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| 1 | Characteristics of non-erosive gastroesophageal reflux disease refractory to proton pump inhibitor therapy显示文摘AIM:To investigate whether potent acid inhibition is effective in non-erosive reflux disease (NERD) refractory to standard rabeprazole (RPZ) treatment. METHODS:We treated 10 Japanese patients with NERD resistant to standard dosages of RPZ:10 mg or 20 mg od,20 mg bid,or 10 mg qid for 14 d. All patients completed a frequency scale for symptoms of gastroesophageal reflux disease questionnaire frequency scale for the symptoms of GERD (FSSG); and underwent 24 h pH monitoring on day 14. RESULTS:With increased dosages and frequency of administration of RPZ,median intragastric pH significantly increased,and FSSG scores significantly decreased. With RPZ 10 mg qid,potent acid inhibition was attained throughout 24 h. However,five subjects were refractory to RPZ 10 mg qid,although the median intragastric pH in these subjects (6.6,range:6.2-7.1) was similar to that in the remaining five responsive subjects (6.5,range:5.3-7.3). With baseline RPZ 10 mg od,FSSG scores in responsive patients improved by > 30%,whereas there was no significant decrease in the resistant group. CONCLUSION:NERD patients whose FSSG score fails to decrease by > 30% after treatment with RPZ 10 mg od for 14 d are refractory to higher dosage. | Mitsushige Sugimoto Masafumi Nishino Chise Kodaira Mihoko Yamade Takahiro Uotani Mutsuhiro Ikuma Kazuo Umemura Takahisa Furuta | 2011 | World Journal of Gastroenterology2011，17，14： | 10 |
| 2 | Experimental and numerical study on hydrodynamics of riparian vegetation显示文摘Recently, many channelized rivers tend to be heavily vegetated due to regime shifts in hydrological, fluvial and ecological processes. Dense vegetation in a river frequently obstructs a flood flow and reduces conveyance capacity of channels. On the other hand, river vegetation provides various ecological services such as habitats for various species and life, natural cycle of organic and inorganic substances, etc.. It is of engineering importance to understand vegetation hydrodynamics in order to preserve vegetation nature and keep a certain level of flow conveyance capacity. In view that willows tend to be densely vegetated along the shoreline of floodplains or sandbars, a field measurement, a physical model experiment and a numerical analysis were carried out for investigating hydrodynamics in an open channel with riparian vegetation. Discussion was made focusing on flow and shear layer structures developed around the vegetation canopy. | UOTANI Takuya KANDA Keiichi MICHIOKU Kohji | 2014 | Journal of Hydrodynamics2014，26，5： | 4 |
| 3 | Efficacy of Tailored Helicobacter pylori Eradication Treatment Based on Clarithromycin Susceptibility and Maintenance of Acid Secretion显示文摘 | Mitsushige Sugimoto Takahiro Uotani Shu Sahara Hitomi Ichikawa Mihoko Yamade Ken Sugimoto Takahisa Furuta | 2014 | Helicobacter2014，，4： | 3 |
| 4 | Rabeprazole 10?mg q.d.s. decreases 24‐h intragastric acidity significantly more than rabeprazole 20 mg b.d. or 40?mg o.m., overcoming CYP 2 C 19 genotype显示文摘 | M. Sugimoto N. Shirai M. Nishino C. Kodaira T. Uotani M. Yamade S. Sahara H. Ichikawa K. Sugimoto H. Miyajima T. Furuta | 2012 | Aliment Pharmacol Ther2012，，7： | 3 |
