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| 1 | Current oncologic applications of radiofrequency ablation therapies显示文摘Radiofrequency ablation (RFA) uses high frequency alternating current to heat a volume of tissue around a needle electrode to induce focal coagulative necrosis with minimal injury to surrounding tissues. RFA can be performed via an open, laparoscopic, or image guided percutaneous approach and be performed under general or local anesthesia. Advances in delivery mechanisms, electrode designs, and higher power generators have increased the maximum volume that can be ablated, while maximizing oncological outcomes. In general, RFA is used to control local tumor growth, prevent recurrence, palliate symptoms, and improve survival in a subset of patients that are not candidates for surgical resection. It's equivalence to surgical resection has yet to be proven in large randomized control trials. Currently, the use of RFA has been well described as a primary or adjuvant treatment modality of limited but unresectable hepatocellular carcinoma, liver metastasis, especially colorectal cancer metastases, primary lung tumors, renal cell carcinoma, boney metastasis and osteoid osteomas. The role of RFA in the primary treatment of early stage breast cancer is still evolving. This review will discuss the general features of RFA and outline its role in commonly encountered solid tumors. | Dhruvil R Shah Sari Green Angelina Elliot John P McGahan Vijay P Khatri | 2013 | World Journal of Gastrointestinal Oncology2013，5，4： | 33 |
| 2 | Comparative clinical trial of S-pantoprazole versus racemic pantoprazole in the treatment of gastro-esophageal reflux disease显示文摘AIM: To compare the effi cacy and tolerability of S-pan- toprazole (20 mg once a day) versus racemic Panto- prazole (40 mg once a day) in the treatment of gastro- esophageal reflux disease (GERD). METHODS: This multi-centre, randomized, double-blind clinical trial consisted of 369 patients of either sex suf- fering from GERD. Patients were randomly assigned to receive either one tablet (20 mg) of S-pantoprazole once a day (test group) or 40 mg racemic pantoprazole once a day (reference group) for 28 d. Patients were evaluated for reduction in baseline on d 0, GERD symptom score on d 14 and 28, occurrence of any adverse effect during the course of therapy. Gastrointestinal (GI) endoscopy was performed in 54 patients enrolled at one of the study centers at baseline and on d 28. RESULTS: Signifi cant reduction in the scores (mean and median) for heart burn (P < 0.0001), acid regurgitation (P < 0.0001), bloating (P < 0.0001), nausea (P < 0.0001) and dysphagia (P < 0.001) was achieved in both groups on d 14 with further reduction on continuing the therapy till 28 d. There was a statistically signifi cant difference in the proportion of patients showing improvement in acid regurgitation and bloating on d 14 and 28 (P = 0.004 for acid regurgitation; P = 0.03 for bloating) and heart burn on d 28 (P = 0.01) between the two groups, with a higher proportion in the test group than in the refer- ence group. Absolute risk reductions for heartburn/acid regurgitation/bloating were approximately 15% on d 14 and 10% on d 28. The relative risk reductions were 26%-33% on d 14 and 15% on d 28. GI endoscopy showed no signifi cant difference in healing of esophagitis (P = 1) and gastric erosions (P = 0.27) between the two groups. None of the patients in either group reported any adverse effect during the course of therapy.CONCLUSION: In GERD, S-pantoprazole (20 mg) is more effective than racemic pantoprazole (40 mg) in improving symptoms of heartburn, acid regurgitation, bloating and equally effective in healing esophagitis and gastric erosions. The relative risk reduction is 15%-33%. Both drugs are safe and well tolerated. | Vikas G Pai Nitin V Pai Hemant P Thacker Jaisingh K Shinde Vijay P Mandora Subhash S Erram | 2006 | World Journal of Gastroenterology2006，12，37： | 19 |
