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| 1 | Rice Brittleness Mutants: A Way to Open the ‘Black Box’ of Monocot Cell Wall Biosynthesis显示文摘Rice is a model organism for studying the mechanism of cell wall biosynthesis and remolding in Gramineae.Mechanical strength is an important agronomy trait of rice (Oryza sativa L.) plants that affects crop lodging and grain yield.As a prominent physical property of cell walls,mechanical strength reflects upon the structure of different wall polymers and how they interact.Studies on the mechanisms that regulate the mechanical strength therefore consequently results in uncovering the genes functioning in cell wall biosynthesis and remodeling.Our group focuses on the study of isolation of brittle culm (bc) mutants and characterization of their corresponding genes.To date,several bc mutants have been reported.The identified genes have covered several pathways of cell wall biosynthesis,revealing many secrets of monocot cell wall biosynthesis.Here,we review the progress achieved in this research field and also highlight the perspectives in expectancy.All of those lend new insights into mechanisms of cell wall formation and are helpful for harnessing the waste rice straws for biofuel production. | Baocai Zhang Yihua Zhou | 2011 | Journal of Integrative Plant Biology2011，53，2： | 23 |
| 2 | The strengthening East Asia summer monsoon since the early 1990s显示文摘Previous studies have documented a weakening tendency of the East Asian summer monsoon (EASM) since the end of the 1970s. In this study, we report that the EASM has been recovering since the early 1990s, although its strength is still less than in previous decades (averaged over the period 1965-1980). Following the recovery of the EASM, there has been a tendency in the last decade toward northward-moving rainbands and excessive rainfall in the Huaihe River valley (110°-120°E, 30°-35°N). There is evidence suggesting that the strengthening EASM since the early 1990s is linked to interdecadal change of land-sea thermal contrast. | LIU HaiWen ZHOU TianJun ZHU YuXiang LIN YiHua | 2012 | Chinese Science Bulletin2012，57，13： | 23 |
| 3 | OsVPS9A Functions Cooperatively with OsRAB5A to Regulate Post-Golgi Dense Vesicle-Mediated Storage Protein Trafficking to the Protein Storage Vacuole in Rice Endosperm Cells显示文摘在米饭内乳房间, glutelins 作为 proglutelins 在不平的 endoplasmic 蜂窝胃上被综合并且被排序到称为蛋白质身体 II (PBII ) 的 theprotein 存储液泡(PSV ) ,在他们被变换成成熟形式的地方。稠密的泡(DV ) 调停了在大米种子的 proglutelins 的 trafficking 被建议了,但是这个过程的 post-Golgi 控制是 largelyunknown。DV 是否能与 PSV 直接熔化,是争论的另一件事。在这研究,我们建议规章的 mechanismunderlying 调停 DV, post-Golgi proglutelin trafficking 到 PBII (PSV ) 。gpa2, OsVPS9A 的 loss-of-function 异种,编码 OsRAB5A 的 GEF,积累了 uncleaved proglutelins。Proglutelins 对到沿着在 DV 形式的房间墙的 apoplast 的 paramural bodiesand 指向 mis,它在 PBII 尺寸导致了伴随物减小。Previouslyreported gpa1,在 OsRab5a 变异,有类似的显型,当时两倍异种加重了的 gpa1gpa2 条件。另外, OsVPS9A 在 vitro 并且在 vivo 与 OsRAB5A 交往了。我们断定 OsVPS9A 和 OsRAB5A 可以一起工作并且在调停 DV 的 post-Golgi proglutelintrafficking 起一个规章的作用到 PBII (PSV ) 。DV 可能直接熔化到 PBII (PSV ) 交付货物的证据也是 presented.Key 词: | Feng Liu Yulong Ren Yihua Wang Cheng Peng Kunneng Zhou Jia Lv Xiuping Guo Xin Zhang Jianmin wan Yiqun Bao | 2013 | Molecular Plant2013，6，6： | 16 |
| 4 | An Uncanonical CCCH-Tandem Zinc-Finger Protein Represses Secondary Wall Synthesis and Controls Mechanical Strength in Rice显示文摘第二等的墙,代表生物资源的体积,在植物生长和改编上有大影响到环境。第二等的墙合成被一个复杂发信号 transduction 网络交换并且调整。然而,有这些规章的小径的有限理解。这里,我们报导(IIP4 )交往 ILA1 蛋白质 4 能镇压第二等的墙合成。IIP4 是象 Raf 一样 MAPKKK 的 phosphorylation 底层,但是它的功能是未知的。由产生 iip4 异种和相关转基因的植物,我们发现在 IIP4 的损害提高第二等的墙形成。基因表示和 transactivation 活动试金表明 IIP4 否定地调整 MYB61 和 CESA 的表示但是不绑 ? 他们的倡导者。IIP4 与 NAC29/NAC31 交往,第二等的墙合成的在上游的管理者,并且在植物压制下游地规章的小径。显示出的 Mutagenesis 分析那 phosphomimic IIP4 从原子核的蛋白质 translocate 到细胞质。而且,我们表明 IIP evolutionarily 被保存并且分享 unreported CCCH 主题,叫作 uncanonical CCCH 双人脚踏车锌手指蛋白质。一起,我们的学习提供机械学的卓见进第二等的墙合成的控制并且为在庄稼改进相关农学的特点介绍一个机会。 | Dongmei Zhang Zuopeng Xu Shaoxue Cao Kunling Chen Shance Li Xiangling Liu Caixia Gao Baocai Zhang Yihua Zhou | 2018 | Molecular Plant2018，11，1： | 14 |
