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| 1 | 皮质下小血管病诊断的共识声明显示文摘血管性认知损害是用于描述一组涉及大血管和小血管的散发性和遗传性异质性疾病的诊断术语。皮质下小血管病可导致腔隙性梗死和进行性白质损害。被称为宾斯旺格病(Binswanger's disease, BD)的进行性白质损害患者构成了从单纯血管性疾病到合并神经变性病变的疾病谱。BD患者是一个相对同质性的亚组,存在缺氧缺血、腔隙性梗死和炎症,它们协同作用破坏血脑屏障和髓鞘。通过临床、脑脊液、神经心理学和影像学检查获得的多模式疾病标记物能促进该亚组患者的鉴别。本共识声明确定了一系列基于基础病理学改变的潜在生物学标记物,这将有助于诊断以及将来协作性治疗试验的患者选择。 | Gary A Rosenberg Anders Wallin Joanna M Wardlaw Hugh S Markus Joan Montaner Leslie Wolfson Costantino Iadecola Berislav V Zlokovic Anne Joutel Martin Dichgans Marco Duering Reinhold Schmidt Amos D Korczyn Lea T Grinberg Helena C Chui Vladimir Hachinski 王训师 张劼 陈涵丰 俞娅美 徐子奇 罗本燕 | 2016 | 国际脑血管病杂志2016，24，6： | 18 |
| 2 | Drain amylase value as an early predictor of pancreatic fistula after cephalic duodenopancreatectomy显示文摘AIM:To determine predictors of clinically relevant pancreatic fistulas(CRPF)by measuring drain fluid amylase(DFA)in the early postoperative period.METHODS:This prospective clinical study included382 patients with periampullary tumors that were surgically resected at our department between March 2005and October 2012.A cephalic duodenopancreatectomy (DP)was performed on all patients.Two closed suction drains were placed at the end of the surgery.The highest postoperative DFA value was recorded and analyzed during the first three postoperative days and on subsequent days if the drains were kept longer.Pancreatic fistula(PF)was classified according to the International Study Group of Pancreatic Fistula(ISGPF)criteria.Postoperative complications were defined according to the Dindo-Clavien classification.All data were statistically analyzed.The optimal thresholds of DFA levels on the first,second and third postoperative days were estimated by constructing receiver operating curves,generated by calculating the sensitivities and specificities of the DFA levels.The DFA level limits were used to differentiate between the group without PF and the groups with biochemical pancreatic fistula(BPF)and CRPF.RESULTS:Pylorus-preserving duodenopancreatectomy was performed on 289(75.6%)patients,while the remaining patients underwent a classic Whipple procedure(CW).The total incidence of PF was 37.7%(grade A22.8%,grade B 11.0%and grade C 3.9%).Soft pancreatic texture(SPT)was present in 58.3%of patients who developed PF.Mortality was 4.2%.The median DFA value on the first postoperative day(DFA1)in patients who developed PF was 4520 U/L(range 350-99000 U/L)for grade A fistula(BPF)with a SPT and a diameter of the main pancreatic duct(MPD)of≤3 mm.For grade B/C(CRPF),the median DFA1 value was 8501 U/L(range377-92060 U/L)with a SPT and MPD of≤3 mm.These values were significantly higher when compared to the patients who did not have PF(122;range 5-37875 U/L).The upper limit of DFA values for the first 3 postoperative days in the examined stages of PF were:DFA1 1200U/L for the BPF and CRPF;DFA3 350 U/L for BPF and DFA3 800 U/L for CRPF.The determined values were highly significant and demonstrated a reliable diagnostic test for both BPF and CRPF.CONCLUSION:DFA1≥1200 U/L is an important predictive factor for PF of any degree.The trend of DFA3(decrease of<50%)compared to DFA1 is a significant factor in the differentiation of CRPF from transient BPF. | Vladimir D Dugalic Djordje M Knezevic Vladan N Obradovic Miroslava G Gojnic-Dugalic Slavko V Matic Aleksandra R Pavlovic-Markovic Predrag D Dugalic Srbislav M Knezevic | 2014 | World Journal of Gastroenterology2014，20，26： | 7 |
