|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Osteopontin: A non-invasive parameter of portal hypertension and prognostic marker of cirrhosis显示文摘AIM: To investigate the relationship between osteopontin plasma concentrations and the severity of portal hypertension and to assess osteopontin prognostic value.METHODS: A cohort of 154 patients with confirmed liver cirrhosis(112 ethylic, 108 men, age 34-72 years)were enrolled in the study. Hepatic venous pressure gradient(HVPG) measurement and laboratory and ultrasound examinations were carried out for all patients. HVPG was measured using a standard catheterization method with the balloon wedge technique. Osteopontin was measured using the enzyme-linked immunosorbent assay(ELISA) method in plasma. Patients were followed up with a specific focus on mortality. The control group consisted of 137 healthy age- and sex- matched individuals.RESULTS: The mean value of HVPG was 16.18 ± 5.6 mm Hg. Compared to controls, the plasma levels of osteopontin in cirrhotic patients were significantly higher(P < 0.001). The plasma levels of osteopontin were positively related to HVPG(P = 0.0022, r = 0.25) and differed among the individual Child-Pugh groups of patients. The cut-off value of 80 ng/m L osteopontin distinguished patients with significant portal hypertension(HVPG above 10 mm Hg) at 75% sensitivity and 63% specificity. The mean follow-up of patients was 3.7 ± 2.6 years. The probability of cumulative survival was 39% for patients with HVPG > 10 mm Hg and 65% for those with HVPG ≤ 10 mm Hg(P = 0.0086, odds ratio(OR), 2.92, 95% confidence interval(CI): 1.09-7.76). Osteopontin showed a similar prognostic value to HVPG. Patients with osteopontin values above 80 ng/m L had significantly lower cumulative survival compared to those with osteopontin ≤ 80 ng/m L(37% vs 56%, P = 0.00035; OR = 2.23, 95%CI: 1.06-4.68).CONCLUSION: Osteopontin is a non-invasive parameter of portal hypertension that distinguishes patients with clinically significant portal hypertension. It is a strong prognostic factor for survival. | Radan Bruha Marie Jachymova Jaromir Petrtyl Karel Dvorak Martin Lenicek Petr Urbanek Tomislav Svestka Libor Vitek | 2016 | World Journal of Gastroenterology2016，22，12： | 20 |
| 2 | Ultrasound-assessed non-culprit and culprit coronary vessels differ by age and gender显示文摘AIM: To investigate age-and gender-related differences in non-culprit versus culprit coronary vessels assessed with virtual histology intravascular ultrasound (VH-IVUS). METHODS: In 390 patients referred for coronary angiography to a single center (Luzerner Kantonsspital, Switzerland) between May 2007 and January 2011, 691 proximal vessel segments in left anterior descending, circumflex and/or right coronary arteries were imaged by VH-IVUS. Plaque burden and plaque composition(fibrous, fibro-fatty, necrotic core and dense calcium volumes) were analyzed in 3 age tertiles, according to gender and separated for vessels containing non-culprit or culprit lesions. To classify as vessel containing a culprit lesion, the patient had to present with an acute coronary syndrome, and the VH-IVUS had to be performed in a vessel segment containing the culprit lesion according to conventional coronary angiography. RESULTS: In non-culprit vessels the plaque burden increased significantly with aging (in men from 37% ± 12% in the lowest to 46% ± 10% in the highest age tertile, P < 0.001; in women from 30% ± 9% to 40% ± 11%, P < 0.001); men had higher plaque burden than women at any age (P < 0.001 for each of the 3 age tertiles). In culprit vessels of the lowest age tertile, plaque burden was significantly higher than that in non- culprit vessels (in men 48% ± 6%, P < 0.001 as compared to non-culprit vessels; in women 44% ± 18%, P = 0.004 as compared to non-culprit vessels). Plaque burden of culprit vessels did not significantly change during aging (plaque burden in men of the highest age tertile 51% ± 9%, P = 0.523 as compared to lowest age tertile; in women of the highest age tertile 49% ± 8%, P = 0.449 as compared to lowest age tertile). In men, plaque morphology of culprit vessels became increasingly rupture-prone during aging (increasing percentages of necrotic core and dense calcium), whereas plaque morphology