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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | Near-infrared fluorescence imaging of a solitary fibrous tumor of the pancreas using methylene blue显示文摘A 67-year-old female presented with unexplained abdominal pain. A contrast-enhanced computed tomography scan of the abdomen incidentally revealed a mass in the uncinate process of the pancreas. This mass was resected and based on histopathological findings, diagnosed as a solitary fibrous tumor (SFT) of the pancreas. A SFT is an extremely rare benign mesenchymal tumor that in 65% of cases affects the visceral pleura but can also affect extra-pleural sites. The intraoperative demarcation of pancreatic tumors, such as SFTs, can bechallenging. In this report, the first clear intraoperative identification of a SFT of the pancreas in a human was shown using near-infrared fluorescence and methylene blue. | Joost R van der Vorst Alexander L Vahrmeijer Merlijn Hutteman Tjalling Bosse Vincent THBM Smit Cornelis JH van de Velde John V Frangioni Bert A Bonsing | 2012 | World Journal of Gastrointestinal Surgery2012，4，7： | 7 |
| 3 | miR147b:白细胞介素-1β介导的人类星形胶质细胞炎症中的新型关键调节因子显示文摘星形胶质细胞是大脑炎症过程的重要介质,可能在包括癫痫在内的几种神经系统疾病中起重要作用。星形胶质细胞中可生产几种miRNA,是炎症通路的关键调节因子,还可能用作治疗靶标。本研究将探索在体外IL-1β介导的炎症条件下,星形胶质细胞内生成的miRNA及其功能,并在人癫痫脑组织中验证。我们通过测序评估IL-1β刺激的人胎儿星形胶质细胞培养物中的miRNA和mRNA表达。使用miRNA模拟物在细胞培养物中过表达miRNA。使用原位杂交技术检测患有结节性硬化症复合体或颞叶癫痫伴海马硬化患者的切除脑组织中miRNA的表达。我们发现了2种差异表达的miRNA:miR146a和miR147b,它们与免疫/炎症反应相关基因的表达增加有关。既往有研究报道,在星形胶质细胞和结节性硬化复合细胞培养物中使用IL-1β刺激后,miR147b的过表达降低了促炎介质IL-6和COX-2的表达。miR146a和miR147b过表达降低了星形胶质细胞的增殖并促进人神经干细胞的神经元分化。miR147b在致癫痫脑中的星形胶质细胞中表达增加。由于其抗炎和恢复异常星形细胞增殖和促进神经元分化的能力,miR146a和miR147b作为与炎症相关的神经疾病(例如癫痫)的潜在治疗靶标值得进一步研究。 | van Scheppingen J Mills JD Zimmer TS Broekaart DWM Iori V Bongaarts A Anink JJ Iyer AM Korotkov A Jansen FE van Hecke W Spliet WG van Rijen PC Baayen JC Vezzani A van Vliet EA Aronica E 聂昊 | 2018 | 神经损伤与功能重建2018，13，12： | 3 |
| 4 | 遗传性肥胖与心房颤动的关系显示文摘观察性研究已经确定了体质量指数(body mass index,BMI)与心房颤动之间的关联。然而,从观察性研究中推断因果关系会受到混杂因素、逆因果关系和偏倚的影响。该研究的主要目的是应用BMI的遗传学预测因子评估BMI与心房颤动之间的因果关系。方法:纳入1987-2002年期间在美国、冰岛和荷兰实施的7个前瞻性人群队列研究中基线无心房颤动的欧洲血统个体51 646人, | 刘莉 叶鹏 Chatterjee NA Giulianini F Geelhoed B Lunetta KL Misialek JR Niemeijer MN Rienstra M Rose LM Smith AV Arking DE Ellinor PT Heeringa J Lin H Lubitz SA Soliman EZ Verweij N Alonso A Benjamin EJ Gudnason V Stricker BH van der Harst P Chasman DI Albert CM | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 5 | Exploiting the diversity of tomato:the development of a phenotypically and genetically detailed germplasm collection显示文摘A collection of 163 accessions,including Solanum pimpinellifolium,Solanum lycopersicum var.cerasiforme and Solanum lycopersicum var.lycopersicum,was selected to represent the genetic and morphological variability of tomato at its centers of origin and domestication:Andean regions of Peru and Ecuador and Mesoamerica.The collection is enriched with S.lycopersicum var.cerasiforme from the Amazonian region that has not been analyzed previously nor used extensively.The collection has been morphologically characterized showing diversity for fruit,flower and vegetative traits.Their genomes were sequenced in the Varitome project and are publicly available(solgenomics.net/projects/varitome).The identified SNPs have been annotated with respect to their impact and a total number of 37,974 out of 19,364,146 SNPs have been described as high impact by the SnpEeff analysis.GWAS has shown associations for different traits,demonstrating the potential of this collection for this kind of analysis.We have not only identified known QTLs and genes,but also new regions associated with traits such as fruit color,number of flowers per inflorescence