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| 1 | Growth-Regulating Factors (GRFs): A Small Transcription Factor Family with Important Functions in Plant Biology显示文摘调整生长的因素(GRF ) 是原来在茎和叶开发为他们的角色被识别的植物特定的抄写因素,但是最近的研究加亮他们为在不利环境条件下面包括生长过程的花和种子形成,根发展,和协作的另外的中央发展过程同样重要。几 GRF 的表达式被 microRNA miR396 控制,并且 GRF-miRNA396 规章的模块看起来对几这些进程中央。另外, GRF 和 miR396 在上游的抄写因素被发现了,并且下游地逐渐地指向 GRF 的基因被解开。这里,我们考察 GRF 执行的生物功能的当前的知识并且调查可得到的分子的数据说明他们怎么在细胞的水平施加角色。 | Mohammad Amin Omidbakhshfard Sebastian Proost Ushio Fujikura Bernd Mueller-Roeber | 2015 | Molecular Plant2015，8，7： | 51 |
| 2 | Endoscopic diagnosis of extrahepatic bile duct carcinoma:Advances and current limitations显示文摘The accurate diagnosis of extrahepatic bile duct carcinoma is difficult,even now.When ultrasonography(US)shows dilatation of the bile duct,magnetic resonance cholangiopancreatography followed by endoscopic US(EUS)is the next step.When US or EUS shows localized bile duct wall thickening,endoscopic retrograde cholangiopancreatography should be conducted with intraductal US(IDUS)and forceps biopsy.Fluorescence in situ hybridization increases the sensitivity of brush cytology with similar specificity.In patients with papillary type bile duct carcinoma,three biopsies are sufficient.In patients with nodular or infiltrating-type bile duct carcinoma,multiple biopsies are warranted,and IDUS can compensate for the limitations of biopsies.In preoperative staging,the combination of dynamic multidetector low computed tomography(MDCT)and IDUS is useful for evaluating vascular invasion and cancer depth infiltration.However,assessment of lymph nodes metastases is difficult.In resectable cases,assessment of longitudinal cancer spread is important.The combination of IDUS and MDCT is useful for revealing submucosal cancer extension,which is common in hilar cholangiocarcinoma.To estimate the mucosal extenextension,which is common in extrahepatic bile duct carcinoma,the combination of IDUS and cholangioscopy is required.The utility of current peroral cholangioscopy is limited by the maneuverability of the“baby scope”.A new baby scope(10 Fr),called“SpyGlass”has potential,if the image quality can be improved.Since extrahepatic bile duct carcinoma is common in the Far East,many researchers in Japan and Korea contributed these studies,especially,in the evaluation of longitudinal cancer extension. | Kiichi Tamada Jun Ushio Kentaro Sugano | 2011 | World Journal of Clinical Oncology2011，2，5： | 26 |
| 3 | Transcatheter arterial chemoembolization with a fine-powder formulation of cisplatin for hepatocellular carcinoma显示文摘AIM:To evaluate the efficacy of transcatheter arterial chemoembolization(TACE) using a suspension of a fine-powder formulation of cisplatin(DDPH) for hepatocellular carcinoma(HCC).METHODS:The study population was comprised of 164 patients who were treated by TACE alone.Of these patients,76 underwent TACE using a suspension of DDPH in lipiodol(LPD)(DDPH group),and the remaining 88 underwent TACE with an emulsion of doxorubicin(ADM) with LPD(ADM group).We compared the DDPH group with the ADM group in terms of the objective early response rate,progression free survival(PFS) and overall survival(OS).RESULTS:The objective early response rate in the DDPH group was significantly higher than that in the ADM group(54% vs 24%,P < 0.001).The PFS rate in the DDPH group was also significantly higher than that in the ADM group(P < 0.001).Moreover,the OS in the DDPH group was significantly longer than that in the ADM group(P = 0.002).Although the incidence rate of nausea or vomiting in the DDPH group was higher than that in the ADM group,the ADM group showed a higher incidence rate of the adverse events of hepatic arterial damage and leucopenia.No other serious complications were observed in either group.CONCLUSION:We conclude that TACE using a suspension of DDPH in LPD could be a useful treatment for HCC. | Kazuhiro Kasai Akira Ushio Kei Sawara Yasuhiro Miyamoto Yukiho Kasai Kanta Oikawa Hidekatsu Kuroda Yasuhiro Takikawa Kazuyuki Suzuki | 2010 | World Journal of Gastroenterology2010，16，27： | 6 |
