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	题名	作者	年代	出处	被引量
1	Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6显示文摘	Hacker H Vabulas RM Takeuchi O	2000	J Exp Med2000，192，4：	1
2	The endoplasmic reticulum-resident heat shock protein gp96 activates dendritic cells via the toll-like receptor 2/4 pathway显示文摘	Vabulas RM Braedel S Hilf N	2002	The Journal of Biological Chemistry2002，277，20：	1
3	Myeloid differentiation factor 88 deficiency improves resistance against sepsiscaused by polymicrobial infection显示文摘	Weighardt H Kaiser MS Vabulas R	2002	J Immunol2002，169，：	1
4	HSP70 as endogenous stimtdus of the Toll/interleuldn - 1 receptor signal pathway显示文摘	Vabulas RM Ahmad -Nejad P Ghose S etal	2002	J Biol Chem2002，277，15：	1
5	Endocytosed HSP60s use toll-like receptor 2(TLR2)and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells显示文摘	Vabulas RM Ahmad-Nejad P Costa C		0，，：	1
6	HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway显示文摘	Vabulas R M Ahmad-Nejad P Ghose S	2002	J Biol Chem2002，277，15：	1
7	Endocytosed HSP60s use toll-like receptor 2 (TLR2) and TLR4 to activate the toll/interleukin-1 receptor signaling pathway in innate immune cells显示文摘	Vabulas R M Ahmad-Nejad P Da Costa C	2001	J Biol Chem2001，276，31：	1
8	The protective role of m A during stress-induced granulation显示文摘Post-transcriptional methylation of N6-adenine and Nl-adenine can affect transcriptome turnover and translation.Furthermore,the regulatory function of N6-methyladenine(m6A)during heat shock has been uncovered,including the enhancement of the phase separation potential of RNAs.In response to acute stress,e.g.heat shock,the orderly sequestration of mRNAs in stress granules(SGs)is considered important to protect transcripts from the irreversible aggregation.Until recently,the role of N1-methyladenine(m^(1)A)on mRNAs during acute stress response remains largely unknown.Here we show that the methyltransferase complex TRMT6/61A,which generates the tag,is involved in transcriptome protection during heat shock.Our bioinformatics analysis indicates that occurrence of the motif is increased in mRNAs known to be enriched in SGs.Accordingly,the m^(1)A-generating methyltransferase TRMT6/61A accumulated in SGs and mass spectrometry confirmed enrichment of in the SG RNAs.The insertion of a single methylation motif in the untranslated region of a reporter RNA leads to more efficient recovery of protein synthesis from that transcript after the return to normal temperature.Our results demonstrate far-reaching functional consequences of a minimal RNA modification on N1-adenine during acute proteostasis stress.	Marion Alriquet Giulia Calloni Adrian Martinez-Limon Riccardo Delli Ponti Gerd Hanspach Martin Hengesbach Gian G.Tartaglia R.Martin Vabulas	2020	Journal of Molecular Cell Biology2020，12，11：	1
9	Immune cell activation by bacterial CpG-DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF) 6显示文摘	Hacker H Vabulas RM Takeuchi O Hoshino K Akira S Wagner H	2000	J Exp Med2000，192，：	1
10	Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells 显示文摘	Sparwasser T Koch ES Vabulas RM	1998	Eur J Immunol1998，28，6：	1
11	Endocytosed HSP60s use Toll-like receptor 2 and TLR4 to activate the Toll/interleukin-1 receptor signaling pathway in innate immunce cells显示文摘	Vabulas RM hmad-Nejad P da Costa C	2001	JBiol Chem2001，276，31：	1
12	Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments显示文摘	Ahmad-Nejad P Hacker H Rutz M Bauer S Vabulas RM Wagner H	2002	Eur J Immunol2002，32，：	1
13	Hsp70 as endogenous stimulus of the Toll/ interleukin-1 receptor signal pathway显示文摘	Vabulas R M Ahmad-Nejad P Ghose S	2002	The Journal of Biological Chemistry2002，277，15：	1
14	HSP70 as endogenous stimulus of the Toll/interleukin - I receptor signal pathway 显示文摘	Vabulas RM Ahmad - Nejad P Ghose S	2002	Bioi Chem2002，277，15：	1
15	Immune cell activation by bacterial CpG2DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor 2 associated factor TRAF6 显示文摘	Hacker H Vabulas RM Takeuchi O	2000	J Mex Med2000，192，4：	1
16	HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway显示文摘	Vabulas RM Ahmad-Nejad P Ghose S		0，，17：	1
17	Immune cell activation by bacterial CpG -DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor-associated factor (TRAF)6显示文摘	Hacker H Vabulas RM Takeuchi 0	2000	J Exp Med2000，192，4：	1
18	Bacterial DNA and immunostimulatory CpG oligonucleotides trigger maturation and activation of murine dendritic cells显示文摘	Sparwasser T Koch ES Vabulas RM	1998	Eur J Immunol1998，28，6：	1
19	Immune cell activation by bacterial CpG - DNA through myeloid differentiation marker 88 and tumor necrosis factor receptor- associated factor (TRAF) 6显示文摘	Hacker H Vabulas RM Takeuchi O	2000	J Exp Med2000，192，4：	1
20	HSP70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway 显示文摘	Vabulas RM Ahmad-Nejad P Ghose S	2002	J Biol Chem2002，277，15：	1

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