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| 1 | 水稻田农药喷雾上层植株雾滴截留影响的试验研究显示文摘精确喷施农药的效果取决于喷施药液在农作物 (靶标 )上的有效沉积。研究作物上层枝叶对农药的雾滴截留 ,为喷雾器具的优化设计、性能改进以及正确使用等提供技术依据 ;对合理喷施农药、提高农药的利用率、减少农药污染、保障食品安全具有重要意义。本试验研究以染料Rhodamine -B溶解成一定浓度的溶液代替农药对水稻田进行喷雾。用采样架沿水稻高度方向分 3层采集水稻植株样品。用荧光分光光度计测定雾滴在水稻某一层间的沉积量。本试验研究提出了定量分析上层水稻植株叶面截留对雾滴沉积影响的方法 ,分别对早稻与晚稻进行了试验。结果表明 :在按距离地面 40cm以上、2 0~ 40cm之间、5~ 2 0cm之间对水稻分层时 ,上层水稻植株的雾滴截留对中层、底层水稻植株雾滴沉积影响的比例系数分别为 :-0 .6615 (早稻为 -0 .7493 )、-0 .3 3 86(早稻为 -0 .2 5 11) ;对地面雾滴损失影响的比例系数为 -1.14 41。提出了喷雾沉积的不均匀系数。试验结果表明 ,上层水稻枝叶对雾滴截留不会改善中层及底层水稻植株喷雾沉积的均匀性。 | 宋淑然 王卫星 洪添胜 王平 罗锡文 Sinfort Carde Tisseyre Bruno Sévila Francis | 2003 | 农业工程学报2003，19，6： | 28 |
| 2 | Diagnosis and treatment of hepatocellular carcinoma: An update显示文摘Hepatocellular carcinoma(HCC) is one of the most common malignancies leading to high mortality rates in the general population; in cirrhotic patients, it is the primary cause of death. The diagnosis is usually delayed in spite of at-risk population screening recommendations, i.e., patients infected with hepatitis B or C virus. Hepatocarcinogenesis hinges on a great number of genetic and molecular abnormalities that lead to tumor angiogenesis and foster their dissemination potential. The diagnosis is mainly based on imaging studies such as computed tomography and magnetic resonance, in which lesions present a characteristic classical pattern of early arterial enhancement followed by contrast medium 'washout' in late venous phase. On occasion, when imaging studies are not conclusive, biopsy of the lesion must be performed to establish the diagnosis. The Barcelona Clinic Liver Cancer staging method is the most frequently used worldwide and recommended by the international guidelines of HCC management. Currently available treatments include tumor resection, liver transplant, sorafenib and locoregional therapies(alcoholization, radiofrequency ablation, chemoembolization). The prognosis of hepatocarcinoma is determined according to the lesion's stage and in cirrhotic patients, on residual liver function. Curative treatments, such as liver transplant, are sought in patients diagnosed in early stages; patients in more advanced stages, were not greatly benefitted by chemotherapy in terms of survival until the advent of target molecules such as sorafenib. | Javier Tejeda-Maldonado Ignacio García-Juárez Jonathan Aguirre-Valadez Adrián González-Aguirre Mario Vilatobá-Chapa Alejandra Armengol-Alonso Francisco Escobar-Penagos Aldo Torre Juan Francisco Sánchez-ávila Diego Luis Carrillo-Pérez | 2015 | World Journal of Hepatology2015，7，3： | 22 |
| 3 | 水稻田农药喷雾分布与雾滴沉积量的试验分析显示文摘借助于荧光分光光度计测定出雾滴在水稻某一区域的沉积量 ,由此获得雾滴沉积量在水稻植株不同层间分布的规律。结果表明 :在按距离地面 4 0 cm以上、2 0~ 4 0 cm之间、5~ 2 0 cm之间对水稻分层时 ,层间的雾滴沉积量与水稻的高度成正比。采用 Matlab,对试验点上拍摄到的照片进行分析 ,建立了雾滴沉积量与对应的水稻植株面积间的相互关系。 | 宋淑然 洪添胜 王卫星 张和兴 罗锡文 Sévila Franci | 2004 | 农业机械学报2004，35，6： | 17 |
| 4 | Insulin sensitizers in treatment of nonalcoholic fatty liver disease:Systematic review显示文摘AIM: To summarize the evidence available for the clinical effectiveness of insulin sensitizers in the treatment of nonalcoholic fatty liver disease (NAFLD) systematically. METHODS: Relevant articles were located using computer-assisted searches of Medline (1966-March 2006), EMBASE (1988-March 2006), CINAHL (1982-March 2003), Educational Resource Information Center (1966-March 2006), Library, Information Science & Technology Abstracts (1967-March 2006), Cochrane Database of Systematic Reviews, Database of Abstracts of Reviews of Effects (1994-2006), dissertations in ProQuest and FirstSearch databases. Manual searches were made in the abstracts from meetings of the American Gastroenterological Association (1999-2006), and the American Association for the Study of Liver Diseases (2003-2005). Studies were retrieved using the following selection criteria: (1) clinical trials using insulin sensitizers in subjects with NAFLD, (2) adult patients, (3) published as full manuscripts or abstracts, and (4) English, Spanish, German, and French languages only. Data were abstracted independently by two reviewers following standardized procedures. A face-to- face comparison of data was conducted to ensure the completeness and reliability of the