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| 1 | Gut barrier failure biomarkers are associated with poor disease outcome in patients with primary sclerosing cholangitis显示文摘AIM To assess the prevalence of a panel of serologic markers that reflect gut barrier dysfunction in a mixed cohort of pediatric and adult primary sclerosing cholangitis(PSC) patients.METHODS Sera of 67 PSC patients [median age(range): 32(5-79) years, concomitant IBD: 67% and cirrhosis: 20%] were assayed for the presence of antibodies against to F-actin(AAA Ig A/Ig G) and gliadin(AGA Ig A/Ig G)] and for serum level of intestinal fatty acid-binding protein(I-FABP) by ELISA. Markers of lipopolysaccharide(LPS) exposure [LPS binding protein(LBP)] and various antimicrobial antibodies [anti-OMP Plus Ig A and endotoxin core Ig A antibody(Endo CAb)] were also determined. Poor disease outcome was defined as orthotopic liver transplantation and/or liver-related death during the follow-up [median: 99(14-106) mo]. One hundred and fifty-three healthy subjects(HCONT) and 172 ulcerative colitis(UC) patients were the controls. RESULTS A total of 28.4%, 28.0%, 9% and 20.9% of PSC patients were positive for AAA Ig A, AAA Ig G, AGA Ig A and AGA Ig G, respectively. Frequencies of AAA Ig A and AAA Ig G(P < 0.001, for both) and AGA Ig G(P = 0.01, for both) but not AGA Ig A were significantly higher compared to both of the HCONT and the UC groups. In survival analysis, AAA Ig A-positivity was revealed as an independent predictor of poor disease outcome after adjusting either for the presence of cirrhosis [HR = 5.15(1.27-20.86), P = 0.022 or for the Mayo risk score(HR = 4.24(0.99-18.21), P = 0.052]. AAA Ig A-positivity was significantly associated with higher frequency of antimicrobial antibodies(P < 0.001 for Endo Cab Ig A and P = 0.012 for anti-OMP Plus Ig A) and higher level of the enterocyte damage marker(median I-FABP_(AAA Ig A pos vs neg): 365 vs 166 pg/m L, P = 0.011), but not with serum LBP level. CONCLUSION Presence of Ig A type AAA identified PSC patients with progressive disease. Moreover, it is associated with enhanced mucosal immune response to various microbial antigens and enterocyte damage further highlighting the importance of the gut-liver interaction in PSC. | Tamas Tornai Eszter Palyu Zsuzsanna Vitalis Istvan Tornai David Tornai Peter Antal-Szalmas Gary L Norman Zakera Shums Gabor Veres Antal Dezsofi Gabriella Par Alajos Par Peter Orosz Ferenc Szalay Peter Laszlo Lakatos Maria Papp | 2017 | World Journal of Gastroenterology2017，23，29： | 5 |
| 2 | Interactive surface -guided segmentation of brain MRI data显示文摘 | KONSTANTIN L ALEXEI S VITALI Z | 2009 | Computers in Biology and Medicine2009，39，： | 1 |
| 3 | Expanding the potentialfor waste polyvinyl alcohol 显示文摘 | ANDREW J H VITALY L B SIMON W B | 2009 | Green Chemistry2009，11，： | 1 |
| 4 | Effect of a synbiotic food consumption on human gut metabolic profiles evaluated by 1H Nuclear Magnetic Resonance spectroscopy 显示文摘 | NDAGIJIMANA M LAGHI L VITALI B | 2009 | Int J Food Microbiol2009，134，12： | 1 |
| 5 | Review of methods to determine chain?breaking antioxidant activity in food显示文摘 | VITALY R EDUARDO A L | 2005 | Food Chemistry2005，92，2： | 1 |
