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| 1 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 2 | TAT-Gap19通过抑制啮齿动物星形胶质细胞的连接蛋白43半通道发挥抗惊厥作用显示文摘越来越多的证据表明,星形胶质细胞连接蛋白43(Cx43)信号在癫痫中发挥至关重要的作用。但是,由于通过实验方法鉴别Cx43间隙连接通道(GJCs)和半通道(HCs)的技术尚不成熟,导致目前尚无法确定哪个通道在癫痫的发生中发挥更重要的作用。因此,本研究观察TAT-Gap19(Cx模拟肽)是否通过抑制Cx43半通道而非Cx43间隙连接通道影响实验诱导的啮齿动物癫痫发作。急性海马切片小鼠染料摄取实验表明,星形胶质Cx43半通道响应化学惊厥毛果芸香碱的作用而开放,并且可被TAT-Gap19抑制。体内实验中,毛果芸香碱诱导的癫痫发作及相伴随的D-丝氨酸微透析液的增长水平被Cx43半通道的抑制所抑制。此外,TAT-Gap19的抗惊厥作用被外源性D-丝氨酸给药逆转,这表明,抑制Cx43半通道可以通过降低细胞外D-丝氨酸水平来防止癫痫发作。抑制Cx43半通道的抗惊厥特性在电癫痫小鼠模型(如急性6 Hz难治性癫痫发作模型和慢性6 Hz角膜点燃模型)中得到了进一步的证实。总而言之,这些结果表明,Cx43半通道在癫痫发作中可以起到一定作用,并且有成为癫痫治疗中新型用药靶点的潜力。 | Walrave L Pierre A Albertini G Aourz N De Bundel D Van Eeckhaut A Vinken M Giaume C Leybaert L Smolders I 聂昊 | 2018 | 神经损伤与功能重建2018，13，6： | 5 |
| 3 | The second European evidence-based Consensus on the diagnosis and management of Crohn’s disease: Current management显示文摘 | A. Dignass G. Van Assche J.O. Lindsay M. Lémann J. S?derholm J.F. Colombel S. Danese A. D’Hoore M. Gassull F. Gomollón D.W. Hommes P. Michetti C. O’Morain T. ?resland A. Windsor E.F. Stange S.P.L. Travis | 2010 | Journal of Crohn’s and Colitis2010，，1： | 2 |
| 4 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 5 | Exploiting the diversity of tomato:the development of a phenotypically and genetically detailed germplasm collection显示文摘A collection of 163 accessions,including Solanum pimpinellifolium,Solanum lycopersicum var.cerasiforme and Solanum lycopersicum var.lycopersicum,was selected to represent the genetic and morphological variability of tomato at its centers of origin and domestication:Andean regions of Peru and Ecuador and Mesoamerica.The collection is enriched with S.lycopersicum var.cerasiforme from the Amazonian region that has not been analyzed previously nor used extensively.The collection has been morphologically characterized showing diversity for fruit,flower and vegetative traits.Their genomes were sequenced in the Varitome project and are publicly available(solgenomics.net/projects/varitome).The identified SNPs have been annotated with respect to their impact and a total number of 37,974 out of 19,364,146 SNPs have been described as high impact by the SnpEeff analysis.GWAS has shown associations for different traits,demonstrating the potential of this collection for this kind of analysis.We have not only identified known QTLs and genes,but also new regions associated with traits such as fruit color,number of flowers per inflorescence or inflorescence architecture.To speed up and facilitate the use of this information,F2 populations were constructed by crossing the whole collection with three different parents.This F2 collection is useful for testing SNPs identified by GWAs,selection sweeps or any other candidate gene.All data is available on Solanaceae Genomics Network and the accession and F2 seeds are freely available at COMAV and at TGRC genebanks.All these resources together make this collection a good candidate for genetic studies. | Estefanía Mata-Nicolás Javier Montero-Pau Esther Gimeno-Paez Víctor Garcia-Carpintero Peio Ziarsolo Naama Menda Lukas A.Mueller JoséBlanca Joaquín Cañizares Esther van der Knaap María JoséDíez | 2020 | Horticulture Research2020，7，1： | 2 |
