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您的检索式：作者名="VALENTINA ROVELLA"
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| 1 | Leptin stimulates both endothelin-l and nitric oxide activity in lean subjects but not in patients with obesity-related metabolic syndrome 显示文摘 | FRANC ESC A SCHINZARI MANFREDI TESAURO VALENTINA ROVELLA et at | 2013 | Endocrinol Metab2013，98，： | 1 |
| 2 | Physical exercise and synaptic protection in human and pre-clinical models of multiple sclerosis显示文摘In multiple sclerosis,only immunomodulato ry and immunosuppressive drugs are recognized as disease-modifying therapies.Howeve r,in recent years,several data from pre-clinical and clinical studies suggested a possible role of physical exe rcise as disease-modifying therapy in multiple sclerosis.Current evidence is sparse and often conflicting,and the mechanisms underlying the neuroprotective and antinflammatory role of exercise in multiple sclerosis have not been fully elucidated.Data,mainly derived from pre-clinical studies,suggest that exe rcise could enhance longterm potentiation and thus neuroplasticity,could reduce neuroinflammation and synaptopathy,and dampen astrogliosis and microgliosis.In humans,most trials focused on direct clinical and MRI outcomes,as investigating synaptic,neuroinflammato ry,and pathological changes is not straightfo rward compared to animal models.The present review analyzed current evidence and limitations in research concerning the potential disease-modifying therapy effects of exercise in multiple sclerosis in animal models and human studies. | Federica Azzolini Ettore Dolcetti Antonio Bruno Valentina Rovella Diego Centonze Fabio Buttari | 2024 | Neural Regeneration Research2024，19，8： | 0 |
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