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| 1 | Efficacy of peroral endoscopic myotomy vs other achalasia treatments in improving esophageal function显示文摘AIM: To assess and compare the esophageal function after peroral endoscopic myotomy(POEM) vs other conventional treatments in achalasia.METHODS: Chart review of all achalasia patients who underwent POEM, laparoscopic Heller myotomy(LHM) or pneumatic dilation(PD) at our institution between January 2012 and March 2015 was performed. Patient demographics, type of achalasia, prior treatments, pre- and post-treatment timed barium swallow(TBE) and high-resolution esophageal manometry(HREM) findings were compared between the three treatment groups. Patients who had both pre- and 2 mo posttreatment TBE or HREM were included in the final analysis. TBE parameters compared were barium column height, width and volume of barium remaining at 1 and 5 min. HREM parameters compared were basal lower esophageal sphincter(LES) pressures and LES-integrated relaxation pressures(IRP). Data are presented as mean ± SD, median [25th, 75 th percentiles] or frequency(percent). Analysis of variance, KruskalWallis test, Pearsons χ~2 test and Fishers Exact tests were used for analysis.RESULTS: A total of 200 achalasia patients were included of which 36 underwent POEM, 22 underwent PD and 142 underwent LHM. POEM patients were older(55.4 ± 16.8 years vs 46.5 ± 15.7 years, P = 0.013) and had higher BMI than LHM(29.1 ± 5.9 kg/m^2 vs 26 ± 5.1 kg/m^2, P = 0.012). More number of patients in POEM and PD groups had undergone prior treatments compared to LHM group(72.2% vs 68.2% vs 44.3% respectively, P = 0.003). At 2 mo post-treatment, all TBE parameters including barium column height, width and volume remaining at 1 and 5 min improved significantly in all three treatment groups(P = 0.01 to P < 0.001) except the column height at 1 min in PD group(P = 0.11). At 2 mo post-treatment, there was significant improvement in basal LES pressure and LES-IRP in both LHM(40.5 mm Hg vs 14.5 mm Hg and 24 mm Hg vs 7.1 mm Hg respectively, P < 0.001) and POEM groups(38.7 mm Hg vs 11.4 mm Hg and 23.6 mm Hg vs 6.6 mm Hg respectively, P < 0.001). However, when the efficacy of three treatments were compared to each other in terms of improvement in TBE or HREM parameters at 2 mo, there was no significant difference(P > 0.05).CONCLUSION: POEM, PD and LHM were all effective in improving esophageal function in achalasia at shortterm. There was no difference in efficacy between the three treatments. | Madhusudhan R Sanaka Umar Hayat Prashanthi N Thota Ramprasad Jegadeesan Monica Ray Scott L Gabbard Neha Wadhwa Rocio Lopez Mark E Baker Sudish Murthy Siva Raja | 2016 | World Journal of Gastroenterology2016，22，20： | 7 |
| 2 | Continuous wound infusion of local anaesthetic agents following colorectal surgery:Systematic review and meta-analysis显示文摘AIM:To provide a specifi c review and meta-analysis of the available evidence for continuous wound infusion of local anaesthetic agents following midline laparoto-my for major colorectal surgery. METHODS: Medline, Embase, trial registries, conference proceedings and article reference lists were searched to identify randomised, controlled trials of continuous wound infusion of local anaesthetic agents following colorectal surgery. The primary outcomes were opioid consumption, pain visual analogue scores (VASs), return to bowel function and length of hospital stay. Weighted mean difference were calculated for continuous outcomes. RESULTS: Five trials containing 542 laparotomy wounds were eligible for inclusion. There was a sig- nificant decrease in post-operative pain VAS at rest on day 3 (weighted mean difference: -0.43; 95% CI: -0.81 to -0.04; P = 0.03) but not on post-operative day 1 and 2. Local anaesthetic infusion was associated with a signifi cant reduction in pain VAS on movement on all three post-operative days (day 1 weighted mean difference: -1.14; 95% CI: -2.24 to -0.041; P = 0.04, day 2 weighted mean difference: -0.97, 95% CI: -1.91to -0.029; P = 0.04, day 3 weighted mean difference: -0.61; 95% CI: 1.01 to -0.20; P = 0.0038). Local an- aesthetic wound infusion was associated with a signifi - cant decrease in total opioid consumption (weighted mean difference: -40.13; 95% CI: -76.74 to -3.53; P = 0.03). There was no signifi cant decrease in length of stay (weighted mean difference: -20.87; 95% CI: -46.96 to 5.21; P = 0.12) or return of bowel function (weighted mean difference: -9.40; 95% CI: -33.98 to 15.17; P = 0.45). CONCLUSION: The results of this systematic re- view and meta-analysis suggest that local anaesthetic wound infusion following laparotomy for major color- ectal surgery is a promising technique but do not pro- vide conclusive evidence of benefi t. Further research is required including cost-effectiveness analysis. | Alan Karthikesalingam Stewart R Walsh Sheraz R Markar Umar Sadat Tjun Y Tang Charles M Malata | 2008 | World Journal of Gastroenterology2008，14，34： | 4 |
