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| 1 | Current clinical approach to achalasia显示文摘Idiopathic achalasia is a rare primary motility disorder of the esophagus. The classical features are incomplete relaxation of a frequently hypertensive lower esophageal sphincter (LES) and a lack of peristalsis in the tubular esophagus. These motor abnormalities lead to dysphagia, stasis, regurgitation, weight loss, or secondary respiratory complications. Although major strides have been made in understanding the pathogenesis of this rare disorder, including a probable autoimmune mediated destruction of inhibitory neurons in response to an unknown insult in genetically susceptible individuals, a definite trigger has not been identified. The diagnosis of achalasia is suggested by clinical features and conf irmed by further diagnostic tests, such as esophagogastroduodenoscopy (EGD), manometry or barium swallow. These studies are not only used to exclude pseudoachalasia, but also might help to categorize the disease by severity or clinical subtype. Recent advances in diagnostic methods, including high resolution manometry (HRM), might allow prediction of treatment responses. The primary treatments for achieving long-term symptom relief are surgery and endoscopic methods. Although limited high-quality data exist, it appears that laparoscopic Heller myotomy with partial fundoplication is superior to endoscopic methods in achieving long-term relief of symptoms in the majority of patients. However, the current clinical approach to achalasia will depend not only on patients' characteristics and clinical subtypes of the disease, but also on local expertise and patient preferences. | Alexander J Eckardt Volker F Eckardt | 2009 | World Journal of Gastroenterology2009，15，32： | 20 |
| 2 | Is the schatzki ring a unique esophageal entity?显示文摘AIM:To study,whether the association of Schatzki rings with other esophageal disorders support one of the theories about its etiology.METHODS:From 1987 until 2007,all patients with newly diagnosed symptomatic Schatzki rings (SRs) were prospectively registered and followed.All of them underwent structured interviews with regards to clinical symptoms,as well as endoscopic and/or radiographic examinations.Endoscopic and radiographic studies determined the presence of an SR and additional morphological abnormalities.RESULTS:One hundred and sixty-seven patients (125 male,42 female) with a mean age of 57.1±14.6 years were studied.All patients complained of intermittent dysphagia for solid food and 113 (79.6%) patients had a history of food impaction.Patients experienced symptoms for a mean of 4.7±5.2 years before diagnosis.Only in 23.4% of the 64 patients who had endoscopic and/or radiological examinations before their first presentation to our clinic,was the SR previously diagnosed.At presentation,the mean ring diameter was 13.9±4.97 mm.One hundred and sixty-two (97%) patients showed a sliding hiatal hernia.Erosive reflux esophagitis was found in 47 (28.1%) patients.Twenty-six (15.6%) of 167 patients showed single or multiple esophageal webs;five (3.0%) patients exhibited eosinophilic esophagitis;and four (2.4%) had esophageal diverticula.Four (7%) of 57 patients undergoing esophageal manometry had nonspecific esophageal motility disorders.CONCLUSION:Schatzki rings are frequently associated with additional esophageal disorders,which support the assumption of a multifactorial etiology.Despite typical symptoms,SRs might be overlooked. | Michaela Müller Ines Gockel Philip Hedwig Alexander J Eckardt Kathrin Kuhr Jochem Knig Volker F Eckardt | 2011 | World Journal of Gastroenterology2011，17，23： | 2 |
| 3 | FOLFIRI plus cetuximab versus FOLFIRI plus bevacizumab as first-line treatment for patients with metastatic colorectal cancer (FIRE-3): a randomised, open-label, phase 3 trial显示文摘 | Volker Heinemann Ludwig Fischer von Weikersthal Thomas Decker Alexander Kiani Ursula Vehling-Kaiser Salah-Eddin Al-Batran Tobias Heintges Christian Lerchenmüller Christoph Kahl Gernot Seipelt Frank Kullmann Martina Stauch Werner Scheithauer J?rg Hielscher | 2014 | Lancet Oncology2014，，10： | 2 |
| 4 | Meningeal carcinomatosis: CSF cytology, immunocytochemistry and biochemical tumor markers 显示文摘 | Oschmann P Kaps M Volker J | 1994 | Acta NeurolScand1994，89，5： | 1 |
| 5 | Thomashow components of the Arabidopsis C repeat/dehydration responsive element bindingfactor cold-response pathway are conserved in Brassica napus and other plant species显示文摘 | KIRSTEN R J SUSANNE K KEENAN L A XIN Z VOLKER H JAMES Z Z THOMAS D MICHAEL F | 2001 | Plant Plzysiology2001，127，3： | 1 |
