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| 1 | FDG-PET/CT response evaluation during EGFR-TKI treatment in patients with NSCLC显示文摘Over recent years,[18F]-fluorodeoxyglucose positron emission tomography acquired together with low dose computed tomography(FDG-PET/CT)has proven its role as a staging modality in patients with non-small cell lung cancer(NSCLC).The purpose of this review was to present the evidence to use FDG-PET/CT for response evaluation in patients with NSCLC,treated with epidermal growth factor receptor(EGFR)-tyrosine kinase inhibitors(TKI).All published articles from 1November 2003 to 1 November 2013 reporting on 18FFDG-PET response evaluation during EGFR-TKI treatment in patients with NSCLC were collected.In total 7studies,including data of 210 patients were eligible for analyses.Our report shows that FDG-PET/CT responseduring EGFR-TKI therapy has potential in targeted treatment for NSCLC.FDG-PET/CT response is associated with clinical and radiologic response and with survival.Furthermore FDG-PET/CT response monitoring can be performed as early as 1-2 wk after initiation of EGFR-TKI treatment.Patients with substantial decrease of metabolic activity during EGFR-TKI treatment will probably benefit from continued treatment.If metabolic response does not occur within the first weeks of EGFR-TKI treatment,patients may be spared(further)unnecessary toxicity of ineffective treatment.Refining FDG-PET response criteria may help the clinician to decide on continuation or discontinuation of targeted treatment. | Matthijs H van Gool Tjeerd S Aukema Koen J Hartemink Renato A Valdés Olmos Houke M Klomp Harm van Tinteren | 2014 | World Journal of Radiology2014，6，7： | 8 |
| 2 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 3 | Mapping aboveground biomass by integrating geospatial and forest inventory data through a k-nearest neighbor strategy in North Central Mexico显示文摘As climate change negotiations progress,monitoring biomass and carbon stocks is becoming an important part of the current forest research.Therefore,national governments are interested in developing forest-monitoring strategies using geospatial technology.Among statistical methods for mapping biomass,there is a nonparametric approach called k-nearest neighbor(kNN).We compared four variations of distance metrics of the kNN for the spatially-explicit estimation of aboveground biomass in a portion of the Mexican north border of the intertropical zone.Satellite derived,climatic,and topographic predictor variables were combined with the Mexican National Forest Inventory(NFI)data to accomplish the purpose.Performance of distance metrics applied into the kNN algorithm was evaluated using a cross validation leave-one-out technique.The results indicate that the Most Similar Neighbor(MSN)approach maximizes the correlation between predictor and response variables(r=0.9).Our results are in agreement with those reported in the literature.These findings confirm the predictive potential of the MSN approach for mapping forest variables at pixel level under the policy of Reducing Emission from Deforestation and Forest Degradation(REDD+). | Carlos A AGUIRRE-SALADO Eduardo J TREVIO-GARZA Oscar A AGUIRRE-CALDERóN Javier JIMNEZ-PREZ Marco A GONZLEZ-TAGLE José R VALDZ-LAZALDE Guillermo SNCHEZ-DíAZ Reija HAAPANEN Alejandro I AGUIRRE-SALADO Liliana MIRANDA-ARAGóN | 2014 | Journal of Arid Land2014，6，1： | 3 |