| 3 | 东方山羊豆脱水蛋白基因的克隆及初步分析显示文摘采用SMART RACE方法,从东方山羊豆盐诱导抑制性差减杂交cDNA文库中分离到了一个脱水蛋白(GoDHN)基因。该基因cDNA全长1 169bp,开放阅读框843bp,编码281个氨基酸,编码的蛋白质分子量为28.71kDa。经实时荧光定量PCR分析,GoDHN基因在东方山羊豆的茎和叶中表达量明显高于根中表达量,并且基因表达受ABA、NaCl和PEG的诱导,随着诱导时间的增加,表达量呈持续增长趋势。这些结果表明,DHN基因在东方山羊豆的抗逆性中可能起到重要的调控作用。本研究成功构建了pCAMBIA1302-DHN植物表达载体,为下一步转基因研究奠定了基础。 | 李玉坤 王学敏 王赞 李俊 Vladimir C Nikolay D 孙桂枝 高洪文 | 2012 | 草业学报2012，21，1： | 6 |
| 4 | Color Doppler sonography and angioscintigraphy in hepatic Hodgkin's lymphoma显示文摘AIM:To estimate the characteristics of Color Doppler findings and the results of hepatic radionuclide angiography (HRA) in secondary Hodgkin's hepatic lymphoma.METHODS:The research included patients with a diagnosis of Hodgkin's lymphoma with metastatic focal lesions in the liver and controls.Morphologic characteristics of focal liver lesions and hemodynamic parameters were examined by pulsed and Color Doppler in the portal,hepatic and splenic veins were examined.Hepatic perfusion index (HPI) estimated by HRA was calculated.RESULTS:In the majority of patients,hepatomegaly was observed.Lesions were mostly hypoechoic and mixed,solitary or multiple.Some of the patients presented with dilated splenic veins and hepatofugal blood flow.A pulse wave was registered in the centre and at the margins of lymphoma.The average velocity of the pulse wave was higher at the margins (P>0.05).A continuous venous wave was found only at the margins of lymphoma.There was no linear correlation between lymphoma size and velocity of pulse and continuous wave (r=390,P<0.01).HPI was significantly lower in patients with lymphomas than in controls (P<0.05),pointing out increased arterial perfusion in comparison to portal perfusion.CONCLUSION:Color Doppler ultrasonography is a sensitive method for the detection of neovascularization in Hodgkin's hepatic lymphoma and estimation of its intensity.Hepatic radionuclide angiography can additionally help in the assesment of vascularisation of liver lesions. | Mirjana V Stojkovi Vera M Artiko Irena B Radoman Slavko J Knezevi Snezana M Luki Mirko D Kerkez Nebojsa S Leki Andrija A Anti Marinko M Zuvela Vitomir I Rankovi Milorad N Petrovi Dragana P obi Vladimir B Obradovi | 2009 | World Journal of Gastroenterology2009，15，26： | 2 |
| 5 | An efficient transformation of the generalized traveling salesman problem into the traveling salesman problem on digraphs 显示文摘 | Vladimir D Zoran S | 1997 | Informatics and Computer Science1997，102，： | 1 |
| 6 | Presynaptic CLC-3 deter-mines quantal size of inhibitory transmission in the hippocampus显示文摘 | Vladimir R Ludmila D Pavel S | 2011 | Nat Neurosci2011，4，： | 1 |
| 7 | The genome of woodland strawberry ( Fragaria vesca) 显示文摘 | Vladimir S Sargent D J Crowhurst R N | 2011 | Nature Genetics2011，43，： | 1 |
| 8 | Decomposition of volatile organ- iccom pounds in Plasma - Catalytic system 显示文摘 | VLADIMIR D JAE O C | 2005 | IEEE Trans Plasma Sci2005，33，1： | 1 |
| 9 | Preparation and biological activity of 6-benzylaminopurine derivatives in plants and human cancer cells显示文摘 | KAREL D IGOR P VLADIMIR K | 2006 | Bioorg Med Chem2006，14，3： | 1 |
| 10 | Dynam- ics of steam accumulation 显示文摘 | VLADIMIR D S BLAZENKA M SANJA P | 2012 | Applied Thermal Engi- neering2012，37，： | 1 |
