|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Bactericidal and anti-adhesive properties of culinary and medicinal plants against Helicobacter pylori显示文摘AIM: To investigate the bactericidal and anti-adhesive properties of 25 plants against Helicobacter pylori (H pylori).METHODS: Twenty-five plants were boiled in water to produce aqueous extracts that simulate the effect of cooking. The bactericidal activity of the extracts was assessed by a standard kill-curve with seven strains of H pylori. The anti-adhesive property was assessed by the inhibition of binding of four strains of FITC-labeled H pylori to stomach sections. RESULTS: Of all the plants tested, eight plants, including Bengal quince, nightshade, garlic, dill, black pepper, coriander, fenugreek and black tea, were found to have no bactericidal effect on any of the isolates. Columbo weed, long pepper, parsley, tarragon, nutmeg, yellow-berried nightshade, threadstem carpetweed, sage and cinnamon had bactericidal activities against H pylori, but total inhibition of growth was not achieved in this study. Among the plants that killed H pylori, turmeric was the most efficient, followed by cumin, ginger, chilli, borage, black caraway, oregano and liquorice. Moreover, extracts of turmeric; borage and parsley were able to inhibit the adhesion of H pylori strains to the stomach sections.CONCLUSION: Several plants that were tested in our study had bactericidal and/or anti-adhesive effects on H pylori. Ingestion of the plants with anti-adhesive properties could therefore provide a potent alternative therapy for H pylori infection, which overcomes the problem of resistance associated with current antibiotic treatment. | Rachel O'Mahony Huda Al-Khtheeri Deepaka Weerasekera Neluka Fernando Dino Vaira John Holton Christelle Basset | 2005 | World Journal of Gastroenterology2005，11，47： | 29 |
| 2 | Cytoreduction and hyperthermic intraperitoneal chemotherapy in the treatment of peritoneal carcinomatosis from pseudomixoma peritonei显示文摘AIM:To investigate the most important aspects of hyperthermic intraperitoneal chemotherapy (HIPEC) that has been accepted as the standard treatment for pseudomyxoma peritonei (PMP),with special regard to morbidity,overall survival (OS) and disease free survival (DFS) over 10 years. METHODS:Fifty-three patients affected by PMP underwent cytoreduction (CCR) and HIPEC with a 'semi-closed' abdomen technique in our institution. The peritonectomy procedure and completeness of CCR were classifi ed according to Sugarbaker criteria. Preoperative evaluation always included thoracic and abdominal CT scan to stage peritoneal disease and exclude distant metastases. Fifty-one patients in our series were treated with a protocol based on administration of cisplatinum 100 mg/m2 plus mitomycin C 16 mg/m2,at a temperature of 41.5℃ for 60 min. Anastomoses were always performed at the end of HIPEC. The mean duration of surgery was 12 h including HIPEC. Continuous monitoring of hepatic and renal functions and hydroelectrolytic balance was performed in the postoperative period. RESULTS:Twenty-four patients presented with postoperative complications:surgical morbidity was observed in 16 patients and 6 patients were re-operated. All complications were successfully treated and no postoperative deaths were observed. Risk factors for postoperative morbidity were considered to be gender,age,body surface,duration of surgery,Peritoneal Cancer Index (PCI) and tumor residual value (CC score). No statistically signifi cant correlation was found during the multivariate analysis:only the CC score was statistically significant. The OS in our experience was 81.8%,with a DFS of 80% at 5 years and of 70% at 10 years. CONCLUSION:In our experience,even if HIPEC combined with cytoreductive surgery involves a high risk of morbidity,postoperative complications can be resolved favorably in most cases with correct patient selection and adequate postoperative care,thus minimizing mortality. The association of CCR and HIPEC can be considered as the standard treatment for PMP. The OS and DFS results confi rm the validity of this combined approach for the treatment of this rare neoplasm. The impact of preoperative chemotherapy on OS,in our opinion,is due to a major aggressiveness of tumors in treated patients. | Tommaso Cioppa Marco Vaira Camilla Bing Silvia D'Amico Alessandro Bruscino Michele De Simone | 2008 | World Journal of Gastroenterology2008，14，44： | 13 |
| 3 | Helicobacter pylori and functional dyspepsia: An unsolved issue?显示文摘Patients with Helicobacter pylori(H. pylori) infection may complain of dyspeptic symptoms without presence of macroscopic lesions on gastroduodenal mucosa. Such a condition is usually recognized as functional dyspepsia, and different pathogenetic mechanisms are involved. The role of H. pylori in these patients is controversial. Several trials assessed the potential role of H. pylori eradication in improving dyspeptic symptoms, and data of some meta-analyses demonstrated that cure of infection is associated with a small(10%), but significant therapeutic gain as compared to placebo. The reason for which dyspeptic symptoms regress in some patients following bacterial eradication, but persist in others remains unclear. Regrettably, trials included in the meta-analyses are somewhat different for study design, definition of symptoms, assessment of symptoms changes, and some may be flawed by potential pitfalls. Consequently, the information could be not consistent. We critically reviewed the main available trials, attempting to address future research in this | Angelo Zullo Cesare Hassan Vincenzo De Francesco Alessro Repici Raffaele Manta Silverio Tomao Bruno Annibale Dino Vaira | 2014 | World Journal of Gastroenterology2014，20，27： | 8 |