or inflorescence architecture.To speed up and facilitate the use of this information,F2 populations were constructed by crossing the whole collection with three different parents.This F2 collection is useful for testing SNPs identified by GWAs,selection sweeps or any other candidate gene.All data is available on Solanaceae Genomics Network and the accession and F2 seeds are freely available at COMAV and at TGRC genebanks.All these resources together make this collection a good candidate for genetic studies. | Estefanía Mata-Nicolás Javier Montero-Pau Esther Gimeno-Paez Víctor Garcia-Carpintero Peio Ziarsolo Naama Menda Lukas A.Mueller JoséBlanca Joaquín Cañizares Esther van der Knaap María JoséDíez | 2020 | Horticulture Research2020，7，1： | 2 |
| 6 | Interaction between cisplatin and gemcitabine in vitro and in vivo 显示文摘 | Peters G J Bergman A M Ruiz van Haperen V W | 1995 | Semin Oncol1995，22，411： | 1 |
| 7 | The relation between morphology and hydrotreating activity for supported MoS2 particles 显示文摘 | HENSEN E J M KOOYMAN P J Van der MEER Y Van der KRAAN A M de BEER V H J Van VEEN J A R Van SANTEN R A | 2001 | J Catal2001，199，2： | 1 |
| 8 | Changes in volatile production during an infection of potatoes by Erwinia carotovora显示文摘 | LYEW D Y VAN GARIEPY G S V RAGHAVAN A C | 2001 | Food Research International2001，34，： | 1 |
| 9 | Process mining for ubiquitous mobile systems: an overview and a concrete algorithm 显示文摘 | Ana K A d M Boudewijn F van D Wil M P v d A | 2004 | Ubiquitous Mobile Information and Collaboration Systems2004，3272，1： | 1 |
| 10 | Supply chain management in food chains:Im proving performance by reducing uncertainty显示文摘 | VAN D V BEULENS A J M WIT W D | 1998 | International Transactions in Operational Research1998，5，6： | 1 |
| 11 | 查看详情显示文摘 | Vlaskin V A Janssen N van Rijssel J Beaulac R Gamelin D R | | 0，，9： | 1 |
| 12 | Globai estimates of ambient fine particulate matter concentrations from satellite-based aerosol optical depth: Development and application显示文摘 | VAN DONKELAAR A MARTIN R V BRAUER M | 2010 | Environ Health Perspectives2010，118，6： | 1 |
| 13 | A siliconbased electrical source of surface plasmon polaritons显示文摘 | Walters RJ van Loon R V A Brunets I | 2009 | Nature Materials2009，，： | 1 |
| 14 | Synergistic interaction between ciaplatin and gemcitabine in vitro 显示文摘 | Bergman A M Ruiz van Haperen V W Veerman G | 1996 | Clin Cancer Res1996，2，3： | 1 |
| 15 | Release to the gas phase of inorganic elements during wood combustion ( 1 ) : Development and evaluation of quantification methods 显示文摘 | VAN LITH S C ALONSO-RAMIREZ V JENSEN P A | 2006 | Energy & Fuels2006，20，3： | 1 |
| 16 | Three-dimensional mesoscale dynamics of block copolymers under shear: The dynamic density-functional approach显示文摘 | Zvelindovsky A V Sevink G J A van Vlimmeren B A C | 1998 | Phys Rev E1998，57，： | 1 |
| 17 | Effect of nitrogen concentration on fructan metabolizing enzymes in young chicory plants (Cichorium intybus)显示文摘 | Van den Ende W Roover J D Laere A V | 1999 | Physiologia Plantarum1999，105，： | 1 |
| 18 | Increased lipolysis and decreased leptin production by human omental as compared with subcutaneous preadipocytes显示文摘 | van Harmelen V Dicker A Ryden M | 2002 | Diabetes2002，51，7： | 1 |
| 19 | Infectious bronchitis subpopulation in vaccinated chickens afterchallenge显示文摘 | Toro H Pennington D Gallardo R A van Santen V L | 2012 | Avian Dis2012，56，3： | 1 |
| 20 | Definition and classification of power system stability 显示文摘 | KUNDUR P PASERBA J AJJARAPU V ANDERSSON G BOSE A CANIZARES C HATZIARGYRIOU N HILL D STANKOVICA TAYLOR C van CUTSEM T VITTAL V | 2004 | IEEE Transactions on Power Systems2004，19，3： | 1 |
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