abstraction process. RESULTS: Nine studies were included, six using metformin and three using thiazolidinediones. Only two studies were placebo-controlled trials. The mediansample size for all studies was 18 subjects. In the placebo-controlled trials, metformin improved insulin resistance markers and liver function tests, but not histological scores. In the single-arm trials, metformin and thiazolidinediones improved insulin resistance markers and liver function tests, and beneficial histological changes were reported. There is limited high-quality information available from which to draw categorical conclusions about the clinical use of insulin sensitizers in NAFLD.CONCLUSION: Current information indicates that the use of insulin sensitizers in NAFLD improves insulin resistance and liver function. Histological changes must be corroborated in randomized controlled trials. | Norberto C Chavez-Tapia Tonatiuh Barrientos-Gutierrez Felix I Tellez-ávila Francisco Sánchez-ávila Maria Antonieta Montao-Reyes Misael Uribe | 2006 | World Journal of Gastroenterology2006，12，48： | 11 |
| 5 | Exploratory study on microRNA profiles from plasma-derived extracellular vesicles in Alzheimer’s disease and dementia with Lewy bodies显示文摘Background:Because of the increasing life expectancy in our society,aging-related neurodegenerative disorders are one of the main issues in global health.Most of these diseases are characterized by the deposition of misfolded proteins and a progressive cognitive decline.Among these diseases,Alzheimer’s disease(AD)and dementia with Lewy bodies(DLB)are the most common types of degenerative dementia.Although both show specific features,an important neuropathological and clinical overlap between them hampers their correct diagnosis.In this work,we identified molecular biomarkers aiming to improve the misdiagnosis between both diseases.Methods:Plasma extracellular vesicles(EVs)-from DLB,AD and healthy controls-were isolated using size-exclusion chromatography(SEC)and characterized by flow cytometry,Nanoparticle Tracking Analysis(NTA)and cryo-electron microscopy.Next Generation Sequencing(NGS)and related bibliographic search was performed and a selected group of EV-associated microRNAs(miRNAs)was analysed by qPCR.Results:Results uncovered two miRNAs(hsa-miR-451a and hsa-miR-21-5p)significantly down-regulated in AD samples respect to DLB patients,and a set of four miRNAs(hsa-miR-23a-3p,hsa-miR-126-3p,hsa-let-7i-5p,and hsamiR-151a-3p)significantly decreased in AD respect to controls.The two miRNAs showing decreased expression in AD in comparison to DLB provided area under the curve(AUC)values of 0.9 in ROC curve analysis,thus suggesting their possible use as biomarkers to discriminate between both diseases.Target gene analysis of these miRNAs using prediction online tools showed accumulation of phosphorylation enzymes,presence of proteasome-related proteins and genes involved in cell death among others.Conclusion:Our data suggest that plasma-EV associated miRNAs may reflect a differential profile for a given dementia-related disorder which,once validated in larger cohorts of patients,could help to improve the differential diagnosis of DLB versus AD. | Ana Gámez-Valero Jaume Campdelacreu Dolores Vilas Lourdes Ispierto Ramón Reñé RamiroÁlvarez MPilar Armengol Francesc E.Borràs Katrin Beyer | 2019 | Translational Neurodegeneration2019，8，1： | 4 |
| 6 | New genes emerging for colorectal cancer predisposition显示文摘Colorectal cancer(CRC)is one of the most frequent neoplasms and an important cause of mortality in the developed world.This cancer is caused by both genetic and environmental factors although 35%of the variation in CRC susceptibility involves inherited genetic differences.Mendelian syndromes account for about5%of the total burden of CRC,with Lynch syndrome and familial adenomatous polyposis the most common forms.Excluding hereditary forms,there is an important fraction of CRC cases that present familial aggregation for the disease with an unknown germline genetic cause.CRC can be also considered as a complex disease taking into account the common diseasecommom variant hypothesis with a polygenic model of inheritance where the genetic components