| 4 | Global eradication rates for Helicobacter pylori infection: systematic review and meta-analysis of sequential therapy显示文摘 | Luigi Gatta Nimish Vakil Dino Vaira Carmelo Scarpignato | 2013 | BMJ (aug )2013，，071： | 7 |
| 5 | Global eradication rates for Helicobacter pylori infection: systematic review and meta-analysis of sequential therapy显示文摘 | Luigi Gatta Nimish Vakil Dino Vaira Carmelo Scarpignato | 2013 | BMJ2013，，0： | 5 |
| 6 | Epidemiological profiles of human immunodeficiency virus and hepatitis C virus infections in Malian women:Risk factors and relevance of disparities显示文摘AIM:To document the epidemiologic patterns and risk factors of human immunodeficiency virus(HIV)and hepatitis C virus(HCV)infections in Mali in order to develop prevention means for both diseases.METHODS:Two prospective studies were conducted in Bamako in 2009 among 1000 pregnant women(i.e.,young women)who consulted six reference health centers,and in 2010,among 231 older women who attended general practice in two hospitals.Antibody tests and molecular analysis(performed only for HCV)were used to quantify the frequencies of both infections.The data were collected from patients recruited through a questionnaire.Transmission risk factors of both diseases were identified by univariate and multivariate analysis.RESULTS:HCV seroprevalence was 0.2% for young and 6.5% for older women.HIV prevalence was similar in both populations(4.1% vs 6.1%).In older women,the analysis of risk factors highlighted an association between HCV infection and episodes of hospitalization(P < 0.01).The study did not show an association between HIV infection and the variables such as hospitalization,transfusion,tattoo,dental care,and endoscopy.A significant decrease of HIV seroprevalence was detected in young women who used condoms for contraception more than for other purposes(P < 0.01).By contrast,HIV seroprevalence was significantly increased in young women using condoms mainly to prevent sexual infections rather than for contraception(P < 0.01).No HCV/HIV coinfection was detected in our study.CONCLUSION:Risk factors and epidemiologic data of HIV and HCV as well as the absence of co-infection strongly suggest epidemiological disparities between these diseases. | Nouhoum Bouare Andre Gothot Jean Delwaide Sebastien Bontems Dolores Vaira Laurence Seidel Paul Gerard Christiane Gerard | 2013 | World Journal of Hepatology2013，5，4： | 4 |
| 7 | Effects of Helicobacter pylori Eradication on Early Stage Gastric Mucosa–Associated Lymphoid Tissue Lymphoma显示文摘 | Angelo Zullo Cesare Hassan Francesca Cristofari Alessandro Andriani Vincenzo De Francesco Enzo Ierardi Silverio Tomao Manfred Stolte Sergio Morini Dino Vaira | 2010 | Clinical Gastroenterology and Hepatology2010，，2： | 3 |
| 8 | Culture-Based Selection Therapy for Patients Who Did Not Respond to Previous Treatment for Helicobacter pylori Infection显示文摘 | Giulia Fiorini Nimish Vakil Angelo Zullo Ilaria M. Saracino Valentina Castelli Chiara Ricci Cristina Zaccaro Luigi Gatta Dino Vaira | 2012 | Clinical Gastroenterology and Hepatology2012，，： | 3 |
| 9 | Treatment for H. pylori Infection: New Challenges With Antimicrobial Resistance显示文摘 | Nimish Vakil Dino Vaira | 2013 | Journal of Clinical Gastroenterology2013，，5： | 3 |
| 10 | Global eradication rates for Helicobacter pylori infection: systematic review and meta-analysis of sequential therapy显示文摘 | Luigi Gatta Nimish Vakil Dino Vaira Carmelo Scarpignato | 2013 | BMJ . 2013 (aug0)2013，，： | 2 |
| 11 | HIV resistance to antiretrovlral drugs: mechanisms, genotypic and phenotypic resistance testing in clinical practice显示文摘 | Blaise P Clevenbergh P Vaira D | 2002 | Acta Clin Belg2002，57，： | 1 |
| 12 | Regulation of lung cancer metastasis by Klf4-Numb-like signaling显示文摘 | Vaira V Faversani A Martin NM | 2013 | Cancer Res2013，73，8： | 1 |
| 13 | Estimating the number of integrations in transformed plants by quantitative real-time PCR显示文摘 | Mason G Provero P Vaira A M | 2002 | BMC Biotechnol2002，2，： | 1 |
| 14 | Newer agents for Helicobacter pylori eradication显示文摘 | Dino Vaira | 2012 | Clinical and Experimental Gastroenterology2012，，： | 1 |
| 15 | The stool antigen test for detection of Hehcobacter pylori after eradication therapy显示文摘 | Vaira D Vakil N Menegatti M | | Ann Intem Med0，136，4： | 1 |
| 16 | Helicobacter pylori in patients with gastric and nongastric cancer显示文摘 | Menegatti M Vaira D Miglioli M | 1995 | Am J Gastroenterogyl1995，90，8： | 1 |
| 17 | Sequential therapy versus standard triple-drug therapy for Helicobacter pylori eradication:a randomized trial显示文摘 | Vaira D Zullo A Vakil N | 2007 | Ann Intern Med2007，146，8： | 1 |
| 18 | Helicobacter pylori in patients with gastric and non-gastric cancer显示文摘 | Menegatt M Vaira D Mighholi M | 1995 | Am J Gastroenteral1995，90，： | 1 |
| 19 | Effects of Helicobacter pylori Eradication on Early Stage Gastric Mucosa–Associated Lymphoid Tissue Lymphoma显示文摘 | Angelo Zullo Cesare Hassan Francesca Cristofari Alessandro Andriani Vincenzo De Francesco Enzo Ierardi Silverio Tomao Manfred Stolte Sergio Morini Dino Vaira | 2010 | Clinical Gastroenterology and Hepatology2010，，2： | 1 |
| 20 | High eradication rates of Helicobacter pylori with a new sequential treatment显示文摘 | Zullo A Vaira D Vakil N | 2003 | Aliment Pharmacol Ther2003，17，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员