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| 1 | Trends in treatment and overall survival among patients with proximal esophageal cancer显示文摘BACKGROUND The management of proximal esophageal cancer differs from that of tumors located in the mid and lower part of the esophagus due to the close vicinity of vital structures.Non-surgical treatment options like radiotherapy and definitive chemoradiation(CRT)have been implemented.The trends in(non-)surgical treatment and its impact on overall survival(OS)in patients with proximal esophageal cancer are unclear,related to its rare disease status.To optimize treatment strategies and counseling of patients with proximal esophageal cancer,it is therefore essential to gain more insight through real-life studies.AIM To establish trends in treatment and OS in patients with proximal esophageal cancer.METHODS In this population-based study,patients with proximal esophageal cancer diagnosed between 1989 and 2014 were identified in the Netherlands Cancer Registry.The proximal esophagus consists of the cervical esophagus and the upper thoracic section,extending to 24 cm from the incisors.Trends in radiotherapy,chemotherapy,and surgery,and OS were assessed.Analyses were stratified by presence of distant metastasis.Multivariable Cox proportional hazards regression analyses was performed to assess the effect of period of diagnosis on OS,adjusted for patient,tumor,and treatment characteristics.RESULTS In total,2783 patients were included.Over the study period,the use of radiotherapy,resection,and CRT in non-metastatic disease changed from 53%,23%,and 1%in 1989-1994 to 21%,9%,and 49%in 2010-2014,respectively.In metastatic disease,the use of chemotherapy and radiotherapy increased over time.Median OS of the total population increased from 7.3 mo[95%confidence interval(CI):6.4-8.1]in 1989-1994 to 9.5 mo(95%CI:8.1-10.8)in 2010-2014(logrank P<0.001).In non-metastatic disease,5-year OS rates improved from 5%(95%CI:3%-7%)in 1989-1994 to 13%(95%CI:9%-17%)in 2010-2014(logrank P<0.001).Multivariable regression analysis demonstrated a significant treatment effect over time on survival.In metastatic disease,median OS was 3.8 mo(95%CI:2.5-5.1)in 1989-1994,and 5.1 mo(95%CI:4.3-5.9)in 2010-2014(logrank P=0.26).CONCLUSION OS significantly improved in non-metastatic proximal esophageal cancer,likely to be associated with an increased use of CRT.Patterns in metastatic disease did not change significantly over time. | Judith de Vos-Geelen Sandra ME Geurts Liselot BJ Valkenburg-van Iersel Evelien JM de Jong Vivianne CG Tjan-Heijnen Margreet van Putten Valery EPP Lemmens Heike I Grabsch Nadia Haj Mohammad Frank JP Hoebers Chantal V Hoge Paul M Jeene Hanneke WM van Laarhoven Tom Rozema Marije Slingerland Grard AP Nieuwenhuijzen | 2019 | World Journal of Gastroenterology2019，25，47： | 2 |
| 2 | Advances in small animal mesentery models for in vivo flow cytometry,dynamic microscopy,and drug screening显示文摘Using animal mesentery with intravital optical microscopy is a well-established experimental model for studying blood and lymph microcirculation in vivo. Recent advances in cell biology and optical techniques provide the basis for extending this model for new applications, which should generate significantly improved experimental data. This review summarizes the achievements in this specific area, including in vivo label-free blood and lymph photothermal flow cytometry, super-sensitive fluorescence image cytometry, light scattering and speckle flow cytometry, microvessel dynamic microscopy, infrared (IR) angiography, and high-speed imaging of individual cells in fast flow. The capabilities of these techniques, using the rat mesentery model, were demonstrated in various studies; e.g., real-time quantitative detection of circulating and migrating individual blood and cancer cells, studies on vascular dynamics with a focus on lymphatics under normal conditions and under different interventions (e.g. lasers, drugs, nicotine), assessment of lymphatic disturbances from experimental lymphedema, monitoring cell traffic between blood and lymph systems, and high-speed imaging of cell transient deformability in flow. In particular, the obtained results demonstrated that individual cell transportation in living organisms depends on cell type (e.g., normal blood or leukemic cells), the cell’s functional state (e.g., live, apoptotic, or necrotic), and the functional status of the organism. Possible future applications, including in vivo early diagnosis and prevention of disease, monitoring immune response and apoptosis, chemo- and radio-sensitivity tests, and drug screening, are also discussed. | Ekaterina I Galanzha Valery V Tuchin Vladimir P Zharov | 2007 | World Journal of Gastroenterology2007，13，2： | 2 |