| 6 | Reevaluation of formulas for predicting creatinine clearance in adults and children,using compensated creatinine methods显示文摘 | Wuyts B Bernard D Van den Noortgate N | 2003 | Clin Chem2003，49，61： | 1 |
| 7 | Claiming more: The increased voluminosity of patent applications and its determinants 显示文摘 | Van Zeebroeck N van Pottelsberghe de la Potterie B Guellec D | 2009 | Research Policy2009，38，6： | 1 |
| 8 | PWM-Switch modeling of DC-DC converters 显示文摘 | Van Dijk E Spruijt J N O'Sullivan D M | 1995 | IEEE Trans on Power Electronics1995，10，6： | 1 |
| 9 | Seismic tomography with P and S data reveals lateral variations in the rigidity of deep slabs显示文摘 | Widiyantoro S Kennett B L N van der Hilst R D | 1999 | Earth and Planetary Science Letters1999，173，： | 1 |
| 10 | In- cidence and determinants of lower extremity running injuries in long distance runners: a systematic submitted for publication 显示文摘 | VAN GENT R N SIEM D VAN MIDDELKOOP M | 2007 | Brit J Sports Med2007，41，8： | 1 |
| 11 | Pectins in processed fruits and vegetables: Part III--stability and catalytic activity of pectinases显示文摘 | Duvetter T Sila D N Van Buggenhout S | 2009 | Comprehensive Reviews in Food Science and Food Safety2009，8，2： | 1 |
| 12 | The cell cycle:a review of regulation, deregulation and therapeutic targets in cancer 显示文摘 | Vermeulen K Van Bockstaele D R Berneman Z N | 2003 | Cell Prolif2003，，16： | 1 |
| 13 | 查看详情显示文摘 | Vlaskin V A Janssen N van Rijssel J Beaulac R Gamelin D R | | 0，，9： | 1 |
| 14 | PWM- switch modeling of DC-DC converters 显示文摘 | Van Dijk E Spruijt H J N O'Sullivan D M | 1995 | IEEE Transactions on Power Electronics1995，10，6： | 1 |
| 15 | Selective formation of para-xylene over H-ZSM-5 coated with polycrystalline sili- calite crystals 显示文摘 | Van Vu D Miyamoto M Nishiyama N | 2006 | Journal of Catalysis2006，243，： | 1 |
| 16 | Func- tional interaction of the ankylosing spondylitis-associated endo- plasmic reticulum aminopeptidase 1 polymorphism and HLA- B27 in vivo显示文摘 | Garcia-Medel N Sanz-Bravo A Van Nguyen D er al | 2012 | Mol Cell Proteomics2012，11，： | 1 |
| 17 | Low level of dopmnin- ergieD2 receptor binding in obsessive-compulsive disorder显示文摘 | Denys D Van Oler Ween N Jansen J | 2005 | Biol Payehiatry2005，54，： | 1 |
| 18 | Synthesis and pharmacological evaluation of thiopyran analogues of the dopamine D3 receptor-selective agonist (4aR,10bR)-(+)-trans-3,4,4a,10b-Tetrahydro-4-n-propyl-2H,5H- benzopyrano-1,4-oxazin-9-ol (PD 128907)显示文摘 | VAN VLIET LA RODENHUIS N DIJKSTRA D | 2000 | JMed Chem2000，43，15： | 1 |
| 19 | The Reverse Supply Chain显示文摘 | Guide J V D Luk N Van W | 2002 | Harvard Business Review2002，80，2： | 1 |
| 20 | The unseen majority: soil microbes as drivers of plant diversity and productivity in terrestrial ecosystems显示文摘 | VAN DER HELIDEN M G A BARDGETT R D VAN STRAALEN N M | 2008 | Ecology Letters2008，11，： | 1 |
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