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| 1 | Signatures from single airgun显示文摘 | Haugland K Utheim T | 1983 | Geophysical Prospecting1983，31，1： | 1 |
| 2 | Apolipoprotein E genotype and risk for development of cataract and age-related macular degeneration显示文摘 | Utheim A Ritland JS Utheim TP | | 0，，： | 1 |
| 3 | MiRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium显示文摘 | Engelsvold DH Utheim TP Olstad OK | 2013 | Exp Eye Res2013，115，4： | 1 |
| 4 | miRNA and mRNA expression profiling identifies members of the miR-200 family as potential regulators of epithelial-mesenchymal transition in pterygium显示文摘 | Engelsvold DH Utheim TP Olstad OK | 2013 | Exp Eye Res2013，115，： | 1 |
| 5 | Assessment of refractive astigmatism and simulated therapeutic refractive surgery strategies in coma-like-aberrations- dominant corneal optics显示文摘Background:The aim of the study is to raise the awareness of the influence of coma-like higher-order aberrations(HOAs)on power and orientation of refractive astigmatism(RA)and to explore how to account for that influence in the planning of topography-guided refractive surgery in eyes with coma-like-aberrations-dominant corneal optics.Methods:Eleven eyes with coma-like-aberrations-dominant corneal optics and with low lenticular astigmatism(LA)were selected for astigmatism analysis and for treatment simulations with topography-guided custom ablation.Vector analysis was used to evaluate the contribution of coma-like corneal HOAs to RA.Two different strategies were used for simulated treatments aiming to regularize irregular corneal optics:With both strategies correction of anterior corneal surface irregularities(corneal HOAs)were intended.Correction of total corneal astigmatism(TCA)and RA was intended as well with strategies 1 and 2,respectively.Results:Axis of discrepant astigmatism(RA minus TCA minus LA)correlated strongly with axis of coma.Vertical coma influenced RA by canceling the effect of the with-the-rule astigmatism and increasing the effect of the against-the-rule astigmatism.After simulated correction of anterior corneal HOAs along with TCA and RA(strategies 1 and 2),only a small amount of anterior corneal astigmatism(ACA)and no TCA remained after strategy 1,while considerable amount of ACA and TCA remained after strategy 2.Conclusions:Coma-like corneal aberrations seem to contribute a considerable astigmatic component to RA in eyes with coma-like-aberrations dominant corneal optics.If topography-guided ablation is programmed to correct the corneal HOAs and RA,the astigmatic component caused by the coma-like corneal HOAs will be treated twice and will result in induced astigmatism.Disregarding RA and treating TCA along with the corneal HOAs is recommended instead. | Wen Zhou Aleksandar Stojanovic Tor Paaske Utheim | 2016 | Eye and Vision2016，3，1： | 1 |
| 6 | Apolipoprotein E genotype and risk for development of cataract and age-related macular degeneration显示文摘 | Utheim φA Ritland JS Utheim TP Espeseth T Lydersen S Rootwelt H | | 0，，04： | 1 |
| 7 | Effects of serum-free storage on morphology,phenotype,and viability of ex vivo cultured human conjunctival epithelium显示文摘 | Eidet JR Utheim OA Raeder S | 2012 | Exp Eye Res2012，94，1： | 1 |
| 8 | Concise review: transplantation of cultured oral mucosal epithelial cells for treating limbal stem cell deficiency-current status and future perspectives显示文摘 | Utheim TP | 2015 | Stem Cells2015，33，6： | 1 |
| 9 | Optimal transcorneal electrical stimulation parameters for preserving photoreceptors in a mouse model of retinitis pigmentosa显示文摘Retinitis pigmentosa is a hereditary retinal disease that affects rod and cone photoreceptors,leading to progressive photoreceptor loss.Previous research supports the beneficial effect of electrical stimulation on photoreceptor survival.This study aims to identify the most effective electrical stimulation parameters and functional advantages of transcorneal electrical stimulation(tcES)in mice affected by inherited retinal degeneration.Additionally,the study seeked to analyze the electric field that reaches the retina in both eyes in mice and post-mortem humans.In this study,we recorded waveforms and voltages directed to the retina during transcorneal electrical stimulation in C57BL/6J mice using an