| 3 | Phosphate-solubilizing microorganisms isolated from rhizospheric and bulk soils of colonizer plants at an abandoned rock phosphate mine显示文摘 | Reyes I Valery A Valduz Z | 2006 | Plant and Soil2006，287，： | 1 |
| 4 | Efficacy and tolerability of escitalopram versus citalopram in major depressive disorder:a 6-week,multicenter,prospective,randomized,double-blind,active-controlled study in adult outpatients显示文摘 | VALERY Y ALEXANDER I YEVGENIA G | 2007 | Clinical Therapeutics2007，11，29： | 1 |
| 5 | Catalytic inhibition of laminar flames by transition metal compounds 显示文摘 | Gregory T Linteris Marc D Rumminger Valeri I Babushok | 2008 | Progress in Energy and Combustion Science2008，，34： | 1 |
| 6 | Subproteomics analysis of phosphorylated proteins: Application to the study of B-lymphoblasts from a patient with Scott syndrome 显示文摘 | Naima I S Isabelle L L Valerie L | 2002 | Proteomics2002，2，7： | 1 |
| 7 | 显示文摘 | Jung H K Valeri I B Thomas A G | 2003 | J Mater Res2003，18，7： | 1 |
| 8 | Lipid a radiosensitizes hypoxic EMT-6 tumor cells:Role of the NF-κB signaling pathway显示文摘 | Mark D Valeri N Martine I | 2003 | Int J Radiation Oncology Biol Phys2003，57，3： | 1 |
| 9 | Macrophages enhance the radiosensitizing activity oflipid A:a novel role for immune cells in tumor cell radioresponse显示文摘 | Mark D Valeri N Martine I | 2004 | Int J Radiation Oncology Biol Phys2004，60，2： | 1 |
| 10 | A nonlinear dynamics perspective of Wolfmm's new kind of science, part VII :isle of Eden显示文摘 | Chua L O Guan J B Valery I S | 2007 | International Journal of Bifurcation and Chaos2007，17，9： | 1 |
| 11 | Accuracy of EUS criteria and primary tumor site for identification of mediastinal lymph node metastasis from non-small-cell lung cancer显示文摘 | Nathan Schmulewitz Stephan M Wildi Shyam Varadarajulu Stacey Roberts Robert H Hawes Brenda J Hoffman Valerie Durkalski Gerard A Silvestri Mark I Block Carolyn Reed Michael B Wallace | 2004 | Gastrointestinal Endoscopy2004，，2： | 1 |
| 12 | Activation of the nuclear factor kappaB pathway by as- trocyte elevated gene-1 : implications for tumor progression and metastasis显示文摘 | Emdad I Sarkar D Su Z Z Randolph A Boukerche H Valerie K | 2006 | Cancer Res2006，66，： | 1 |
| 13 | Efficient Multi-frequency Generation of Ultrashort Light Pulses Using Stimulated Raman Scattering and Optical Parametric Amplification 显示文摘 | Alexander Vodchits I Valery Kozich P Wolfgang Wemcke | 2006 | Optics Communications2006，260，： | 1 |
| 14 | Phosphate-solubilizing microorganisms isolated from rhizospheric and bulksoils of colonizer plants at an abandoned rock phosphate mine显示文摘 | Reyes I Valery A Valduz Z | 2006 | Plant and Soil2006，287，12： | 1 |
| 15 | Generation of powerful subnanosecond microwave pulses in the range of 38-150 GHz显示文摘 | Michael I Y Valery G S Sergei A S | 2000 | IEEE Trans on Plasma Sci2000，28，5： | 1 |
| 16 | Mechanical properties ofthermo mechanically treated titanium alloys显示文摘 | VALERY M RENAL I ANDREY K | 2003 | Script Material2003，49，10： | 1 |
| 17 | On the lognormal distribution of network traffic显示文摘 | Antoniou I Ivanov V V Ivanov Valery V etal | 2002 | Physica D: Nonlinear Phenomena2002，167，12： | 1 |
| 18 | Cosolvent-assisted spray pyrolysis for the generation of metal particles显示文摘 | Jung H K Valeri I Thomas A | 2003 | J Mater Res Soc2003，18，7： | 1 |
| 19 | Effect of oxide shell growth on nano-aluminum thermite propagation rates 显示文摘 | Jeffrey Gesner Michelle L P Valery I L | 2012 | Com- bustion and Flame2012，159，11： | 1 |
| 20 | Increased Platelet Reactivity and Circulating Monocyte-Platelet Aggregates in Patients With Stable Coronary Artery Disease显示文摘 | Mark I Furman Stephen E Benoit Marc R Barnard C.Robert Valeri Marie L Borbone Richard C Becker Herbert B Hechtman Alan D Michelson | 1998 | Journal of the American College of Cardiology1998，，2： | 1 |
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