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| 1 | Anti-HIV Ⅰ/Ⅱ Activity and Molecular Cloning of a Novel Mannose/Sialic Acidbinding Lectin from Rhizome of Polygonatum cyrtonema Hua显示文摘 | Jie AN Jin-Zhi LIU Chuan-Fang WU Jian LI Lei DAI Els Van DAMME Jan BALZARINI Erik De CLERCQ Fang CHEN Jin-Ku BAO | 2006 | Acta Biochimica et Biophysica Sinica2006，38，2： | 8 |
| 2 | Purification and Characterization of a Mannose-binding Lectin from the Rhizomes of Aspidistra elatior Blume with Antiproliferative Activity显示文摘有一个新奇 N 终端氨基酸序列的凝集素被硫酸铵降水,离子交换层析 ondiethylaminoethyl-Sepharose 和 carboxymethyl-Sepharose 和凝胶过滤层析 onSephacryl S-100 从蜘蛛抱蛋 elatior 布鲁坶的根茎净化。A。elatior 布鲁坶凝集素(AEL ) 是有 56kDa 的一个分子的团的 heterotetramer 并且一起由 13.5 kDa 和 14.5 kDaheld 的二不同多肽组成由的二 homodimers 创作非共有原子价相互作用。Hapten 抑制试金显示向兔子红血球的 AEL 的那项 hemagglutinating 活动能被 D 甘露糖禁止,甘露聚糖, thyroglobulinand ovomucoid。凝集素是稳定的直到 70 ° C,并且在 7.0-8.0 的一个狭窄的 pH 范围显示出最大的活动。化学修正和光谱分析显示色氨酸,精氨酸,半胱氨酸和 carboxyl 组织残余为它的 hemagglutinating 活动是必要的。然而,他们可能不在活跃中心是在场的,除了一些 carboxyl 组残余。AEL 也出现了在向 Bre-04 (66%) 的 antiproliferative 活动, Lu-04 (60%) 和人的癌症房间的 HepG2 (56%) 衬里的 vitro 重要。 | Xiaochao XU Chuanfang WU Chao LIU Yongting LUO Jian LI Xinping ZHAO Els Van DAMME Jinku BAO | 2007 | Acta Biochimica et Biophysica Sinica2007，39，7： | 8 |
| 3 | Three decades of hepatitis B control with vaccination显示文摘Hepatitis B virus(HBV) continues to represent a major health problem and can lead to acute liver failure, acute hepatitis, chronic carriership, chronic hepatitis of HBV, liver cirrhosis, liver cancer, liver transplantation and death. There is a marked difference in the geographic distribution of carriers. More than 240 million people worldwide are chronic HBV carriers. Mother-to-child transmission remains the most important mechanism of infection in countries with a high prevalence of HBV. Percutaneous/parenteral transmission and unsafe sexual practices are important mode of spread transmission of HBV in other countries. Vaccination against HBV is the gold measure for primary prevention and control of the disease. Currently, 179 countries have added HBV vaccination to their routine vaccination programs with great results. Neonatal immunization with HBV vaccine has been one of the most highly effective measures in public health and the first anti-cancer program to be launched. In this paper we review the achievements for the last three decades. | Liliane C Meireles Rui Tato Marinho Pierre Van Damme | 2015 | World Journal of Hepatology2015，7，18： | 5 |
| 4 | 世界艺术史的起源和原则显示文摘德国对世界艺术的研究可以追溯到19世纪80年代到90年代,相关著作有文化人类学和心理学的跨学科语境。当时的德国艺术史家关注原始艺术,不仅仅是'殖民思维'的结果,更由于德国艺术史面临着方法论危机和制度性危机。民族心理学和人类学为艺术研究提供了心理学基础,为1900年左右的世界艺术史提供了核心动力。德国的人类学、心理学以及关于文化进化的相关讨论,影响了新生的艺术学科的地位。然而,德语学界对世界艺术史的开端性研究极少得到国际性关注,甚至在1930年以后被彻底遗忘,这是在德国内部开始的。究其原因,诸民族学目标的变化,魏玛共和国上升的民族主义以及精神科学的普遍危机,特别是20世纪30年代纳粹开始干预学术研究,导致了这种状况。有意思的是,1900年和2000年,德国世界艺术史的体制条件显得相似,如果说最初的问题是在大学里创立艺术史/艺术科学,今天则是艺术史要在一些更新的,据称更为跨学科的领域争得一席之地。 | 尤里西.普菲斯特雷尔 李修建 Kitty Zijlmans Wilfried van Damme(eds.) | 2016 | 民族艺术2016，，6： | 4 |
