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| 1 | Isomeric Mannich bases derived from ethyl 5-hydroxy-2- methylindole-3-carboxylate 显示文摘 | Bell MR Oesterlin R Beyler AL | 1967 | JMed Chem1967，10，： | 2 |
| 2 | Potent inhibitors of proteasome 显示文摘 | Iqbal M Chatterjee S Kauer JC | 1995 | JMed Chem1995，38，13： | 1 |
| 3 | Discovery of 1- (4-methoxyphenyl) -7-oxo-6- (4- (2-oxopiperidin- 1 - yl) phenyl) -4,5,6,7-tetrahydro-1H-pyrazolo t3,4-c] pyridine- 3-carboxamide (Apixaban, BMS-562247), a highly potent, selective, efficacious, and orally bioavailable inhibitor of blood coagulation factor Xa 显示文摘 | Donald J Michael JO Stephanie K | 2007 | JMed Chem2007，50，22： | 1 |
| 4 | Highly potent and orally active CCR5 antagonists as anti-HIV-1 agents: synthesis and biological activities of 1-benzazocine derivatives containing a sulfoxide moiety 显示文摘 | Seto M Aikawa K Miyamoto N | 2006 | JMed Chem2006，49，6： | 1 |
| 5 | Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-Tetrahydro-4-n-propyl-2H,5H- benzopyrano-1,4-oxazin-9-ol (PD 128907)显示文摘 | VAN VLIET LA RODENHUIS N DIJKSTRA D | 2000 | JMed Chem2000，43，15： | 1 |
| 6 | A new simple and high-yield synthesis of subemylanifide hydroxamic acid and its inhibitory effect alone or in eombination with retinoids on proliferation of human prostate cancer cells显示文摘 | Gediya L K Chopra P Purushottamachar P | 2005 | JMed Chem2005，48，15： | 1 |
| 7 | Synthesis and sttuctureactivity relationships of substituted 1,4-dihydroquinoxaline2,3-diones: antagonists of N-methyl-D-aspartate (NMDA)receptor glycine sites and non-NMDA glutamate receptors 显示文摘 | Keana JFW Kher SM Cai SX | 1995 | JMed Chem1995，38，： | 1 |
| 8 | Atropisomeric 4-phenyl-4H-1,2,4-triazoles as selective glycine transporter 1 inhibitors 显示文摘 | Sugane T Tobe T Hamaguchi W | 2013 | JMed Chem2013，56，14： | 1 |
| 9 | Discovery of tofogliflozin, a novel C-arylglucoside with an O-spiroketal ring system, as a highly selective sodium glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes 显示文摘 | Ohtake Y Sato T Kobayashi T | 2012 | JMed Chem2012，55，17： | 1 |
| 10 | 5-(diethoxyphosphoryl)-5-methyl-1-pyrroline-N-oxide:A new efficient phosphorylated Nitrone for the in vitro and in vivio Spin Trapping of Oxygen-Centered Radicals显示文摘 | FREJAVILLE C KAROUI H TUCCIO B | 1995 | Jmed Chem1995，38，： | 1 |
| 11 | Synthesis, biological activity, and molecular modeling studies of 1H- 1,2,3-triazole derivatives of carbohydrates a-glucosidases inhibitors 显示文摘 | Ferreira S B Sodero A C Cardoso M F | 2010 | JMed Chem2010，53，6： | 1 |
| 12 | Novel synthesis of 3, 4-diarylisoxazole analogues of valdecoxib: reversal cyclooxygenase-2 selectivity by sulfonamide group removal显示文摘 | Di N L Vitale P Scilimati A | 2004 | JMed Chem2004，47，20： | 1 |
| 13 | Asymmetric synthesis and properties of the enantiomers of the antibacterial agent 7- (3-aminopyrrolidin- 1-yl) - 1- (2,4-difluorophenyl) - 1,4-dihydro-6-fluoro-4-oxo- 1,8-naphthyridine-3-carboxylic acid hydrochloride显示文摘 | Rosen T Chu DTW Lico IM | 1988 | JMed Chem1988，31，8： | 1 |
| 14 | Design, synthesis, and biological evaluation of deuterated C-aryl glycoside as a potent and long-acting renal sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes 显示文摘 | Xu G Lv B Roberge JY | 2014 | JMed Chem2014，57，4： | 1 |
| 15 | Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases 显示文摘 | Sun L Tran N Tang F | 1998 | JMed Chem1998，41，14： | 1 |
| 16 | Discovery of 5- -2,4-dimethyl- 1 H-pyrrole-3-carboxylic acid (2-diethy-laminoethyl) amide, a novel tyrosine kinase inhibitor targeting vascular endothelial and platelet-derived growth factor receptor tyrosine kinase显示文摘 | SUN L LIANG C SHIRAZIAN S | 2003 | JMed Chem2003，46，7： | 1 |
| 17 | DiScovery of N- (2-aminophenyl) -4- E (4-pyridin-3-ylpyrimidin-2- ylamino) methyl:benzamide (MGCD0103), an orally active histone deacetylase inhibitor 显示文摘 | Zhou N Moradei O Raeppel S | 2008 | JMed Chem2008，51，14： | 1 |
| 18 | Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of Jumonji domain-containing protein 2 histone demethylase inhibitors 显示文摘 | Hamada S Suzuki T Mino K etal | 2010 | JMed Chem2010，53，15： | 1 |
| 19 | Hydroxycoumarin derivatives: novel and potent ct-glucosidase inhibitors 显示文摘 | Shen Q Shao J Peng Q | 2010 | JMed Chem2010，53，23： | 1 |
| 20 | Irreversible inhibition of epidermal growth faetor receptor aetivity by 3-aminopropanamides 显示文摘 | Carmi 12 Galvani E Vaeondio F | 2012 | JMed Chem2012，55，5： | 1 |
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