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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Accuracy of nurse- performed compression ultrasonography in the diagnosis of proximal symptomatic deep vein thrombosis: a prospective cohort study显示文摘 | Mumoli N Vitale J Cocciolo M | 2014 | J Thromb Haemost2014，12，4： | 1 |
| 3 | Clinical evaluation of a lumbar interspinous dynamic stabilization device(the Wallis system)with a 13-year mean follow-up显示文摘 | Sénégas J Vital JM Pointillart V | 2009 | Neurosurg Rev2009，32，3： | 1 |
| 4 | Consumer Trust in an Internet Store显示文摘 | JARVENPAA S TRACTINSKY N VITALE M | 2000 | Information Technology and Management2000，1，12： | 1 |
| 5 | Dose-dependent fetal complications of warfarin in pregnant women with mechanical heart valves显示文摘 | VITALE N DE FEO M DE SANTO L S | 1999 | J Am Coll Cardiol1999，33，6： | 1 |
| 6 | Novel synthesis of 3, 4-diarylisoxazole analogues of valdecoxib: reversal cyclooxygenase-2 selectivity by sulfonamide group removal显示文摘 | Di N L Vitale P Scilimati A | 2004 | JMed Chem2004，47，20： | 1 |
| 7 | Surgery improves pain, function and quality of life in patients with spinal metastases: a prospective study on 11 8 patients显示文摘 | Quan GMY Vital JM Aurouer N | 2011 | Eur Spine J2011，20，11： | 1 |
| 8 | Purification and characterization of GIT familyof ADP-ribosylation factor ( ARF) GTPase-activating proteins 显示文摘 | Premont R T Vitale N | 2001 | Methods Enzymol2001，329，： | 1 |
| 9 | Dose-dependem fetal complications of war farin in pregnant women with me chanical heart valves 显示文摘 | Vitale N DeFeoM De Santo L S | 1999 | J Am Coll Cardiol1999，33，6： | 1 |
| 10 | GIT proteins, A novel familyof phosphatidylinositol 3,4, 5- trisphosphate-stimulated GTPase-activating proteins for ARF6 显示文摘 | Vitale N Patton W A Moss J | 2000 | J Biol Chem2000，275，18： | 1 |
| 11 | Scrib controls Cdc42 lo- calization and activity to promote cell polarization during as- trocyte migration 显示文摘 | Osmani N Vitale N Borg JP | 2006 | Curr Biol2006，16，24： | 1 |
| 12 | Obstruction of mechanical mitral prostheses: analysis of pathologic findings显示文摘 | Vitale N Renzulli A Agozzino L | 1997 | Ann Thorac Surg1997，63，4： | 1 |
| 13 | Is unilateral antegrade ear- ebral perfusion equivalent to bilateral cerebral perfusion for pa- tients undergoing aortic arch surgery 显示文摘 | Malvindi PC Scrascia G Vitale N | 2008 | Interact Cardiovasc Thorac Surg2008，7，5： | 1 |
| 14 | Long-term actuarial survivorship analysis of an interspinous stabilization system显示文摘 | Sénégas J Vital JM Pointillart V | 2007 | Eur Spine J2007，16，8： | 1 |
| 15 | Annexin2 promotes the formation of lipid mi- crodomains required for calciumregulated exocytosis of dense -core vesicles显示文摘 | Chasserot - Golaz S Vitale N Umbrecht - Jenck E | 2005 | Mol Biol Cell2005，16，3： | 1 |
| 16 | Long-term actuarial survivorship analysis of an interspinous stabilization system显示文摘 | Jacques Sénégas Jean-Marc Vital Vincent Pointillart Paolo Mangione | 2007 | European Spine Journal2007，，8： | 1 |
| 17 | Dose-dependent fetal complications of warfarin in pregnant women with mechanical heart valves 显示文摘 | Vitale N De Feo M De Santo LS | 1999 | J Am Coll Cardiol1999，33，6： | 1 |
| 18 | STEP(satellite test of the equivalence principle)显示文摘 | Sumner T J Anderson J Blaser J P Cruise A M Damour T Dittus D Everitt C W F Fou-lon B Jafry Y Kent B J Lockerbie N Loeffler F Mann G Mester J Pegrum C ReinhardtR Sandford M Scheicher A Speake C C Torii R Theil S Touboul P Vitale S Vodel W Worden P W | 2007 | Advance in Space Re-search2007，39，2： | 1 |
| 19 | Early results with carbo-seal composite valve conduit for aortic root replacement显示文摘 | Vitale N Owens W A Hamilton J R | 1999 | J Heart Valve Dis1999，8，1： | 1 |
| 20 | Verification and rapididentification of soybean rhizobia in Indian soils 显示文摘 | ANNAPUMA K BALAKRISHNAN N VITAL L | 2007 | Curr Mierobiol2007，54，： | 1 |
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