|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 2 | Current trends of liver cirrhosis in Mexico: Similitudes and differences with other world regions显示文摘AIM To investigate the main current etiologies of cirrhosis in Mexico.METHODS We performed a cross-sectional retrospective multicenter study that included eight hospitals in different areas of Mexico. These hospitals provide health care to people of diverse social classes. The inclusion criteria were a histological, clinical, biochemical, endoscopic, or imaging diagnosis of liver cirrhosis. Data were obtained during a 5-year period(January 2012-December 2017). RESULTS A total of 1210 patients were included. The mean age was 62.5 years(SD = 12.1), and the percentages of men and women were similar(52.0% vs 48.0%). The most frequent causes of liver cirrhosis were hepatitis C virus(HCV)(36.2%), alcoholic liver disease(ALD)(31.2%), and nonalcoholic steatohepatitis(23.2%), and the least frequent were hepatitis B virus(1.1%), autoimmune disorders(7.3%), and other conditions(1.0%).CONCLUSION HCV and ALD are the most frequent causes of cirrhosis in Mexico. However, we note that non-alcoholic fatty liver disease(NAFLD) as an etiology of cirrhosis increased by 100% compared with the rate noted previously. We conclude that NAFLD will soon become one of the most frequent etiologies of liver cirrhosis in Mexico. | Nahum Méndez-Sánchez Felipe Zamarripa-Dorsey Arturo Panduro Emma Purón-González Edgar Ulises Coronado-Alejandro Carlos Alejandro Cortez-Hernández Fátima Higuera de la Tijera José Luis Pérez-Hernández Eira Cerda-Reyes Heriberto Rodríguez-Hernández Vania César Cruz-Ramón Oscar Lenin Ramírez-Pérez Nancy Edith Aguilar-Olivos Olga Fabiola Rodríguez-Martínez Samantha Cabrera-Palma Guillermo Cabrera-álvarez | 2018 | World Journal of Clinical Cases2018，6，15： | 2 |
| 3 | Security in Stockholms underground stations: The importance of environmental attributes and context 显示文摘 | VANIA C ADRIAAN U ROYA B | 2013 | Security Journal2013，26，： | 1 |
| 4 | Stability and rheological behaviour of salad dressing obtained with whey and different combinations of stabilizers 显示文摘 | Vania de C da F Charles W I H Dayane R I | 2009 | International Journal of Food Science and Technology2009，44，： | 1 |
| 5 | Comparison of three different methods for trehalose determination in yeast extracts显示文摘 | Julio C Ferreira Vania M Paschoalin F | 1997 | Food Chemistry1997，60，2： | 1 |
| 6 | Comparison of three different methods for trehalose determination in yeast extracts显示文摘 | JULIO C F VANIA F P ANITA D P | 1997 | Food Chemistry1997，60，2： | 1 |
| 7 | Evaluating mobility pattern space routing for DTNs显示文摘 | Jeremie L Timur F Vania C | 2009 | IEEE Computer Science2009，12，7： | 1 |
| 8 | Development and validation of passive samplers for atmospheric monitoring of SO2, NO2, O3 and H2S in tropical areas 显示文摘 | Vania P C Llcia P S C Ricardo H M G | 2010 | Microchemical Journal2010，96，1： | 1 |
| 9 | HYMAD:Hybrid DTN-MANET Routing for Dense and Highly Dynamic Wireless Networks显示文摘 | John W Vania C | 2010 | Journal of Computer Communications2010，33，13： | 1 |