| 5 | A cyclic nucleotide-gated channel mediates cytoplasmic calcium elevation and disease resistance in rice显示文摘The transient elevation of cytoplasmic calcium is essential for pathogen-associated molecular pattern(PAMP)-triggered immunity(PTI).However,the calcium channels responsible for this process have remained unknown.Here,we show that rice CDSI(CELL DEATH and SUSCEPTIBLE to BLAST 1)encoding OsCNGC9;a cyclic nucleotide-gated channel protein,positively regulates the resistance to rice blast disease.We show that OsCNGC9 mediates PAMP-induced Ca2+influx and that this event is critical for PAMPs-triggered ROS burst and induction of PTI-related defense gene expression.We further show that a PTI related receptor-lih cytoplasmic kinase OsRLCK185 physically interacts with and phosphorylates OsCNGC9 to activate its channel activity.Our results suggest a signaling cascade linking pattern recognition to calcium channel activation,which is required for initiation of PTI and disease resistance in rice. | Jiachang Wang Xi Liu An Zhang Yulong Ren Fuqing Wu Gang Wang Yang Xu Cailin Lei Shanshan Zhu Tian Pan Yongfei Wang Huan Zhang Fan Wang Yan-Qiu Tan Yupeng Wang Xin Jin Sheng Luo Chunlei Zhou Xiao Zhang Jinling Liu Shuai Wang Lingzhi Meng Yihua Wang Xi Chen Qibing Lin Xin Zhang Xiuping Guo Zhijun Cheng Jiulin Wang Yunlu Tian Shijia Liu Ling Jiang Chuanyin Wu Ertao Wang Jian-Min Zhou Yong-Fei Wang Haiyang Wang Jianmin Wan | 2019 | Cell Research2019，29，10： | 13 |
| 6 | The plant cell wall: Biosynthesis, construction, and functions显示文摘The plant cell wall is composed of multiple biopolymers, representing one of the most complex structural networks in nature. Hundreds of genes are involved in building such a natural masterpiece. However, the plant cell wall is the least understood cellular structure in plants. Due to great progress in plant functional genomics,manyachievementshavebeenmadein uncovering cell wall biosynthesis, assembly, and architecture, as well as cell wall regulation and signaling. Such information has significantly advanced our understanding of the roles of the cell wall in many biological and physiological processes and has enhanced our utilization of cell wall materials. The use of cutting-edge technologies such as single-molecule imaging,nuclear magnetic resonance spectroscopy, and atomic force microscopy has provided much insight into the plant cell wall as an intricate nanoscale network, opening up unprecedented possibilities for cell wall research. In this review,we summarize the major advances made in understanding the cell wall in this era of functional genomics, including the latest findings on the biosynthesis, construction, and functions of the cell wall. | Baocai Zhang Yihong Gao Lanjun Zhang Yihua Zhou | 2021 | Journal of Integrative Plant Biology2021，63，1： | 11 |