| 3 | Laparoscopic 肝切除术: 当前的角色和限制显示文摘 Laparoscopic liver resection (LLR) for the treatment of benign and malignant liver lesions is often performed at specialized centers. Technological advances, such as laparoscopic ultrasonography and electrosurgical tools, have afforded surgeons simultaneous improvements in surgical technique. The utilization of minimally invasive techniques for liver resection has been reported to reduce operative time, decrease blood loss, and shorten length of hospital stay with equivalent postoperative mortality and morbidity rates compared to open liver resection (OLR). Non-anatomic liver resection and left lateral sectionectomy are now routinely performed laparoscopically at many institutions. Furthermore, major hepatic resections are performed by pure laparoscopy, hand-assisted technique, and the hybrid method. In addition, robotic surgery and single port surgery are revealing early promising results. The consensus recommendation for the treatment of benign liver disease and malignant lesions remains unchanged when considering a laparoscopic approach, except when comorbidities and anatomic limitations of the liver lesion preclude this technique. Disease free and survival rates after LLR for hepatocellular carcinoma and metastatic colon cancer correspond to OLR. Patient selection is a significant factor for these favorable outcomes. The limitations include LLR of superior and posterior liver lesions; however, adjustments in technique may now consider a laparoscopic approach as a viable option. As growing data continue to reveal the feasibility and efficacy of laparoscopic liver surgery, this skill is increasingly being adopted by hepatobiliary surgeons. Although the full scope of laparoscopic liver surgery remains infrequently used by many general surgeons, this technique will become a standard in the treatment of liver diseases as studies continue to show favorable outcomes. | Rouzbeh Mostaedi Zoran Milosevic Ho-Seong Han Vijay P Khatri | 2012 | World Journal of Gastrointestinal Oncology2012，4，8： | 8 |
| 4 | Sacroiliac joint stability: Finite element analysis of implant number, orientation, and superior implant length显示文摘AIM To analyze how various implants placement variables affect sacroiliac(SI) joint range of motion. METHODS An experimentally validated finite element model of the lumbar spine and pelvis was used to simulate a fusion of the SI joint using various placement configurations of triangular implants(iF use Implant System~?). Placement configurations were varied by changing implant orientation, superior implant length, and number of implants. The range of motion of the SI joint was calculated using a constant moment of 10 N-m with a follower load of 400 N. The changes in motion were compared between the treatment groups to assess how the different variables affected the overall motion of the SI joint. RESULTS Transarticular placement of 3 implants with superior implants that end in the middle of the sacrum resulted in the greatest reduction in range of motion(flexion/extension = 73%, lateral bending = 42%, axial rotation = 72%). The range of motions of the SI joints were reduced with use of transarticular orientation(9%-18%) when compared with an inline orientation. The use of a superior implant that ended mid-sacrum resulted in median reductions of(8%-14%) when compared with a superior implant that ended in the middle of the ala. Reducing the number of implants, resulted in increased SI joint range of motions for the 1 and 2 implant models of 29%-133% and 2%-39%, respectively,when compared with the 3 implant model.CONCLUSION Using a validated finite element model we demonstrated that placement of 3 implants across the SI joint using a transarticular orientation with superior implant reaching the sacral midline resulted in the most stable construct. Additional clinical studies may be required to confirm these results. | Derek P Lindsey Ali Kiapour Scott A Yerby Vijay K Goel | 2018 | World Journal of Orthopedics2018，9，3： | 3 |
