|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Anti-bacterial activity and brine shrimp lethality bioassay of methanolic extracts of fourteen different edible vegetables from Bangladesh显示文摘Objective:To investigate the antibacterial and cytotoxic activity of fourteen different edible vegetables methanolic extract from Bangladesh.Methods:The antibacterial activity was evaluated using disc diffusion assay method against 12 bacteria(both gram positive and gram negative).The plant extracts were also screened for cytotoxic activity using the brine shrimp lethality bioassay method and the lethal concentrations(LC_(50))were determined at confidence intervals by analyzing the data on a computer loaded with'Finney Programme??Results:All the vegetable extracts showed low to elevated levels of antibacterial activity against most of the tested strains(zone of inhibition=5-28 mm).The most active extract against all bacterial strains was from Xanthium indicum which showed remarkable antibacterial activity having the diameter of growth inhibition zone ranging from 12 to 28 mm followed by Alternanthera sessilis(zone of inhibition=6-21 mm).All extracts exhibited considerable general toxicity towards brine shrimps.The LC_(50)value of the tested extracts was within the range of 8.447 to 60.323μg/mL with respect to the positive control(vincristine sulphate)which was 0.91μg/mL.Among all studied extracts,Xanthium indicum displayed the highest cytotoxic effect with LC_(50)value of 8.447μg/mL.Conclusions:The results of the present investigation suggest that most of the studied plants are potentially good source of antibacterial and anticancer agents. | M.Obayed Ullah Mahmuda Haque Kaniz Fatima Urmi Abu Hasanat Md.Zulfiker Elichea Synthi Anita Momtaj Begum Kaiser Hamid | 2013 | Asian Pacific Journal of Tropical Biomedicine2013，3，1： | 5 |
| 2 | LAP: the protector against autoimmunity显示文摘 | Urmi Bandyopadhyay Michael Overholtzer | 2016 | Cell Research2016，26，8： | 2 |
| 3 | The GM – CSF / IL‐3 / IL‐5 cytokine receptor family: from ligand recognition to initiation of signaling显示文摘 | Sophie E. Broughton Urmi Dhagat Timothy R. Hercus Tracy L. Nero Michele A. Grimbaldeston Claudine S. Bonder Angel F. Lopez Michael W. Parker | 2012 | Immunol Rev2012，，1： | 1 |
| 4 | Evaluation of Chitosan and Their Self-Assembled Nanoparticles with pDNA for the Application in Gene Therapy显示文摘 | Kishor Sarkar Rishi Srivastava Urmi Chatterji | | 0，，： | 1 |
| 5 | Cloning,expression,purification and bioinformatic analysis of 2-methylcitrate synthase from Mycobacterium tuberculosis显示文摘Objective:To clone,express and purify 2—methylcitrale synthase(Rv1131) gene of Mycobacterium tuberculosis(M.tuberculosis) and to study its structural characteristics using various bioinformatics tools.Methods:Rv1131 gene was amplified In polymerase chain reaction using M.tuberculosis H37 Rv genomic DNA and cloned into pGEM-T easy vector and sequenced.The gene was sub-cloned in pET28 c vector,expressed in Escherichia coli RL22(E.coli BL21)(DE3) cells and the recombinant protein was identified by Western blotting.The protein was purified using Nickel affinity chromatography and the structural characteristics like sub-cellular localization.presence of transmembrane helices and secondary structure of the protein were predicted by bioinformaties tools.Tertiary structure of the protein and phylogenetic analysis was aiso established by in silico analysis.Results:The expression of the recombinant protein(Rv1131) was confirmed by western blotting using anti-HIS antibodies and the protein was purified from the soluble fraction.In silico analysis showed that the protein contains no signal peptide and transmembrane helices,Active site prediction showed that the protein has histidine and aspartie acid residues at 242.281 & 332 positions respectively.Phylogenetic analysis showed100%homology with major mycobacterial species.Secondary structure predicts 2-methyleitrate synthase contain 51.9%;alpha-helk.8.7%extended strand and 39.4%random coils.Tertiary structure of the protein was also established.Conclusions:The enzyme 2-methylcitrate synthase from M.tuberculosis H37 Rv has been successfully expressed and purified.The purified protein will further be utilized to develop assay methods lor screening new inhibitors. | Kasamy Eniyan Urmi Bajpai | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，1： | 1 |
| 6 | Phytochelatin plays a role in UV-B tolerance in Nz-fix- ing cyanobacterium Anabaena doliolum 显示文摘 | BHARGAVA P KUMAR SRIVASTAVA A URMI S | 2005 | J Plant Physi- ol2005，162，11： | 1 |
| 7 | Comparative efficacy and safety of oxcarbazepine versus divalproex sodium in the treatment of acute mania: a pilot study 显示文摘 | Kakkar AK Rehan HS Urmi KE | 2009 | Eur Psychiatry2009，24，3： | 1 |
| 8 | Ultrastructural and hormonal modulations of the thyroid gland following arecoline treatment in albino mice显示文摘 | ROMI D URMI C NAG T C | 2010 | Molecular and Cellular Endocrinology2010，319，12： | 1 |
| 9 | Assessment of biofilm formation by the causative organisms of ventilator associated pneumonia at Intensive Care Unit of a tertiary care hospital显示文摘 | Mulla Summaiya A Jethwani Urmi N | | 0，，01： | 1 |
| 10 | Bilateral phasic increases in dorsal root ganglia nerve growth factor synthesis after unilateral sciatic nerve crush显示文摘 | Michael R. Wells Urmi Vaidya Joan P. Schwartz | 1994 | Experimental Brain Research1994，，1： | 1 |