| 7 | Transcriptional activation and phosphorylation of OsCNGC9 confer enhanced chilling tolerance in rice显示文摘Low temperature is a major environmental factor that limits plant growth and productivity.Although transient elevation of cytoplasmic calcium has long been recognized as a critical signal for plant cold tolerance,the calcium channels responsible for this process have remained largely elusive.Here we report that OsCNGC9,a cyclic nucleotide-gated channel,positively regulates chilling tolerance by mediating cytoplasmic calcium elevation in rice(Oryza sativa).We showed that the loss-of-function mutant of OsCNGC9 is defective in cold-induced calcium influx and more sensitive to prolonged cold treatment,whereas OsCNGC9 overexpression confers enhanced cold tolerance.Mechanistically,we demonstrated that in response to chilling stress,OsSAPK8,a homolog of Arabidopsis thaliana OST1,phosphorylates and activates OsCNGC9 to trigger Ca2+influx.Moreover,we found that the transcription of OsCNGC9 is activated by a rice dehydration-responsive element-binding transcription factor,OsDREB1A.Taken together,our results suggest that OsCNGC9 enhances chilling tolerance in rice through regulating cold-induced calcium influx and cytoplasmic calcium elevation. | Jiachang Wang Yulong Ren Xi Liu Sheng Luo Xiao Zhang Xin Liu Qibing Lin Shanshan Zhu Hua Wan Yang Yang Yu Zhang Bin Lei Chunlei Zhou Tian Pan Yongfei Wang Mingming Wu Ruonan jing Yang Xu Meng Han Fuqing Wu Cailin Lei Xiuping Guo Zhijun Cheng Xiaoming Zheng Yihua Wang Zhigang Zhao Ling Jiang Xin Zhang Yong-Fei Wang Haiyang Wang Jianmin Wan | 2021 | Molecular Plant2021，14，2： | 10 |
| 8 | Pathogenesis, diagnosis and treatment of cerebral fat embolism显示文摘 | Yihua Zhou Ying Yuan Chahua Huang Lihua Hu Xiaoshu Cheng | 2015 | Chinese Journal of Traumatology2015，18，2： | 7 |
| 9 | Quantitative Trait Loci Mapping of Flag-leaf Ligule Length in Rice and Alignment with ZmLG1 Gene显示文摘A doubled haploid(DH) population,which consists of 120 lines derived from anther culture of a typical indica and japonica hybrid 'CJ06'/'TN1',was used in this study.Ligule lengths of flag leaf were investigated for quantitative trait loci(QTL) mapping using the DH population.Five QTLs(qLL-2,qLL-4,qLL-6,qLL-10 and qLL-12) controlling the ligule length(LL) were detected on chromosomes 2,4,6,10 and 12,with the variances explained 11.4%,13.6%,27.8%,22.1% and 11.0%,respectively.Using four known genes of ZmGL1,ZmGL2,ZmGL3 and ZmGL4 in maize from the MaizeGDB,their homologs in rice were aligned and integrated into the existing simple sequence repeats linkage map by in silico mapping.A ZmLG1 homolog gene,OsLG1 encoding a squamosa promoter binding protein,was located between the markers RM255 and RM280,which is just identical to the interval of qLL-4 on the long arm of chromosome 4.The results are beneficial to dissection of the ligule molecular mechanism and the study of cereal evolution. | Dali Zeng Jiang Hu Guojun Dong Jian Liu Longjun Zeng Guangheng Zhang Longbiao Guo Yihua Zhou Qian Qian | 2009 | Journal of Integrative Plant Biology2009，51，4： | 6 |
| 10 | Quantum network communication: a discrete-time quantum-walk approach显示文摘We study the problem of quantum multi-unicast communication over the butterfly network in a quantum-walk architecture, where multiple arbitrary single-qubit states are transmitted simultaneously between multiple source-sink pairs. Here, by introducing quantum walks, we demonstrate a quantum multiunicast communication scheme over the butterfly network and the inverted crown network, respectively,where the arbitrary single-qubit states can be efficiently transferred with both the probability and the state fidelity one. The presented result concerns only the butterfly network and the inverted crown network, but our techniques can be applied to a more general graph. It paves a way to combine quantum computation and quantum network communication. | Yuguang YANG Jiajie YANG Yihua ZHOU Weimin SHI Xiubo CHEN Jian LI Huijuan ZUO | 2018 | Science China(Information Sciences)2018，61，4： | 5 |