| 5 | Ability of Rabeprazole to Prevent Gastric Mucosal Damage From Clopidogrel and Low Doses of Aspirin Depends on CYP2C19 Genotype显示文摘 | Takahiro Uotani Mitsushige Sugimoto Masafumi Nishino Chise Kodaira Mihoko Yamade Shu Sahara Takanori Yamada Satoshi Osawa Ken Sugimoto Tatsuo Tanaka Kazuo Umemura Hiroshi Watanabe Hiroaki Miyajima Takahisa Furuta | 2012 | Clinical Gastroenterology and Hepatology2012，，8： | 2 |
| 6 | Ability of rabeprazole to prevent gastric mucosal damage from clopidogrel and low doses of aspirin depends on CYP2C19 genotype显示文摘 | Uotani T Sugimoto M Nishino M | 2012 | Clin Gastroenterol Hepatol2012，10，8： | 1 |
| 7 | Ability of rabeprazole to prevent gastric mucosal damage from clopidogrel and low doses of aspirin depends on CYP2C19 genotype显示文摘 | Uotani T Sugimoto M Nishino M | 2012 | Clin Gastroenterol Hepatol2012，10，8： | 1 |
| 8 | DNA base flipping by a base pair -mimic nucleoside 显示文摘 | Nakano S Uotani Y Uenishi K | 2005 | Nucleic Acids Research2005，，33： | 1 |
| 9 | Prevention of gastric mucosal injury induced by anti-platelet drugs by famotidine显示文摘 | Uotani T Sugimoto M Nishino M | 2014 | J Clin Pharmacol2014，54，8： | 1 |
| 10 | Divergent signaling capacities of the long and short isoforms of the leptin recep- tor显示文摘 | Bjorbaek C Uotani S Silva BD | 1997 | J Biol Chem1997，272，32： | 1 |
| 11 | Sitafloxacin‐based third‐line rescue regimens for H elicobacter pylori infection in J apan显示文摘 | Takahisa Furuta Mitsushige Sugimoto Chise Kodaira Masafumi Nishino Mihoko Yamade Takahiro Uotani Shu Sahara Hitomi Ichikawa Takanori Yamada Satoshi Osawa Ken Sugimoto Hiroshi Watanabe Kazuo Umemura | 2014 | J Gastroenterol Hepatol2014，，3： | 1 |
| 12 | Novel uterine sarcoma preoperative diagnosis score predicts the need for surgery in patients presenting with a uterine mass显示文摘 | Tomonori Nagai Yasushi Takai Taichi Akahori Hiroaki Ishida Tatsuya Hanaoka Takahiro Uotani Sho Sato Shigetaka Matsunaga Kazunori Baba Hiroyuki Seki | 2014 | SpringerPlus2014，，： | 1 |
| 13 | Electrodeposition method for controlled formation of CdS films from aqueous solutions 显示文摘 | Nishino J Chatani S Uotani Y | 1999 | Journal of Electroanalytical Chemistry1999，473，： | 1 |
| 14 | Dual-energy direct bone removal CT angingraphy for evaluation of intracranial aneurysm or stenosis:comparison with conventional digital subtraction angiosraphy显示文摘 | Watanabe Y Uotani K NakazawaT | 2009 | Eur Radiol2009，19，4： | 1 |
| 15 | In vivo administration of leptin activates signal transduction directly in insulin - sensitive tissues: overlapping but distinct pathways from insulin 显示文摘 | Kim YB Uotani S Pierroz DD | 2000 | Endocrinology2000，141，7： | 1 |
| 16 | Vanadate enhances leptin-induced activation of JAK/STAT pathway in CHO cells 显示文摘 | Kita A Uotani S Kuwahara H | 2003 | Biochem Biophys Res Commun2003，302，： | 1 |
| 17 | Preoperative visualization of the artery of Adamkiewicz by intraarterial CT angiography 显示文摘 | Uotani K Yamada N Kono AK | 2008 | Am J Neuroradiol2008，29，2： | 1 |
| 18 | Vandate enhances leptin-induced activation of JAK/STAT pathway in CHO cells显示文摘 | Kita A Uotani S Kuwahara H | 2003 | Biophys Res Commun2003，302，4： | 1 |
| 19 | Production of poly(γ-glutamic acid) by Bacillus subtilis F-2-01显示文摘 | Kubota H Matsunobu T Uotani K | 1993 | Biosci Biotechnol Biochem1993，57，： | 1 |
| 20 | Divergent signaling capacities of the long and short isoforms of the leptin receptor显示文摘 | Bjorbaek C Uotani S da Silva B | 1997 | J Biol Chem1997，272，32： | 1 |
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