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| 1 | Insulin sensitizers in treatment of nonalcoholic fatty liver disease:Systematic review显示文摘AIM: To summarize the evidence available for the clinical effectiveness of insulin sensitizers in the treatment of nonalcoholic fatty liver disease (NAFLD) systematically. METHODS: Relevant articles were located using computer-assisted searches of Medline (1966-March 2006), EMBASE (1988-March 2006), CINAHL (1982-March 2003), Educational Resource Information Center (1966-March 2006), Library, Information Science & Technology Abstracts (1967-March 2006), Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects (1994-2006), dissertations in ProQuest and FirstSearch databases. Manual searches were made in the abstracts from meetings of the American Gastroenterological Association (1999-2006), and the American Association for the Study of Liver Diseases (2003-2005). Studies were retrieved using the following selection criteria: (1) clinical trials using insulin sensitizers in subjects with NAFLD, (2) adult patients, (3) published as full manuscripts or abstracts, and (4) English, Spanish, German, and French languages only. Data were abstracted independently by two reviewers following standardized procedures. A face-to- face comparison of data was conducted to ensure the completeness and reliability of the abstraction process. RESULTS: Nine studies were included, six using metformin and three using thiazolidinediones. Only two studies were placebo-controlled trials. The mediansample size for all studies was 18 subjects. In the placebo-controlled trials, metformin improved insulin resistance markers and liver function tests, but not histological scores. In the single-arm trials, metformin and thiazolidinediones improved insulin resistance markers and liver function tests, and beneficial histological changes were reported. There is limited high-quality information available from which to draw categorical conclusions about the clinical use of insulin sensitizers in NAFLD.CONCLUSION: Current information indicates that the use of insulin sensitizers in NAFLD improves insulin resistance and liver function. Histological changes must be corroborated in randomized controlled trials. | Norberto C Chavez-Tapia Tonatiuh Barrientos-Gutierrez Felix I Tellez-ávila Francisco Sánchez-ávila Maria Antonieta Montao-Reyes Misael Uribe | 2006 | World Journal of Gastroenterology2006，12，48： | 11 |
| 2 | Prevalence of metabolic syndrome, obesity and diabetes type 2 in cryptogenic cirrhosis显示文摘AIM: To evaluate the prevalence of metabolic syndrome (MS), obesity and type 2 diabetes mellitus (T2DM) in a group of Mexican Mestizo patients with cryptogenic cirrhosis (CC) and to compare this group with patients with cirrhosis secondary to other causes (disease controls). METHODS: Patients with CC, diagnosed between January, 1990 and April, 2005, were included in a retrospective study. Patients with cirrhosis caused by chronic hepatitis C, alcohol abuse or autoimmune hepatitis (AIH) served as disease controls. RESULTS: A total of 134 patients with CC were analyzed. Disease controls consisted of 81 patients with chronic hepatitis C, 33 with alcohol abuse and 20 with AIH. The median age of patients with CC was 57 years (range, 16-87); 83 (61.9%) patients were female; 53 (39.6%) were Child A, 65 (48.5%) Child B, and 16 (11.9%) were Child C cirrhosis. The prevalence of MS (29.1% vs 6%; P < 0.001), obesity (16.4% vs 8.2%; P = 0.04) and T2DM (40% vs 22.4%; P = 0.013) was higher in CC patients than in disease controls. There were no differences in sex, age or liver function tests between the two groups. CONCLUSION: The prevalence of MS, obesityand T2DM were higher in patients with CC than in patients with cirrhosis secondary to others causes. Our findings support the hypothesis that non-alcoholic steatohepatitis (NASH) plays an under-recognized role in CC. | Felix I Tellez-Avila Francisco Sanchez-Avila Mauricio García-Saenz-de-Sicilia Norberto C Chavez-Tapia Ada M Franco-Guzman Gustavo Lopez-Arce Eduardo Cerda-Contreras Misael Uribe | 2008 | World Journal of Gastroenterology2008，14，30： | 6 |
