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| 1 | Cerebrospinal fluid levels of total-tau,phospho-tau and A beta 42 predicts development of Alzheimer's disease in patients with mild cognitive impairment显示文摘 | Andreasen N Vanmechelen E Vanderstichele H | 2003 | Acta Neurol Scand Suppl2003，179，： | 1 |
| 2 | Increased total-Tau levels in cerebrospinal fluid of pediatric hydrocephalus and brain tumar patients显示文摘 | Bont M J Vanderstichele H Reddingius RE | 2007 | Eur J Paediat Neurol2007，9，1： | 1 |
| 3 | Diagnosis-Independent Alzheimer Disease Biomarker Signature in Cognitively Normal Elderly People显示文摘 | De Meyer G Shapiro F Vanderstichele H | | 0，，08： | 1 |
| 4 | Tau and Abeta42 in cerebrospinal fluid from healthy adults 21 -93 years of age:establishment of reference values显示文摘 | Sjogren M Vanderstichele H Agren H | 2001 | Clin Chem2001，47，： | 1 |
| 5 | Effect of the micro-environment on α-synuclein conversion and implication in seeded conversion assays显示文摘Background: α-Synuclein is a small soluble protein,whose physiological function in the healthy brain is poorly understood.Intracellular inclusions of α-synuclein,referred to as Lewy bodies(LBs),are pathological hallmarks ofαsynucleinopathies,such as Parkinson’s disease(PD)or dementia with Lewy bodies(DLB).Main body:Understanding of the molecular basis as well as the factors or conditions promoting α-synuclein misfolding and aggregation is an important step towards the comprehension of pathological mechanism ofαsynucleinopathies and for the development of efficient therapeutic strategies.Based on the conversion and aggregation mechanism of α-synuclein,novel diagnostic tests,such as protein misfolding seeded conversion assays,e.g.the real-time quaking-induced conversion(RT-QuIC),had been developed.In diagnostics, α-synuclein RT-QuIC exhibits a specificity between 82 and 100%while the sensitivity varies between 70 and 100%among different laboratories.In addition,the α-synuclein RT-QuIC can be used to study the α-synuclein-seeding-characteristics of different α-synucleinopathies and to differentiate between DLB and PD.Conclusion:The variable diagnostic accuracy of current α-synuclein RT-QuIC occurs due to different protocols,cohorts and material etc..An impact of micro-environmental factors on the α-synuclein aggregation and conversion process and the occurrence and detection of differential misfolded α-synuclein types or strains might underpin the clinical heterogeneity of α-synucleinopathies. | Niccolo Candelise Matthias Schmitz Katrin Thüne Maria Cramm Alberto Rabano Saima Zafar Erik Stoops Hugo Vanderstichele Anna Villar-Pique Franc Llorens Inga Zerr | 2020 | Translational Neurodegeneration2020，9，1： | 1 |
| 6 | Plasma levels of β- Amyloid(1-40), β-Amyloid (1-42 ), and total β-Amyloid remain unaffected in adult patients with hypercholesterolemia after treatment with statins 显示文摘 | Hoglund K Wiklund O Vanderstichele H | 2004 | Arch Neurol2004，61，： | 1 |
| 7 | Azithromycin for prevention of exacer- bations in severe asthma (AZISAST): a muhicentre randomized double- blind placebo-controlled trial显示文摘 | Brusselle GG VanderStichele G | 2013 | Thorax2013，，68： | 1 |
| 8 | Tau and Abeta42 in eerebrospinal fluid from healthy adults 21-93 years of age: estab- lishment of reference values显示文摘 | Sjogren M Vanderstichele H Agren H | 2001 | Clin Chem2001，47，10： | 1 |
| 9 | An in vitro model for the study of microglia-induced neurodegeneration:involvement of nitric oxide and tumor necrosis factor-alpha显示文摘 | Hemmer K Fransen L Vanderstichele H | 2001 | Neurochem Int2001，38，： | 1 |
| 10 | Cerebrospinal fluid levels of total-tau,phospho-tau and A beta 42 predicts development of Alzheimer′s disease in patients with mild cognitive impairment显示文摘 | Andreasen N Vanmechelen E Vanderstichele H | 2003 | Acta Neurol Scand Suppl2003，179，： | 1 |
| 11 | Quantification of tau phosphory lated at threonine 181 in human cerebrospinal fluid : a sandwich ELISA with a synthetic phosphopeptide for standardization显示文摘 | Vammechelen E Vanderstichele H Davidsson P | 2000 | Neurosci Lett2000，285，1： | 1 |
| 12 | Cerebrospinal fluid tau and beta-amyloid(1-42) in dementia disorders 显示文摘 | Vanmechelen E Vanderstichele H Hulstaert F | 2001 | Mech Ageing Dev2001，122，16： | 1 |
| 13 | Cerebrospinal fluid biomarker signature in Alzheimcr' s disease neumimaging initiative subjects显示文摘 | Shaw LM Vanderstichele H Knapik-Czajka M | 2009 | Ann Neural2009，65，4： | 1 |
| 14 | Cerebrospinal fluid tau and beta-amyloid (1-42) in dementia disorders显示文摘 | Vanmechelen E Vanderstichele H Hulstaert F | 2001 | Mech Ageing Dev2001，122，： | 1 |
| 15 | Increased total-Tau levels in cerebrospinal fluid of pediatric hydrocephalus and brain tumor patients显示文摘 | de Bont JM Vanderstichele H Reddingius RE | | 0，，04： | 1 |
| 16 | The Alzheimer’s Disease Neuroimaging Initiative 2 Biomarker Core: A review of progress and plans显示文摘 | Ju-Hee Kang Magdalena Korecka Michal J. Figurski Jon B. Toledo Kaj Blennow Henrik Zetterberg Teresa Waligorska Magdalena Brylska Leona Fields Nirali Shah Holly Soares Robert A. Dean Hugo Vanderstichele Ronald C. Petersen Paul S. Aisen Andrew J. Saykin Mic | 2015 | Alzheimer’s & Dementia: The Journal of the Alzhei2015，，7： | 1 |
| 17 | Cere brospinal fluid levels of total-tau,phospho-tau and Aβ42 predicts development of Alzheimer's disease in patients with mild cognitive impairment显示文摘 | Andreasen N Vanmechelen E Vanderstichele H | 2003 | Acta Neurol Scand2003，107，179： | 1 |
| 18 | Cerebrospinal fluid levels of total Tau,phosphor Tau and A beta 42 predicts development of Alzheimer's disease in patients with mild cognitive impairment显示文摘 | Andreasen N Vanmechelen E Vanderstichele H | 2003 | Acta Neurol Scand Suppl2003，179，1： | 1 |
| 19 | Cerebrospinal fluid levels of total tau, phospho tau and A β42 predictsdevelopmentofAlzheimer's diseaseinpatients with mild cognitive impairment显示文摘 | Andreasen N Vanmechelen E Vanderstichele H | 2003 | ActaNeurolScandSuppl2003，179，： | 1 |
| 20 | Diagnosis-independent Alzheimer disease biomarker signature in cognitively normal elderly people显示文摘 | De Meyer G Shapiro F Vanderstichele H | 2010 | Arch Neurol2010，67，： | 1 |
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