| 6 | Video over IP using standard-compatible multiple description coding: an IETF proposal显示文摘Standard-compatible multiple description coding (MDC) and layered coding (LC) are efficient ways to ensure erasure resilient, scalable transmission of encoded multimedia sources via RTP, allowing a gradual degradation of the application quality with increasing packet loss rate and decreasing bandwidth/throughput on the network. In this paper we review the stan- dard-compatible framework proposed to IETF. Alternative techniques such as robust source coding and channel coding techniques (ARQ: automatic repeat request, FEC: forward error correction) are presented; their integration into the proposed framework is also discussed. The performances of MDC and LC either coupled with channel coding or not, are summarized by reference to current literature. Typical cases and examples are illustrated. | VITALI Andrea L BORNEO Antonio FUMAGALLI Marco RINALDO Roberto | 2006 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2006，7，5： | 1 |
| 7 | Molecular networks in melanorr invasi and metastasis 显示文摘 | Aladowicz E Ferro L Vitali GC | 2013 | Future Oncol2013，9，5： | 1 |
| 8 | Expansion and evolution of a virulent,extensively drug-resistant(polymyxin Bresistant),QnrS1-,CTX-M-2-,and KPC-2-producing Klebsiella pneumoniae ST11international high-risk clone显示文摘 | Andrade LN Vitali L Gaspar GG | 2014 | J Clin Microbiol2014，52，7： | 1 |
| 9 | Effects of pseudo zereals, legumes and inulin addition on selected nutritional properties and glycemic index of whole grain wheat based bis- zuits 显示文摘 | Vuji C L Vitali Cepo D Sebe Ci C B | 2014 | Journal of Food ~ Nutrition Research2014，53，2： | 1 |
| 10 | Spatial modulation of the Dirac gap in epitaxial graphene显示文摘 | Vitali L Riedl C Ohmann R | | 0，，22： | 1 |
| 11 | Sepsis induces albuminuria and alterations in the glomerular filtration barrier: a morphofunctional study in the rat显示文摘 | Adembri C Sgambati E Vitali L | 2011 | Crit Care2011，15，6： | 1 |
| 12 | Bending capacity of pipes subject to point loads 显示文摘 | VITALI L TORSELLETTI E | 2003 | International Conference on Offshore Mechanics and Arctic Engineering2003，，： | 1 |
| 13 | A new apporach to obtain polyploid forms of apple显示文摘 | Igor V Bartish Vitaly I Korkhovoy Yelena L Fomina | 1998 | Acta Hort (ISHS)1998，484，： | 1 |
| 14 | Seasonal pattern of mortality and relationships between mortality and temperature-humidity index in dairy cows显示文摘 | Vitali A Segnalini M Bertocchi L | 2009 | J Dairy Sci2009，92，： | 1 |
| 15 | Acute histologic effects of temperature-based radiofrequency ablation on renal tumor pathologic interpretation显示文摘 | Vitaly M Edward M Guy L | 2004 | Urology2004，64，4： | 1 |
| 16 | Stereochemistry of lead ( II ) complexes with oxygen donor lig- ands显示文摘 | Ruven L Davidovicha Vitalie Stavilab Dmitry V Marinin | 2009 | CoordChem Rev2009，253，910： | 1 |
| 17 | Localization of a wheeled mobile robot by sensor data fusion based on a fuzzy logic adapted Kalman filter显示文摘 | Jetto L Longhi S Vitali D | 1999 | Control Engineering Practice1999，7，： | 1 |
| 18 | Glucose oxidase catalyses the reduction of O2 to H2O2 in the presence of irradiated TiO2 and isopropyl alcohol显示文摘 | Ganadu ML Andreotti L Vitali I | 2002 | Photochemical & Photobiological Sciences2002，1，12： | 1 |
| 19 | Effect of Metal-Containing Additives on NOx Reduction in Combustion and Reburning显示文摘 | Vitali V L Vladimir M Z Peter M M | 2001 | Combustion and flame2001，125，： | 1 |
| 20 | Development of a fast and selective separation method to determine histamine in tuna fish samples using capillary zone electrophoresis显示文摘 | VITALI L VALESE A C AZEVEDO M S | 2013 | Talanta2013，106，： | 1 |
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