| 11 | Malignant lesions arising in chronic osteomyelitis显示文摘 | McGrory JE Pritchard DJ Urmi KK | 1999 | Clin Orthop Relat Res1999，，362： | 1 |
| 12 | Government intervention and public-private partnerships in housing delivery in Kolkata显示文摘 | Urmi S | | 0，，03： | 1 |
| 13 | Government intervention and public private partnerships in housing delivery in Klolkata显示文摘 | Urmi Sengupta | 2006 | Habitat International2006，，03： | 1 |
| 14 | Giant cell tumor of the skull显示文摘 | Bertoni F Urmi KK Beabout JW | 1992 | Cancer1992，70，5： | 1 |
| 15 | Effect of local competition on the willingness of community pharmacies to supply medication therapy management services显示文摘 | BROOKS J M KLEPSER D G URMI J M | 2007 | J Health Hum Serv Adm2007，30，1： | 1 |
| 16 | Government intervention and Public - Private Partnerships in Housing Delivery in Kolkata 显示文摘 | Urmi Sengupta | 2006 | Habitat Interna- tional2006，，3： | 1 |
| 17 | Shapes of appurtenances in basins显示文摘 | Narayana N P Urmy T E | 1964 | Journal of Hydraulic Division1964，90，3： | 1 |
| 18 | Transcriptional co-activators: emerging roles in signaling pathways and potential therapeutic targets for diseases显示文摘Specific cell states in metazoans are established by the symphony of gene expression programs that necessitate intricate synergic interactions between transcription factors and the co-activators.Deregulation of these regulatory molecules is associated with cell state transitions,which in turn is accountable for diverse maladies,including developmental disorders,metabolic disorders,and most significantly,cancer.A decade back most transcription factors,the key enablers of disease development,were historically viewed as‘undruggable’;however,in the intervening years,a wealth of literature validated that they can be targeted indirectly through transcriptional co-activators,their confederates in various physiological and molecular processes.These co-activators,along with transcription factors,have the ability to initiate and modulate transcription of diverse genes necessary for normal physiological functions,whereby,deregulation of such interactions may foster tissue-specific disease phenotype.Hence,it is essential to analyze how these co-activators modulate specific multilateral processes in coordination with other factors.The proposed review attempts to elaborate an in-depth account of the transcription co-activators,their involvement in transcription regulation,and context-specific contributions to pathophysiological conditions.This review also addresses an issue that has not been dealt with in a comprehensive manner and hopes to direct attention towards future research that will encompass patient-friendly therapeutic strategies,where drugs targeting co-activators will have enhanced benefits and reduced side effects.Additional insights into currently available therapeutic interventions and the associated constraints will eventually reveal multitudes of advanced therapeutic targets aiming for disease amelioration and good patient prognosis. | Priyanka Dey Talukdar Urmi Chatterji | 2023 | Signal Transduction and Targeted Therapy2023，8，12： | 0 |
| 19 | Cysteine Residues in Receptor Proteins: Structural Insights from Two E. coil Periplasmic Binding Proteins显示文摘 | Urmi Roy Linda A. Luck | 2011 | Journal of Chemistry and Chemical Engineering2011，5，9： | 0 |
| 20 | ANTIVIRAL EFFECTS OF BACTERIOCIN AGAINST ANIMAL-TO-HUMAN TRANSMITTABLE MUTATED SARS-COV-2:A SYSTEMATIC REVIEW显示文摘The COVID-19 caused by SARS-CoV-2 has resulted in millions of people being infected and thousands of deaths globally since November 2019.To date,no unique therapeutic agent has been developed to slow the progression of this pandemic.Despite possessing antiviral traits the potential of bacteriocins to combat SARS-CoV-2 infection has not been fully investigated.This review summarizes the mechanisms by which bacteriocins can be manipulated and implemented as effective virus entry blockers with infection suppression potential properties to highly transmissible viruses through comprehensive immune modulations that are potentially effective against COVID-19.These antimicrobial peptides have been suggested as effective antiviral therapeutics and therapeutic supplements to prevent rapid virus transmission.This review also provides a new insight into the cellular and molecular alterations which have made SARS-CoV-2 self-modified with diversified infection patterns.In addition,the possible applications of antimicrobial peptides through both natural and induced mechanisms in infection prevention perspectives on changeable virulence cases are comprehensively analyzed.Specific attention is given to the antiviral mechanisms of the molecules along with their integrative use with synthetic biology and nanosensor technology for rapid detection.Novel bacteriocin based therapeutics with cutting-edge technologies might be potential substitutes for existing time-consuming and expensive approaches to fight this newly emerged global threat. | Dipta DEY Tanzila Ismail EMA Partha BISWAS Sharmin AKTAR Shoeba ISLAM Urmi Rahman RINIK Mahmudul FIROZ Shahlaa Zernaz AHMED Salauddin AL AZAD Ahsab RAHMAN Sadia AFRIN Rezwan Ahmed MAHEDI MdNasir Uddin BADAL | 2021 | Frontiers of Agricultural Science and Engineering2021，8，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员