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| 1 | Anti-inflammatory activity of probiotic Bifidobacterium: Enhancement of IL-10 production in peripheral blood mononuclear cells from ulcerative colitis patients and inhibition of IL-8 secretion in HT-29 cells显示文摘AIM: To determine the anti-inflammatory activity of probiotic Bifidobacteria in Bifidobacteria-fermented milk (BFM) which is effective against active ulcerative colitis (UC) and exacerbations of UC, and to explore the immunoregulatory mechanisms. METHODS: Peripheral blood mononuclear cells (PBMNC) from UC patients or HT-29 cells were co-cultured with heat-killed probiotic bacteria or culture supernatant of Bifidobacterium breve strain Yakult (BbrY) or Bifidobacterium bifidum strain Yakult (BbiY) to estimate the amount of IL-10 or IL-8 secreted. RESULTS: Both strains of probiotic Bifidobacteria contained in the BFM induced IL-10 production in PBMNC from UC patients, though BbrY was more effective than BbiY. Conditioned medium (CM) and DNA of both strains inhibited IL-8 secretion in HT-29 cells stimulated with TNF-α, whereas no such effect was observed with heat- killed bacteria. The inhibitory effect of CM derived from BbiY was greater than that of CM derived from BbrY. DNAs of the two strains had a comparable inhibitory activity against the secretion of IL-8. CM of BbiY induced a repression of IL-8 gene expression with a higher expression of IκB-ζ mRNA 4 h after culture of HT-29 cells compared to that in the absence of CM.CONCLUSION: Probiotic Bifidobacterium strains in BFM enhance IL-10 production in PBMNC and inhibit IL-8 secretion in intestinal epithelial cells, suggesting that BFM has anti-inflammatory effects against ulcerative colitis. | Akemi Imaoka Tatsuichiro Shima Kimitoshi Kato Shigeaki Mizuno Toshiki Uehara Satoshi Matsumoto Hiromi Setoyama Taeko Hara Yoshinori Umesaki | 2008 | World Journal of Gastroenterology2008，14，16： | 37 |
| 2 | Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria显示文摘 | Ivaylo I. Ivanov Koji Atarashi Nicolas Manel Eoin L. Brodie Tatsuichiro Shima Ulas Karaoz Dongguang Wei Katherine C. Goldfarb Clark A. Santee Susan V. Lynch Takeshi Tanoue Akemi Imaoka Kikuji Itoh Kiyoshi Takeda Yoshinori Umesaki Kenya Honda Dan R. Littma | 2009 | Cell2009，，3： | 3 |
| 3 | Growth-inhibitory signals by activin A do not affect anticancer drug-sensitivity and acquired multi-drug-resistance in human ovarian endometrioid adenocarcinoma OVK-18 cells显示文摘 | Tanaka T Toujima S Umesaki N | 2004 | Oncol Rep2004，11，3： | 1 |
| 4 | Structure of the intestinal flora re- sponsible for development of the gut immune system in a rodent mod- el 显示文摘 | UMESAKI Y SETOYAMA H | 2000 | Microbes and Infection2000，2，11： | 1 |
| 5 | Radiation reduces carboplatin sensitivity and enhances nedaplatin sensitivity in cervical squamous cell carcinoma in vitro 显示文摘 | anaka T Yukawa K Umesaki N | 2007 | Eur J Gynaecol 0ncol2007，，28： | 1 |
| 6 | Cervical adenocarcinoma,a novel combination chemotherapy with mitomycin C,etoposide,and cisplatin for advanced or recurrent disease 显示文摘 | Umesaki N Izumi R Fushiki H | 1999 | Gynecol Oncol1999，75，1： | 1 |
| 7 | Altered profiles of intestinalmicrobiota and organic acids may be the origin of symptoms in irritablebowel syndrome显示文摘 | Tana C Umesaki Y Imaoka A | | 0，，05： | 1 |
| 8 | Randomized placebo-controlled trial assessing the effect of bifidobacteria-fermented milk on active ulceratire colitis显示文摘 | Kato K Mizuno S Umesaki Y | 2004 | Aliment Pharmacol Ther2004，20，10： | 1 |
| 9 | Raman spectroscopic study of alkali silicate glasses and melts显示文摘 | UMESAKI N TAKAHASHI M TATSUMISAGO M | 1996 | J Non-Cryst Solids1996，，： | 1 |
| 10 | Successful preoperative diagnosis of massive ovarian edema aided by comparative imaging study using magnetic resonance and ultrasound 显示文摘 | Umesaki N Tanaka T Miyama M | 2000 | Eur J Obstet Gynecol Repord B iol2000，89，1： | 1 |
| 11 | Cervical adenocarcinoma,a novel combination chemotherapy with mitomycin C,etoposide,and cisplatin for advanced or recurrent disease 显示文摘 | Umesaki N Izumi R Fushiki H | 1999 | Gynecol Oncol1999，75，1： | 1 |
| 12 | Growth-inhibitory signals by activin A do not affect anticaneer drugsensi- tivity and acquired multi-drug-resistance in human o- varian endometrioid OVK-I 8 cell 显示文摘 | Tanaka T Toujima S Umesaki N | 2004 | Oncol Rep2004，11，3： | 1 |
| 13 | Randomized controlledtrial of the effect of bifidobacteria fermented milk on ulcerativecoiltis显示文摘 | Is Ishikawa H Akedo I Umesaki Y | 2003 | J Am Coil Nutr2003，22，： | 1 |
| 14 | Proinflam- matory T-cell responses to gut microhiota promote experimental autoimmune encephalomyelitis显示文摘 | Lee YK Menezes JS Umesaki Y Mazmanian SK | 2011 | Proc Natl Acad Sci USA2011，108，1： | 1 |
| 15 | Microbiotal influence on T cell subset development 显示文摘 | Atarashi K Umesaki Y Honda K | 2011 | Semin Immunol2011，23，2： | 1 |
| 16 | Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells显示文摘 | Hsin-Jung Wu Ivaylo I. Ivanov Jaime Darce Kimie Hattori Tatsuichiro Shima Yoshinori Umesaki Dan R. Littman Christophe Benoist Diane Mathis | 2010 | Immunity2010，，6： | 1 |
| 17 | Structure of the intestinal flora responsible for development of the gut immune system in arodent model显示文摘 | UMESAKI Y SETOYAMA H | 2000 | Microbes Infect2000，2，1： | 1 |
| 18 | Expression of vascular endothelial growth factor by granulated metrial gland cells in pregnant murine uteri显示文摘 | Chunlian Wang Naohiko Umesaki Hiroaki Nakamura Tetsuji Tanaka Kazuki Nakatani Ikuyo Sakaguchi Sachio Ogita Kenji Kaneda | 2000 | Cell and Tissue Research2000，，2： | 1 |
| 19 | Intermittent cisplatin therapy for stage-Ⅲ ovarian cancer patients following clinical remission显示文摘 | Umesaki N Tanaka T Muso H | 1999 | Gynecologic and Obstetric Investigation1999，47，： | 1 |
| 20 | Binding of ovarian cancer antigen CA125/MUC16 to mesothein mediates cell adhesion显示文摘 | Rump A Morikawa Y Tanaka M Minami S Umesaki N Takeuchi M Miyajima A | 2004 | J Biol Chem2004，279，： | 1 |
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