| 3 | Clinical heterogeneity in autoimmune acute liver failure显示文摘AIM: To describe the outcome and prognosis in a cohort of patients with acute liver failure due to autoimmune hepatitis without liver transplantation. METHODS: A retrospective trial was conducted in 11 patients with acute liver failure due to autoimmune hepatitis who attended the Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubiran. Demographic, biochemical and severity indexes, and treatment and outcome were assessed. RESULTS: Among the 11 patients, with a median age of 31 years, 72% had inflammatory response syndrome, and six patients received corticosteroids. The mortality rate within four weeks was 56%, and the one-year survival was 27%. In the survivors, severity indexes were lower and 83% received corticosteroids. CONCLUSION: We observed a relatively high survival rate in patients with acute liver failure due to autoimmune hepatitis. This survival rate could be influenced by severity of the disease and/or use of corticosteroids. | Norberto C Chavez-Tapia Julio Martinez-Salgado Julio Granados Misael Uribe Felix I Tellez-Avila | 2007 | World Journal of Gastroenterology2007，13，12： | 1 |
| 4 | Extraction of oil from chia seeds with supercritical CO2显示文摘 | URIBE J A R PEREZ J I N KAUIL H C | | 0，，02： | 1 |
| 5 | 显示文摘 | Martinez F Obieta G Uribe I | 2009 | ProcediaChemistry2009，1，： | 1 |
| 6 | Extraction of oil from chia seeds with supercritical CO2显示文摘 | Uribe J A 1k Perez J I N Kauil H C | 2011 | The Journal of Supercritical Fluids2011，56，2： | 1 |
| 7 | PEMFC poisoning with H2S: Dependence on operating conditions显示文摘 | Urdampilleta I Uribe F Rockward T | 2007 | ECS Transactions2007，11，1： | 1 |
| 8 | Effect of the EMDR psychotherapeutic approach on emotional cognitive processing in patients with depression显示文摘 | Rosas Uribe ME López Ramirez EO Jarero Mena I | 2010 | Span J Psychol2010，13，1： | 1 |
| 9 | Sealing pereutaneous hephroslithotomy tracts with gelatin matrix hemostatie sealant : Initial clinical use 显示文摘 | Lee I uribe C Eichel | 2004 | Jurol2004，171，2： | 1 |
| 10 | Clinical characteristics of different hislologic types of breast caueer显示文摘 | I i CI Uribe DJ Daling JR | 2005 | Br J Cancer2005，93，9： | 1 |
| 11 | Concentrations of endotoxins in waters around the Island of Montreal,and treatment options显示文摘 | Gehr R Uribe P U Baptista I F D S | 2008 | Water Qual Res J Can2008，43，4： | 1 |
| 12 | Thyroid hormone preconditioning:protection against ischemia-reperfusion liver injury in the rat显示文摘 | Fernández V Castillo I Tapia G Romanque P Uribe-Echevarría S Uribe M | | 0，，： | 1 |
| 13 | Concentrations of endotoxins in waters around the island of Montreal, and treatment options显示文摘 | Gehr R Uribe S P Baptista I F D | 2008 | Water Quality Research Journal of Canada2008，43，4： | 1 |
| 14 | The nutritional status and respiratory function of patients diagnosed with COPD显示文摘 | Gil Canalda I Gimeno Uribes C Cos Blanco AI | | 0，，02： | 1 |
| 15 | Therapeutic benefit of spironolactone in experimental chronic cyclosporine A nephrotoxicity显示文摘 | Feria I Pichardo I Juárez P Ramírez V González MA Uribe N | | 0，，01： | 1 |
| 16 | The Role of Virtual Reality in Sur gical Training in Otorhinolaryngology显示文摘 | Fried M P Uribe J I Sadoughi B | 2007 | Curr Opin Otolaryngo Head Neck Surg2007，15，3： | 1 |
| 17 | Comparison of the depressant action of sulfite and metabisulfite for Cu-activated sphalerite显示文摘 | Davila-Pulido G I Uribe·Salas A Espinosa-Gomez R | 2011 | Intemational Joumal of Mineral Processing2011，101，14： | 1 |
| 18 | Hydrogen permeation in gamma titanium aluminides显示文摘 | Estupinan H A Uribe I Sundaram P A | 2006 | Corrosion Science2006，48，12： | 1 |
| 19 | Sealin percutaneous nephrosllthotomy tracts with gelatin matrixhemostatic sealant Initial clinical use 显示文摘 | LEE DI URIBE C EICHEL I | 2000 | J Urol2000，171，2： | 1 |
| 20 | Effects of commonly used hemostatic agents on the porcine collecting system显示文摘 | Kim I Y Eichel L Edwards R Uribe C Chou D S Abdelshehid C | 2007 | J Endourol2007，21，： | 1 |
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