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| 1 | TAT-Gap19通过抑制啮齿动物星形胶质细胞的连接蛋白43半通道发挥抗惊厥作用显示文摘越来越多的证据表明,星形胶质细胞连接蛋白43(Cx43)信号在癫痫中发挥至关重要的作用。但是,由于通过实验方法鉴别Cx43间隙连接通道(GJCs)和半通道(HCs)的技术尚不成熟,导致目前尚无法确定哪个通道在癫痫的发生中发挥更重要的作用。因此,本研究观察TAT-Gap19(Cx模拟肽)是否通过抑制Cx43半通道而非Cx43间隙连接通道影响实验诱导的啮齿动物癫痫发作。急性海马切片小鼠染料摄取实验表明,星形胶质Cx43半通道响应化学惊厥毛果芸香碱的作用而开放,并且可被TAT-Gap19抑制。体内实验中,毛果芸香碱诱导的癫痫发作及相伴随的D-丝氨酸微透析液的增长水平被Cx43半通道的抑制所抑制。此外,TAT-Gap19的抗惊厥作用被外源性D-丝氨酸给药逆转,这表明,抑制Cx43半通道可以通过降低细胞外D-丝氨酸水平来防止癫痫发作。抑制Cx43半通道的抗惊厥特性在电癫痫小鼠模型(如急性6 Hz难治性癫痫发作模型和慢性6 Hz角膜点燃模型)中得到了进一步的证实。总而言之,这些结果表明,Cx43半通道在癫痫发作中可以起到一定作用,并且有成为癫痫治疗中新型用药靶点的潜力。 | Walrave L Pierre A Albertini G Aourz N De Bundel D Van Eeckhaut A Vinken M Giaume C Leybaert L Smolders I 聂昊 | 2018 | 神经损伤与功能重建2018，13，6： | 5 |
| 2 | Connexin32 hemichannels contribute to the apoptotic-to-necrotic transition during Fas-mediated hepatocyte cell death显示文摘 | Mathieu Vinken Elke Decrock Elke Vuyst Marijke Bock Roosmarijn E. Vandenbroucke Bruno G. Geest Joseph Demeester Niek N. Sanders Tamara Vanhaecke Luc Leybaert Vera Rogiers | 2010 | Cellular and Molecular Life Sciences2010，，6： | 2 |
| 3 | Plasma procalcitonin and C-reactive protein in a cute septic shock:clinical and biological correlate显示文摘 | Clae ys R Vinken S Spapen H | 2002 | Crit Care Med2002，30，4： | 1 |
| 4 | Epigenetic regulation of gap junctional intercellular communication: More than a way to keep cells quiet? 显示文摘 | Vinken M De Rop E Decrock E | 2009 | Biochim Biophys Acta2009，1795，1： | 1 |
| 5 | Rapid response:a toronto-area health facility manager recounts his experiences with the SARS scare显示文摘 | Vinken J | 2003 | Health Facil Manage2003，16，9： | 1 |
| 6 | Inhibition of gap junctional intercellular communication by toxic metals显示文摘 | Vinken M Ceelen L Vanhaecke T | 2010 | Chem Res Toxicol2010，23，12： | 1 |
| 7 | Connexin-related signaling in cell death: to live or let die? 显示文摘 | Decrock E Vinken M De Vuyst E | 2009 | Cell Death Differ2009，16，4： | 1 |
| 8 | Connexin-related signaling in cell death:to live or let die显示文摘 | Deeroek E Vinken M De Vuyst E | 2009 | Cell Death Differ2009，16，4： | 1 |
| 9 | Plasma procalciton and Creactive protein in acute septic Shock:clinical and biological correlates显示文摘 | Claey R Vinken S Spaptn H | 2002 | Crit care Med2002，30，4： | 1 |
| 10 | Abiotic association of soil-borne monomeric phenols with humic acids显示文摘 | VINKEN R SCHAFFER A JI Rong | 2005 | Organic Geochemistry2005，36，4： | 1 |
| 11 | Synthesis of Branched para-Nonylphenol Isomers:Occurrence and Quantification in Two Commercial Mixtures显示文摘 | RUSS A S VINKEN R SCHUPHAN I | 2005 | Chemosphere2005，60，11： | 1 |
| 12 | Drug-induced liver injury: mechanisms, types and biomarkers显示文摘 | VINKEN M MAES M VANHAECKE T eta! | 2013 | Curr Med Chem2013，20，24： | 1 |
| 13 | Plasma procalcitonin andC-reactive protein in acute septic shock: clinical and biologi-cal correlates 显示文摘 | Claeys R Vinken S Spapen H | 2002 | Crit Care Med2002，30，4： | 1 |
| 14 | Epigenetic regulation of gap junctional intercellular com- munication:more than a way to keep cells quiet显示文摘 | VINKEN | 2009 | Biochim Bio- phys Acta2009，1795，1： | 1 |
| 15 | Epigenetic regulation of gap junctional intercellular communication: more than a way to keep cells quiet? 显示文摘 | Vinken M De-Rop E Decrock E | 2009 | Biochim Biophys Acta2009，1795，1： | 1 |
| 16 | Long-term management of extensive tracheal stenosis due to formic acid chemical burn显示文摘 | Stratakos G Noppen M Vinken W | | 0，，03： | 1 |
| 17 | Gap junctional intercellular communication as a target for liver toxicity and carcinogenicity显示文摘 | Mathieu Vinken Tatyana Doktorova Elke Decrock Luc Leybaert Tamara Vanhaecke Vera Rogiers | 2009 | Critical Reviews in Biochemistry and Molecular Biology2009，，4： | 1 |
| 18 | Connexins : sensors and regulators of cell cycling显示文摘 | Vinken M Decrock E De Vuyst E | 2011 | Biochim Biophys Acta2011，1815，1： | 1 |
| 19 | Degradation of the radioactive and non-labeled branched 4 ( 3', 5'-dimethyl -3'-heptyl ) -phenol nonylphenol isomer by Sphingomonas TTNP3 显示文摘 | Corvini P F X Vinken R | 2004 | Biodegradation2004，15，1： | 1 |
| 20 | The role of intercellular communication via “gap junctions” in disease显示文摘 | Vinken M Vanhaecke T Rogiers V | 2003 | Ned Tijdschr Geneeskd2003，147，50： | 1 |
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