察到的类似,可以用系列推导方程描述。 | Evgenii ARYSHENSKII Jürgen HIRSCH Vladimir BAZHIN Rudolf KAWALLA Ulrich PRAL | 2019 | Transactions of Nonferrous Metals Society of China2019，29，5： | 2 |
| 10 | Distinct Types of Tumor-Initiating Cells Form Human Colon Cancer Tumors and Metastases显示文摘 | Sebastian M. Dieter Claudia R. Ball Christopher M. Hoffmann Ali Nowrouzi Friederike Herbst Oksana Zavidij Ulrich Abel Anne Arens Wilko Weichert Karsten Brand Moritz Koch Jürgen Weitz Manfred Schmidt Christof von Kalle Hanno Glimm | 2011 | Cell Stem Cell2011，，4： | 2 |
| 11 | Survival and revival times of the retina:ERG studies at total ocular ischemia in rabbits and cats显示文摘 | Ulrich WD Reimann J | 1986 | Doc Ophthalmol1986，63，： | 2 |
| 12 | Common and epithelioid variants of hepatic angiomyolipoma exhibit clonal growth and share a distinctive immunophenotype显示文摘 | Peer Flemming Ulrich Lehmann Thomas Becker Jürgen Klempnauer Hans Kreipe | 2000 | Hepatology2000，，： | 2 |
| 13 | Stem cell trafficking in tissue-development, growth, and disease 显示文摘 | Diana J UlriCh H Amy J | 2008 | Cell2008，132，： | 1 |
| 14 | Subplantation effect in magnetron sputtered superhard boron carbide thin films 显示文摘 | Ulrich S Ehrhardt H Schwan J | 1998 | Diamond and Related Materials1998，6，7： | 1 |
| 15 | Upregulation of endothelial nitric oxide synthase by HMG-COA reductase inhibitors显示文摘 | Ulrich L Fata VL Plutzky J | 1998 | Circulation1998，97，2： | 1 |
| 16 | Cyclooxygenase 1 (COX1) polymorphisms in African-American and Caucasian populations显示文摘 | Ulrich CM Bigler J Sibert J | 2002 | Hum Mutat2002，5，： | 1 |
| 17 | 显示文摘 | Ulrich S Scherer J Schwan J | 1996 | Appl Phys Lett1996，68，： | 1 |
| 18 | Definition and grading of anastomotic leakage following anterior resection of the rectum: A proposal by the International Study Group of Rectal Cancer显示文摘 | Nuh N. Rahbari Jürgen Weitz Werner Hohenberger Richard J. Heald Brendan Moran Alexis Ulrich Torbj?rn Holm W. Douglas Wong Emmanuel Tiret Yoshihiro Moriya S?ren Laurberg Marcel den Dulk Cornelis van de Velde Markus W. Büchler | 2010 | Surgery2010，，3： | 1 |
| 19 | Genetic and biochemical analyses of Escherichia coli mu- tants altered in the temperature-dependent regulation of membrane lipid composition 显示文摘 | ULRICH A K DE MENDOZA D GARWIN J L | 1983 | J Bacteriol1983，154，1： | 1 |
| 20 | Signal transduction by receptor with tyrosine kinase activity显示文摘 | Ulrich A Schlessinper J | 1990 | Cell1990，61，： | 1 |
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