| 5 | The Cellulose Synthases Are Cargo of the TPLATE Adaptor Complex显示文摘 | Clara Sanchez-Rodriguez Yanyun Shi Christopher Kesten Dongmei Zhang Gloria Sancho-Andres Alexander Ivakov Edwin R. Lampugnani Kamil Sklodowski Masaru Fujimoto Akihiko Nakano Antony Bacic Ian S. Wallace Takashi Ueda Daniel Van Damme Yihua Zhou Staffan Persson | 2018 | Molecular Plant2018，11，2： | 3 |
| 6 | Chemoattractants and cytokines in primary ciliary dyskinesia and cystic fibrosis: key players in chronic respiratory diseases显示文摘Patients with primary ciliary dyskinesia(PCD)and cystic fibrosis(CF),two inherited disorders,suffer from recurrent airway infections characterized by persistent bacterial colonization and uncontrollable inflammation.Although present in high counts,neutrophils fail to clear infection in the airways.High levels of C-X-C motif chemokine ligand 8/interleukin-8(CXCL8/IL-8),the most potent chemokine to attract neutrophils to sites of infection,are detected in the sputum of both patient groups and might cause the high neutrophil influx in the airways.Furthermore,in CF,airway neutrophils are highly activated because of the genetic defect and the high levels of proinflammatory chemoattractants and cytokines(e.g.,CXCL8/IL-8,tumor necrosis factor-αand IL-17).The overactive state of neutrophils leads to lung damage and fuels the vicious circle of infection,excessive inflammation and tissue damage.The inflammatory process in CF airways is well characterized,whereas the lung pathology in PCD is far less studied.The knowledge of CF lung pathology could be useful to guide molecular investigations of the inflammatory processes in PCD lungs.Current available therapies can not completely remedy the chronic airway infections in these diseases.This review gives an overview of the role that chemoattractants and cytokines play in these neutrophil-dominated lung pathologies.Finally,the most frequently applied treatments in CF and PCD and new experimental therapies to reduce neutrophil-dominated airway inflammation are described. | Maaike Cockx Mieke Gouwy Jo Van Damme Sofie Struyf | 2018 | Cellular & Molecular Immunology2018，15，4： | 3 |
| 7 | Antinuclear antibodies following infliximab treatment in patients with rheumatoid arthritis or spondylarthropathy显示文摘 | De Rycke L Kruithof E Van Damme N | 2003 | Arthritis Rheum2003，48，4： | 2 |
| 8 | 农业氨减排对大气PM_(2.5)污染治理日趋重要显示文摘在新冠肺炎疫情期间,中国采取的管制封锁措施大幅减少了交通和工业排放,但农业排放没有受到影响,甚至有所增加.通过全国大气氨浓度地面监测、实时连续观测和卫星观测等手段,我们发现,新冠肺炎疫情管制措施实施期间中国大气氨浓度大范围显著增加,上升幅度在农村地区最为明显(增加22%),在城市和偏远地区变化不明显;而且,管控期间大气氨浓度上升幅度与2015~2019年相同月份相比更大.基于大气化学模式模拟发现,中国北方大气氨浓度上升主要是由农业氨排放增加所致.随着未来我国二氧化硫和氮氧化物等酸性气体排放控制的强化,农业氨排放的协同减排对于进一步削减大气PM污染、提升空气质量尤为重要.进一步分析表明,疫情期间50%农业氨排放可有效抵消氨浓度上升造成的二次无机气溶胶的形成. | 许稳 赵园红 温章 常运华 潘月鹏 孙业乐 马昕 沙志鹏 李紫玥 康嘉慧 刘磊 唐傲寒 王锴 张颖 郭怡鑫 张霖 盛立芳 张秀明 谷保静 宋宇 Martin Van Damme Lieven Clarisse Pierre-Francois Coheur Jeffrey L.Collett Jr Keith Goulding 张福锁 贺克斌 刘学军 | 2022 | Science Bulletin2022，67，17： | 2 |