| 4 | Therapeutic efficacy of transarterial chemo-embolization with a fine-powder formulation of cisplatin for hepatocellular carcinoma显示文摘AIM:To evaluate the efficacy of transarterial chemoembolization(TACE) using a suspension of a finepowder formulation of cisplatin(DDPH) in lipiodol(LPD) in the treatment of hepatocellular carcinoma(HCC).METHODS:The subjects were 262 HCC patients treated with TACE using a DDPH-LPD suspension.The DDPH-LPD suspension was prepared by mixing 50 mg of DDPH into 10 mL of LPD.TACE was repeated when treated lesions relapsed and/or new hepatic lesions were detected.These patients received additional TACE using the same agent.TACE was repeated until complete regression of the tumor was obtained.The primary efficacy endpoint of the current study was the objective early response rate.Secondary efficacy endpoints were progression-free survival(PFS) and overall survival.RESULTS:The objective early response rate was 43.6%.Cumulative PFS rates were 56.7% at 6 mo,23.1% at 12 mo,13.4% at 18 mo,and 10.5% at 24 mo.The median PFS was 6.6 mo.Cumulative survival rates were 90.6% at 6 mo,81.9% at 12 mo,70.5% at 24 mo,and 58.8% at 36 mo.Median survival time was 46.6 mo.All adverse reactions were controllable by temporary suspension of treatment.No serious complications or treatment-related deaths were observed.CONCLUSION:TACE using a suspension of DDPH in LPD may be a useful treatment for HCC. | Kazuhiro Kasai Akira Ushio Yukiho Kasai Kei Sawara Yasuhiro Miyamoto Kanta Oikawa Yasuhiro Takikawa Kazuyuki Suzuki | 2013 | World Journal of Gastroenterology2013，19，14： | 3 |
| 5 | K-type breakdown process of intracloud discharge in Chinese inland plateau | 郄秀书 余晔 刘欣生 张广庶 USHIO Tomo-O | 2000 | Progress in Natural Science:Materials International2000，10，8： | 2 |
| 6 | Transient receptor potential channel A1 involved in calcitonin gene-related peptide release in neurons显示文摘Transient receptor potential channel A1 is one of the important transducers of noxious stimuli in the primary afferents,which may contribute to generation of neurogenic inflammation and hyperalgesia.The present study was designed to investigate if activation of transient receptor potential channel A1 may induce calcitonin gene-related peptide release from the primary afferent neurons.We found that application of allyl isothiocyanate,a transient receptor potential channel A1 activator,caused calcitonin gene-related peptide release from the cultured rat dorsal root ganglion neurons.Knockdown of transient receptor potential channel A1 with an antisense oligodeoxynucleotide prevented calcitonin gene-related peptide release by allyl isothiocyanate application in cultured dorsal root ganglion neurons.Thus,we concluded that transient receptor potential channel A1 activation caused calcitonin gene-related peptide release in sensory neurons. | Nobumasa Ushio Yi Dai Shenglan Wang Tetsuo Fukuoka Koichi Noguchi | 2013 | Neural Regeneration Research2013，8，32： | 2 |
| 7 | Electrochemical modification of active carbon fiber electrode and its application to double-layer capacitor显示文摘 | Toshiyuki Momma Xingjiang Liu Tetsuya Osaka Yousuke Ushio Yoshimitsu Sawada | 1995 | Journal of Power Sources1995，，2： | 2 |
