维普期刊资源整合服务平台（V6.5）

77篇 您的检索式：作者名="Kreipe"

选中清除导出查看参考文献查看引证文献引用追踪共4页首页上一页第1页下一页末页 /4 跳转

	题名	作者	年代	出处	被引量
1	hsa-mir-183 is frequently methylated and related to poor survival in human hepatocellular carcinoma显示文摘AIM To screen clinically relevant micro RNAs (mi RNAs) silenced by DNA methylation in human hepatocellular carcinoma(HCC).METHODS Knockdown of DNA methyltransferases (DNMTs) using si RNAs and mi RNA profiling in HCC cell lines were performed to identify DNA hypermethylation-mediated mi RNA downregulation. Confirmation using individual quantitative real-time PCR (qR T-PCR) assays was thenperformed followed by DNA methylation quantification at the promoter of the mi RNA genes. Quantification of DNA methylation and mi RNA expression was then performed in primary HCC tumor samples and related with clinicopathological variables.RESULTS mi RNA profiling after DNMT knockdown in HCC cell lines revealed upregulation of mi R-23, mi R-25 and mi R-183. After q RT-PCR confirmation and Cp G island methylation quantification of these miR NAs in cell lines, further analysis in primary HCC specimens showed that hsa-mi R-183 is hypermethylated in 30% of HCC (n = 40). Expression of mature miR-183 showed an inverse correlation with DNA methylation levels. In HCC cells, DNMT knockdown and 5-aza-2'-deoxycytidine treatment reduced methylation and stimulated expression of mi R-183. In HCC patients, hypermethylation at hsami R-183 promoter significantly correlates with poor survival (log-rank test P = 0.03). DNA methylation analysis in healthy liver, benign liver tumors (hepatocellular adenoma and focal nodular hyperplasia) and their corresponding adjacent tissues showed absence of hypermethylation supporting the notion that aberrant methylation at hsa-miR-183 is specific for the malignant transformation of hepatocytes.CONCLUSION Our data indicate that hypermethylation of hsa-miR-183 is a frequent event in HCC and potentially useful as a novel surrogate diagnostic and prognostic marker.	Sumadi Lukman Anwar Till Krech Britta Hasemeier Elisa Schipper Nora Schweitzer Arndt Vogel Hans Kreipe Reena Buurman Britta Skawran Ulrich Lehmann	2017	World Journal of Gastroenterology2017，23，9：	3
2	Common and epithelioid variants of hepatic angiomyolipoma exhibit clonal growth and share a distinctive immunophenotype显示文摘	Peer Flemming Ulrich Lehmann Thomas Becker Jürgen Klempnauer Hans Kreipe	2000	Hepatology2000，，：	2
3	Limited value of KAI1/CD82 protein expression as a prognosticmarker in human gastric cancer显示文摘	Maximilian Knoener Till Krech Florian Puls Ulrich Lehmann Hans Kreipe Matthias Christgen	2012	Disease Markers2012，，6：	1
4	Feeding and eating disorders in childhood 显示文摘	Bryant Waugh R Markham L Kreipe RE	2010	Int J Eat Disord2010，43，2：	1
5	Cell cycle and no end 显示文摘	TESSEMA M LEHMANN U KREIPE H	2004	Virchows Areh2004，444，4：	1
6	HER2 diagnostics in gastric cancer—guideline validation and development of standardized immunohistochemical testing显示文摘	Josef Rüschoff Manfred Dietel Gustavo Baretton Susanne Arbogast Axel Walch Geneviéve Monges Marie-Pierre Chenard Frédérique Penault-Llorca Iris Nagelmeier Werner Schlake H. H?fler H. H. Kreipe	2010	Virchows Archiv2010，，3：	1
7	Reliable micro RNA profiling in routinely processed formalin-fixed paraffin-embedded breast cancer specimens using fluorescence labelled bead technology显示文摘	Hasemeier B Christgen M Kreipe H	2008	BMC Biotechnol2008，8，：	1
8	Feeding and eating dis- orders in childhood显示文摘	Bryant WR Markham L Kreipe RE	2010	Int J Eat Disord2010，43，2：	1
9	Alveolar macrophages inidiopathic pulmonary fibrosis displyamoremonocyte-like immunophenotype and an increased released of free oxygen radicals 显示文摘	Kiemie - kallee J Kreipe H Radzun H J	1991	Eur Respir1991，4，4：	1
10	Quality assessment of HER2 testing by monitoring of positivity rates 显示文摘	HARAID CHORITZ GUNTRAM BUSCHE HANS KREIPE	2011	Virchows Arch2011，459，：	1
11	Eating disorders in adolescents and young adults显示文摘	Kreipe R E Birndorf S A	2000	Med Clin North Am2000，84，：	1
12	Correlation of MRI and CT findings with histopathology in hepatic angiomyolipoma显示文摘	Hogemann D Flemming P Kreipe H	2001	Eur Radio2001，11，1：	1
13	Quality assessment of HER-2testing by monitoring of positivity rates 显示文摘	Choritz H Busche G Kreipe H	2011	Virchows Arch2011，459，3：	1
14	HER2 diagnostics in gastric cancer—guideline validation and development of standardized immunohistochemical testing显示文摘	Josef Rüschoff Manfred Dietel Gustavo Baretton Susanne Arbogast Axel Walch Geneviéve Monges Marie-Pierre Chenard Frédérique Penault-Llorca Iris Nagelmeier Werner Schlake H. H?fler H. H. Kreipe	2010	Virchows Archiv2010，，3：	1
15	IPH-926 lobular breast cancer cells are triple-negative but their micro array profile uncovers a luminal subtype显示文摘	Christgen M Geffers R Kreipe H et a1	2013	Cancer Sci2013，104，12：	1
16	Cavernous hemangioma of the internal auditory canal显示文摘	Minoo Lenarz Martin Durisin Petr Kamenetzki Hartmut Becker Hans-Heinrich Kreipe Thomas Lenarz	2007	European Archives of Oto-Rhino-Laryngology2007，，5：	1
17	Determination of proliferation in breast cancer by immunohistochemical detection of Ki-67显示文摘	Christgen M Winkens W Kreipe H	2014	Pathologe2014，35，1：	1
18	Role of epigenetic changes in hematological malignancies 显示文摘	LEHMANN U BRAKENSIEK K KREIPE H	2004	Ann Hematol2004，83，3：	1
19	Correlation of MRI and CT findings with histopathology in hepatic angiomy- olipoma 显示文摘	Hogemann D Flemming P Kreipe H	2001	EuroRadio2001，11，：	1
20	Quality assurance inimmunohistochemistry:results of an interlaboratory trial involving172 pathologists显示文摘	Rüdiger T H?fler H Kreipe HH	2002	Am J Surg Pathol2002，26，7：	1

返回顶部每页显示：

共4页首页上一页第1页下一页末页 /4 跳转

互联网出版许可证新出网证(渝)字10号全国400电话 - 免长途话费

用户提示