|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Non invasive blood flow measurement in cerebellum detects minimal hepatic encephalopathy earlier than psychometric tests显示文摘AIM: To assess whether non invasive blood flow measurement by arterial spin labeling in several brain regions detects minimal hepatic encephalopathy. METHODS: Blood flow(BF) was analyzed by arterial spin labeling(ASL) in different brain areas of 14 controls, 24 cirrhotic patients without and 16 cirrhotic patients with minimal hepatic encephalopathy(MHE). Images were collected using a 3 Tesla MR scanner(Achieva 3T-TX, Philips, Netherlands). Pulsed ASL was performed. Patients showing MHE were detected using the battery Psychometric Hepatic Encephalopathy Score(PHES) consisting of five tests. Different cognitive and motor functions were also assessed: alterations in selective attention were evaluated using the Stroop test. Patients and controls also performed visuo-motor and bimanual coordination tests. Several biochemical parameters were measured: serum pro-inflammatory interleukins(IL-6 and IL-18), 3-nitrotyrosine, cGMP and nitrates+nitrites in plasma, and blood ammonia. Bivariate correlations were evaluated.RESULTS: In patients with MHE, BF was increased in cerebellar hemisphere(P = 0.03) and vermis(P = 0.012) and reduced in occipital lobe(P = 0.017). BF in cerebellar hemisphere was also increased in patients without MHE(P = 0.02). Bimanual coordination was impaired in patients without MHE(P = 0.05) and much more in patients with MHE(P < 0.0001). Visuo-motor coordination was impaired only in patients with MHE(P < 0.0001). Attention was slightly affected in patients without MHE and more strongly in patients with MHE(P< 0.0001). BF in cerebellar hemisphere and vermis correlated with performance in most tests of PHES [(number connection tests A(NCT-A), B(NCT-B)and line tracing test] and in the congruent task of Stroop test. BF in frontal lobe correlated with NCT-A. Performance in bimanual and visuomotor coordination tests correlated only with BF in cerebellar hemisphere. BF in occipital lobe correlates with performance in the PHES battery and with CFF. BF in cerebellar hemisphere correlates with plasma cGMP and nitric oxide(NO) metabolites. BF in vermis cerebellar also correlates with NO metabolites and with 3-nitrotyrosine. IL-18 in plasma correlates with BF in thalamus and occipital lobe.CONCLUSION: Non invasive BF determination in cerebellum using ASL may detect MHE earlier than the PHES. Altered NO-cGMP pathway seems to be associated to altered BF in cerebellum. | Vicente Felipo Amparo Urios Carla Giménez-Garzó Omar Cauli Maria-Jesús Andrés-Costa Olga González Miguel A Serra Javier Sánchez-González Roberto Aliaga Remedios Giner-Durán Vicente Belloch Carmina Montoliu | 2014 | World Journal of Gastroenterology2014，20，33： | 12 |
| 2 | Individual repeatability in timing and spatial flexibility of migration routes of trans-Saharan migratory raptors显示文摘 | Pascual LOPEZ-LOPEZ Clara GARCLA-RIPOLLES Vicente URIOS | 2014 | Current Zoology2014，60，5： | 4 |
| 3 | Wind effects on the migration routes of trans-Saharan soaring raptors: geographical, seasonal, and interspecific variation显示文摘 | Javier VIDAL-MATEO Ugo MELLONE Pascual LOPEZ-LOPEZ Javier De LA PUENTE clara GARCIA-RIPOLLES Ana BERMEJO Vicente URIOS | 2016 | Current Zoology2016，62，2： | 2 |
| 4 | Contribution of hyperam- monemia and inflammatory factors to cognitive impairment in mini- mal hepatic encephalopathy 显示文摘 | Felipo V Urios A Montesinos E | 2012 | Metab Brain Dis2012，27，1： | 1 |
| 5 | Urinary KIM-1,NGALand L-FABP for the diagnosis of AKI in patients with acute coronarysyndrome or heart failure undergoing coronary angiography 显示文摘 | Torregrosa I Montoliu Cf Urios A | 2015 | Heart Vessels2015，306，： | 1 |