| 8 | Changes in physicochemical properties of proteins in Kayserian Pastirma made from the M.semimembranosus muscle of cows during traditional processing显示文摘In the current study,we examined the effects of beef processing to produce pastirma on the physicochemical properties of proteins in M.semimembranosus(SEM)muscle.Protein concentrations significantly increased in pastirma muscles(P<0.01),as a result of the salting and curing process.The surface hydrophobicity values of processed samples were higher than those without processing at all guanidine-HCl concentrations,suggesting hydrophobicity increased,which may attribute to the new generated peptides during the traditional pastirma-making process.The metmyoglobin content greatly increased(by as much as 89%)in pastirma samples compared with the unprocessed samples.The images of histology also demonstrate that the pastirma processing had no negative impact on the structure of the muscle.The results from this study suggest that the traditional pastirma-making process catalyzed the enzymatic digestion of muscle proteins,and the differences in some physicochemical parameters between the control and pastirma samples were thus likely to be contributable to protein digestion.Thus,the traditional pastirma-making process results in the degradation of many proteins into peptides,which might then be obtainable as functional components to treat human dietand lifestyle-related diseases such as hypertension,hyperglycemia syndromes or to be used as nutraceuticals.©2013 Beijing Academy of Food Sciences.Production and hosting by Elsevier B.V.All rights reserved. | Abdulatef Mrghni Ahhmed Gen Kaneko Hideki Ushio Tomo Inomata Hasan Yetim Safa Karaman Michio Muguruma Ryoichi Sakata | 2013 | Food Science and Human Wellness2013，2，1： | 2 |
| 9 | Cloning of the cDNA for human IFN-gamma-inducing factor, expression in Escherichia coli, and studies on the biologic activities of the protein 显示文摘 | NAMBA M OKURA T | 1996 | J Immunol1996，156，4： | 1 |
| 10 | Protective roles of mast cells against enterobacterial infection are mediated by toll-like receptor 4显示文摘 | Supajatura V Ushio H Nakao A | 2002 | J Clin Invest2002，109，10： | 1 |
| 11 | Effect of saikosaponin on the immune responses in mice显示文摘 | Ushio Y Oda Y Abe H | 1991 | Int J mmunopharmacol1991，13，5： | 1 |
| 12 | Temperature-dependency of rigor-mortis of fish muscle: MyofibrillarMg2+-ATPase activity and Ca2+ uptake by sarcoplasmicreticulum显示文摘 | Watabe S Ushio H Iwamoto M | 1989 | Journal of Food Science1989，54，12： | 1 |
| 13 | Fukuhisa matsuda numerical computation of arc pressured distribution 显示文摘 | Ding Fan Masao Ushio | 1996 | Transactions of JWRI1996，15，1： | 1 |
| 14 | Correlation of molecular genetic analysis of p53, MDM2, p16, PTEN, and EGFR and survival of patients with anaplastic astrocytoma and glioblastoma 显示文摘 | Ushio Y Tada K Shiraishi S | 2003 | Front Biosci2003，8，2： | 1 |
| 15 | Inhibitory effect of enokitake extract on melanosis of shrimp 显示文摘 | Jang M S Sanada A Ushio H | 2003 | Fisheries Science2003，69，2： | 1 |
| 16 | Reverse vesicles: counter structure of biological membranes 显示文摘 | KUNIEDA H AKIMARU M USHIO N | 1993 | Journal of Colloid and Interface Science1993，156，2： | 1 |
| 17 | The uptake,distribution and anti-tumor activity of bleomycin in gliomas in the mouse显示文摘 | Hayakawa T Ushio Y Mogami H | | 0，，： | 1 |
| 18 | The ocular vestibular-evoked myogenic potential to air-conducted sound; probable superior vestibular nerve origin显示文摘 | Ian S. Curthoys Shinichi Iwasaki Yasuhiro Chihara Munetaka Ushio Leigh A. McGarvie Ann M. Burgess | 2010 | Clinical Neurophysiology2010，，3： | 1 |
| 19 | Inhibitors of prostagland in biosynthesis from Mucuna birdwoodiana显示文摘 | Yukihiro G Masaaki S Ushio S | 1987 | Chem Pharm Bull1987，35，： | 1 |
| 20 | Cloning of the cDNA for humma IFN-r-inducing factor expression in escherichia coli and studies on the biologic activities of the protein显示文摘 | Nomba M Okura T | 1996 | J Immunol1996，156，11： | 1 |
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