| 5 | Conversion from prolonged intravenous fentanyl infusion to enteral methadone in critically ill children显示文摘AIM To describe our institutional experience with conversion from intravenous(IV) fentanyl infusion directly to enteral methadone and occurrence of withdrawal in critically ill mechanically ventilated children exposed to prolonged sedation and analgesia.METHODS With Institutional Review Board approval,we retrospectively studied consecutively admitted invasively mechanically ventilated children(0-18 years) sedated with IV fentanyl infusion > 5 d and subsequently converted directly to enteral methadone.Data were obtained onsubject demographics,illness severity,daily IV fentanyl and enteral methadone dosing,time to complete conversion,withdrawal scores(WAT-1),pain scores,and need for rescue opioids.Patients were classified as rapid conversion group(RCG) if completely converted ≤ 48 h and slow conversion group(SCG) if completely converted in > 48 h.Primary outcome was difference in WAT-1 scores at 7 d.Secondary outcomes included differences in overall pain scores,and differences in daily rescue opioids.RESULTS Compared to SCG(n = 21),RCG(n = 21) had lower median WAT-1 scores at 7 d(2.5 vs 5,P = 0.027).Additionally,RCG had lower overall median pain scores(3 vs 6,P = 0.007),and required less median daily rescue opioids(3 vs 12,P = 0.003) than SCG.The starting daily median methadone dose was 2.3 times the daily median fentanyl dose in the RCG,compared to 1.1 times in the SCG(P = 0.049).CONCLUSION We observed wide variation in conversion from IV fentanyl infusion directly to enteral methadone and variability in withdrawal in critically ill mechanically ventilated children exposed to prolonged sedation.In those children who converted successfully from IV fentanyl infusion to enteral methadone within a period of 48 h,a methadone:fentanyl dose conversion ratio of approximately 2.5:1 was associated with less withdrawal and reduced need for rescue opioids. | Vijay Srinivasan Daniel Pung Sean P O'Neill | 2017 | World Journal of Clinical Pediatrics2017，6，2： | 3 |
| 6 | Efficacy and safety of tadalafil taken as needed for the treatment of erectile dysfunction in Asian men: results of an integrated analysis显示文摘我们在一张多样的临床的人口评估了同样需要的 tadalafil 的功效和安全(与改变耐心的人口分布,疾病严厉,和 comorbid 医药条件) 有可勃起的机能障碍(编辑) 的亚洲人。五双窗帘的综合分析,控制安慰剂的试用(N = 1 046 ) 被执行。病人们随机被分配收到 10 mg tadalafil (N = 185 ) , 20 mg tadalafil (N = 510 ) ,或安慰剂(N = 351 ) 。功效评价包括了可勃起的功能(IIEF ) 的国际索引,性相遇侧面(9 月) 日记和全球评价问题(GAQ ) 。收到 10 mg 或 20 mg tadalafil 从 baseline-to-end 看了重要改进的病人指在在分析的所有临床的亚人口的可勃起的功能(IIEF-EF ) 领域 20 的国际索引的可勃起的功能领域上,与收到安慰剂的病人相比(P < 0.001 ) 。给吝啬的成功看的 10-mg 和 20-mg tadalafil 组为性交尝试64.1%和70.5%评价( SEP3 ,成功的性交)分别地,在安慰剂与33.4%相比组织( P < 0.001 ),并且分别地,在结束的85.5%和85.4%报导改进勃起削尖 GAQ 对43.5%在安慰剂组织( P < 0.001 )。Tadalafil 很好越过学习的所有组被容忍。头疼和背疼痛是最经常报导的不利事件。总的来说, tadalafil 越过有编辑的亚洲男人的一个多样的临床的系列有效、很好容忍。 | Ying-Lu Guo Vijay P Viswanathan Han-Sun Chiang Hyung Ki Choi Andrew Wai Chun Yip Wei Shen Vladimir Kopernicky | 2009 | Asian Journal of Andrology2009，11，4： | 3 |
