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| 1 | Fecal lactoferrin accurately reflects mucosal inflammation in inflammatory bowel disease显示文摘BACKGROUND Studies have demonstrated a potential role for fecal biomarkers such as fecal calprotectin(FC)and fecal lactoferrin(FL)in monitoring inflammatory bowel diseases(IBD)-Crohn's disease(CD)and ulcerative colitis(UC).However,their correlation to endoscopic scores,disease severity and affected intestinal surface has not been extensively investigated.AIM To correlate FL,and for comparison white blood cell(WBC)and C-reactive protein(CRP),with endoscopic scores,disease extent and location in CD and UC.METHODS Retrospective analysis in 188 patients who had FL,CRP and WBC determined within 30 d of endoscopy.Disease location,disease extent(number of intestinal segments involved),disease severity(determined by endoscopic scores),timing of FL testing in relation to colonoscopy,as well as the use of effective fast acting medications(steroids and biologics)between colonoscopy and FL measurement,were recorded.RESULTS In 131 CD and 57 UC patients,both CRP and FL-but not WBC-distinguished disease severity(inactive,mild,moderate,severe).In patients receiving fastacting(steroids or biologics)treatment in between FL and colonoscopy,FL showed a higher correlation to endoscopic scores when tested before vs after the procedure(r=0.596,P<0.001,vs r=0.285,P=0.15 for the Simple Endoscopic Score for CD;and r=0.402,P=0.01 vs r=0.054 P=0.84 for Disease Activity Index).Finally,FL was significantly correlated with the diseased mucosal surface(colon-ileocolon>small bowel)and the number of inflamed colon segments.CONCLUSION FL and CRP separated disease severity categories with FL showing lower discriminating P-values.FL showed a close correlation with the involved mucosal surface and with disease extent and was more closely correlated to endoscopy when determined before the procedure–this indicating that inflammatory activity changes associated with therapy might be rapidly reflected by FL levels.FL can accurately and timely characterize intestinal inflammation in IBD. | Marrieth G Rubio Kofi Amo-Mensah James M Gray Vu Q Nguyen Sam Nakat Douglas Grider Kim Love James H Boone Dario Sorrentino | 2019 | World Journal of Gastrointestinal Pathophysiology2019，10，5： | 4 |
| 2 | The Super-oxide synt hases of rose cells-comparison of Assays 显示文摘 | MURPHY TM vU H NGUYEN T | 1998 | Plant Physiol1998，17，： | 1 |
| 3 | Symmetric and asymmetric DNA methylation in the human IGF2-H19 imprinted region 显示文摘 | Vu T H Li T Nguyen D | 2000 | Genomies2000，64，2： | 1 |
| 4 | Phase 1 study of concurrent sunitinib and image guided radiotherapy followed by maintenance sunitinib for patients with oligometastases: acute toxicity and pre- liminary response显示文摘 | KAO J PACKER S VU H L | 2009 | Cancer2009，115，15： | 1 |
| 5 | Skyframe: a framework for skyline query processing in peer-to-peer systems 显示文摘 | Wang Shi-yuan Vu Q H Ooi B C | 2009 | The VLDB Journal2009，18，： | 1 |
| 6 | The Cytomegaloviral Protein pUL138Acts as Potentiator of Tumor Necrosis Factor(TNF)Receptor 1Surface Density To Enhance ULb'-Encoded Mod?lation of TNF-alpha Signaling显示文摘 | Vu T Trilling M Hengel H | 2011 | JOURNAL OF VIROLOGY2011，85，13： | 1 |
| 7 | Telomerase activity in human development is regulated by human telomerase reverse transcriptase (hTERT)transcription and by alternate splicing of hTERT transcripts显示文摘 | Ulaner G A Hu J F Vu T H | 1998 | Cancer Res1998，58，： | 1 |
| 8 | CELESTID:an implicit, fully kinetic model for low-frequency, electromagnetic plasma simulation 显示文摘 | Vu H X Brackbill J U | 1992 | Computer Physics Communications1992，69，： | 1 |
| 9 | Leaching of Manganese Deep O- eean Nodules in FeSO4-HzSO4-HzO Solutions显示文摘 | Vu H Jandova J Lisal K | 2005 | Hydro- metallurgy2005，77，12： | 1 |
| 10 | Effects if ebgabced UV-B radiation (280~320 nm) on ribulise-1,5-bisphos-phate carbox yla se in pea and soybean显示文摘 | VU C V ALLEN L H GARRARD L A | 1983 | Environ Exp Bot1983，23，： | 1 |
| 11 | Blocking probability for priority classes in optical burst switching networks 显示文摘 | Vu H L Zukerman M | 2002 | IEEE Communications Letters2002，6，5： | 1 |
| 12 | Lutein and zeaxanthin and the risk of cataract: the Melbourne visual impairment project 显示文摘 | Vu H T Robman L Hodge A | 2006 | Invest Ophthalmol Vis Sci2006，47，： | 1 |
| 13 | Effect of pre-treatment on convective drying of tomatoes显示文摘 | Lewicki P P Vu Le H Pomarafiska-Lazuka W | 2002 | Journal of Food Engineering2002，54，2： | 1 |
| 14 | Fabrication of photocatalytic composite of multi-walled carbon nanotubes/TiO2 and its application for desulfurization of diesel显示文摘 | VU T H T NGUYEN T T T NGUYEN P H T | 2012 | Mater Res Bull2012，47，2： | 1 |
| 15 | Simulation and optimisation of direct contact membrane distillation for energy efficiency显示文摘 | Bui V A Vu L T T Nguyen M H | 2010 | Desalination2010，259，13： | 1 |
| 16 | Predictive parameters of CyberKnife fiducial-less (XSight Lung) applicability for treatment of early non-small cell lung cancer:a single-center experience显示文摘 | Bahig H Campeau MP Vu T | 2013 | Int J Radiat Oncol Biol Phys2013，87，3： | 1 |
| 17 | Interactions of human mesang ial cells with IgA and IgA containing immune complexes显示文摘 | Novak J Vu H L Novak L | 2002 | Kidney Int2002，62，： | 1 |
| 18 | An improved voltage control on large-scale powersystem 显示文摘 | Vu H Pruvot P Launay C | 1996 | 1EEE Trans on Power Systems1996，11，3： | 1 |
| 19 | Humidity control materials prepared from diatomite and volcanic ash 显示文摘 | Vu D H Wang K S Bac D H | 2013 | Construction and Building Materials2013，38，1： | 1 |
| 20 | Matrix metalloproteinases:effectors of development and normal physiology显示文摘 | Vu Zena Werb | 2000 | Genes Dev2000，14，17： | 1 |
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