| 10 | Combustion process in the synthesis of ZnO- Bi2O3显示文摘 | Vania C de Sousa Morelli Marcio R Kiminami Ruth H G | 2000 | Ceramics International2000，26，： | 1 |
| 11 | HYMAD: hybrid DTN-MANET routing for dense and highly dynamic wireless networks显示文摘 | JOHN W VANIA C | 2010 | Computer Communi- cations2010，33，13： | 1 |
| 12 | Toxi- cological responses of Cyprinus carpio exposed to the herbicide penoxsulam in rice field conditions 显示文摘 | BARBARA C R VANIA L L CAVALHEIRO M C | 2011 | Journal of Applied Toxicology2011，31，7： | 1 |
| 13 | Texture and microstructure of gelatin/corn starch-based gummy confections 显示文摘 | Paulo H M Marfil Ana C B M Anh6 Vania R N Telis | 2012 | Food Biophysics2012，，6： | 1 |
| 14 | Diversity and antibiotic resistance of Aeromonas spp. in drinking and waste water treatment plants显示文摘 | Vania Figueira Ivone Vaz-Moreira Márcia Silva Célia M. Manaia | 2011 | Water Research2011，，17： | 1 |
| 15 | Optimization of parameters of sampling and determination of reduced sulfur compounds using cryogenic capture and gas chromatography in tropical urban atmosphere 显示文摘 | Vania P C Adriana S O Lfcia P S | 2010 | Microchemical Journal2010，，96： | 1 |
| 16 | Comparison of aqueous hu- mor cytokine and chemokine levels in diabetic patients with and without retinopathy显示文摘 | Cheung C M Vania M Ang M | 2012 | Moi Vis2012，18，： | 1 |
| 17 | Extension of Hasselman' s thermal shock theory forcrack/microstructure interac- tions in refractories 显示文摘 | Vania R Salvini Victor C Pandolfelli Richard C Bradt | 2012 | Ceram Int2012，38，3： | 1 |
| 18 | CadF expression in Campflobacter jejuni strains incubated under low-temperature water microcesm conditions which induce the viable but non-culturable(VBNC)state显示文摘 | VANIA P RAFFAELLA C LUCIANA V | 2013 | Antonie van Leeuwenhoek2013，103，5： | 1 |
| 19 | Influence of the concentration of polyols on the rheological and spectral characteristics of guar gum显示文摘 | Poliana M Marinonio L C Vania R N T | 2013 | LWT-Food Science and Technology2013，53，1： | 1 |
| 20 | Functional and structural changes in internal pudendal arteries underlie erectile dysfunction induced by androgen deprivation显示文摘雄激素缺乏强烈与可勃起的机能障碍(编辑) 被联系。不适当的阴茎动脉的血流动是到阴茎海绵体的血流动主要是的编辑的原因从内部 pudendal 动脉(国际语音学协会) 导出的专业之一;然而,没有学习在国际语音学协会功能上评估了雄激素剥夺的效果。我们假设了那阉割损害国际语音学协会反应和结构,在我们的学习贡献编辑, Wistar 雄的老鼠, 8-week-old,被阉割并且在 orchiectomy 以后学习了 30 天。老鼠国际语音学协会的功能、结构的性质是坚定的分别地使用电线和压力肌动描记器系统。蛋白质表示被西方的污点和 immunohistochemistry 决定。血浆睾丸激素层次用 IMMULITE 1000 免疫分析系统被决定。展出的阉割的老鼠损害了可勃起的功能,由减少的 intracavernosal 压力 / 平均数代表了动脉的压力比率。从阉割的老鼠的国际语音学协会展出了减少的 phenylephrine- ,电场刺激(EFS ) 导致了收缩并且减少导致醋胆素、导致 EFS 的 vasodilatation。从阉割的老鼠的国际语音学协会展出了减少的内部直径,外部直径,动脉的墙的厚度,和代表性的区域。阉割减少了 nNOS 和肌动朊表示和增加的骨胶原表示, p38 (Thr180/Tyr182 ) phosphorylation,以及 caspase 3 劈开。在结论,雄激素缺乏与国际语音学协会反应和结构的缺陷被联系并且增加了表明标记的 apoptosis。我们的调查结果建议导致缺乏的脉管的机能障碍是的那雄激素包含 hypotrophic 的一个事件国际语音学协会的脉管的改变。 | Rheure Alves-Lopes Karla B Neves Marcondes AB Silva Vania C Olivon Silvia G Ruginsk Jose Antunes-Rodrigues Leandra NZ Ramalho Rita C Tostes Fernando Silva Carneiro | 2017 | Asian Journal of Andrology2017，19，5： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员