| 11 | Butterfly distribution of Earth's radiation belt relativistic electrons induced by dayside chorus显示文摘Previous theoretical studies have shown that dayside chorus can produce butterfly distribution of energetic electrons in the Earth's radiation belts by preferentially accelerating medium pitch angle electrons, but this requires the further confirmation from highresolution satellite observation. Here, we report correlated Van Allen Probes data on wave and particle during the 11-13 April,2014 geomagnetic storm. We find that a butterfly pitch angle distribution of relativistic electrons is formed around the location L = 4.52, corresponding to the presence of enhanced dayside chorus. Using a Gaussian distribution fit to the observed chorus spectra, we calculate the bounce-averaged diffusion rates and solve two-dimensional Fokker-Planck equation. Numerical results demonstrate that acceleration by dayside chorus can yield the electron flux evolution both in the energy and butterfly pitch angle distribution comparable to the observation, providing a further evidence for the formation of butterfly distribution of relativistic electrons driven by very low frequency(VLF) plasma waves. | jin yuyue yang chang he yihua liu si zhou qinghua xiao fuliang | 2018 | Science China(Technological Sciences)2018，61，2： | 5 |
| 12 | Introduction of pokeweed antiviral protein cDNA into Brassica napus and acquisition of transgenic plants resistant to viruses显示文摘Using cotyledonary petioles as explants, the PAP cDNA controlled by wound-in-ducible promoter has been introduced into Brassica napus by coculture with Agrobacterium tumefaciens and laser microbeam puncture respectively. Regenerated plants resistant to gen-tamycin have been selected out. PCR amplification and Southern blotting analysis indicated that PAP cDNA together with wound-inducible promoter had been integrated into Brassica genome with transformation frequencies of 2.0% and 1.7% for two transformation methods respectively. The test of virus challenge showed that these transgenic Brassica plants were resistant in different degrees to mechanically inoculated TuMV. | ZHANG Haiyan , TIAN Yingchuan , ZHOU Yihua , DANG Benyuan LAN Haiyan , SONG Guiying , WANG Lanlan , LIU Guizhen , ZHANG Lihua and CHEN ZhenghuaInstitute of Genetics , Chinese Academy of Sciences , Beijing 100101, China Institute of Microbiology , Chinese Academy of Sciences , Beijing 100080, China | 1999 | Chinese Science Bulletin1999，44，8： | 3 |
| 13 | The Cellulose Synthases Are Cargo of the TPLATE Adaptor Complex显示文摘 | Clara Sanchez-Rodriguez Yanyun Shi Christopher Kesten Dongmei Zhang Gloria Sancho-Andres Alexander Ivakov Edwin R. Lampugnani Kamil Sklodowski Masaru Fujimoto Akihiko Nakano Antony Bacic Ian S. Wallace Takashi Ueda Daniel Van Damme Yihua Zhou Staffan Persson | 2018 | Molecular Plant2018，11，2： | 3 |
| 14 | 中美放射科住院医师培训有感显示文摘简要介绍美国医学院毕业生从参加职业医师考试到申请住院医师培训,以及接受培训的全过程,重点介绍了美国严谨的放射诊断专业住院医师培训方式,同时对国内住院医师培训中存在的一些问题进行了分析。 | 梁宇霆 Zhou Yihua 贺文 潘丽恩 | 2013 | 国际医学放射学杂志2013，36，1： | 3 |
| 15 | Upward propagation of lightning-generated whistler waves into the radiation belts显示文摘Lightning-generated whistler(LGW) waves which induce energetic electron precipitation provide an important coupling between the ionosphere and radiation belts. Using the ray-tracing technique, we examine the propagation behaviour of LGW waves and show that they can travel upward into the radiation belts during higher geomagnetic activities due to the plasmapause inward compression, particularly in cases of lower wave frequencies, lower wave normal angles and azimuthal angles. Both perpendicular and parallel group velocities of LGW waves remain in relatively small values inside the plasmasphere but change rapidly to high values outside the plasmasphere. The launching latitude increases with increasing LGW wave normal angle. These results here further reveal a detailed picture on how LGW waves escape out of the plasmasphere and onto the radiation belts. | GUO MingYue ZHOU QingHua XIAO FuLiang LIU Si HE YiHua YANG Chang | 2020 | Science China(Technological Sciences)2020，63，2： | 3 |
