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1Neuroprotective effect of systemic and/or intravitreal rosuvastatin administration in rat glaucoma model显示文摘AIM:To evaluate the neuroprotective effect of rosuvastatin,in a rat experimental glaucoma model.· METHODS:Ocular hypertension was induced in right eyes of Long-Evans rats(n=30) by cauterization of three episcleral veins.Left eyes were defined as controls.Rats were divided into five groups:oral rosuvastatin,intravitreal rosuvastatin,oral +intravitreal rosuvastatin,intravitreal sham and glaucoma without intervention.Rats were sacrificed at day 14.Retinal ganglion cell(RGC) number was assessed by histopathological analysis.Terminal deoxynucleotidyl transferase-mediated dUTP-nick end-labeling(TUNEL) staining and the expression of glial fibrillary acidic protein(GFAP) in RGC layer was also examined.· RESULTS:A significant intraocular pressure(IOP)elevation was seen(P=0.002).Elevated IOP resulted in a significant decrease in number of RGCs in group 5(70.33±8.2 cells/mm^2) when compared with controls(92.50±13.72 cells/mm^2;P=0.03).The RGC number in group 1(92.4±7.3 cells/mm^2) was significantly higher than group 5(P=0.03).The numbers of RGC in groups 2,3(57.3±8.2 cells/mm^2,60.5±12.9 cells/mm^2) were comparable with that of group 5(P=0.18 and P=0.31).The apoptosis rates with TUNEL staining were also parallel to RGC number.Animals with experimentally induced glaucoma showed an increase in retinal GFAP immunoreactivity.· CONCLUSION:Decrease in RGC loss and apoptosis suggest the neuroprotective potential of oral rosuvastatin treatment in a rat model of ocular hypertension.However intravitreal rosuvastatin showed a contrary effect and further studies are required.Metin Unlu Zeynep Aktas Pinar Uyar Gocun Sevil Ozger Ilhan Murat Hasanreisoglu Berati Hasanreisoglu 2016International Journal of Ophthalmology(English edition)2016,9,3:7
2Spontaneous Perforation of Pyometra显示文摘Yildizhan B Uyar E Sismanoglu A 2006Infect Dis Obstet Gynecol2006,2006,26:1
3Effect of light intensity, wavelength and illumination protocol on hydrogen production in photobioreactors 显示文摘Uyar B Eroglu I Yucel M 2007International Journal of Hydrogen Energy2007,52,18:1
4Formal methods for generating protocol conformance test sequence显示文摘Dahbura A T Sabnani K K Uyar M U 1990Proceedings of the IEEE1990,78,8:1
5Is posterior leaflet preservation in the surgical treatment of rheumatic mitral insufficiency without left ventricular dysfunction necessary显示文摘Kirali K Tuncer A Uyar I 0,,01:1
6Electrospun polystyrene fibers containing high temperature stable facilitated by cyclodextrin volatile fragrance/flavor inclusion complexes 显示文摘UYAR Tamer HACALOGLU Jale BESENBACHER Flemming 2009Reactive & Functional Polymers2009,69,:1
7Exposure to low outdoor temperature in the midtrimester is associated with low birth weight显示文摘 Ay E Uyar E 2004Aust N Z J Obstet Gynaecol2004,44,:1
8An effective wavelet-based feature extraction method for classification of power quality disturbance signals显示文摘Uyar M Yildirim S Gencoglu M T 2008Electric Power Systems Research2008,78,10:1
9Effect of raloxifene and atorvastatin in atherosclerotic process in ovariectomized rats显示文摘Cetinkaya Demir B Uyar Y Ozbilgin K 2013J Obstet Gynaecol Res2013,39,1:1
10Laparoscopy can aggravate the severity of pancreatitis in an experimental rat model显示文摘POLAT C UYAR H BASSORGUN I 2012J Laparoendosc Adv Surg Tech A2012,22,10:1
11Magnesium in chronic kidney disease:challenges and opportunities显示文摘Kanbay M Goldsmith D Uyar ME 2010Blood Purif2010,29,3:1
12Electrospinning of cyclodextrin functionalized poly( methyl methacrylate ) ( PMMA ) nanofibers 显示文摘UYAR Tamer BALAN Abidin TOPPARE Levent 2009Polymer2009,50,:1
13Risk factors for development of posttransplant diabetes mellitus in renal transplant recipients显示文摘Sezer S Bilgic A Uyar M 2006Transplant Proc2006,38,:1
14An effective wavelet-based feature extraction method for classification of power quality disturbance signals显示文摘Uyar M Yildirim S Gencoglu M T 2008Electric Power Systems Research2008,78,10:1
15Churg-Strauss syndrome related to montelukast 显示文摘Uyar M Elbek O Bakir K 2012Tuberk Toraks2012,60,1:1
16A method enabling feasible conformance test sequence generation for EFSM models显示文摘Duale A Y Uyar M U 2004I EEE Transactions on Computers2004,53,5:1
17Surgical approach in symptomatic myocardial bridge显示文摘Rahman A Burma O Uyar J 2000Asian Cardiovaso Thorac Ann2000,8,:1
18Spontaneous Perfora- tion of Pyometra显示文摘Yildizhan B Uyar E Sismanoglu A 2006Infect Dis Obstet Gynecol2006,26,786:1
19显示文摘Uyar T Havelund R Nut Y 2010Journal of Membrane Science2010,365,12:1
20The effect of music therapy on pain andanxiety in intensive care patients 显示文摘Uyar M Akn Korhan E 2011Agri2011,23,4:1
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