| 3 | Molecular imaging显示文摘 | Weissleder R Umar Mahmood | 2001 | Radiology2001，219，： | 2 |
| 4 | Fecal microbes, short chain fatty acids, and colorectal cancer across racial/ethnic groups显示文摘AIM:To investigate differences in microbes and short chain fatty acid(SCFA) levels in stool samples from Hispanic and non-Hispanic African American,American Indian,and White participants.METHODS:Stool samples from twenty participants were subjected to analysis for relative levels of viable bacteria and for SCFA levels.Additionally,the samples were subjected to 16 S r RNA gene pyrosequencing for identification of bacteria present in the stool.We used a metagenome functional prediction technique to analyze genome copy numbers and estimate the abundance of butyrate kinase in all samples.RESULTS:We found that African Americans had significantly lower levels of acetate,butyrate,and total SCFAs than all other racial/ethnic groups.We also found that participant microbial profiles differed by racial/ethnic group.African Americans had significantly more Firmicutes than Whites,with enriched Ruminococcaceae.The Firmicutes /Bacteroidetes ratio was also significantly higher for African Americans than for Whites(P =0.049).We found Clostridium levels to be significantly and inversely related to total SCFA levels(P =0.019) and we found Bacteroides to be positively associated(P =0.027) and Clostridium to be negatively associated(P =0.012) with levels of butyrate.We also identified a correlation between copy number for a butyrate kinase predicted from 16 S r RNA gene abundance and levels of butyrate in stool.CONCLUSION:The identified differences in gut flora and SCFA levels may relate to colorectal cancer mortality differentials and may be useful as targets for future clinical and behavioral interventions. | Christina M Hester Venkatakrishna R Jala Morgan GI Langille Shahid Umar K Allen Greiner Bodduluri Haribabu | 2015 | World Journal of Gastroenterology2015，21，9： | 2 |
| 5 | Association of commonpolymorphisms in TNFA,NFkBl and NFKBIA with risk and prog-nosis of esophageal squamous cell carcinoma显示文摘 | Umar M Upadhyay R Kumar S | 2013 | Plos One2013，8，81： | 1 |
| 6 | Biosorption of lead from aqueous so-lution by Ficus religiosa leaves:batch and column study显示文摘 | QAISER S SALEEMI A R UMAR M | 2009 | Journal ofHazardous Materials2009，166，23： | 1 |
| 7 | Synthesis and characterization of polyaniline-Fe3O4 nanocmoposite:Electrical conductivity,magnetic,electrochemical studies显示文摘 | Umare S S Shambharkar B H Ningthoujam R S | 2010 | Synthetic Metals2010，160，： | 1 |
| 8 | Hydrogeological and hydrochemical framework of regional aquifer system in Kali-Ganga Sub-basin,India显示文摘 | Umar A Umar R Ahmad M S | 2001 | Environmental Geology2001，40，45： | 1 |
| 9 | Feature-tracking cardiovascular magnetic resonance as a novel technique for the assessment of me- chanical dyssynchrony 显示文摘 | Taylor R J Umar F Moody WE | 2014 | Int J Cardio12014，175，： | 1 |
| 10 | High-density lipoprotein cholesterol regulates endothelial progenitor cells by increasing eNOS and prevent- ing apoptosis 显示文摘 | Noor R Umar S Wang CX | 2007 | Atherosclerosis2007，192，1： | 1 |
| 11 | An efficient maximum likeli- hood carrier frequency offset estimator for OFDM using null subcarri- ers and cycle prefix 显示文摘 | SAMEER S M RAJA K UMAR R V | 2011 | Wireless Personal Communications2011，58，2： | 1 |
| 12 | The effect of longterm steroid therapy on linear growth of nephritic children 显示文摘 | Madani A Umar S Taghaodi R | 2011 | Iran J Pediatr2011，21，1： | 1 |
| 13 | Molecular imaging显示文摘 | WEISSLEDER R UMAR MAHMOOD | 2001 | Radiology2001，219，2： | 1 |
| 14 | Biosorption of lead from aqueous solution by Ficus religiosa leaves:Batch and column study 显示文摘 | QAISER S SALEEMI A R UMAR M | 2009 | Journal of Hazardous Materials2009，166，23： | 1 |
| 15 | Biosorptian of lead from aqueous solution by Ficus religiosa leaves:batch and column study 显示文摘 | QAISER S SALEEMI A R UMAR M | 2009 | J Hazard Mater2009，166，23： | 1 |
| 16 | Synthesis, characterization and biodegradable based polyesters 显示文摘 | Umare S S Chandure A S Pandey R A | 2007 | Polymer Degradation and Stability2007，92，3： | 1 |
| 17 | ZnO nano-mushrooms for photocatalytic degradation of methyl orange显示文摘 | KUMAR R KUMAR G UMAR A | 2013 | Materials Letters2013，97，8： | 1 |
| 18 | Treatment of HaileyHailey disease with tacrolimus ointment and clobetasol propionate foam显示文摘 | Umar S Bhattacharjee P Brodell R | 2004 | J Drugs Dermatol2004，3，2： | 1 |
| 19 | Synthesis, characterization and biodegradable studies of 1, 3-propane- diol based polyesters 显示文摘 | UMARE S S CHANDURE A S PANDEY R A | 2007 | Polym Degrad Stab2007，92，3： | 1 |
| 20 | Chemical characteristics of ground-water in parts of the Gambhir river basin, Bharatpur district, Rajathan, India显示文摘 | Umar R Absar A | 2003 | Envirnmental Geology2003，，44： | 1 |
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