in non-culprit vessels was less rupture-prone and remained constant during aging. In women, necrotic core in non-culprit vessels was very low at young age, but increased during aging resulting in a plaque morphology that was very similar to men. Plaque morphology in culprit vessels of young women and men was similar. CONCLUSION: This study provides evidence that age-and gender-related differences in plaque burden and plaque composition significantly depend on whether the vessel contained a non-culprit or culprit lesion. | Andreas W Schoenenberger Nadja Urbanek Stefan Toggweiler Andreas E Stuck Thérèse J Resink Paul Erne | 2013 | World Journal of Cardiology2013，5，3： | 7 |
| 3 | Varation in resistin gene promoter not associated with polycystic ovary syndrome 显示文摘 | Urbanek M Du Y Silander K | 2003 | Diabetes2003，52，1： | 1 |
| 4 | Cardiac stem cells delivered intravascularly traverse the vessel barrier,regenerate infarcted myocardium,and improve cardiac function显示文摘 | STEIN AB URBANEK K et al | 2005 | Proc Natl Acad Sci U S A2005，102，10： | 1 |
| 5 | A single nucleotide polymorphism in the matrix metalloproteinase-1 ( MMP-1 ) promoter influences amnion cell MMP-1 expression and risk for preterm premature rupture of the fetal membranes 显示文摘 | Fujimoto T Parry S Urbanek M | 2002 | J Biol Chem2002，277，8： | 1 |
| 6 | Cardiomyogenesis in the adult human heart显示文摘 | Kajstura J Urbanek K Perl S | 2010 | Circ Res2010，107，2： | 1 |
| 7 | Cardiac stem cells delivered intravascularly traverse the vessel barriet, regenerate infarcted myocardium, and improve cardiac function 显示文摘 | Dawn B Stein AB Urbanek K | 2005 | Proc Natl Acad Sci USA2005，102，10： | 1 |
| 8 | Common infections and the risk of stroke显示文摘 | Grau A J C Urbanek F Palm | 2010 | Nat Rev Neurol2010，6，12： | 1 |
| 9 | Facial paresis after stroke and its impact on patients' facial movement and mental sta- tus 显示文摘 | Konecny P Elfmark M Urbanek K | 2011 | J Rehabil Med2011，43，： | 1 |
| 10 | Intense myocyte formation from cardiac stem ceils in human cardiac hypertrophy显示文摘 | Urbanek K Quaini F Tasca G | 2003 | Proc Natl Acad Sci USA2003，100，10： | 1 |
| 11 | Time-frequency approach to extraction of selected second-order cyclostationary vibration components for varying operational conditions显示文摘 | URBANEK J BARSZCZ T ANTONI J | 2013 | Measurement2013，46，4： | 1 |
| 12 | Evidence that human cardiac myocytes divide after myocardial infarction显示文摘 | Beltrami AP Urbanek K Kajstura J | 2001 | N-Engl-J-Med2001，344，23： | 1 |
| 13 | Cardiac stem cells delivered intravascularly traverse the vessel barrier,regenerate infracted myocardium,and improve cardiac function显示文摘 | DAWN B STEIN A B URBANEK K | 2005 | Proc Natl Acad Sci USA2005，102，10： | 1 |
| 14 | Evidence thathuman cardiac myocytes divide after myocardial infarction显示文摘 | Beltrami A P Urbanek K Kajstura J | 2001 | NEngl J Med2001，344，23： | 1 |
| 15 | Evidence that human cardiac myocytes divide after myocardial infarction显示文摘 | Beltrami AP Urbanek K Kajstura J | 2001 | N Engl J Med2001，344，： | 1 |
| 16 | Mammaglobin gene expression: a superior marker of breast cancer cells in peripheral blood in comparison to epidermal-growth-faclor receptor and cytokeratin-19 显示文摘 | Granewald K Haun M Urbanek M | 2000 | Lab Invest2000，80，7： | 1 |
| 17 | Chimerism of the transplanted heart显示文摘 | Quaini F Urbanek K Beltrami AP | 2002 | N Engl J Med2002，346，： | 1 |
| 18 | Cardiac stem cells possess growth facto receptor systems that after activation regenerate the infarcted myoeardium,improving ventricular function and long-term survival显示文摘 | Urbanek K Rota M Cascapera S | 2005 | Circ Res2005，97，7： | 1 |
| 19 | Diabetes Promotes Cardiac Stem Cell Aging and Heart Failure, Which Are Prevented by Deletion of the p66shc Gene显示文摘 | Marcello Rota Nicole LeCapitaine Toru Hosoda Alessandro Boni Antonella De Angelis Maria Elena Padin-Iruegas Grazia Esposito Serena Vitale Konrad Urbanek Claudia Casarsa Marco Giorgio Thomas F. Lüscher Pier Giuseppe Pelicci Piero Anversa Annarosa Leri Jan | 2006 | Circulation Research2006，，1： | 1 |
| 20 | The influence of antibi otic use on the occurrence of vancomycin resistant enterococci显示文摘 | Kolar M Urbanek K Vagnerova I | 2006 | J Clin Pharm Ther2006，31，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员