| 16 | An Android Malware Detection System Based on Feature Fusion显示文摘In order to improve the detection efficiency of Android malicious application, an Android malware detection system based on feature fusion is proposed on three levels. Feature fusion especially emphasizes on ten categories, which combines static and dynamic features and includes 377 features for classification. In order to improve the accuracy of malware detection, attribute subset selection and principle component analysis are used to reduce the dimensionality of fusion features. Random forest is used for classification. In the experiment, the dataset includes 43,822 benign applications and 8,454 malicious applications. The method can achieve 99.4% detection accuracy and 0.6% false positive rate. The experimental results show that the detection method can improve the malware detection efficiency in Android platform. | LI Jian WANG Zheng WANG Tao TANG Jinghao YANG Yuguang ZHOU Yihua | 2018 | Chinese Journal of Electronics2018，27，6： | 3 |
| 17 | β-Catenin/TCF pathway upregulates STAT3 expression in human esophageal squamous cell carcinoma显示文摘 | Shuang Yan Cuiqi Zhou Wei Zhang Guo Zhang Xuejian Zhao Shangbin Yang Yihua Wang Ning Lu Hongxia Zhu Ningzhi Xu | 2008 | Cancer Letters2008，，1： | 2 |
| 18 | Construction of single-chromosome DNA library from Lilium regale Wilson显示文摘A protocol of simple rapid microdissection of single-chromosome, amplification and cloning of its DNA from Lilium regale Wilson is described. Single-chromosome, microdissected by micromanipulator, was put into a 0 5 mL Eppendorf tube and digested with Sau3A, and then the Sau3A linker adaptors were ligated to the ends of DNA fragments. After 2 rounds of PCR amplification with one chain of linker adaptor as primer, the PCR products thus obtained have a length of 300-2 500 base pairs (bp) with predominant fragments at about 1 000 bp. Southern blot analysis confirmed that the PCR products originated from the genome of Lilium regale Wilson. By cloning the amplification products from the second round of PCR, single-chromosome DNA library was constructed, in which about as many as 100 000 recombinant clones were produced. A total number of 84 clones were analysed, and it was revealed that the inserts ranged in size from 300 to 1 800 bp, with an average of 780 bp. Compared with the methods described in other literature, this protocol, eliminating the need for enzymatic digestion and ligating micromanipulation of chromosomal DNA in nanoliter volumes, permits the efficient amplification of single chromosome (not tens of chromosomes as reported before) and the fragments (780 bp in average) cloned in this study are longer than those reported before (650 bp in average). | Benyuan Dang Zanmin Hu Yihua Zhou Lihua Cui Lanlan Wang Liangcai Li Zhenghua Chen | 1998 | Chinese Science Bulletin1998，43，5： | 2 |
| 19 | Dietary ellagic acid supplementation attenuates intestinal damage and oxidative stress by regulating gut microbiota in weanling piglets显示文摘Intestinal oxidative stress triggers gut microbiota dysbiosis,which is involved in the etiology of postweaning diarrhea and enteric infections.Ellagic acid(EA)can potentially serve as an antioxidant supplement to facilitate weaning transition by improving intestinal oxidative stress and gut microbiota dysbiosis.Therefore,we aimed to investigate the effects of dietary EA supplementation on the attenuation of intestinal damage,oxidative stress,and dysbiosis of gut microbiota in weanling