|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 初级医疗机构中协同护理对阿尔茨海默病老年患者的疗效观察:一项随机对照试验显示文摘Context: Most older adults with dementia will be cared for by primary care physicians, but the primary care practice environment presents important challenges to providing quality care. Objective: To test the effectiveness of a collaborative care model to improve the quality of care for patients with Alzheimer disease. Design, Setting, and Patients: Controlled clinical trial of 153 older adults with Alzheimer disease and their caregivers who were randomized by physician to receive collaborative care management (n=84) or augmented usual care (n=69)-at primary care practices within 2 US university-affiliated health care systems from January 2002 through August 2004. Eligible patients (identified via screening or medical record) met diagnostic criteria for Alzheimer disease and had a self-identified caregiver. Intervention: Intervention patients received 1 year of care management by an interdisciplinary team led by an advanced practice nurse working with the patient’s family caregiver and integrated within primary care. The team used standard protocols to initiate treatment and identify, monitor, and treat behavioral and psychological symptoms of dementia, stressing nonpharmacological management. Main Outcome Measures: Neuropsychiatric Inventory (NPI)-administered at baseline and at 6, 12, and 18 months. Secondary outcomes included the Cornell Scale for Depression in Dementia (CSDD), cognition, activities of daily living, resource use, and caregiver’s depression severity. Results: Initiated by caregivers’reports, 89%of intervention patients triggered at least 1 protocol for behavioral and psychological symptoms of dementia with a mean of 4 per patient from a total of 8 possible protocols. Intervention patients were more likely to receive cholinesterase inhibitors (79.8%vs 55.1%; P=.002) and antidepressants (45.2%vs 27.5%; P= .03). Intervention patients had significantly fewer behavioral and psychological symptoms of dementia as measured by the total NPI score at 12 months (mean difference, -5.6; P= .01) and at 18 months (mean difference, -5.4; P=.01). Intervention caregivers also reported significant improvements in distress as measured by the caregiver NPI at 12 months; at 18 months, caregivers showed improvement in depression as measured by the Patient Health Questionnaire-9. No group differences were found on the CSDD, cognition, activities of daily living, or on rates of hospitalization, nursing home placement, or death. Conclusions: Collaborative care for the treatment of Alzheimer disease resulted in significant improvement in the quality of care and in behavioral and psychological symptoms of dementia among primary care patients and their caregivers. These improvements were achieved without significantly increasing the use of antipsychotics or sedative-hypnotics. Trial Registration: clinicaltrials.gov Identifier: NCT00246896. | Callahan C. M. Boustani M. A. Unverzagt F. W. 周永(译) | 2006 | 世界核心医学期刊文摘(神经病学分册)2006，2，9： | 3 |
| 2 | Chemotherapy for advanced gastric cancer显示文摘 | Wagner AD Unverzagt S Grothe W | | 0，，03： | 2 |
| 3 | Analyses of free prostate-specific antigen (PSA) after chemical release from the complex with alpha ( 1 )-antichymotrypsin (PSA-ACT) 显示文摘 | Peter J Unverzagt C Hoesel W | 2000 | Clin Chem2000，46，4： | 1 |
| 4 | The effect of speed-of-processing training on depressive symptoms in ACTIVE显示文摘 | Wolinsky F.D Vander Weg M.W Martin R Unverzagt F.W Ball K.K Jones R.N | | 0，，04： | 1 |
| 5 | Chemotherapy for advanced gastric cancer显示文摘 | Wagner AD Unverzagt S Grothe W | 2010 | Cochrane Database Syst Rev2010，3，00： | 1 |
| 6 | Identification of precursor forms of free prostate-specific antigen in serum of prostate cancer patients by immunosorption and mass spectrometry 显示文摘 | Peter J Unverzagt C Krogh TN | 2001 | CancerRes2001，61，： | 1 |
| 7 | Idenitficaiton and comparison of CD34-positive ceils and their subpopulations from normal peripheral blood and bone marrow using muhicolor flow cytometry 显示文摘 | Bender JG Unverzagt KL Walker DE | 1991 | Blood1991，7，12： | 1 |
| 8 | Chemotherapy for advanced gastric cancer 显示文摘 | Wagner AD Unverzagt S Grothe W | 2010 | Cochrane Database Syst Rev2010，，： | 1 |
| 9 | Prevalence of cognitive impairment: data from the Indianapolis study of health and aging显示文摘 | Gao S Baiyewu O | 2001 | Neurology2001，57，： | 1 |
| 10 | Chemotherapy for advanced gastric cancer显示文摘 | Wagner AD Unverzagt S Grothe W | 2010 | Cochrane Database Syst Rev2010，17，00： | 1 |
| 11 | Prevalence of cognitive impairment:data from the indianapolis study of health and aging显示文摘 | Unverzagt FW Gao S Baiyewu O | | 0，，： | 1 |
| 12 | Interleukin -6, - 7, -8 and - 10 predict outcome in acute myocardial infarction complicated by cardiogenic shock 显示文摘 | Prondzinsky R Unverzagt S Lemm H et at | 2012 | Clin Res Cardiol2012，101，5： | 1 |
| 13 | Optimization of a 200 kW SOFC cogeneration power plant Part I: Variation of process parameters 显示文摘 | Ernst Riensche Ulrich Stimming Guido Unverzagt | 1998 | Journal of Power Sources1998，73，2： | 1 |
| 14 | Chemotherapy for ad- vanced gastric cancer 显示文摘 | Wagner AD Unverzagt S Grothe W | 2010 | Cochrane Database Syst Rev2010，17，00： | 1 |
| 15 | Hypertension and cognitive decline in rural elderly Chinese显示文摘 | Gao S Jin Y Unverzagt FW | 2009 | J Am Geriatr Soc2009，57，6： | 1 |
| 16 | Prevalence of cognitive impairment:data from the Indianapolis study of health and aging显示文摘 | Unverzagt FW Gao S Baiyewu O | 2001 | Neurology2001，57，： | 1 |
| 17 | Cognitive pre dictors of everyday functioning in older adults: results from the ACTIVE Cognitive Intervention Trial显示文摘 | Gross A L Rebok G W Unverzagt F W | 2011 | J Gerontol B Psychol Sci Soc Sci2011，66，5： | 1 |
| 18 | Hemodynamic effects of intra-aortic balloon counterpulsation in patients with acute myocardial infarction complicated by cardiogenic shock: the prospective, randomized IABP shock trial显示文摘 | Prondzinsky R Unverzagt S Russ M | 2012 | Shock2012，37，4： | 1 |
| 19 | Chemotherapy for advanced gastric cancer显示文摘 | Wagner AD Unverzagt S Grothe W | 2010 | Cochrane Database Syst Rev2010，17，3： | 1 |
| 20 | Low education and child- hood rural residence: risk for Alzheimer's disease in African Americans 显示文摘 | Hall KS Gao S Unverzagt FW | 2000 | Neurology2000，54，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员