| 6 | Prostaglandin endoperoxide-dependent vasospasm in bovine coronary arteries after nitration of prostacyclin synthase显示文摘 | Michelle J Volker U | 1999 | British J pharmacology1999，12，6： | 1 |
| 7 | A polyketide synthase in glycopeptide biosynthesis 显示文摘 | Volker Pfeifer Graeme J N Johannes R | 2001 | J Biol Chem2001，276，38： | 1 |
| 8 | Round buoyant jet entering shallow water in motion显示文摘 | Johnston A J Nguyen N Volker R E | 1993 | Journal of Hydraulic Research1993，31，1： | 1 |
| 9 | Uterine artery embolization vs hysterectomy in the treatment of symptomatic uterine fibroids:5-year outcome from the randomized EMMY trial显示文摘 | van der Kooij S M Hehenkamp W J Volkers N A | 2010 | Am J Obstet Gynecol2010，203，2： | 1 |
| 10 | Round buoyant jet entering shallow water: bed shear velocity显示文摘 | Johnston A J Nguyen N Volker R E | 1994 | Journal of Hydraulic Research1994，32，2： | 1 |
| 11 | Deletion of CD73 promotes dyslipidemia and intramyocellular lipid accumulation in muscle of mice显示文摘 | Sandra Burghoff Ulrich Fl?gel Sabine Bongardt Volker Burkart Henrike Sell Sara Tucci Kathrin Ikels Daniel Eberhard Matthias Kern Nora Kl?ting Jürgen Eckel Jürgen Schrader | 2013 | Archives Of Physiology And Biochemistry2013，，2： | 1 |
| 12 | Spatially-Resolved Measurement of Dissolved Oxygen in Multi-Stream Microfluidic Devices显示文摘 | VOLKER NOCKk RICHARD J BLA1KIE | 2010 | Sensors2010，10，12： | 1 |
| 13 | , Regulation of bacterial sulfate reduction and hydrogen sulfide fluxes in the central Namibian coastal upwelling zone显示文摘 | Volker Bruehert Bo Barkera JФRGensen | 2003 | Geochimica et Cosmochimica Acta2003，67，2： | 1 |
| 14 | Management of dynamic knowledge显示文摘 | Haase P Volker J | 2005 | Journal of Knowledge Management2005，9，5： | 1 |
| 15 | Recombinant Newcastle disease virus expressing human interleukin -2 serves as a potential candidate for tumor therapy 显示文摘 | Heng Z Markus J Volker S | 2008 | Virus Res2008，136，12： | 1 |
| 16 | Technical aspects of railguns 显示文摘 | Hilmar P Francis J Volker W | 1995 | IEEE Transaetions on Magnetics1995，31，1： | 1 |
| 17 | Identification and monitoring of Ulmus americana transcripts during in vitro interactions with the Dutch elm disease pathogen Ophiostoma novo-ulmi显示文摘 | MIRELLA A VOLKER J BRIAN B | 2010 | Physiological and Molecular Plant Pathology2010，5，： | 1 |
| 18 | Early cisternal fibrinolysis is more effective than rescue spasmolysis for the prevention of delayed infarction after subarachnoid haemorrhage显示文摘Background To compare the efficacy of two different concepts of cisternal therapy—PREVENTIVE fibrinolysis plus on-demand spasmolysis versus RESCUE spasmolysis—for the prevention of cerebral vasospasm(CVS)and delayed cerebral infarction(DCI)in patients with aneurysmal subarachnoid haemorrhage(aSAH).Methods Retrospective analysis of 84 aSAH patients selected for cisternal therapy for DCI prevention.66 high-risk patients received PREVENTIVE cisternal therapy to enhance blood clearance.Either stereotactic catheter ventriculocisternostomy(STX-VCS)or intraoperative placement of a cisterno-ventriculostomy catheter(CVC),followed by fibrinolytic cisternal lavage using urokinase was performed.In case of vasospasm,nimodipine was applied intrathecally.22 low-risk patients who developed CVS against expectations were selected for STX-VCS as RESCUE intervention for cisternal spasmolysis with nimodipine.Rates of DCI and mean flow velocities of daily transcranial Doppler(TCD)ultrasonographies were evaluated.Results Despite a higher prespecified DCI risk,patients selected for PREVENTIVE intervention primarily aiming at blood clearance had a lower DCI rate compared with patients selected for intrathecal spasmolysis as a RESCUE therapy(11.3%vs 18.2%).After intrathecal treatment onset,CVS(TCD>160 cm/s)occurred in 45%of patients with PREVENTIVE and 77%of patients with RESCUE therapy(p=0.013).A stronger response of CVS to intrathecal nimodipine was observed in patients with PREVENTIVE intervention as the mean CVS duration after start of intrathecal nimodipine was 3.2 days compared with 5.8 days in patients with RESCUE therapy(p=0.026).Conclusions PREVENTIVE cisternal therapy directed at blood clearance is more effective for the prevention of CVS and delayed infarction compared with cisternal RESCUE spasmolysis. | Roland Roelz Christian Scheiwe Jürgen Grauvogel Istvan Csok Volker Arnd Coenen Jürgen Beck Peter C Reinacher | 2022 | Stroke & Vascular Neurology2022，7，2： | 1 |
| 19 | Effects of omega- 3 fatty acid deficiency on rat intestinal structure and microbiology 显示文摘 | Ralph H Volker D Chin J | 2004 | Asia Psc J Clin Nutr2004，，： | 1 |
| 20 | Round buoyant jet entering shallow water in motion显示文摘 | Johnston A J Nguyen N Volker R E | 1993 | Journal of Hydraulic Research1993，31，1： | 1 |
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