intraocular needle probe with rectangular,sine,and ramp waveforms.To investigate the functional effects of electrical stimulation on photoreceptors,we used human retinal explant cultures and rhodopsin knockout(Rho^(-/-))mice,demonstrating progressive photoreceptor degeneration with age.Human retinal explants isolated from the donors’eyes were then subjected to electrical stimulation and cultured for 48 hours to simulate the neurodegenerative environment in vitro.Photoreceptor density was evaluated by rhodopsin immunolabeling.In vivo Rho^(-/-)mice were subjected to two 5-day series of daily transcorneal electrical stimulation using rectangular and ramp waveforms.Retinal function and visual perception of mice were evaluated by electroretinography and optomotor response(OMR),respectively.Immunolabeling was used to assess the morphological and biochemical changes of the photoreceptor and bipolar cells in mouse retinas.Oscilloscope recordings indicated effective delivery of rectangular,sine,and ramp waveforms to the retina by transcorneal electrical stimulation,of which the ramp waveform required the lowest voltage.Evaluation of the total conductive resistance of the post-mortem human compared to the mouse eyes indicated higher cornea-to-retina resistance in human eyes.The temperature recordings during and after electrical stimulation indicated no significant temperature change in vivo and only a subtle temperature increase in vitro(~0.5-1.5°C).Electrical stimulation increased photoreceptor survival in human retinal explant cultures,particularly at the ramp waveform.Transcorneal electrical stimulation(rectangular+ramp)waveforms significantly improved the survival and function of S and M-cones and enhanced visual acuity based on the optomotor response results.Histology and immunolabeling demonstrated increased photoreceptor survival,improved outer nuclear layer thickness,and increased bipolar cell sprouting in Rho^(-/-)mice.These results indicate that transcorneal electrical stimulation effectively delivers the electrical field to the retina,improves photoreceptor survival in both human and mouse retinas,and increases visual function in Rho^(-/-)mice.Combined rectangular and ramp waveform stimulation can promote photoreceptor survival in a minimally invasive fashion. | Sam Enayati Karen Chang Anton Lennikov Menglu Yang Cherin Lee Ajay Ashok Farris Elzaridi Christina Yen Kasim Gunes Jia Xie Kin-Sang Cho Tor Paaske Utheim Dong Feng Chen | 2024 | Neural Regeneration Research2024，19，11： | 0 |
| 10 | Corneal collagen cross-linking(CXL)in thin corneas显示文摘Corneal collagen cross-linking(CXL)is a therapeutic procedure aiming at increasing the corneal stiffness in the keratoconus eyes by induction of cross-links within the extracellular matrix.It is achieved by ultraviolet-A(370 nm)irradiation of the cornea after saturation with the photosensitizer riboflavin.In the conventional CXL protocol,a minimum de-epithelialized corneal thickness of 400μm is recommended to avoid potential irradiation damage to the corneal endothelium.In advanced keratoconus,however,stromal thickness is often lower than 400μm,which limits the application of CXL in that category.Efforts have been undertaken to modify the conventional CXL procedure to be applicable in thin corneas.The current review discusses different techniques employed to achieve this end and their results.The overall safety and efficacy of the modified CXL protocols are good,as most of them managed to halt the progression of keratectasia without postoperative complications.However,the evidence of safety and efficacy in the use of modified CXL protocols is still limited to few studies with few patients involved.Controlled studies with long-term follow-up are required to confirm the safety and efficacy of the modified protocols. | Xiangjun Chen Aleksandar Stojanovic Jon Roger Eidet Tor Paaske Utheim | 2015 | Eye and Vision2015，2，1： | 0 |
| 11 | 干眼与睡眠质量的相关性显示文摘睡眠问题可严重影响身体健康和生活质量,既往已有研究提示干眼患者普遍睡眠时间较短,睡眠质量较差,而有睡眠问题的个体患干眼的概率也更大,但是样本量均较小。为了防止抽样偏倚和多种因素的干扰,该研究使用基于人群的大型队列来阐明干眼与睡眠质量之间的关联。研究者从荷兰北部167729人的健康与健康相关行为数据库中,筛选了2014至2018年期间完成数据采集的71761人的资料进行分析,年龄(50.2±12.3)岁,其中女性占59.4%。 | Magno MS Utheim TP Snieder H 胡皎月(编译) | 2021 | 中华医学杂志2021，101，32： | 0 |
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