| 7 | Computerized tomography based “patient specific blocks” improve postoperative mechanical alignment in primary total knee arthroplasty显示文摘AIM: To compare the postoperative mechanical alignment achieved after total knee arthroplasty(TKA) using computer tomography(CT) based patient specific blocks(PSB) to conventional instruments(CI).METHODS: Total 80 knees were included in the study, with 40 knees in both the groups operated using PSB and CI. All the knees were performed by a single surgeon using the same cruciate sacrificing implants. In our study we used CT based PSB to compare with CI. Postoperative mechanical femoro-tibial angle(MFT angle) was measured on long leg x-rays using picture archiving and communication system(PACS). We compared mechanical alignment achieved using PSB and CI in TKA using statistical analysis.RESULTS: The PSB group(group 1) included 17 females and seven males while in CI group(group 2) there were 15 females and eight males. The mean age of patients in group 1 was 60.5 years and in group 2 it was 60.2 years. The mean postoperative MFT angle measured on long-leg radiographs in group 1 was 178.23°(SD = 2.67°, range: 171.9° to 182.5°) while in group 2, the mean MFT angle was 175.73°(SD = 3.62°, range: 166.0° to 179.8°). There was significant improvement in postoperative mechanical alignment(P value = 0.001), in PSB group compared to CI. Number of outliers were also found to be less in group operated with PSB(7 Knee) compared to those operated with CI(17 Knee).CONCLUSION: PSB improve mechanical alignment after total knee arthroplasty, compared to CI. This may lead to lower rates of revision in the PSB based TKA as compared to the conventional instrumentation. | Raju Vaishya Vipul Vijay Vikas P Birla Amit K Agarwal | 2016 | World Journal of Orthopedics2016，7，7： | 2 |
| 8 | On the True Minimum Distarce of Hermitian codes显示文摘 | Kyeongcheol Yang Vijay Kumar P | 1991 | Coding Theory and Algebraic Gometry Proceeding Luminy1991，1518，： | 2 |
| 9 | An Invariance Principle for Nonlinear Hybrid and Impulsive Dynamical Sys terns 显示文摘 | VIJAY S C SANJAY P B WASSIM M H | 2003 | Nonlinear Analysis2003，53，： | 1 |
| 10 | Entropy-based assessment of water quality monitoring networks显示文摘 | Sevinc Ozkul Nilgun B Harmnaciou Vijay P Singh | 2000 | Journal of Hydrologic Engineering2000，5，1： | 1 |
| 11 | Mufti-signal flow graphs:a novel approach for system testability analysis and fault diagnosis显示文摘 | Somnath Deb Krishna R P Vijay R | 1995 | IEEE Aerospace and Electronics Magazine1995，10，5： | 1 |
| 12 | A review of drought concepts显示文摘 | MISHRA ASHOK K SINGH VIJAY P | 2010 | Journal of Hydrology2010，391，： | 1 |
| 13 | Modeling of material removal and surface roughness in abrasive flow machining process显示文摘 | Jain Rajendra K Jain Vijay K Dixit P M | 1999 | International Journal of Machine Tools ~ Manufacture1999，，3： | 1 |
| 14 | Right ventricular outflow tract reconstruction with a polytetrafluoroethylene monocusp valve:atwelve-year experience显示文摘 | Brown JW Ruzmetov M Vijay P | | 0，，05： | 1 |
| 15 | Larvicidal activity of bis ( 2-ethyl hexyl) benzene-I, 3- dicarboxylate from sterculia guattata seeds against two mosquito species 显示文摘 | SUSHAMA R K PUSHPA V P VIJAY B T | 2006 | Chemical biodivesity2006，，3： | 1 |
| 16 | Critical parameters effecting the rapid prototyping surface finish显示文摘 | VIJAY P DANAIAH P RAJESH K | 2011 | Journal of Mechanical Engineering and Automation2011，1，1： | 1 |
| 17 | Bending behavior and deformability of GFRP reinforced concrete members显示文摘 | Vijay P V Hota V S Ganga Rao | 2001 | ACI Structure Journal2001，98，6： | 1 |
| 18 | A review of drought concepts显示文摘 | Ashok K M Vijay P S | 2010 | Journal of Hydrology2010，，391： | 1 |
| 19 | Detection and optimization of temperature distribution across largearea power MOSFETs to Improve Energy Capability显示文摘 | Vishnu Khemka Vijay P Zhu Ronghua | 2004 | IEEE Trans ED2004，51，6： | 1 |
| 20 | Smgieal results of arterial switch operation for Taussig-Bing anomaly is position of the great arteries a risk factor 显示文摘 | Rodcfdd MD Ruzmotov M Vijay P | 2007 | Ann Thorac Suvg2007，83，4： | 1 |
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