of common complex diseases correspond mostly to variants of low/moderate effect.So far,30 common,low-penetrance susceptibility variants have been identified for CRC.Recently,new sequencing technologies including exomeand whole-genome sequencing have permitted to add a new approach to facilitate the identification of new genes responsible for human disease predisposition.By using whole-genome sequencing,germline mutations in the POLE and POLD1 genes have been found to be responsible for a new form of CRC genetic predisposition called polymerase proofreading-associated polyposis. | Clara Esteban-Jurado Pilar Garre Maria Vila Juan José Lozano Anna Pristoupilova Sergi Beltrán Anna Abulí Jenifer Muoz Francesc Balaguer Teresa Ocaa Antoni Castells Josep M Piqué Angel Carracedo Clara Ruiz-Ponte Xavier Bessa Montserrat Andreu Luis Bujanda Trinidad Caldés Sergi Castellví-Bel | 2014 | World Journal of Gastroenterology2014，20，8： | 3 |
| 7 | Bacterial infections in cirrhosis: Epidemiological changes with invasive procedures and norfloxacin prophylaxis显示文摘 | Javier Fernández Miquel Navasa Juliá Gómez Jordi Colmenero Jordi Vila Vicente Arroyo Juan Rodés | 2002 | Hepatology2002，，1： | 3 |
| 8 | Germanene: a novel two-dimensional germanium allotrope akin to graphene and silicene显示文摘 | M E Dávila L Xian S Cahangirov A Rubio G Le Lay | 2014 | New Journal of Physics2014，，： | 3 |
| 9 | Initial experience with EUS-guided cholangiopancreatography for biliary and pancreatic duct drainage: a Spanish national survey显示文摘 | Juan J. Vila Manuel Pérez-Miranda Enrique Vazquez-Sequeiros Monder Abu-Suboh Abadia Antonio Pérez-Millán Ferrán González-Huix Joan Gornals Julio Iglesias-Garcia Carlos De la Serna José R. Aparicio José C. Subtil Alberto álvarez Felipe de la Morena Jesús G | 2012 | Gastrointestinal Endoscopy2012，，6： | 2 |
| 10 | Proinflammatory Cytokines and Early Neurological Worsening in Ischemic Stroke显示文摘 | Nicolás Vila José Castillo Antonio Dávalos ángel Chamorro | 2000 | Stroke: Journal of the American Heart Association2000，，10： | 2 |
| 11 | Hydrodynamics and mass transfer characteristics of gas-liquid ejectors显示文摘 | Balamurugan S Mayank D Lad Vilas G Gaikar | 2007 | Chemical Engineering Journal2007，137，： | 1 |
| 12 | Design of biodegradable particles for protein delivery显示文摘 | Vila A Sánchez A Tobio M | 2002 | J Control Release2002，78，： | 1 |
| 13 | Increased lysophosphatidylcholine and non-esterified fatty acid content in LDL induces chemokine release in endothelial cell:Relationship with electronegative LDL显示文摘 | Benitez S Camacho M Arcelus R Vila L Bancell C Ordonez-Llanos J | 2004 | Atherosclerosis2004，177，2： | 1 |
| 14 | Shallow gas features in incised valley fills ( Ria de Vigo, NW Spain ) : A case study 显示文摘 | Garcia Gil S Vilas F Garcia Garcia A | 2002 | Continental Shelf Research2002，22，： | 1 |
| 15 | Analysis of mortality and risk factors associated with native valve endocarditis in drug users: The importance of vegetation size显示文摘 | Pilar Martín-Dávila Enrique Navas Jesús Fortún Jose Luis Moya Javier Cobo Vicente Pintado Carmen Quereda Manuel Jiménez-Mena Santiago Moreno | 2005 | American Heart Journal2005，，5： | 1 |
| 16 | Relationship of lipid oxidation with subclinical atherosclerosis and 10-year coronary events in general population显示文摘 | Miquel Gómez Joan Vila Roberto Elosua Lluís Molina Jordi Bruguera Joan Sala Rafel Masià Maria Isabel Covas Jaume Marrugat Montserrat Fitó | 2014 | Atherosclerosis2014，，1： | 1 |
| 17 | Porins, efflux pumps and multidrug resistance in Acinetobacter baumannii显示文摘 | Vila J Marti S Samchez-Cespedes J | 2007 | J Antimicrob Chemother2007，59，6： | 1 |
| 18 | Porins, efflux pumps and multidrug resistance in Acinetobacter baumannii 显示文摘 | VILA J MARTI S SANCHEZ-CESPEDES J | 2007 | J Antimicrob Chemother2007，59，6： | 1 |
| 19 | Community structure and PAH ring-hydroxylating dioxygenase genes of a marine pyrene-degrading microbial consortium显示文摘 | GALLEGO S VILA J TAULER M | 2014 | Biodegradation2014，25，4： | 1 |
| 20 | Effect of biofilm formation on the survival of Acinetobacter baumannii on dry surfaces显示文摘 | Espinal P Mart S Vila J | 2012 | J Hosp Infecti2012，，80： | 1 |
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