| 6 | Urinary KIM-1,NGAL and L-FABP for the diagnosis of AKI in patients withacute coronary syndrome or heart failure undergoing coronaryangiography显示文摘 | Torregrosa I Montoliu C Urios A | 2015 | Heart Vessels2015，30，6： | 1 |
| 7 | Regional and age-dependent differences in the effect of wind on the mi^ratorv routes of Eleonora's falcon显示文摘 | Ugo MELLONE Rube LIMINAN Pascual LOPEZ-LOPEZ Vicente URIOS | 2015 | Current Zoology2015，61，3： | 1 |
| 8 | Urinary KIM - 1, NGAL and L - FABP for the diagnosis of AKI in patients with a- cute coronary syndrome or heart failure undergoing coronary angiog- raphy显示文摘 | TORREGROSA I MONTOLIU C URIOS A | 2014 | Heart Vessels2014，，： | 1 |
| 9 | Aspirin inhibits the formation of pentosidine, a cross-linking advanced glycation end product, in collagen 显示文摘 | Urios P | 2007 | Diabetes Research and Clinical Practice2007，77，2： | 1 |
| 10 | A flavonoid fraction purified from Rutaceae aurantiae (DaflonR) inhibiting AGE formation, reduces urinary albumin clearance and corrects bypoalbuminemia in normotensive and hypertensive diabetic rats显示文摘 | Urios P Kassab I Grigorova-Borsos AM | 2014 | Diabetes Res Clin Pract2014，105，3： | 1 |
| 11 | Screening formetabolites from Penicillium novae-zeelandiae displaying radical-scavenging activity and oxidative mutagenicity: Isolation of genti-syl alcohol显示文摘 | ALFARO C URIOS A GONZALEZ M C ei al | 2003 | Mutat Res2003，539，12： | 1 |
| 12 | Serum nitrotyrosine and psychometric tests as indicators of impaired fitness to drive in cirrhotic patients with minimal hepatic encephalopathy显示文摘 | Vicente Felipo Amparo Urios Pedro Valero Mar Sánchez Miguel A. Serra Ignacio Pareja Felicidad Rodríguez Carla Gimenez‐Garzó Jaime Sanmartín Carmina Montoliu | 2013 | Liver Int2013，，10： | 1 |
| 13 | Low mitochondrial DNA diversity in the endangered Bonelli's eagle (I-/ieraaetus fasciatus) from SW Europe (Iberia) 显示文摘 | Cadalda L Negro J J Urios V | 2007 | Journal of Ornithology2007，148，： | 1 |
| 14 | Flavonoids inhibit the fMmation of the cross- linking AGE pentosidine in collagen incubated with glucose,according to their structure显示文摘 | URIOS P STERNBERG M | 2007 | European Jtnimal of Nutrition2007，46，3： | 1 |
| 15 | 3-nitro-tyrosine as a peripheral biomarker of minimal hepatie eneephalopathy in patients with liver eirrhosis 显示文摘 | Montoliu C Cauli O Urios A | 2011 | Am J Gastroenterol2011，106，9： | 1 |
| 16 | Is cognitive impairment in cirrhotic patients due to increased peroxynitrite and oxidative stress?显示文摘 | Gimenez C C Urios A AgustíA | 2015 | Antioxid Redox Sig2015，22，10： | 1 |
| 17 | Urinary KIM-1,NGAL and L-FABP for the diagnosis of AKI in patients with acute coronary syndrome or heart failure undergoing coronary angiography显示文摘 | Torregrosa I Montoliu C Urios A | 2014 | Heart Vessels2014，3，： | 1 |
| 18 | 3-nitro-tyrosine as a peripheral biomarker of minimal hepatic encephalopathy in patients with livercirrhosis 显示文摘 | Montoliu C Cauli O Urios A | 2011 | Am J Gastroenterol2011，106，9： | 1 |
| 19 | Urinary KIM-1, NGAL and L-FABP for the diagnosis of AKI in patients with acute coro- nary syndrome or heart failure undergoing coronary angiography 显示文摘 | Torregrosa I Montoliu C Urios A | 2015 | Heart Vessels2015，30，6： | 1 |
| 20 | A flavonoid fraction purified from Rutaceae aurantiae(Daflon R)inhibiting AGE formation,reduces urinary albumin clearance and corrects hypoalbuminemia in normotensive and hypertensive diabetic rats显示文摘 | Urios P Kassab I Grigorova-Borsos A M | 2014 | Diabetes Research and Clinical Practice2014，105，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员