| 4 | Comparison between type-2 and type-1 myocardial infarction:clinical features, treatment strategies and outcomes显示文摘ObjectiveTo 与尖锐心肌的梗塞(AMI ).MethodsWe 包括了的 type-2 对 type-1 在病人在发生,临床的特征,当前的治疗策略和结果估计差别有 type-1 或 type-2 AMI 的诊断的 824 个连续病人。在索引住院期间,临床的特征和治疗策略详细被收集。在 1 年的后续,死亡,击,流血的非致命的心肌的梗塞和专业是 recorded.ResultsType-1 AMI 在 707 是在场的(86%) 盒子当(14%) 117 作为 type-2 被分类时。有 type-2 AMI 的病人更经常是象糖尿病那样的女、有的更高的合作病态,以前的非圣片断举起急性冠的症候群,损害肾的功能,贫血症, atrial 纤维性颤动和恶意。然而,保存了左室的喷射部分,正常冠的动脉是经常看见的更多,侵略治疗是不太普通的,并且反血小板药, statins 和 beta-blockers 是在有 type-2 AMI 的病人规定的更少。在 1 年的后续, type-2 AMI 与更高粗略的死亡风险被联系(HR:1.75, 95% CI:1.14-2.68;P = 0.001 ) ,但是这个协会没在 multivariable 调整以后仍然保持重要(P = 0.785 ) 。而且,我们没发现 type-2 AMI 与另外的临床的 outcomes.ConclusionsIn 被联系这张真实人口与 type-1 相比, type-2 AMI 是主要女人们并且有更多的合作病态。侵略治疗策略和 cardioprotective 药是在 type-2 使用的更少,当 1 年的临床的结果是类似的时。 | Angel Lopez-Cuenca Miriam Gomez-Molina Pedro J Flores-Blanco Marianela Sanchez-Martinez Andrea Garcia-Narbon Ignacio De Las Heras-Gomez Maria J Sainchez-Galian Esther Guerrero-Perez Mariano Valdes Sergio Manzano-Femandez | 2016 | Journal of Geriatric Cardiology2016，13，1： | 2 |
| 5 | Soman intoxication alters regional brain muscarinic and GABA receptrs显示文摘 | Valdes James J Shih Tsuing-ming Whalley Christopher | 1985 | Pesticide Biochem Physi1985，24，3： | 1 |
| 6 | High Concen- tration Linear Fresnel Reflectors 显示文摘 | Abbas R Mufioz-Ant6n J Vald@s M | 2013 | Energy Conversion and Management2013，72，： | 1 |
| 7 | Influence of sodium fumarate addition on rumen fermentation in vitro显示文摘 | López S Valdes C Newbold C J | 1999 | British Journal of Nutrition1999，81，： | 1 |
| 8 | Effect of ozone treatment on surface properties of activated carbon显示文摘 | VALDES H SANcHEZ-POLO M RIVERA-UTRILLA J | 2002 | Langmuir2002，18，6： | 1 |
| 9 | The antennal sensilla of Zamagiria dixolophella Dyar(Lepidoptera : Pyrali- dae) 显示文摘 | Castrejon Gomez V R Nieto G Valdes J | 2003 | Ann Entomol Soc Am2003，96，5： | 1 |
| 10 | Bikunin (uriary trypsin inhi- bitor) :structure,biological relevance,and measurement显示文摘 | Pugia M J Valdes R Jr Jortani SA | 2007 | Adv Clin Chem2007，44，： | 1 |
| 11 | Numeri cal Investigation of the Influence of Roughness on the Laminar Incompressible Fluid Flow through Annular Microchannels显示文摘 | Valdes J R Miana M J Pelegay J L | 2007 | International Journal of Heat and Mass Transfer2007，50，910： | 1 |
| 12 | Influence of sodium fumar- ate addition on rumen fermentation in vitro 显示文摘 | LOPEZ S VALDES C NEWBOLD C J | 1999 | British Journal of Nutrition1999，81，： | 1 |
| 13 | Effect of ozone treatment on surface properties of activated carbon显示文摘 | VALDES H SANEHEZ M RIVERA J | 2002 | Langmuir2002，18，6： | 1 |
| 14 | Growth, growth velocity and adult height in Mexican girls with Turner's syndrome显示文摘 | Robles Valdes Del Castillo Ruiz V Oyoqui J | 2003 | J Pediatr Endocrinol Endocrlnol Metab2003，16，8： | 1 |
| 15 | The ICL1 gene of Pichia pastoris, transcriptional regulation and use of its promoter显示文摘 | Menendez J Valdes I Cabrera N | 2003 | Yeast2003，20，13： | 1 |
| 16 | On the existence of storm-tracks显示文摘 | HOSKINS B J VALDES P J | 1990 | J Atmos Sci1990，47，15： | 1 |
| 17 | Corporate governance, ownership structure and performance in Mexico显示文摘 | Martin-Reyna J M S Durim-Vezquez R Valdes A L | 2012 | International Business Research2012，5，： | 1 |
| 18 | A method to determine the economic cost of fouling of gas turbine compressors显示文摘 | MARTiN-ARAGON J VALDES M | 2014 | Applied Thermal Engineering2014，69，12： | 1 |
| 19 | Genome-wide association scan identifies a prostaglandin-endoperoxide synthase 2 variant involved in risk of knee osteoarthritis显示文摘 | Valdes AM Loughlin J Timms KM | | 0，，06： | 1 |
| 20 | Deglacial rapid sea level rises caused by ice-sheet saddle collapses显示文摘 | Gregoire L J Payne A J Valdes P J | 2012 | Nature2012，487，7406： | 1 |
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