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| 1 | The role of IL4,IL 10 and TNF-alpha in the immune suppression induced by ultraviolet radiation显示文摘 | Rivas JM Ulrich SE | 1994 | J Leukoc Biol1994，56，6： | 1 |
| 2 | Trefoil factor family domain p-eptides in the human respiratory tract 显示文摘 | Dos Santos SE Ulrich M Doring G | 2000 | J Pathol2000，190，： | 1 |
| 3 | Trefoil factor family domain peptides in the human respiratory tract显示文摘 | Dos Santos SE Ulrich M Doring G | 2000 | J Pathol2000，190，： | 1 |
| 4 | The staphylococcal respiratory response regulator SrrAB induces ica gene transcription and polysaccharide intercellular adhesin expression, protecting Staphylococcus aureus from neutrophil killing under anaerobic growth conditions显示文摘 | Ulrich M Bastian M Cramton SE | 2007 | Molecular Microbiology2007，65，5： | 1 |
| 5 | Oligomeric and fibrillar species of β-amyloid(Aβ42) both impair mitochondrial function in P301L tau transgenic mice显示文摘We recently provided evidence for a mitochondrial dysfunction in P301L tau transgenic mice,a strain modeling the tau pathology of Alzheimer's disease(AD)and frontotemporal dementia(FTD).In addition to tau aggregates,the AD brain is further characterized by Aβpeptide-containing plaques.When we addressed the role of Aβ,this indicated a synergistic action of tau and Aβpathology on the mitochondria.In the present study,we compared the toxicity of different Aβ42 conformations in light of recent studies suggesting that oligomeric rather than fibrillar Aβmight be the actual toxic species.Interestingly,both oligomeric and fibrillar,but not disaggregated(mainly monomeric)Aβ42 caused a decreased mitochondrial membrane potential in cortical brain cells obtained from FTD P301L tau transgenic mice.This was not observed with cerebellar preparations indicating selective vulnerability of cortical neurons.Furthermore,we found reductions in state 3 respiration,the respiratory control ratio,and uncoupled respiration when incubating P301L tau mitochondria either with oligomeric or fibrillar preparations of Aβ42.Finally,we found that aging specifically increased the sensitivity of mitochondria to oligomeric Aβ42 damage indicating that oligomeric and fibrillar Aβ42 are both toxic,but exert different degrees of toxicity. | Anne Eckert Susanne Hauptmann Isabel Scherping Jessica Meinhardt Virginie Rhein Stefan Drse Ulrich Brandt Marcus Fndrich Walter E.Müller Jiirgen Gtz | 2016 | 世界最新医学信息文摘2016，16，2： | 1 |
| 6 | Mitochondrial respiratory chain complexes as sources and targets of thiol-based redox-regulation显示文摘 | Stefan Dr?se Ulrich Brandt Ilka Wittig | 2014 | BBA - Proteins and Proteomics2014，，： | 1 |
| 7 | Verification of barley seed dormancy loci via linked molecular markers显示文摘 | Han F Ulrich SE Clancy JA | 1996 | Theoretical and Applied Genetics1996，92，： | 1 |
| 8 | Trefoil factor family domain peptides in the human respiratory tract 显示文摘 | Dos Santos SE Ulrich M Doting G | 2000 | J Pathol2000，190，： | 1 |
| 9 | Comparative eye-tracking evaluation of scatterplots and parallel coordinates显示文摘We investigate task performance and reading characteristics for scatterplots(Cartesian coordinates)and parallel coordinates.In a controlled eye-tracking study,we asked 24 participants to assess the relative distance of points in multidimensional space,depending on the diagram type(parallel coordinates or a horizontal collection of scatterplots),the number of data dimensions(2,4,6,or 8),and the relative distance between points(15%,20%,or 25%).For a given reference point and two target points,we instructed participants to choose the target point that was closer to the reference point in multidimensional space.We present a visual scanning model that describes different strategies to solve this retrieval task for both diagram types,and propose corresponding hypotheses that we test using task completion time,accuracy,and gaze positions as dependent variables.Our results show that scatterplots outperform parallel coordinates significantly in 2 dimensions,however,the task was solved more quickly and more accurately with parallel coordinates in 8 dimensions.The eye-tracking data further shows significant differences between Cartesian and parallel coordinates,as well as between different numbers of dimensions.For parallel coordinates,there is a clear trend toward shorter fixations and longer saccades with increasing number of dimensions.Using an area-of-interest(AOI)based approach,we identify different reading strategies for each diagram type:For parallel coordinates,the participants’gaze frequently jumped back and forth between pairs of axes,while axes were rarely focused on when viewing Cartesian coordinates.We further found that participants’attention is biased:toward the center of the whole plot for parallel coordinates and skewed to the center/left side for Cartesian coordinates.We anticipate that these results may support the design of more effective visualizations for multidimensional data. | Rudolf Netzel Jenny Vuong Ulrich Engelke Seán O’Donoghue Daniel Weiskopf Julian Heinrich | 2017 | Visual Informatics2017，1，2： | 0 |
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