piglets.A total of126 piglets were randomly assigned into 3 groups and treated with a basal diet and 2 m L saline orally(Ctrl group),or the basal diet supplemented with 0.1%EA and 2 m L saline orally(EA group),or the basal diet and 2 m L fecal microbiota suspension from the EA group orally(FEA group),respectively,for 14 d.Compared with the Ctrl group,EA group improved growth performance by increasing average daily feed intake and average daily weight gain(P<0.05)and decreasing fecal scores(P<0.05).EA group also alleviated intestinal damage by increasing the tight junction protein occludin(P<0.05),villus height,and villus height-to-crypt depth ratio(P<0.05),while decreasing intestinal epithelial apoptosis(P<0.05).Additionally,EA group enhanced the jejunum antioxidant capacity by increasing the total antioxidant capacity(P<0.01),catalase(P<0.05),and glutathione/oxidized glutathione(P<0.05),but decreased the oxidative metabolite malondialdehyde(P<0.05)compared to the Ctrl group.Compared with the Ctrl group,EA and FEA groups increased alpha diversity(P<0.05),enriched beneficial bacteria(Ruminococcaceae and Clostridium ramosum),and increased metabolites short-chain fatty acids(P<0.05).Correspondingly,FEA group gained effects comparable to those of EA group on growth performance,intestinal damage,and intestinal antioxidant capacity.In addition,the relative abundance of bacteria shifted in EA and FEA groups was significantly related to the examined indices(P<0.05).Overall,dietary EA supplementation could improve growth performance and attenuate intestinal damage and oxidative stress by regulating the gut microbiota in weanling piglets. | Wenxia Qin Baoyang Xu Yuwen Chen Wenbo Yang Yunzheng Xu Juncheng Huang Ting Duo Yihua Mao Guozong Zhou Xianghua Yan Libao Ma | 2022 | Animal Nutrition2022，，4： | 2 |
| 20 | Single-cell Transcriptomic Analysis Reveals the Cellular Heterogeneity of Mesenchymal Stem Cells显示文摘Ex vivo-expanded mesenchymal stem cells(MSCs)have been demonstrated to be a heterogeneous mixture of cells exhibiting varying proliferative,multipotential,and immunomodulatory capacities.However,the exact characteristics of MSCs remain largely unknown.By singlecell RNA sequencing of 61,296 MSCs derived from bone marrow and Wharton’s jelly,we revealed five distinct subpopulations.The developmental trajectory of these five MSC subpopulations was mapped,revealing a differentiation path from stem-like active proliferative cells(APCs)to multipotent progenitor cells,followed by branching into two paths:1)unipotent preadipocytes or 2)bipotent prechondro-osteoblasts that were subsequently differentiated into unipotent prechondrocytes.The stem-like APCs,expressing the perivascular mesodermal progenitor markers CSPG4/MCAM/NES,uniquely exhibited strong proliferation and stemness signatures.Remarkably,the prechondrocyte subpopulation specifically expressed immunomodulatory genes and was able to suppress activated CD3^(+T) cell proliferation in vitro,supporting the role of this population in immunoregulation.In summary,our analysis mapped the heterogeneous subpopulations of MSCs and identified two subpopulations with potential functions in self-renewal and immunoregulation.Our findings advance the definition of MSCs by identifying the specific functions of their heterogeneous cellular composition,allowing for more specific and effective MSC application through the purification of their functional subpopulations. | Chen Zhang Xueshuai Han Jingkun Liu Lei Chen Ying Lei Kunying Chen Jia Si Tian-yi Wang Hui Zhou Xiaoyun Zhao Xiaohui Zhang Yihua An Yueying Li Qian-Fei Wang | 2022 | Genomics, Proteomics & Bioinformatics2022，20，1： | 2 |
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