| 9 | 核糖体失活蛋白及其在黄瓜中的表达分析(英文)显示文摘核糖体失活蛋白是一类具有高度特异性r RNA N-糖苷酶活性的蛋白,它们能够使原核或真核细胞的核糖体失活因而具有细胞毒性.由于其独特的生物学性质,核糖体失活蛋白被认为在农业和医学中都有着巨大的应用潜力.我们之前的研究表明,黄瓜的基因组中共包含2个2类核糖体失活蛋白基因,分别命名为Cumsa AB1和Cumsa AB2.以蓖麻毒蛋白Ricin为代表,2类核糖体失活蛋白通常由2条二硫键连接的肽链组成:具有N-糖苷酶活性的A链与具有凝集素活性的B链.本文研究了黄瓜中核糖体失活蛋白的表达情况.亚细胞定位研究表明Cumsa AB1经过蛋白分泌通路表达于细胞外,这与蛋白质序列分析显示的Cumsa AB1包含一个信号肽而不含转膜区域相一致.对黄瓜的不同生长阶段的不同组织中的转录水平分析表明,Cumsa AB1在大部分组织中以极低的水平表达,而Cumsa AB2表达水平则明显更高,尤其在第一片真叶阶段和刚开花的植物中.最后,我们使用分子模拟对黄瓜中核糖体失活蛋白的结构及糖结合位点进行了分析.本研究对黄瓜中核糖体失活蛋白的亚细胞定位、表达水平和可能的蛋白质结构进行了研究,为其进一步的生物学功能研究提供了重要信息. | 党刘毅 Pierre Rougé Els JM Van Damme | 2017 | 生物化学与生物物理进展2017，44，10： | 2 |
| 10 | Fas and Fas ligand: strong co-expression in human hepatceytes surrounding hepatoconular carcinoma; can cancer induce suicide in peritumoural cells? 显示文摘 | Roskams T Libbrecht L Van Damme B | 2000 | J Pathol2000，191，2： | 1 |
| 11 | Heat stability of a recombinant DNA hepatitis B vacine显示文摘 | Van Damme P | 1992 | Vaccine1992，10，6： | 1 |
| 12 | Preexposure prophylaxis for HIV infection among African women显示文摘 | Van Damme L Corneli A Ahmed K | 2012 | N Engl J Med2012，367，5： | 1 |
| 13 | Long-term persistence of antibodies induced by vaccination and safety follow-up, with the first combined vaccine against hepatitis A and B in children and adults显示文摘 | Van Damme P Leroux-Roels G Law B | 2001 | J Med Virol2001，65，1： | 1 |
| 14 | Subclinical Peritubular Capillaritis at 3 Months Is Associated With Chronic Rejection at 1 Year显示文摘 | Evelyne Lerut Maarten Naesens Dirk R. Kuypers Yves Vanrenterghem Boudewijn Van Damme | 2007 | Transplantation2007，，11： | 1 |
| 15 | Mutant hepatitis Bvirus: A matter of academic interest only of a problem with far-reaching implications显示文摘 | Francois G Kew M P Van Damme Mphahlele M J Meheus A | 2001 | Vaccine2001，19，32： | 1 |
| 16 | Bone marrow stromal cells as targets for gene therapy 显示文摘 | Van Damme A Vanden Driessche T Collen D | 2002 | Curr Gene Ther2002，2，： | 1 |
| 17 | Microbial inulinases: fermentation process, properties, and applications显示文摘 | van DAMME E J DERYCKE D G | 1983 | Adv Appl Microbiol1983，29，： | 1 |
| 18 | Molecular dissection of plant cytokinesis and phragmoplast structure: A survey of GFP-tagged proteins 显示文摘 | Van Damme D Bouget F Y Van Poucke K etal | 2004 | Plant Journal2004，40，： | 1 |
| 19 | Monocyte chemotactic protein-1 in proliferative vitreoretinal disorders 显示文摘 | Abu El-Asrar A M Van Damme J Put W | 1997 | Am J Ophthalmol1997，123，5： | 1 |
| 20 | The retrograde in tremedullarysupracindylar nail:an alrernarive in the treatment of distal femoral fractures in the elderly显示文摘 | Jan Zing HMJ Stockan B Van Damme C | 1998 | Arch Orthop trauma Surg1998，118，1： | 1 |
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