| 11 | Heavy metals in lake sediments of the Kola Peninsula, Russia显示文摘 | Vladimir D | 1994 | The Science of the Total Environment1994，158，： | 1 |
| 12 | Low-grade fibromyxoid sarcoma of the liver: A case report显示文摘BACKGROUND Low grade fibromyxoid sarcoma(LGFMS)is a rare and benign mesenchymal tumor with indolent course,most commonly found in young or middle-aged men.The majority of the LGFMSs are located in the trunk and deep soft tissue of the lower extremities.They appear as well circumscribed,although not encapsulated,which often leads to incomplete surgical resection.Despite their seemingly benign appearance,these tumors have aggressive behavior with high metastatic and recurrence rates.Accurate histopathologic examination of the specimen and its immunohistochemical analysis are mandatory for a precise diagnosis.CASE SUMMARY We report a case of a 38 year-old-man who presented with jaundice and upper abdominal discomfort.Multi-detector computed tomography and magnetic resonance imaging showed a large left liver tumor mass,extending to the hepatoduodenal ligament.Left hepatectomy was performed with resection and reconstruction of hepatic artery and preservation of middle hepatic vein.Histopathologic examination confirmed the tumor being a low-grade fibromyxoid sarcoma.Three and a half years after surgery,the patient died after being diagnosed with spine metastasis.CONCLUSION Due to poor response to all modalities of adjuvant treatment,we consider that the focus of treatment should be on surgery as the only option for curing the disease. | Vladimir Dugalic Igor I Ignjatovic Jelena Djokic Kovac Nikola Ilic Jelena Sopta Slavenko R Ostojic Dragan Vasin Marko D Bogdanovic Igor Dumic Tamara Milovanovic | 2021 | World Journal of Clinical Cases2021，9，1： | 1 |
| 13 | On the mechanisms of internalization and intracellular delivery mediated by pH-sensitive liposomes显示文摘 | Sergio S Vladimir S Nejat D | 2001 | Biochim Biophys Acta2001，1515，1： | 1 |
| 14 | Auto modulation classifi-cation algorithm using higher-order cumulants under real-world channel conditions显示文摘 | VLADIMIR D O MIROSLAV L D | 2009 | IEEE Communications Let-ters2009，12，13： | 1 |
| 15 | Microstructure and properties of pead-free Bi1/2 Na1/2 TiO3 based piezoelectric ceramics doped with different cations显示文摘 | ZHENG B Y VLADIMIR D K BINU K M | 2007 | J Mater Sci2007，42，10： | 1 |
| 16 | Damage induced by thermal cycling of thermal barrier coatings显示文摘 | VLADIMIR K TOLPYGO V K CLARKE D R | 2001 | TMS Proceeding2001，4，： | 1 |
| 17 | The potential role of curcumin in patients with monoclonal gammopathy of undefined significance--its effect on paraproteinemia and the urinary n-telopeptide of type I collagen bone turnover marker显示文摘 | Golombick T Terrence H D Vladimir B | 2009 | Clin Cancer Res2009，15，18： | 1 |
| 18 | Geometrically precisely defined multinanometer expansion/contraction motions in a resorcin arene cavitand based molecular switch显示文摘 | Vladimir A A Anna S Francois D | 2005 | Angew Chem Int Ed2005，44，29： | 1 |
| 19 | Sterically stabilized pH- sensitive liposomes intracellular delivery of aqueous contents and prolonged circulation in vivo显示文摘 | Vladimir AS Sergio SS Paul D | 1997 | Biological Chemistry1997，272，4： | 1 |
| 20 | Oscillatory cluster pat- terns in a homogeneous chemical system with global feedback显示文摘 | Vanag Vladimir K Yang L F Milos D | 2000 | Nature2000，406，： | 1 |
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