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| 1 | 血脂、脂蛋白和载脂蛋白作为心肌梗死风险标志物(INTER-HEART研究):在52个国家进行的一项病例对照研究显示文摘背景载脂蛋白作为冠心痛的标志物是否优于血脂和脂蛋白,目前存在广泛争议。本研究旨在对载脂蛋白和胆固醇作为急性心肌梗死风险指标进行比较.
方法在52个国家的12461例急性心肌梗死患者和14637例年龄(±5岁)、性别匹配的对照者中进行了一项有关急性心肌梗死的大型、标准化病例对照研究。获得了9345例急性心肌梗死患者和12120例对照者的非空腹血液样本。测定了血脂、脂蛋白和载脂蛋白浓度,并计算了胆固醇和栽脂蛋白比值通过比较五分位数的上四位与最低位,计算每一总体测值和每一种族组的优势比(0R)及其95%CI以及人群归因危险度(PAR)。
结果载脂蛋白B100(ApoB)/载脂蛋白A1(ApoA1)比值的PAR最高(54%),其每一标准差差别的OR最高(1.59,95%CI1.53~1.64)。LDL胆固醇/HDL-胆固醇比值的PAR为37%;总胆固醇/HDL-胆固醇的PAR为32%,其显著低于ApoB/A1比值的PAR(P〈0.0001)。这些结果在所有种族组、男女两性组及所有年龄组均一致。
结论在所有种族组、男女两性组及所有年龄组,非空腹ApoB/A1比值在评估急性心肌梗死风险方面优于任何胆固醇比值,其应当被引入全世界的临床实践中。 | Matthew J McQueen Steven Hawken Xingyu Wang Stephanie Ounpuu Allan Sniderman Jeffrey Probstfield Krisela Steyn John E Sanderson Mahammad Hasani Emilia Volkova Khawar Kazmi Salim Yusuf 郭战宏(译) | 2008 | 世界临床医学2008，2，6： | 3 |
| 2 | IRES-driven expres- sion of the capsid protein of the Venezuelan equine encephalitis virus TC-83 vaccine strain increases its attenuation and safety显示文摘 | Guerbois M Volkova E Forrester NL | 2013 | PLoS Negl Trop Dis2013，7，5： | 1 |
| 3 | Psychotherapeutic rehabilitation of patients after surgical treatment of ulcer and cholelithiasis at a spa显示文摘 | Volkova E V Vorotyntsev G F | 2008 | Vopr Kurortol Fizioter Lech Fiz Kult2008，1，1： | 1 |
| 4 | Chimeric alphavirus vaccine candidates for chikungunya 显示文摘 | Wang E Volkova E Adams AP Forrester N Xiao SY Frolov I Weaver SC | 2008 | Vaccine2008，26，39： | 1 |
| 5 | 显示文摘 | Sorokin A D Volkova E V Naberezhnykh R A | 1972 | Radiat Khim1972，2，： | 1 |
| 6 | Yield stress in magnetorheological and electrorheological fluids: A comparison between microscopic and macros - copic structural models显示文摘 | E LEMAIREG B VOLKOVA O | 1997 | Rheol1997，41，3： | 1 |
| 7 | 显示文摘 | Naberezhnykh R A Sorokin A D Volkova E V | 1974 | Izv Akad Nauk SSR Ser Khim1974，1，： | 1 |
| 8 | IRES-dependent replica- tion of Venezuelan equine encephalitis virus makes it highly attenuated and incapable of replicating in mosquito cells 显示文摘 | Volkova E Frolova E Darwin J | 2008 | Virology2008，377，1： | 1 |
| 9 | Lipids, lipoproteins, and apolipoproteins as risk markers of myocardial infarction in 52 countries (the INTERHEART study): a case-control study显示文摘 | Matthew J McQueen Steven Hawken Xingyu Wang Stephanie Ounpuu Allan Sniderman Jeffrey Probstfield Krisela Steyn John E Sanderson Mohammad Hasani Emilia Volkova Khawar Kazmi Salim Yusuf | 2008 | The Lancet2008，，9634： | 1 |
| 10 | Hollow silicate microspheres from fly ashes of the Chelyabinsk brown coals (South Urals, Russia) 显示文摘 | Sokol E V Maksimova N V Volkova N I | 2000 | Fuel Processing Technology2000，67，： | 1 |
| 11 | Cognitive learning technology:DI-approach1显示文摘 | Volkova E V | 2015 | Procedia-Social and Behavioral Sciences2015，，1： | 1 |
| 12 | Effect of alloying elements on the formation of rolling texture in Mg-Nd-Zr and Mg-Li alloys显示文摘 | Betsofen S Y Volkova E F Shaforostov A A | 2011 | Russian Metallurgy(Metally)2011，，1： | 1 |
| 13 | Composition of Li-F granite melt and itsevolution during the formation of the ore-bearing Orlovkamassif in Eastern Transbaikalia显示文摘 | Badanina E V Syritso L F Volkova E V Thomas R Trumbull R B | 2010 | Petrology2010，18，2： | 1 |
| 14 | The apoptosis inhibitor survivin in transitional cell carcinoma of the urinary bladder显示文摘 | Vol'pina O M Zavalishina L E Volkova T D | | 0，，02： | 1 |
| 15 | Features of ultrasound diagnosis of non-epithelial ovarian carcinoma显示文摘 | Meshkova I E Volkova A V Semenov I I | 2007 | Vopr Onkol2007，53，3： | 1 |
| 16 | Association of angiopoietin-2, C-reactive protein and markers of obesity and insulin resistance with survival outcome in colorectal cancer 显示文摘 | Volkova E Willis J A Wells J E | 2011 | Sr J Cancer2011，104，1： | 1 |
| 17 | Marginal effects of glucose, insulin and insulin - like growth factor on chemotherapy response in endothelial and colorectal cancer cells 显示文摘 | Volkova E Robinson BA Willis J | 2013 | Oncol Lett2013，7，2： | 1 |
| 18 | 显示文摘 | Skipetrov E P Zvereva E A Volkova O S | 2002 | Mater Sci Eng B2002，91，： | 1 |
| 19 | Cytokine status in patients with chronic obstructive puonary diseases and its relationship with bone tissue functional state显示文摘 | KOCHETKOVA E A VOLKOVA M V SUROVENKO T N | 2004 | Ter Arkh2004，76，3： | 1 |
| 20 | Walking improves your cognitive map in environments that are large-scale and large in extent显示文摘 | RUDDLE R A VOLKOVA E BLTHOFF H H | 2011 | ACM Transactions on computer-human interaction(TOCHI)2011，18，2： | 1 |
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